Keiichi I Nakayama


Affiliation: Kyushu University
Country: Japan


  1. Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, et al. Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. J Exp Med. 2019;216:950-965 pubmed publisher
    ..In addition, dysregulation of FBXL5-mediated cellular iron homeostasis was found to be associated with poor prognosis in human HCC, suggesting that FBXL5 plays a key role in defense against hepatocarcinogenesis. ..
  2. Kita Y, Katayama Y, Shiraishi T, Oka T, Sato T, Suyama M, et al. The Autism-Related Protein CHD8 Cooperates with C/EBP? to Regulate Adipogenesis. Cell Rep. 2018;23:1988-2000 pubmed publisher
    ..Our findings reveal a mode of C/EBP? regulation by CHD8 during adipogenesis, with CHD8 deficiency resulting in a defect in the development of white adipose tissue. ..
  3. Mikamo M, Kitagawa K, Sakai S, Uchida C, Ohhata T, Nishimoto K, et al. Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis. Int J Mol Sci. 2018;19: pubmed publisher
    ..Our study suggests that Skp2 is a potential molecular target for human pulmonary fibrosis including IPF. ..
  4. Nakayama S, Yumimoto K, Kawamura A, Nakayama K. Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3. J Biol Chem. 2018;293:5705-5714 pubmed publisher
    ..Our results thus suggest that Fbxw7 controls the transcription of MyRF target genes in various tissues through regulation of MyRF protein stability in a manner dependent on MyRF phosphorylation by GSK-3. ..
  5. Matsumoto M, Nakayama K. The promise of targeted proteomics for quantitative network biology. Curr Opin Biotechnol. 2018;54:88-97 pubmed publisher
    ..Such assays will establish a new paradigm for data-driven science. ..
  6. Hatano A, Matsumoto M, Nakayama K. Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling. Genes Cells. 2016;21:1095-1112 pubmed publisher
  7. Nakayama K, Nagahama H, Minamishima Y, Miyake S, Ishida N, Hatakeyama S, et al. Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell. 2004;6:661-72 pubmed
    ..These data suggest that p27 proteolysis is necessary for the activation of not only Cdk2 but also Cdc2, and that Skp2 contributes to regulation of G(2)-M progression by mediating the degradation of p27. ..
  8. Moroishi T, Yamauchi T, Nishiyama M, Nakayama K. HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism. J Biol Chem. 2014;289:16430-41 pubmed publisher
    ..Our results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism. ..
  9. Yamauchi T, Nishiyama M, Moroishi T, Yumimoto K, Nakayama K. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. Mol Cell Biol. 2014;34:3321-40 pubmed publisher
    ..Our results thus suggest an unexpected role of MDM2 in the nonproteolytic ubiquitylation of DDX24, which may contribute to the regulation of pre-rRNA processing. ..

More Information


  1. Nakatsumi H, Matsumoto M, Nakayama K. Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages. Cell Rep. 2017;21:2471-2486 pubmed publisher
    ..Our results suggest that FOXK1 directly links mTORC1 signaling and CCL2 expression in a manner independent of NF-?B and that CCL2 produced by this pathway contributes to tumor progression. ..