Yoichi Nakanishi

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. pmc Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma
    Keiko Kan-o
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Respir Res 14:28. 2013
  2. pmc Impact of treatment with bevacizumab beyond disease progression: a randomized phase II study of docetaxel with or without bevacizumab after platinum-based chemotherapy plus bevacizumab in patients with advanced nonsquamous non-small cell lung cancer (WJOG
    Masayuki Takeda
    Department of Medical Oncology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    BMC Cancer 12:327. 2012
  3. ncbi request reprint Phase II trial of combination chemotherapy with cisplatin, carboplatin and etoposide in stage IIIB and IV small-cell lung cancer. Fukuoka Lung Cancer Study Group
    Y Nakanishi
    Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Cancer Chemother Pharmacol 41:453-6. 1998
  4. ncbi request reprint Phase I study of weekly irinotecan combined with weekly cisplatin in patients with advanced solid tumors
    Yoichi Nakanishi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Chemotherapy 48:205-10. 2002
  5. ncbi request reprint [Questionnaire about impression and knowledge of tuberculosis in employees and students in a university hospital]
    Yoichi Nakanishi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuokashi, Fukuoka 812 8582, Japan
    Kekkaku 77:457-63. 2002
  6. ncbi request reprint Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21
    Y Nakanishi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Respir Cell Mol Biol 22:747-54. 2000
  7. ncbi request reprint Expression of p53 and glutathione S-transferase-pi relates to clinical drug resistance in non-small cell lung cancer
    Y Nakanishi
    Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Oncology 57:318-23. 1999
  8. ncbi request reprint Adenovirus-mediated inhibitor kappaB gene transfer improves the chemosensitivity to anticancer drugs in human lung cancer in vitro and in vivo
    Jian Ni
    Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
    Anticancer Res 28:601-8. 2008
  9. doi request reprint Biphasic effects of free radical scavengers against bleomycin-induced pulmonary fibrosis
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pulm Pharmacol Ther 21:805-11. 2008
  10. doi request reprint A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo
    Satoru Fukuyama
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Allergol Int 60:259-66. 2011

Collaborators

Detail Information

Publications99

  1. pmc Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma
    Keiko Kan-o
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Respir Res 14:28. 2013
    ....
  2. pmc Impact of treatment with bevacizumab beyond disease progression: a randomized phase II study of docetaxel with or without bevacizumab after platinum-based chemotherapy plus bevacizumab in patients with advanced nonsquamous non-small cell lung cancer (WJOG
    Masayuki Takeda
    Department of Medical Oncology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    BMC Cancer 12:327. 2012
    ....
  3. ncbi request reprint Phase II trial of combination chemotherapy with cisplatin, carboplatin and etoposide in stage IIIB and IV small-cell lung cancer. Fukuoka Lung Cancer Study Group
    Y Nakanishi
    Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Cancer Chemother Pharmacol 41:453-6. 1998
    ..A phase II trial combining cisplatin, carboplatin and etoposide was conducted in previously untreated patients with stage IIIB and IV small-cell lung cancer, in an attempt to increase response rates and prolong survival...
  4. ncbi request reprint Phase I study of weekly irinotecan combined with weekly cisplatin in patients with advanced solid tumors
    Yoichi Nakanishi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Chemotherapy 48:205-10. 2002
    ..Previous studies have reported a synergistic effect between irinotecan and cisplatin. We have conducted a phase I trial combining these agents to find the optimal dose of irinotecan in combination with a fixed dose of cisplatin...
  5. ncbi request reprint [Questionnaire about impression and knowledge of tuberculosis in employees and students in a university hospital]
    Yoichi Nakanishi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuokashi, Fukuoka 812 8582, Japan
    Kekkaku 77:457-63. 2002
    ..Since they have some risk of TB infection through a service at window, the strengthening of health education on TB for them would be necessary...
  6. ncbi request reprint Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21
    Y Nakanishi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Respir Cell Mol Biol 22:747-54. 2000
    ..PAHs treatment increased the level of ubiquitinated p21. These results suggest that the p21 product is degraded by the ubiquitin-proteasome system. We conclude that PAHs-induced p53 protein is transcriptionally active...
  7. ncbi request reprint Expression of p53 and glutathione S-transferase-pi relates to clinical drug resistance in non-small cell lung cancer
    Y Nakanishi
    Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Oncology 57:318-23. 1999
    ..Combined use of these two biomarkers may be a useful predictor of clinical chemoresistance...
  8. ncbi request reprint Adenovirus-mediated inhibitor kappaB gene transfer improves the chemosensitivity to anticancer drugs in human lung cancer in vitro and in vivo
    Jian Ni
    Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
    Anticancer Res 28:601-8. 2008
    ..In this study the combination effect of chemotherapy and inhibition of NFkappaB on the human lung cancer cell line, NCI-H460, in vitro and in vivo was investigated...
  9. doi request reprint Biphasic effects of free radical scavengers against bleomycin-induced pulmonary fibrosis
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pulm Pharmacol Ther 21:805-11. 2008
    ..These data indicate that MCI-186, radical scavenger, has a biphasic effect on bleomycin-induced pulmonary fibrosis in mice. Careful attention should be paid before clinical application of new remedies for pulmonary fibrosis...
  10. doi request reprint A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo
    Satoru Fukuyama
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Allergol Int 60:259-66. 2011
    ....
  11. pmc Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis
    Mizuho Yamada
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Clin Pathol 60:916-20. 2007
    ..Transforming growth factor-beta1 (TGF-beta1) has the potential to induce acute inflammation and apoptosis in lung epithelial cells and plays a central role in subsequent fibrosis...
  12. doi request reprint Amphiregulin attenuates bleomycin-induced pneumopathy in mice
    Jutaro Fukumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu Univ, 3 1 1, Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Am J Physiol Lung Cell Mol Physiol 298:L131-8. 2010
    ..Amphiregulin may play a protective role in bleomycin-induced pneumopathy in mice, probably through the activation of survival signals. Administration of amphiregulin may be a novel therapeutic strategy against lung injury and fibrosis...
  13. ncbi request reprint Different roles of interleukin-10 in onset and resolution of asthmatic responses in allergen-challenged mice
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Respirology 10:18-26. 2005
    ..The aim of this study was to investigate the role of IL-10 in experimental asthma using ovalbumin (OVA)-sensitized mice...
  14. ncbi request reprint The role of collagenases in experimental pulmonary fibrosis
    Hiroshi Ouchi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pulm Pharmacol Ther 21:401-8. 2008
    ..Collagenase has a greater effect on fibrosis phase than inflammatory phase in the bleomycin-induced pulmonary fibrosis in the mice...
  15. ncbi request reprint Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice
    Naoki Hamada
    Research Institute for Diseases of the Chest, Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 175:1224-31. 2005
    ..Furthermore, this method may be beneficial for treating lung injury and fibrosis from the viewpoint of clinical application, since it does not require the use of a viral vector or neutralizing Ab...
  16. doi request reprint Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Respirology 14:187-94. 2009
    ..Using mouse models and peripheral blood mononuclear cells (PBMC) from subjects with allergic asthma, we aimed to explore whether Foxp3(+)CD4(+)CD25(+) T regulatory cells associate with asthma phenotypes...
  17. doi request reprint The role of high mobility group box1 in pulmonary fibrosis
    Naoki Hamada
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Respir Cell Mol Biol 39:440-7. 2008
    ..HMGB1 significantly induced proliferation, but not apoptosis or collagen synthesis on cultured fibroblasts. HMGB1 may be a promising target against pulmonary fibrosis as well as acute lung injury...
  18. doi request reprint Recombinant human erythropoietin reduces epithelial cell apoptosis and attenuates bleomycin-induced pneumonitis in mice
    Michihiro Yoshimi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Respirology 13:639-45. 2008
    ..The purpose of this study was to determine whether human recombinant EPO reduces epithelial cell apoptosis and attenuates bleomycin-induced pneumonitis in mice...
  19. doi request reprint Demethylallosamidin, a chitinase inhibitor, suppresses airway inflammation and hyperresponsiveness
    Takafumi Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 390:103-8. 2009
    ..These findings suggest that Dma attenuates asthmatic responses induced by IL-13 without affecting PGE(2) synthesis. Dma may have potential as therapeutic agents for asthma...
  20. doi request reprint Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma
    Yuko Matsunaga
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 404:261-7. 2011
    ..These findings suggest that the JAK inhibitor P6 suppresses asthmatic responses by inhibiting Th2 inflammation and that application of PLGA nanoparticles improves the therapeutic potency of P6...
  21. ncbi request reprint B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 365:170-5. 2008
    ..These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-gamma production during the effector phase of allergic asthma...
  22. doi request reprint IL-6 induced by double-stranded RNA augments allergic inflammation via suppression of Foxp3+ T-cell/IL-10 axis
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Am J Respir Cell Mol Biol 46:740-7. 2012
    ..IL-6 may be a target for preventing asthma augmentation related to severe virus infection...
  23. ncbi request reprint Niflumic acid suppresses interleukin-13-induced asthma phenotypes
    Takako Nakano
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Respir Crit Care Med 173:1216-21. 2006
    ..Interleukin (IL)-13 induces the cardinal features of bronchial asthma, and glucocorticoids are not sufficient to suppress IL-13-induced airway hyperresponsiveness or goblet cell hyperplasia...
  24. doi request reprint Phase II study of uracil-tegafur plus cisplatin in patients with previously untreated advanced non-small cell lung cancer
    Koichi Takayama
    Research Institute for Diseases of the Chest, Kyushu University, Fukuoka, Japan
    Respirology 13:103-7. 2008
    ....
  25. doi request reprint Attenuation of pulmonary hypertension, but not emphysematous change, by breeding emphysema model mice at sea level
    Masaki Fujita
    Research Institute for Diseases of Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cytokine 41:286-92. 2008
    ..In contrast, the effect of altitude was not clear regarding the development of pulmonary emphysema...
  26. doi request reprint Nicotine induces resistance to epidermal growth factor receptor tyrosine kinase inhibitor by α1 nicotinic acetylcholine receptor-mediated activation in PC9 cells
    Shuo Wang
    Research Institute for Diseases of the Chest, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Thorac Oncol 8:719-25. 2013
    ..We investigated the role of α1 nAChR subunit in this phenomenon...
  27. doi request reprint Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype
    Satoru Fukuyama
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Respir Crit Care Med 179:992-8. 2009
    ....
  28. ncbi request reprint A case of diffuse large B-cell lymphoma of the lung demonstrating diffuse ground-glass shadows
    Saiko Ogata-Suetsugu
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Thorac Cardiovasc Surg 17:591-4. 2011
    ..DLBCL should be considered in the differential diagnosis of diffuse ground-glass shadows in the chest CT, and gene rearrangement analysis may have an impact on the diagnosis of pulmonary DLBCL...
  29. ncbi request reprint Gene transfer of inhibitor kappaB in human lung cancer cell line NCI-H460 inhibits tumorigenesis and angiogenesis in vivo
    Jian Ni
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
    Anticancer Res 25:69-77. 2005
    ..Research on the effect of NFkappaB in inhibiting cancer cell growth, however, remains controversial...
  30. doi request reprint IL-13 suppresses double-stranded RNA-induced IFN-λ production in lung cells
    Atsushi Moriwaki
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 404:922-7. 2011
    ..These findings suggest that IL-13 may be a putative cytokine suppressing IFN-λ production against airway viral infections in asthmatics...
  31. doi request reprint Identifying risk factors for refractory febrile neutropenia in patients with lung cancer
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Infect Chemother 18:53-8. 2012
    ..11; 95% confidence interval (CI) 1.85-20.14) and C-reactive protein more than 10 mg/dl (OR 4.39; 95% CI 1.22-15.74). These factors could predict outcome for patients with lung cancer who develop refractory febrile neutropenia...
  32. ncbi request reprint Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka, Japan
    Pulm Pharmacol Ther 20:669-75. 2007
    ..Our data indicated that doxycycline could attenuate acute lung injury through a biological effect that was different from its antibiotic effect...
  33. doi request reprint Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small-cell lung cancer
    Masafumi Takeshita
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Biol Ther 10:933-41. 2010
    ..CHFR gene promoter methylation and EGFR gene mutation were observed in 11 cases (15.9%) and 7 cases (10.1%), respectively. The SDI method revealed that CHFR gene methylation was significantly related to high sensitivity to paclitaxel (p...
  34. ncbi request reprint [hTERT promoter-based conditionally replicative adenoviruses are useful for lung cancer and other solid cancer treatment]
    Junji Uchino
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 100:338-48. 2009
    ..We concluded that the use of hTERT promoter-based CRAds may be a potentially effective strategy for cancer treatment...
  35. doi request reprint Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer
    Masafumi Takeshita
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Lung Cancer 80:85-90. 2013
    ..Thus, Aurora-B may serve as a new therapeutic target in against patients with NSCLC, although further studies will be necessary...
  36. doi request reprint The clinical efficacy and safety of micafungin-itraconazole combination therapy in patients with pulmonary aspergilloma
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Infect Chemother 18:668-74. 2012
    ..Adverse events occurred in 6 of the 17 patients (35.3%), but there were no severe adverse events. MCFG-ITCZ combination therapy appeared to be relatively safe and effective in patients with pulmonary aspergilloma...
  37. doi request reprint The clinical efficacy and safety of a fluoroquinolone-containing regimen for pulmonary MAC disease
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Infect Chemother 18:146-51. 2012
    ..The fluoroquinolone-containing regimen demonstrated both high efficacy and relative safety for pulmonary MAC disease that was similar to that of the CAM-containing regimen, which is considered to be the standard regimen...
  38. doi request reprint T cell treatment with small interfering RNA for suppressor of cytokine signaling 3 modulates allergic airway responses in a murine model of asthma
    Atsushi Moriwaki
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Am J Respir Cell Mol Biol 44:448-55. 2011
    ..These findings suggest that the therapeutic modulation of SOCS3 expression in CD4(+) T cells might be effective in preventing the development of allergic asthma...
  39. ncbi request reprint Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA
    Miyuki Tsuda
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 330:263-70. 2005
    ..These results suggest that epithelial B7-H1 and B7-DC play a role in virus-associated immune responses in the airways...
  40. doi request reprint Dual-immunohistochemistry provides little evidence for epithelial-mesenchymal transition in pulmonary fibrosis
    Mizuho Yamada
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Histochem Cell Biol 129:453-62. 2008
    ..Another is that EMT may occur in pulmonary fibrosis but the time during this transition in which cells express detectable levels of epithelial and mesenchymal markers is too small to be detected by double immunohistochemistry...
  41. ncbi request reprint Immunohistochemical expression of MRP2 and clinical resistance to platinum-based chemotherapy in small cell lung cancer
    Rie Ushijima
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Anticancer Res 27:4351-8. 2007
    ..This is the first report which indicates that the immunohistochemical expression of MRP2 is positively related to a clinical resistance to platinum...
  42. doi request reprint Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia
    Yuko Matsunaga
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    FASEB J 27:3306-14. 2013
    ..These findings indicate that BLT2 has a protective role in allergic airway inflammation and that diminished BLT2 expression in CD4(+) T cells may contribute to the pathophysiology of asthma...
  43. ncbi request reprint A new cancer cell detection method using an infectivity-enhanced adenoviral vector
    Junji Uchino
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan
    Asian Pac J Cancer Prev 13:5551-6. 2012
    ..This study provides proof-of-concept for a more reliable and sensitive diagnostic tool for epithelium-derived cancer...
  44. ncbi request reprint Efficacy of aprepitant in patients with advanced or recurrent lung cancer receiving moderately emetogenic chemotherapy
    Junji Uchino
    Department of Respiratory Medicine, Fukuoka University Faculty of Medicine, Fukuoka, Japan
    Asian Pac J Cancer Prev 13:4187-90. 2012
    ..To evaluate the efficacy of a combination of aprepitant and conventional antiemetic therapy in patients with advanced or recurrent lung cancer receiving moderately emetogenic chemotherapy (MEC)...
  45. doi request reprint A phase II trial of gefitinib monotherapy in chemotherapy-naïve patients of 75 years or older with advanced non-small cell lung cancer
    Noriyuki Ebi
    Department of Respiratory Medicine, Iizuka Hospital, Fukuoka, Japan
    J Thorac Oncol 3:1166-71. 2008
    ..A multicenter phase II trial was conducted to evaluate the efficacy and tolerability of gefitinib for elderly patients with chemotherapy-naïve NSCLC...
  46. doi request reprint TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cytokine 44:298-303. 2008
    ..The present study confirmed that TNFR1 and TNFR2 play a crucial, but different role in the control of L. pneumophila-induced mortality...
  47. ncbi request reprint Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils
    Kentaro Machida
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Lung Cell Mol Physiol 288:L860-7. 2005
    ..These findings indicate that the PI3K-Akt-FKHR pathway conveys a critical survival signal induced by beta-agonists in airway eosinophils...
  48. doi request reprint IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    J Thorac Oncol 5:299-304. 2010
    ..Interleukin 1B (IL1B) is involved in pulmonary inflammation induced by environmental or occupational toxins. Chronic inflammation has been implicated in the development of lung cancer...
  49. ncbi request reprint Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Oncol Rep 23:1361-8. 2010
    ..Our findings indicate the possible association of the Glu allele of the TP53BP1 Asp353Glu polymorphism with lower risk of lung cancer especially among the Pro allele carriers of the TP53 Arg72Pro polymorphism...
  50. ncbi request reprint Endogenous metalloprotease solubilizes IL-13 receptor alpha2 in airway epithelial cells
    Mikiko Matsumura
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 360:464-9. 2007
    ..Metalloprotease(s) are responsible for the proteolytic cleavage of cell surface IL-13Ralpha2...
  51. doi request reprint EGFR tyrosine kinase inhibition worsens acute lung injury in mice with repairing airway epithelium
    Chika Harada
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Am J Respir Crit Care Med 183:743-51. 2011
    ..Characteristics of patients who develop interstitial pneumonia include older age, smoking history, and preexisting interstitial pneumonia suggesting a connection between airway injury and alveolar dysfunction...
  52. doi request reprint Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors
    Kazuto Furuyama
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 104:584-9. 2013
    ..This study underscores the importance of reporting the clinical outcome of treatment in relation to different EGFR mutations...
  53. doi request reprint Effects of tiotropium on lung function in severe asthmatics with or without emphysematous changes
    Makoto Yoshida
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Pulm Pharmacol Ther 26:159-66. 2013
    ..These findings suggest that tiotropium will provide a new strategy for the treatment of bronchial asthma and of overlapping asthma and COPD...
  54. doi request reprint Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer
    Kyoko Okamura
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan
    Lung Cancer 78:100-6. 2012
    ..Our results indicate that expression of TrkB and BDNF is associated with poor prognosis in NSCLC patients...
  55. ncbi request reprint Decrease of interleukin-10-producing T cells in the peripheral blood of severe unstable atopic asthmatics
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int Arch Allergy Immunol 134:295-302. 2004
    ..Objective: The profiles of IL-10 production in circulating CD4+ T cells of atopic asthmatics were investigated with respect to clinical severity...
  56. doi request reprint Clinical efficacy and safety of cefepime in febrile neutropenic patients with lung cancer
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Infect Chemother 16:113-7. 2010
    ..In this study, cefepime demonstrated a high degree of clinical efficacy and safety in the treatment of FN. Empiric monotherapy using cefepime is a recommended regimen for FN in patients with lung cancer in Japan...
  57. doi request reprint Non-transmissible Sendai virus encoding granulocyte macrophage colony-stimulating factor is a novel and potent vector system for producing autologous tumor vaccines
    Hiroyuki Inoue
    Department of Advanced Cell and Molecular Therapy, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University Hospital, Kyushu University, Fukuoka, Japan
    Cancer Sci 99:2315-26. 2008
    ..05). Taken together, our results suggest that the SeV/dF/G vector is a potential candidate for the production of effective autologous GM-CSF-transduced tumor vaccines in clinical cancer immune gene therapy...
  58. pmc Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    BMC Cancer 11:459. 2011
    ..We examined if smoking or alcohol consumption modify associations between MTHFR polymorphisms and lung cancer risk...
  59. ncbi request reprint Effects of salmeterol in patients with persistent asthma receiving inhaled corticosteroid plus theophylline
    Hiromasa Inoue
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Respiration 74:611-6. 2007
    ..The use of long-acting inhaled beta(2)-agonists plus theophylline in addition to high doses of inhaled corticosteroids (ICSs) for the treatment of severe asthma has not been extensively studied...
  60. ncbi request reprint A pregnant woman with complications of lymphangioleiomyomatosis and idiopathic thrombocytopenic purpura
    Kazuhiro Toyoda
    The Research Institute for Diseases of the Chest, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Intern Med 45:1097-100. 2006
    ..Underlying lymphangioleiomyomatosis and idiopathic thrombocytopenic purpura may be obviated by pregnancy...
  61. doi request reprint Cigarette smoke impairs phagocytosis of apoptotic neutrophils by alveolar macrophages via inhibition of the histone deacetylase/Rac/CD9 pathways
    Naotaka Noda
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Int Immunol 25:643-50. 2013
    ..Aminophylline/theophylline is effective in restoring the impairment of efferocytosis and might have benefit for the treatment of patients with COPD. ..
  62. doi request reprint Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Japan
    J Thorac Oncol 7:954-62. 2012
    ..Several components of overall lung carcinogenesis, carcinogen metabolic and DNA repair pathways may be involved in individual genetic susceptibility to lung cancer...
  63. pmc Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness
    Hiromasa Inoue
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Exp Med 201:73-82. 2005
    ..These data indicate that Spred-1 negatively controls eosinophil numbers and functions by modulating IL-5 signaling in allergic asthma...
  64. ncbi request reprint Successful treatment of refractory chronic necrotizing pulmonary aspergillosis with micafungin
    Hiroshi Ouchi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    J Infect Chemother 13:258-62. 2007
    ..it is difficult to treat cases that are refractory to voriconazole. The treatment of this case provides invaluable information on how to treat pulmonary aspergillosis related to diseases other than hematologic malignancies...
  65. ncbi request reprint Codon 64 of K-ras gene mutation pattern in hepatocellular carcinomas induced by bleomycin and 1-nitropyrene in A/J mice
    Feng Bai
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Teratog Carcinog Mutagen . 2003
    ..As far as we know, this is the first report of a codon 64 mutation in the K-ras gene in a chemically induced tumor...
  66. ncbi request reprint Lung cancer susceptibility: are we on our way to identifying a high-risk group?
    Chikako Kiyohara
    Kyushu University, Department of Preventive Medicine, Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Future Oncol 3:617-27. 2007
    ..This review evaluates whether or not a specific polymorphism or a combination of such polymorphisms can effectively predict high-risk groups...
  67. pmc Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka 812, Japan
    Antimicrob Agents Chemother 50:739-43. 2006
    ..Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity...
  68. ncbi request reprint A multicenter phase II study of carboplatin and paclitaxel with a biweekly schedule in patients with advanced non-small-cell lung cancer: Kyushu thoracic oncology group trial
    Masao Ichiki
    Department of Respiratory Medicine, National Hospital Organization Kyushu Medical Center, Chuo Ku, Fukuoka, Japan
    Cancer Chemother Pharmacol 58:368-73. 2006
    ....
  69. ncbi request reprint Infectivity enhanced, hTERT promoter-based conditionally replicative adenoviruses are useful for SCLC treatment
    Junji Uchino
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Cancer Gene Ther 12:737-48. 2005
    ..We concluded that the use of hTERT promoter-based CRAds may be a potentially effective strategy for cancer treatment...
  70. ncbi request reprint Carboplatin plus paclitaxel in the successful treatment of advanced inflammatory myofibroblastic tumor
    Naoki Kubo
    Research Institute for Disease of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan
    Intern Med 51:2399-401. 2012
    ..This regimen is well tolerated and may be considered the treatment of choice for unresectable IMT...
  71. doi request reprint Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems
    Yosuke Yokota
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Blood 120:3444-54. 2012
    ..Our data collectively underscore a negative role of LTB4/BLT1 signaling in effective generation and maintenance of GM-CSF-induced antitumor memory CD4(+) T cells...
  72. ncbi request reprint [A case of pulmonary nocardiosis diagnosed five years after hemoptysis]
    Kyoko Kudo
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
    Nihon Kokyuki Gakkai Zasshi 45:952-6. 2007
    ..Oral cotrimoxazole (Trimetoprim 15 mg/kg) was started, the dosage was halved because of adverse effects. Six months of treatment with cotrimoxazole resulted in improvement of the Nocardiosis...
  73. ncbi request reprint The influence of dendritic cell infiltration and vascular endothelial growth factor expression on the prognosis of non-small cell lung cancer
    Naoko Inoshima
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka 812 8582, Japan
    Clin Cancer Res 8:3480-6. 2002
    ..The patient group with a high VEGF expression/low DC infiltration showed a worse prognosis (P < 0.0001), whereas the group with a low VEGF expression/high DC infiltration had a better prognosis (P = 0.0001)...
  74. doi request reprint Incidence of hypertrophic pulmonary osteoarthropathy associated with primary lung cancer
    Miiru Izumi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Respirology 15:809-12. 2010
    ..The clinical features of confirmed HPO were also evaluated...
  75. ncbi request reprint Serum CC-10 in inflammatory lung diseases
    Qing Ye
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Respiration 71:505-10. 2004
    ..Although Clara cell secretory protein (CC-10) has been ascribed an anti-inflammatory role in lung diseases, its precise role remains unclear...
  76. doi request reprint Non-small cell lung cancer: detection of early response to chemotherapy by using contrast-enhanced dynamic and diffusion-weighted MR imaging
    Hidetake Yabuuchi
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Radiology 261:598-604. 2011
    ..To evaluate the ability of dynamic contrast material-enhanced and diffusion-weighted (DW) magnetic resonance (MR) imaging to help detect early response to chemotherapy in patients with non-small cell lung cancer (NSCLC)...
  77. doi request reprint TARC and RANTES enhance antitumor immunity induced by the GM-CSF-transduced tumor vaccine in a mouse tumor model
    Hiroyuki Inoue
    Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Immunol Immunother 57:1399-411. 2008
    ....
  78. ncbi request reprint A case of multiple squamous cell papillomas of the trachea
    Saiko Ogata-Suetsugu
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Thorac Cardiovasc Surg 17:212-4. 2011
    ..After removal of the tumor, the patient received radical therapy: semiconductor laser transpiration. Polymerase chain reaction (PCR) detected human papilloma virus (HPV) type 6, thought to be the cause of the respiratory papilloma...
  79. ncbi request reprint Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads
    Kentaro Tanaka
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 180:3746-56. 2008
    ..SOCS1-deficient T cells will be very useful to investigate the molecular mechanism for the STAT1-mediated suppression of Th17 development...
  80. ncbi request reprint Enhancement of antigen-presenting capacity and antitumor immunity of dendritic cells pulsed with autologous tumor-derived RNA in mice
    Takahiro Minami
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashiku, Fukuoka, Japan
    J Immunother 26:420-31. 2003
    ..Therapy with DCs pulsed with tumor-derived RNA is sufficiently effective and safe, and thus it is considered to be clinically useful for tumor-immunotherapy...
  81. ncbi request reprint Structural and quantitative analysis of astrocytes in the mouse hippocampus
    K Ogata
    Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Neuroscience 113:221-33. 2002
    ....
  82. ncbi request reprint Sporadic amyotrophic lateral sclerosis showing abnormal somatosensory evoked potentials: a report of three cases
    K Ogata
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 92:242-50. 2001
    ..We therefore performed a clinico-electrophysiological analysis of sporadic ALS patients...
  83. ncbi request reprint Serum surfactant protein D is increased in acute and chronic inflammation in mice
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Cytokine 31:25-33. 2005
    ..These data clarified profile of SP-A and SP-D in acute and chronic inflammation and indicated that serum SP-D can serve as a biomarker of lung inflammation in both acute and chronic lung injury in mice...
  84. ncbi request reprint EPHX1 polymorphisms and the risk of lung cancer: a HuGE review
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Epidemiology 17:89-99. 2006
    ..The aim of this study is to review and summarize the available molecular epidemiologic studies of lung cancer and EPHX1...
  85. ncbi request reprint B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 172:2530-41. 2004
    ..These results suggest a unique role for B7-DC in the regulation of asthmatic response through an IFN-gamma-dependent, but PD-1-independent, mechanism...
  86. ncbi request reprint The pathogenesis of COPD: lessons learned from in vivo animal models
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Med Sci Monit 13:RA19-24. 2007
    ..This article aims at offering valuable information for both proceeding with COPD research as well as for developing a new medicines for the treatment of COPD...
  87. ncbi request reprint Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Lung Cancer 54:267-83. 2006
    ..Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls...
  88. ncbi request reprint [A case of pulmonary mycobacterium intracellulare infection complicated with pneumothorax and pleurisy]
    Jutaro Fukumoto
    Research Institute for Disease of the Chest, Graduate School of Medical Science, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka shi, Fukuoka 812 8582 Japan
    Kekkaku 80:571-5. 2005
    ..We concluded that the pneumothorax and pleural effusion were caused by NTM infection. Since pneumothorax is an extremely rare complication in NTM infections we thought it is worth-while to report our case...
  89. ncbi request reprint A case of extrapleural empyema
    Shin ichi Osaki
    Nishi Fukuoka Hospital, Graduate School of Sciences, Kyushu University, Fukuoka, Japan
    Respirology 7:83-5. 2002
    ..However, as he did not improve, he was then treated with open drainage. During open drainage, the patient was diagnosed to have an extrapleural empyema and improved following open drainage treatment...
  90. doi request reprint CHFR expression is preferentially impaired in smoking-related squamous cell carcinoma of the lung, and the diminished expression significantly harms outcomes
    Masafumi Takeshita
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 123:1623-30. 2008
    ..We also revealed that CHFR expression was predominantly impaired in smoking-related squamous cell carcinoma and might be a useful prognostic marker in NSCLC...
  91. ncbi request reprint Involvement of alveolar macrophages in the formation of 8-oxodeoxyguanosine associated with exogenous particles in human lungs
    Hiroshi Tokiwa
    Department of Environmental Health Science, Kyushu Women s University, Higashiku, Fukuoka, Japan
    Inhal Toxicol 17:577-85. 2005
    ..Especially, particles from which organic chemicals were removed were highly reactive to oxidative damage and formed 8-oxo-dG...
  92. ncbi request reprint [Why does smoking cause lung cancer?]
    Yoichi Nakanishi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 93:6-10. 2002
  93. ncbi request reprint NQO1, MPO, and the risk of lung cancer: a HuGE review
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Genet Med 7:463-78. 2005
    ....
  94. ncbi request reprint [Molecular mechanism of lung carcinogenesis]
    Yoichi Nakanishi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
    Nihon Rinsho 60:58-62. 2002
  95. ncbi request reprint Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis
    Ichiro Inoshima
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu Univ, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Lung Cell Mol Physiol 286:L727-33. 2004
    ..Therefore, the forced expression of p21 exerted both anti-apoptotic and anti-fibrotic effects, which would facilitate the ultimate goal of treatment for pulmonary fibrosis...
  96. ncbi request reprint [A case of rapidly growing inflammatory myofibroblastic tumor in the lung]
    Saiko Suetsugu
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
    Nihon Kokyuki Gakkai Zasshi 47:1156-60. 2009
    ..In the future, new therapy incorporating ALK inhibitors would be expected to treat those cases of IMT in which local recurrences and distant metastases occur...
  97. ncbi request reprint [Heparin-induced thrombocytopenia and disseminated intravascular coagulation in a patient with drug-induced pneumonia]
    Kyoko Okamura
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
    Nihon Kokyuki Gakkai Zasshi 48:157-61. 2010
    ..The clinical course, and the fact that testing for heparin-induced thrombocytopenia (HIT) antibodies was positive, supported the diagnosis of HIT and DIC. We report a rare case of HIT and DIC during treatment for drug-induced pneumonia...
  98. ncbi request reprint [Management of paraneoplastic syndrome in lung cancer]
    Koji Inoue
    Research Institute for Diseases of the Chest, Postgraduate School of Medical Sciences, Kyushu University
    Nihon Rinsho 60:536-9. 2002
  99. ncbi request reprint [How to promote translational research: the points at issue]
    Yoichi Nakanishi
    ARO Clinical Research Center, Kyushu University Hospital, Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
    Fukuoka Igaku Zasshi 95:249-52. 2004