Hiroshi Nakanishi

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. doi request reprint The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior
    Hiroshi Nakanishi
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neuron Glia Biol 7:17-23. 2011
  2. doi request reprint Microglia-aging: roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging
    Hiroshi Nakanishi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Behav Brain Res 201:1-7. 2009
  3. ncbi request reprint Microglial functions and proteases
    Hiroshi Nakanishi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Mol Neurobiol 27:163-76. 2003
  4. ncbi request reprint Neuronal and microglial cathepsins in aging and age-related diseases
    Hiroshi Nakanishi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Ageing Res Rev 2:367-81. 2003
  5. doi request reprint Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia
    Kayo Terada
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    Glia 58:114-24. 2010
  6. ncbi request reprint Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain
    Li Sun
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 32:11330-42. 2012
  7. doi request reprint Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1beta
    Ruoyu Zhang
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neurobiol Dis 38:68-77. 2010
  8. ncbi request reprint Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice
    Ryo Yamasaki
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Mol Cell Neurosci 35:573-84. 2007
  9. ncbi request reprint Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Free Radic Biol Med 42:945-54. 2007
  10. ncbi request reprint Involvement of prostaglandin E2 released from leptomeningeal cells in increased expression of transforming growth factor-beta in glial cells and cortical neurons during systemic inflammation
    Zhou Wu
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    J Neurosci Res 85:184-92. 2007

Collaborators

Detail Information

Publications43

  1. doi request reprint The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior
    Hiroshi Nakanishi
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neuron Glia Biol 7:17-23. 2011
    ..Therefore, 'microglia-aging' plays important roles in the age-dependent enhanced behavioral consequences of infection...
  2. doi request reprint Microglia-aging: roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging
    Hiroshi Nakanishi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Behav Brain Res 201:1-7. 2009
    ..Furthermore, the prevention of lysosomal autophagic dysfunction and mitochondrial DNA damage in microglia may therefore be a potentially effective new pharmaceutical intervention against brain aging...
  3. ncbi request reprint Microglial functions and proteases
    Hiroshi Nakanishi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Mol Neurobiol 27:163-76. 2003
    ....
  4. ncbi request reprint Neuronal and microglial cathepsins in aging and age-related diseases
    Hiroshi Nakanishi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Ageing Res Rev 2:367-81. 2003
    ..This review describes the pathological roles of neuronal and microglial cathepsins in brain aging and age-related diseases...
  5. doi request reprint Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia
    Kayo Terada
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    Glia 58:114-24. 2010
    ..Therefore, either pharmacological or genetic inhibition of CB may provide therapeutic intervention in inflammation-associated neurological diseases...
  6. ncbi request reprint Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain
    Li Sun
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 32:11330-42. 2012
    ..Therefore, CatB-specific inhibitors may represent a useful new strategy for treating inflammation-associated pain...
  7. doi request reprint Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1beta
    Ruoyu Zhang
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neurobiol Dis 38:68-77. 2010
    ..These results suggest that IL-1beta increases the excitability of hippocampal CA1 neurons in the p38-dependent inhibition of I(NMDA-OUT)...
  8. ncbi request reprint Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice
    Ryo Yamasaki
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Mol Cell Neurosci 35:573-84. 2007
    ..The activated p38 MAP kinase cascade then promotes the expression of iNOS and CAT-2, thereby inducing the overproduction of NO...
  9. ncbi request reprint Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Free Radic Biol Med 42:945-54. 2007
    ..These results suggest that PS/PC liposomes have both neuroprotective and antioxidative properties through the inhibition of microglial activation, thus supporting the nootropic and antidementia effect of PS...
  10. ncbi request reprint Involvement of prostaglandin E2 released from leptomeningeal cells in increased expression of transforming growth factor-beta in glial cells and cortical neurons during systemic inflammation
    Zhou Wu
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    J Neurosci Res 85:184-92. 2007
    ..Furthermore, TGF-beta1 may also exert a protective effect directly on the cortical neurons...
  11. ncbi request reprint Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors
    Yoshinori Hayashi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    Glia 53:660-8. 2006
    ..These observations strongly suggest that glycine is a major causative molecule released from microglia that potentiates the NMDA-induced currents...
  12. doi request reprint Phosphatidylserine-containing liposomes suppress inflammatory bone loss by ameliorating the cytokine imbalance provoked by infiltrated macrophages
    Hong mei Ma
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    Lab Invest 91:921-31. 2011
    ....
  13. doi request reprint Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice
    Yoshinori Hayashi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 28:8624-34. 2008
    ..Together, an overexpression of TFAM is therefore considered to ameliorate age-dependent impairment of the brain functions through the prevention of oxidative stress and mitochondrial dysfunctions in microglia...
  14. ncbi request reprint Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice
    Tokiko Shimizu
    Laborarory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    J Neurochem 94:680-90. 2005
    ....
  15. doi request reprint Possible involvement of aiPLA2 in the phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in microglia
    Fumiko Takayama
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 262:121-4. 2013
    ..We thus hypothesize that free arachidonic acid is supplied through aiPLA2-mediated lipolysis of phagocytosed phosphatidylcholine, leading to the production of PGH2 and its downstream metabolites...
  16. doi request reprint Age-dependent responses of glial cells and leptomeninges during systemic inflammation
    Zhou Wu
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neurobiol Dis 32:543-51. 2008
    ..These findings establish that age strongly influences the barrier functions of the leptomeninges through the age-dependent differential glial responses during systemic inflammation...
  17. doi request reprint Reduced synaptic activity precedes synaptic stripping in vagal motoneurons after axotomy
    Jun Yamada
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Glia 56:1448-62. 2008
    ..These observations strongly suggest that presynaptic inhibition through glia-derived ATP and adenosine, thus precedes synaptic stripping in regenerating DMV neurons following nerve injury...
  18. ncbi request reprint Leptomeningeal cells activate microglia and astrocytes to induce IL-10 production by releasing pro-inflammatory cytokines during systemic inflammation
    Zhou Wu
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 167:90-8. 2005
    ..The activated astrocytes and microglia may in turn regulate anti-inflammatory response in the brain by providing IL-10...
  19. doi request reprint Phosphatidylserine-containing liposomes inhibit the differentiation of osteoclasts and trabecular bone loss
    Zhou Wu
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 184:3191-201. 2010
    ..Because PS is a component of the cell membrane, PSLs therefore can be a potentially effective pharmacological intervention against abnormal bone loss, such as osteoporosis without deleterious side effects...
  20. ncbi request reprint Involvement of COX-1 and up-regulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia
    Jian Zhang
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 172:112-20. 2006
    ....
  21. doi request reprint Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse
    Li Sun
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 399:391-5. 2010
    ..Conversely, expression of neither Noxa or LC3-II was observed in the HGN of adult CB-/- mice after nerve injury. These observations strongly suggest that CB plays a critical role in axotomy-induced mortor neuron death in adult mice...
  22. doi request reprint Inhibition of NMDA-induced outward currents by interleukin-1beta in hippocampal neurons
    Ruoyu Zhang
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 372:816-20. 2008
    ..These results strongly suggest that IL-1beta increases the neuronal excitability by inhibition of ChTX-sensitive K(Ca) channels activated by Ca(2+) influx through both NMDA receptors and voltage-gated Ca(2+) channels...
  23. doi request reprint Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat
    Misao Sakamoto
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Neurosci Lett 442:292-6. 2008
    ..The treatment of CA074 could be a potentially effective therapeutic intervention to prevent the pathological changes in the cerebellum caused by ingestion of MeHg-contaminated food...
  24. ncbi request reprint Cell cycle-dependent regulation of kainate-induced inward currents in microglia
    Jun Yamada
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 349:913-9. 2006
    ..These results strongly suggest that microglia have functional KA receptors mainly consisting of GluR5 and GluR6, and the expression levels of these subunits are closely regulated by the cell cycle mechanism...
  25. ncbi request reprint Impairment of microglial responses to facial nerve axotomy in cathepsin S-deficient mice
    Hai Peng Hao
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    J Neurosci Res 85:2196-206. 2007
    ..The present study strongly suggests that CS plays a role in the migration and activation of microglia to protect facial motoneurons against axotomy-induced injury...
  26. ncbi request reprint Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medicine, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Neurochem Int 50:499-506. 2007
    ..Therefore, PS/PC liposomes appear to have both neuroprotective and anti-oxidative properties through the inhibition of microglial activation...
  27. ncbi request reprint Potentiation of NMDA receptor-mediated synaptic responses by microglia
    Shigeki Moriguchi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Brain Res Mol Brain Res 119:160-9. 2003
    ..These observations strongly suggest that NMDA receptor-mediated responses can be potentiated by both heat- and protease-labile (presumably 70-kDa proteins) molecules released from microglia...
  28. ncbi request reprint Amyloid-beta fibril formation is not necessarily required for microglial activation by the peptides
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurochem Int 47:369-76. 2005
    ..These results suggest that Abeta fibril formation is not necessarily required for microglial activation by the peptides...
  29. pmc Brazilian green propolis suppresses the hypoxia-induced neuroinflammatory responses by inhibiting NF-κB activation in microglia
    Zhou Wu
    Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    Oxid Med Cell Longev 2013:906726. 2013
    ..Furthermore, increased generation of ROS from the mitochondria is responsible for the NF-κB activation. Therefore, propolis may be beneficial in preventing hypoxia-induced neuroinflammation...
  30. pmc The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S
    Yoshinori Hayashi
    Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Sci Rep 3:2744. 2013
    ..Disruption of CatS therefore induces hyperlocomotor activity due to failure to downscale the synaptic strength. ..
  31. doi request reprint Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia
    Zhou Wu
    Faculty of Dental Sciences, Department of Aging Science and Pharmacology, Kyushu University, Fukuoka, Japan Electronic address
    Neurobiol Aging 34:2715-25. 2013
    ..These observations indicate differential pathways for the microglial IL-1β production by CGA and fAβ, which may aid in better understanding of the pathological significance of neuroinflammation in AD. ..
  32. doi request reprint Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain
    Yoshinori Hayashi
    Department of Aging Science and Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 31:17370-82. 2011
    ..Therefore, the preferential inhibition of microglial BK channels in addition to neuronal NMDA receptors may account for the preferential and potent analgesic effects of S-ketamine on neuropathic pain...
  33. doi request reprint Phosphatidylserine-containing liposomes: potential pharmacological interventions against inflammatory and immune diseases through the production of prostaglandin E(2) after uptake by myeloid derived phagocytes
    Zhou Wu
    Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    Arch Immunol Ther Exp (Warsz) 59:195-201. 2011
    ..Moreover, PSLs inhibit the maturation of dendritic cells and osteoclast precursors. Therefore, PSLs will be potential pharmacological interventions for inflammatory and immune diseases through feedback mechanism utilizing PGE(2)...
  34. doi request reprint Peripheral role of cathepsin s in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state
    Xinwen Zhang
    Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan, and Japan Science and Technology Agency, CREST, Tokyo, 102 0075, Japan
    J Neurosci 34:3013-22. 2014
    ..After activation, CD4(+) T-cells infiltrate into the dorsal spinal cord and secrete IFN-γ to reactivate microglia, which contribute to the transition of acute pain to a chronic pain state. ..
  35. pmc Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in reponse to Porphyromonas gingivalis LPS
    Yicong Liu
    Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan Department of Implantology, School of Stomatology, Jilin University, Changchun 130021, China
    Mediators Inflamm 2013:407562. 2013
    ..Together with the inhibitory effect on microglial activation, propolis may be beneficial in preventing neuroinflammation during chronic periodontitis...
  36. ncbi request reprint Pepstatin A induces extracellular acidification distinct from aspartic protease inhibition in microglial cell lines
    Mitsuko Okada
    Laboratory of Molecular and Cellular Neurogenetics, LTA Medical Corporation, Fukuoka, Japan
    Glia 43:167-74. 2003
    ....
  37. ncbi request reprint Activation of mu-calpain in developing cortical neurons following methylmercury treatment
    Jian Zhang
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Brain Res Dev Brain Res 142:105-10. 2003
    ..Our results indicate that mu-calpain activation and mu-calpain-mediated proteolysis of alpha-spectrin preceded neuronal damage in the developing cerebral cortex induced by chronic treatment of MeHg...
  38. ncbi request reprint Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia
    Tsuyoshi Nishioku
    Department of Pharmacology, Graduate School of Dental Science, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 277:4816-22. 2002
    ..In conclusion, CE is required for the generation of an antigenic epitope from OVA but not for the processing of Ii in microglia...
  39. ncbi request reprint Proteases involved in long-term potentiation
    Yoshiro Tomimatsu
    Laboratory of Oral Aging Science, Division of Oral Biological Sciences, Faculty of Dental Sciences, Kyushu University, 812 8582, Fukuoka, Japan
    Life Sci 72:355-61. 2002
    ..After cleavage, some substrates are inactivated and others are activated to gain new functions. Therefore, the issue to identify substrates for each protease is very important to understand the molecular basis of LTP...
  40. ncbi request reprint Enhancement of N-methyl- D-aspartate receptor-mediated excitatory postsynaptic potentials in the neostriatum after methamphetamine sensitization. An in vitro slice study
    Shigeki Moriguchi
    Graduate School of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Exp Brain Res 144:238-46. 2002
    ..This enhancement is probably associated with phosphorylation of NMDA receptors mediated by the simultaneous activation of PKC and PKA...
  41. ncbi request reprint Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice
    Masato Koike
    Department of Cell Biology and Neurosciences, Osaka University Graduate School of Medicine, 565 0871, Suita, Osaka, Japan
    Mol Cell Neurosci 22:146-61. 2003
    ....
  42. ncbi request reprint Synthesis and conformational properties of phosphopeptides related to the human tau protein
    Jin Tang Du
    Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China
    Regul Pept 130:48-56. 2005
    ....
  43. ncbi request reprint How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus?
    Mitsuko Okada
    Laboratory of Molecular and Cellular Neurogenetics, LTA Medical Corporation, Fukuoka 810 0064, Japan
    Brain Res Mol Brain Res 111:175-81. 2003
    ..Caloric restriction might prevent age-related reduction in hippocampal synaptic transmission by enhancing non-N-methyl-D-aspartate mechanisms...