Yutaka Kiyohara

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. doi request reprint Circulating resistin is increased with decreasing renal function in a general Japanese population: the Hisayama Study
    Ryoichi Kawamura
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Nephrol Dial Transplant 25:3236-40. 2010
  2. doi request reprint Glucose tolerance status and risk of dementia in the community: the Hisayama study
    T Ohara
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Neurology 77:1126-34. 2011
  3. pmc Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    Cardiovasc Diabetol 8:60. 2009
  4. pmc Prevention of type 2 diabetes in a primary healthcare setting: three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance
    Naoki Sakane
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    BMC Public Health 11:40. 2011
  5. doi request reprint Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009)
    Jun Hata
    Department of Environmental Medicine J H, T N, Y H, M N, N M, S G, M F, F I, K S, D Y, Y K and Department of Medicine and Clinical Science J H, T N, Y H, M N, N M, S G, M F, F I, K S, M K, T K, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan and Biostatistics Center, Kurume University, Kurume, Japan K Y
    Circulation 128:1198-205. 2013
  6. doi request reprint QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama study
    Daisuke Maebuchi
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertens Res 33:916-21. 2010
  7. pmc Gender differences in the association between metabolic syndrome and periodontal disease: the Hisayama Study
    Michiko Furuta
    Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    J Clin Periodontol 40:743-52. 2013
  8. doi request reprint Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study
    Toshiaki Nakano
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Kidney Int 84:373-80. 2013
  9. pmc Impact of metabolic syndrome compared with impaired fasting glucose on the development of type 2 diabetes in a general Japanese population: the Hisayama study
    Naoko Mukai
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Care 32:2288-93. 2009
  10. doi request reprint Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Stroke 40:1187-94. 2009

Collaborators

Detail Information

Publications81

  1. doi request reprint Circulating resistin is increased with decreasing renal function in a general Japanese population: the Hisayama Study
    Ryoichi Kawamura
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Nephrol Dial Transplant 25:3236-40. 2010
    ..The purpose of this study is to investigate the relationship between serum resistin levels and chronic kidney disease (CKD)...
  2. doi request reprint Glucose tolerance status and risk of dementia in the community: the Hisayama study
    T Ohara
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Neurology 77:1126-34. 2011
    ..We investigated the association between glucose tolerance status defined by a 75-g oral glucose tolerance test (OGTT) and the development of dementia...
  3. pmc Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    Cardiovasc Diabetol 8:60. 2009
    ..In the present study, the association between serum resistin concentration and cardiovascular disease (CVD) was investigated in a general Japanese population...
  4. pmc Prevention of type 2 diabetes in a primary healthcare setting: three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance
    Naoki Sakane
    Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    BMC Public Health 11:40. 2011
    ..The results of 3 years' intervention are summarized...
  5. doi request reprint Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009)
    Jun Hata
    Department of Environmental Medicine J H, T N, Y H, M N, N M, S G, M F, F I, K S, D Y, Y K and Department of Medicine and Clinical Science J H, T N, Y H, M N, N M, S G, M F, F I, K S, M K, T K, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan and Biostatistics Center, Kurume University, Kurume, Japan K Y
    Circulation 128:1198-205. 2013
    ..Changes in lifestyle and advances in medical technology during the past half century are likely to have affected the incidence and mortality of cardiovascular disease and the prevalence of its risk factors in Japan...
  6. doi request reprint QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama study
    Daisuke Maebuchi
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertens Res 33:916-21. 2010
    ..Measurement of QTc intervals is likely to provide additional information for the detection of individuals at high risk of future CVD events...
  7. pmc Gender differences in the association between metabolic syndrome and periodontal disease: the Hisayama Study
    Michiko Furuta
    Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    J Clin Periodontol 40:743-52. 2013
    ..This study examined the gender difference in this association, considering the definition of periodontal disease...
  8. doi request reprint Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study
    Toshiaki Nakano
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Kidney Int 84:373-80. 2013
    ..73 m(2). Thus, elderly patients with CKD have intimal neoangiogenesis and an increased risk of intraplaque hemorrhage in coronary arteries, possibly favored by local accumulation of oxLDL and VEGF...
  9. pmc Impact of metabolic syndrome compared with impaired fasting glucose on the development of type 2 diabetes in a general Japanese population: the Hisayama study
    Naoko Mukai
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Care 32:2288-93. 2009
    ..We examined whether metabolic syndrome predicts incident type 2 diabetes more effectively than impaired fasting glucose (IFG) in a general Japanese population...
  10. doi request reprint Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Stroke 40:1187-94. 2009
    ..The current criteria of metabolic syndrome (MetS) are not based on evidence derived from prospective studies on cardiovascular disease (CVD)...
  11. doi request reprint Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese: the Hisayama study
    Jun Hata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cerebrovasc Dis 31:477-84. 2011
    ..We examined the influence of smoking on the development of stroke and CHD and the effects of interactions between smoking and hypercholesterolemia on these outcomes in a general Japanese population...
  12. ncbi request reprint Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population: the Hisayama study
    Keiichi Tanaka
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Causes Control 16:573-8. 2005
    ..In conclusion, our findings suggest that in a Japanese population, the mortality from gastric cancer declined during the past 40 years, due mainly to the improvement of survival in both sexes and a decrease in the incidence for women...
  13. doi request reprint Impact of blood pressure levels on different types of stroke: the Hisayama study
    Hisatomi Arima
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Fukuoka, Japan
    J Hypertens 27:2437-43. 2009
    ....
  14. doi request reprint Body mass index and stroke incidence in a Japanese community: the Hisayama study
    Koji Yonemoto
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertens Res 34:274-9. 2011
    ..In conclusion, our findings suggest that overweight and obesity are independent risk factors for ischemic stroke in Japanese men...
  15. ncbi request reprint High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study
    Hisatomi Arima
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 28:1385-91. 2008
    ..The purpose of this study was to investigate the effects of high-sensitivity C-reactive protein (hs-CRP) on the risks of coronary heart disease (CHD) in a general population of Japanese...
  16. doi request reprint Impact of glucose tolerance status on development of ischemic stroke and coronary heart disease in a general Japanese population: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Stroke 41:203-9. 2010
    ..Few studies have shown the association between glucose tolerance status defined by a 75-g oral glucose tolerance test and the development of different types of cardiovascular disease...
  17. doi request reprint Hyperglycemia increases risk of gastric cancer posed by Helicobacter pylori infection: a population-based cohort study
    Fumie Ikeda
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gastroenterology 136:1234-41. 2009
    ..The aim of this study was to evaluate the impact of hemoglobin A1c (HbA1c) levels on gastric cancer occurrence and their interaction with Helicobacter pylori infection...
  18. doi request reprint LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: the Hisayama study
    Tsuyoshi Imamura
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Stroke 40:382-8. 2009
    ..Although the relation between serum LDL cholesterol level and coronary heart disease (CHD) is well established, its relation with stroke subtypes is less clear...
  19. ncbi request reprint Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: the Hisayama Study
    Hisatomi Arima
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Cancer Prev 15:196-201. 2006
    ..77; 95% confidence interval 1.04-3.00; P=0.03). In conclusion, our findings suggest that ACE genotype DD enhances the association between smoking and cancer death in the general population...
  20. ncbi request reprint C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in a general Japanese population: the Hisayama Study
    Yoshiyuki Wakugawa
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka City 812 8582, Japan
    Stroke 37:27-32. 2006
    ..The role of high-sensitivity C-reactive protein (hsCRP) in the development of stroke is not clearly understood. We investigated the relationship between serum hsCRP levels and stroke occurrence in a general Japanese population...
  21. ncbi request reprint Trends in the incidence, mortality, and survival rate of cardiovascular disease in a Japanese community: the Hisayama study
    Michiaki Kubo
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Stroke 34:2349-54. 2003
    ..The slowdown of a steeply declining trend in cardiovascular mortality has been reported in Japan, but precise reasons for this trend are uncertain...
  22. doi request reprint White blood cell count and risk of gastric cancer incidence in a general Japanese population: the Hisayama study
    Masahiro Iida
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Fukuoka City, Japan
    Am J Epidemiol 175:504-10. 2012
    ..There was no evidence of heterogeneity in the association (P for heterogeneity = 0.65). The study findings suggest that higher WBC levels are a risk factor for gastric cancer, especially in subjects with H. pylori infection...
  23. ncbi request reprint Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: The Hisayama Study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes 56:2829-33. 2007
    ..2 and diabetes has been reported in Caucasians but not in Asians. We examined this issue in follow-up and cross-sectional studies in a general Japanese population...
  24. doi request reprint Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study
    Toshiaki Nakano
    Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Am J Kidney Dis 55:21-30. 2010
    ..This study investigated the relationship between CKD and severity of coronary atherosclerosis in population-based autopsy samples...
  25. doi request reprint Prevalence and systemic risk factors for retinal vein occlusion in a general Japanese population: the Hisayama study
    Miho Yasuda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 51:3205-9. 2010
    ..To examine the prevalence of retinal vein occlusion (RVO) and its systemic relevant factors in a general Japanese population aged 40 years or older...
  26. doi request reprint Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population
    Yasufumi Doi
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Clin Endocrinol Metab 93:3425-9. 2008
    ..1 mmol/liter, the gold standard diagnostic criterion, in a general Japanese population...
  27. doi request reprint Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study
    Mio Ozawa
    Departments of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Clin Nutr 97:1076-82. 2013
    ..To our knowledge, there are no previous reports that assessed the association between dietary patterns and risk of dementia in Asian populations...
  28. doi request reprint Association between glucose tolerance level and cancer death in a general Japanese population: the Hisayama Study
    Yoichiro Hirakawa
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Epidemiol 176:856-64. 2012
    ..These findings suggest that both prediabetic hyperglycemia and diabetes are significant risk factors for cancer death in the general Japanese population...
  29. doi request reprint Nine-year incidence and risk factors for retinal vein occlusion in a general Japanese population: the Hisayama Study
    Satoshi Arakawa
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 52:5905-9. 2011
    ..To estimate the long-term cumulative incidence and risk factors for retinal vein occlusion (RVO) in a population-based cohort study of Japanese...
  30. ncbi request reprint A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: the Hisayama study
    Kentaro Shikata
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 119:196-201. 2006
    ..14-7.24]). Our findings suggest that high dietary salt intake is a significant risk factor for gastric cancer; moreover, this association was found to be strong in the presence of Helicobacter pylori infection with atrophic gastritis...
  31. ncbi request reprint Population-based prospective study of the combined influence of cigarette smoking and Helicobacter pylori infection on gastric cancer incidence: the Hisayama Study
    Kentaro Shikata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Epidemiol 168:1409-15. 2008
    ..6%. Findings suggest that cigarette smoking and H. pylori infection are significant risk factors for gastric cancer in Japanese men, and the magnitude of their combined influence is considerable...
  32. ncbi request reprint Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study
    Tomoko Usui
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
    Circ J 77:2311-7. 2013
    ..The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD)...
  33. doi request reprint Risk factors for coronary atherosclerosis in a general Japanese population: the Hisayama study
    Yutaka Nakashima
    Pathophysiological and Experimental Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Pathol Res Pract 205:700-8. 2009
    ....
  34. doi request reprint Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study
    Masaharu Nagata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Nephrol Dial Transplant 25:2557-64. 2010
    ..Chronic kidney disease (CKD) is increasingly recognized as a leading public health issue. However, there are limited data assessing secular trends in the prevalence of CKD in general Asian communities...
  35. doi request reprint Development and validation of a cardiovascular risk prediction model for Japanese: the Hisayama study
    Hisatomi Arima
    Department of Environmental Medicine, Kyushu University, Fukuoka, Japan
    Hypertens Res 32:1119-22. 2009
    ..The risk prediction model would provide a useful guide to estimate absolute risk of cardiovascular disease and to treat individual risk factors...
  36. pmc Seroprevalence of herpes simplex virus 1 and 2 in a population-based cohort in Japan
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Epidemiol 19:56-62. 2009
    ..There have been few population-based studies of the seroprevalence and correlates of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in Japan...
  37. doi request reprint Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: the Hisayama Study
    Tomoyuki Ohara
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Am Geriatr Soc 59:1074-9. 2011
    ..To estimate the effects of the apolipoprotein E (APOE)-ɛ4 allele on the development of dementia and to elucidate its usefulness in the risk prediction of dementia in Japanese...
  38. ncbi request reprint Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction
    Jun Hata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Mol Genet 16:630-9. 2007
    ..00, 95% CI = 1.22-3.29, P = 0.006). Our results indicate that the SNP in the AGTRL1 gene is associated with the susceptibility to brain infarction...
  39. ncbi request reprint Ten-year prognosis of stroke and risk factors for death in a Japanese community: the Hisayama study
    Yutaka Kiyohara
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka City, 812 8582 Japan
    Stroke 34:2343-7. 2003
    ..There have been very few population-based cohort studies of long-term prognosis and risk factors for death after stroke. We examined the 10-year prognosis, causes, and risk factors of death after stroke in a Japanese cohort...
  40. ncbi request reprint Liver enzymes as a predictor for incident diabetes in a Japanese population: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Obesity (Silver Spring) 15:1841-50. 2007
    ..We studied the relationship between liver enzymes and the development of diabetes in a general Japanese population...
  41. ncbi request reprint Intake of dairy products and periodontal disease: the Hisayama Study
    Yoshihiro Shimazaki
    Department of Preventive Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    J Periodontol 79:131-7. 2008
    ..A previous study showed the relationship between the intake of dairy products and periodontitis, but the types of dairy products that confer a benefit on periodontal health status have not been determined...
  42. doi request reprint White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama study
    Masayo Fukuhara
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Stroke 44:1512-7. 2013
    ..The objective of this study was to investigate the associations of WCHT, MHT, and SHT with carotid atherosclerosis in a general population...
  43. doi request reprint Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population: the Hisayama Study
    Masashi Miyazaki
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gastric Cancer 15:162-9. 2012
    ..The objective of this study was to investigate this issue in a general Japanese population...
  44. doi request reprint Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study
    Mio Ozawa
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Am Geriatr Soc 60:1515-20. 2012
    ..To investigate whether higher intake of potassium, calcium, and magnesium reduces the risk of incident dementia...
  45. doi request reprint Impact of lower range of prehypertension on cardiovascular events in a general population: the Hisayama Study
    Masayo Fukuhara
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Hypertens 30:893-900. 2012
    ..The objective of the present analysis was to examine the impact of prehypertension and its population-attributable fraction for development of cardiovascular events in a general Japanese population...
  46. ncbi request reprint The influence of current and former smoking on gingival bleeding: the Hisayama study
    Yoshihiro Shimazaki
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    J Periodontol 77:1430-5. 2006
    ..This study examined the relationship between smoking, including past smoking, and periodontal conditions, mainly gingival bleeding, in a community-based health investigation...
  47. ncbi request reprint The serum pepsinogen test as a predictor of gastric cancer: the Hisayama study
    Yoshinori Oishi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Epidemiol 163:629-37. 2006
    ..These findings suggest that the SPT can serve as a predictor of intestinal-type gastric cancer, irrespective of H. pylori infection...
  48. ncbi request reprint Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population: the Hisayama Study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes Care 28:2497-500. 2005
    ..We examined the association between high-sensitivity C-reactive protein (CRP) levels and the development of diabetes in a general Japanese population...
  49. ncbi request reprint Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study
    Kouhei Fujimi
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Dement Geriatr Cogn Disord 23:423-31. 2007
    ..In addition, it has been suggested that alterations in the balance of polyunsaturated fatty acids are associated with brain dysfunctions such as neurodegerative pathologies of the aging brain...
  50. ncbi request reprint Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population: the Hisayama study
    Toshiharu Ninomiya
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Stroke 38:2063-9. 2007
    ..The metabolic syndrome (MetS) is associated with an increased risk of cardiovascular disease (CVD) events in general populations. However, well-designed prospective studies in Asian populations are very limited...
  51. ncbi request reprint Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama study
    Toshiharu Ninomiya
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Kidney Dis 44:437-45. 2004
    ..Hyperhomocysteinemia has been linked with various atherosclerotic diseases, but has not been evaluated sufficiently as a risk factor for the development of chronic kidney disease (CKD) in the general population...
  52. doi request reprint Temporal trends in sudden unexpected death in a general population: the Hisayama study
    Masaharu Nagata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am Heart J 165:932-938.e1. 2013
    ..Studies addressing the temporal trends in the prevalence of sudden unexpected death (SUD) and its underlying causes in the general population are limited...
  53. doi request reprint Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: the Hisayama Study
    Kentaro Shikata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Scand J Gastroenterol 47:669-75. 2012
    ..However, there have been few prospective investigations which investigated the predictive performance of sPG for future gastric cancer incidence...
  54. ncbi request reprint The prevalence of pseudoexfoliation syndrome in a Japanese population: the Hisayama study
    Miho Miyazaki
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Glaucoma 14:482-4. 2005
    ..To examine the prevalence and systemic associations of pseudoexfoliation syndrome (PXS) in a Japanese population...
  55. doi request reprint Midlife and late-life blood pressure and dementia in Japanese elderly: the Hisayama study
    Toshiharu Ninomiya
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka City 812 8582, Japan
    Hypertension 58:22-8. 2011
    ..Midlife hypertension is especially strongly associated with a greater risk of vascular dementia, regardless of late-life blood pressure levels...
  56. ncbi request reprint Metabolic syndrome and CKD in a general Japanese population: the Hisayama Study
    Toshiharu Ninomiya
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Kidney Dis 48:383-91. 2006
    ..Metabolic syndrome has been linked with various atherosclerotic diseases, but has not been evaluated sufficiently as a risk factor for the development of chronic kidney disease (CKD) in the general population...
  57. ncbi request reprint Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study
    Toshiharu Ninomiya
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Kidney Int 68:228-36. 2005
    ..Chronic kidney disease has been shown to be an independent risk factor for cardiovascular disease in high-risk populations. However, this relationship is inconclusive in community-based populations...
  58. ncbi request reprint Impact of serum total cholesterol on the incidence of gastric cancer in a population-based prospective study: the Hisayama study
    Kouichi Asano
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 122:909-14. 2008
    ..In conclusion, our findings suggest that low serum cholesterol levels are an independent risk factor for developing gastric cancer, especially intestinal-type gastric cancer...
  59. ncbi request reprint Insulin-mediated effects of alcohol intake on serum lipid levels in a general population: the Hisayama Study
    Isao Kato
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka City, 812 8582 Japan
    J Clin Epidemiol 56:196-204. 2003
    ..Our data suggest that regular alcohol consumption dose-dependently increased insulin sensitivity among male nondiabetics, but the insulin-mediated beneficial effects of alcohol on lipid concentrations were relatively small...
  60. ncbi request reprint Validity of the JNC VI recommendations for the management of hypertension in a general population of Japanese elderly: the Hisayama study
    Hisatomi Arima
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka City, 812 8582 Japan
    Arch Intern Med 163:361-6. 2003
    ....
  61. ncbi request reprint Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population: the Hisayama study
    Hajime Yamagata
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes Care 28:789-94. 2005
    ..Several studies have shown associations between diabetes and various types of cancer other than gastric cancer. The aim of this cohort study was to evaluate the impact of fasting plasma glucose (FPG) levels on gastric cancer occurrence...
  62. ncbi request reprint Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama study
    Seiji Gotoh
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Atheroscler Thromb 19:977-85. 2012
    ..Although several surrogate measures of insulin resistance have been proposed, their associations with cardiovascular disease (CVD) have not been evaluated sufficiently...
  63. ncbi request reprint Prevalence and risk factors for myopic retinopathy in a Japanese population: the Hisayama Study
    Tomoko Asakuma
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ophthalmology 119:1760-5. 2012
    ..To examine the prevalence of myopic retinopathy and its risk factors in a general Japanese population...
  64. ncbi request reprint Relationship between C-reactive protein and glucose levels in community-dwelling subjects without diabetes: the Hisayama Study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes Care 28:1211-3. 2005
  65. doi request reprint Arterial stiffness and QT interval prolongation in a general population: the Hisayama study
    Daisuke Maebuchi
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Hypertens Res 31:1339-45. 2008
    ..0001 for trend). In conclusion, baPWV is independently associated with QT interval prolongation...
  66. doi request reprint N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 31:2997-3003. 2011
    ..Few studies have examined the association between natriuretic peptides and the incidence of cardiovascular disease (CVD) in Asian populations...
  67. ncbi request reprint Prehypertension increases the risk for renal arteriosclerosis in autopsies: the Hisayama Study
    Toshiharu Ninomiya
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka, Japan
    J Am Soc Nephrol 18:2135-42. 2007
    ..42 [95% CI 1.29 to 32.04]). These findings suggest that both hypertension and prehypertension are associated significantly with the severity of renal arteriosclerosis, regardless of the presence or absence of target organ damage...
  68. ncbi request reprint Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study
    Haruki Shimizu
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka City, 812 8582 Japan
    Stroke 35:2072-7. 2004
    ..However, there are very few reports on this subject. In a community-based case-control study, we tested the hypothesis that low levels of plasma GSH are closely associated with CVD and its clinical types...
  69. doi request reprint The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population
    Jun Hata
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka City 812 8582, Japan
    Atherosclerosis 210:249-55. 2010
    ..We evaluated the impact of metabolic syndrome (MetS) defined by various criteria on the occurrence of ischemic stroke subtypes in a general Japanese population...
  70. doi request reprint High serum bilirubin levels and diabetic retinopathy: the Hisayama Study
    Miho Yasuda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ophthalmology 118:1423-8. 2011
    ..To assess the association between serum total bilirubin levels and diabetic retinopathy prevalence in participants of the Hisayama Study who had diabetes and impaired glucose metabolism...
  71. pmc Prevalence and causes of functional disability in an elderly general population of Japanese: the Hisayama study
    Daigo Yoshida
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Epidemiol 22:222-9. 2012
    ..There are limited data on the prevalence and causes of disability in the elderly general population in Japan...
  72. doi request reprint Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study
    A Sekita
    Department of Environmental Medicine, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka City, Japan
    Acta Psychiatr Scand 122:319-25. 2010
    ..To examine secular trends in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) in a general Japanese population...
  73. doi request reprint Impact of kidney disease and blood pressure on the development of cardiovascular disease: an overview from the Japan Arteriosclerosis Longitudinal Study
    Toshiharu Ninomiya
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582 Japan
    Circulation 118:2694-701. 2008
    ..Recent epidemiological studies have suggested that a lower blood pressure level may be associated with an increased risk of CVD in individuals with kidney dysfunction...
  74. doi request reprint Nine-year incidence and risk factors for age-related macular degeneration in a defined Japanese population the Hisayama study
    Miho Yasuda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ophthalmology 116:2135-40. 2009
    ..To estimate the 9-year incidence and risk factors for age-related macular degeneration (AMD) in a general Japanese population...
  75. doi request reprint Smoking cessation improves mortality in Japanese men: the Hisayama study
    Fumie Ikeda
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka City 812 8582, Japan
    Tob Control 21:416-21. 2012
    ..Although the smoking rate among Japanese men has been the highest in developed countries, the epidemiological evidence about whether smoking cessation can extend their lifespan is not well established...
  76. doi request reprint Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: the Hisayama study
    Kouhei Fujimi
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Brain Pathol 18:317-25. 2008
    ....
  77. doi request reprint Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population. The Fukuoka Stroke Registry and the Hisayama Study
    Noriko Hagiwara
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cerebrovasc Dis 25:417-22. 2008
    ..We conducted a case-control study to clarify the association of LTA gene polymorphisms with ischemic stroke in a large Japanese population...
  78. ncbi request reprint [Lifestyle-related diseases as risk factors for dementia]
    Atsuko Sekita
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka City, Japan
    Brain Nerve 62:709-17. 2010
    ..Some cohort studies have examined the associations of hypercholesterolemia with the risk of AD, but the results were inconsistent. Further studies are required to resolve these issues...
  79. ncbi request reprint The 5-year incidence and risk factors for age-related maculopathy in a general Japanese population: the Hisayama study
    Miho Miyazaki
    Departments of Ophthalmology, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 46:1907-10. 2005
    ..To estimate the 5-year incidence and risk factors for age-related maculopathy (ARM) in a representative older Japanese population...
  80. ncbi request reprint Quantitative analysis of neurofibrillary pathology in a general population to reappraise neuropathological criteria for senile dementia of the neurofibrillary tangle type (tangle-only dementia): the Hisayama Study
    Kazuhito Noda
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Neuropathology 26:508-18. 2006
    ....
  81. ncbi request reprint Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study
    Miho Miyazaki
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, 812 8582 Fukuoka, Japan
    Graefes Arch Clin Exp Ophthalmol 241:642-6. 2003
    ..To examine the prevalence and risk factors for epiretinal membranes (ERMs) in a sample Japanese population...