Chikako Kiyohara

..Cigarette smoking may be associated with increased risk of systemic lupus erythematosus (SLE), whereas the role of alcohol consumption is unknown. We examined the association between SLE risk and smoking or drinking...

..Several components of overall lung carcinogenesis, carcinogen metabolic and DNA repair pathways may be involved in individual genetic susceptibility to lung cancer...

..Metabolic enzymes are involved in ROS production. The aim of this study was to evaluate the modifying effect of metabolic polymorphisms on the association of cigarette smoking with SLE risk in a Japanese population...

..Several epidemiologic and molecular epidemiologic studies have indicated that, for a given number of cigarettes smoked, women may be at higher risk of lung cancer compared with men...

..Interleukin 1B (IL1B) is involved in pulmonary inflammation induced by environmental or occupational toxins. Chronic inflammation has been implicated in the development of lung cancer...

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..Hopefully, in future studies it will be possible to screen for lung cancer using specific biomarkers...

..Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples...

..Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls...

..This review evaluates whether or not a specific polymorphism or a combination of such polymorphisms can effectively predict high-risk groups...

..We examined if smoking or alcohol consumption modify associations between MTHFR polymorphisms and lung cancer risk...

..Consortia and international collaborative studies, which may maximize study efficacy and overcome the limitations of individual studies, are needed to help further illuminate the complex landscape of AD risk and genetic variations...

..Future studies involving larger control and case populations and better pesticide exposure histories will undoubtedly lead to a more thorough understanding of the role of the GST polymorphisms in PD development...

..50, 95% CI = 0.12-0.88), compared with the NAT2 rapid acetylator genotype and no history of smoking. This study suggests that, in this Japanese population, the NAT2 slow acetylator status may be a determinant in susceptibility to SLE...

..Hopefully, in the future we will be able to screen for major depressive disorder susceptibility by using specific biomarkers...

..Along with environmental factors such as smoking, both polymorphisms may modulate an individual's susceptibility to SLE. We investigated these relationships in a case-control study to evaluate risk factors for SLE among Japanese women...

..To elucidate the relationship, we applied meta-analysis techniques to molecular studies of 5-HTTLPR and MDD...

..Our findings indicate the possible association of the Glu allele of the TP53BP1 Asp353Glu polymorphism with lower risk of lung cancer especially among the Pro allele carriers of the TP53 Arg72Pro polymorphism...

..Parkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved in dopaminergic neurotransmission may influence susceptibility to PD...

..This meta-analysis indicated that smokers have a lower risk of PD. As PD is a multifactorial disease, further investigation of the smoking-gene interaction on PD risk may lead to a better understanding of the pathogenesis of PD...

..In contrast, the GSTM1 null genotype posed an increased, although not significant, risk among them. Additional studies are warranted to confirm the ETS-GSTM1 polymorphism interaction suggested in our present study...

..Hopefully, in the future we will be able to screen for lung cancer susceptibility by using specific biomarkers...

..CYP1A1 inducing potential may be one of the most convenient biomarkers with which to estimate the overall carcinogenicity/mutagenicity of airborne particle extracts...

..Hopefully, in the future we will be able to screen for lung cancer susceptibility by using specific biomarkers...

..The aim of this study is to review and summarize the available molecular epidemiologic studies of lung cancer and EPHX1...

..These findings suggest that coffee drinking may be associated with lower concentrations of serum uric acid, and further studies are needed to confirm the association...

..These three genes are involved in the generation of reactive oxygen species (ROS), which play a critical role for autoimmune diseases...

..We do not find evidence for interactions between smoking or caffeine intake and SNP rs11724635 affecting sporadic PD...

..In addition, we provide new evidence for the biological interaction between the polymorphism and smoking with regard to the risk of sporadic PD...

..We confirmed that the intake of coffee and caffeine reduced the risk of PD. Furthermore, this is the first study to show a significant inverse relationship between the intake of Japanese and Chinese teas and the risk of PD...

..We also present new evidence for biological interactions between SNPs rs356219 and rs356220 and smoking that affect sporadic PD...

..We examined the relationship between alcohol intake and PD among Japanese subjects using data from a case-control study...

..50 (95% CI: 0.26-0.95, P for trend=0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD...

..Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD...

..Further well-designed investigations of the association of vascular risk factors with the risk of PD are needed, particularly large-scale prospective studies in Asia...

..We examined the relationship between UCHL1 S18Y single nucleotide polymorphism (SNP) and sporadic PD in Japan...

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..The evidence for associations between occupational factors and the risk of Parkinson's disease (PD) is inconsistent. We assessed the risk of PD associated with various occupational factors in Japan...

..20-12.36), respectively]. The authors found that, overall, neither exclusive nor partial breastfeeding had a strong impact on the risk of atopic eczema. However, a parental allergic history may affect the risk...

..We conducted a case-control study of the relationship between the polymorphisms of rs1800925 and rs20541 and the risk of eczema in Japanese children aged 3 years...

..This prospective study investigated the relationship of consumption of selected high-fat foods and specific types of fatty acids with the risk of postpartum depression...

..The relationship between single nucleotide polymorphisms (SNPs) in ADAM33 and atopic dermatitis (AD) in Japanese children was examined using case-control design...

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..Our results suggest that the C3435T polymorphism may not play an important role in PD susceptibility in Japanese. Evidence of an interaction between the C3435T polymorphism and alcohol consumption was suggested...

..These results indicate that pyrosequence-based 16S rRNA gene profiling is valid to find the intestinal microbiotal disorder that correlates with allergy development in later life...

..These results indicate that antibiotic exposure at the beginning of life greatly influences the development of neonatal intestinal microbiota...

..Identification of the association of killer cell immunoglobulin-like receptor (KIR) genes with SLE and accompanying infections...

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..We examined the relation between plasma folate status and colorectal adenomas with reference to effect modification by the genetic polymorphism (C677T) of MTHFR...

..Therefore, the relationship between those mental disorders and tobacco addiction should be cleared up considering the interactive effect of genetic and environmental factors...

..A history of high-dose oral corticosteroids was associated with the preservation of BMD at the lumbar spine, however, further study is needed considering the limited sample size...

..This prospective study examined the relationship of dietary consumption of folate and B vitamins during pregnancy with the risk of postpartum depression...

..These data show the urgency of developing anti-smoking educational programs that could be developed and introduced prior to admission to high school...

..In this study, we determined the function of these ERCC1 polymorphisms in the survival of NSCLC patients...

..03) and 2 months (P=0.05) than in the non-allergic group, while no statistically significant difference was observed for the other bacterial populations...

..Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls...

..It is also very important that an evidence-based, standardized methodology of DC treatment should be immediately established in Japan...

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..The purpose of the present study was to investigate the actual conditions of tobacco smoking among boys in Japan...

..2 mg/kg tributyltin and 10 mg/kg p,p'-DDE. Moreover, the simultaneous administration of p,p'-DDE with tributyltin counterbalanced the effects that were attributed to tributyltin alone...

..0 %). Almost all cases (95.7 %) concerned patients whose relatives suffered from periodic fever. These findings suggest that the clinical features of Japanese TRAPS patients may be milder than those of patients in Western countries...

..g., Pseudomonas, appeared first and were then immediately replaced by facultative anaerobe, Enterococcus, Streptococcus, and Enterobacteriaceae through the first month, and finally strictly anaerobic Bifidobactrerium appeared...

..Additional studies with detailed assessments of alcohol consumption and potential confounding factors will undoubtedly lead to a better understanding of the role of alcohol consumption in lung cancer development...

..52; 95% CI 0.12-2.35). The present findings suggest that DC treatment may be preventive against readmission for schizophrenic out-patients...

..However, in Hokkaido, this association between smoking and SLE did not reach statistical significance after adjusting for alcohol drinking. The present study suggests that smoking may increase the risk of SLE among Japanese females...

..The analyses were more inconsistent and failed to reach statistical significance in Asians. This observation might be due to design specificities or unknown effect modifiers in the Asian studies...

..However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking...

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..People with rare combinations of common gene variants have a high risk of cancer and can be assimilated to subjects with highly penetrant mutations...

..No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected...

..The association was stronger in elderly patients. As for tumor site, surgery was most strongly associated with an increased risk of LRT in patients with malignant tumors of the digestive organs...

..We examined the association between dietary GI and glycemic load (GL) and postpartum depression...

..Thus, considering that ADHD is a multifactorial disease, a comprehensive therapic strategy involving medication, education, judicature, and administration should be established for primary and secondary prevention...