Takuya Kishi

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. pmc Oxidative stress in the brain causes hypertension via sympathoexcitation
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences Fukuoka, Japan
    Front Physiol 3:335. 2012
  2. doi request reprint Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats
    T Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Conf Proc IEEE Eng Med Biol Soc 2012:6764-7. 2012
  3. doi request reprint Heart failure as an autonomic nervous system dysfunction
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Cardiol 59:117-22. 2012
  4. doi request reprint Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiol 60:489-94. 2012
  5. doi request reprint Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Exp Hypertens 34:278-83. 2012
  6. ncbi request reprint Combination therapy of atorvastatin and amlodipine inhibits sympathetic nervous system activation and improves cognitive function in hypertensive rats
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Circ J 76:1934-41. 2012
  7. doi request reprint Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT1 receptor in the brainstem
    T Kishi
    Department of Advanced Therapeutics forCardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Conf Proc IEEE Eng Med Biol Soc 2011:1969-72. 2011
  8. doi request reprint Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Exp Hypertens 33:240-5. 2011
  9. doi request reprint Atorvastatin might improve ventricular electrostability and decelerate the deterioration of renal function in patients with heart failure and diabetes mellitus
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Higashi ku, Fukuoka, Japan
    J Cardiol 53:341-8. 2009
  10. doi request reprint Cilnidipine inhibits the sympathetic nerve activity and improves baroreflex sensitivity in patients with hypertension
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University, Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Clin Exp Hypertens 31:241-9. 2009

Collaborators

Detail Information

Publications63

  1. pmc Oxidative stress in the brain causes hypertension via sympathoexcitation
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences Fukuoka, Japan
    Front Physiol 3:335. 2012
    ....
  2. doi request reprint Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats
    T Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Conf Proc IEEE Eng Med Biol Soc 2012:6764-7. 2012
    ..In conclusion, exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in the hippocampus of stroke-prone hypertensive rats...
  3. doi request reprint Heart failure as an autonomic nervous system dysfunction
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Cardiol 59:117-22. 2012
    ....
  4. doi request reprint Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiol 60:489-94. 2012
    ....
  5. doi request reprint Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Exp Hypertens 34:278-83. 2012
    ..SNA and oxidative stress in the RVLM were significantly lower in SHRSP-EX than in SHRSP-C. These results suggest that exercise training inhibits SNA via reduction of oxidative stress through blocked AT(1)R in the RVLM of hypertension...
  6. ncbi request reprint Combination therapy of atorvastatin and amlodipine inhibits sympathetic nervous system activation and improves cognitive function in hypertensive rats
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Circ J 76:1934-41. 2012
    ..The aim of the present study was to determine whether a combination of atorvastatin and amlodipine causes sympathoinhibition via reduction of oxidative stress in the RVLM and improves cognitive dysfunction of hypertensive rats...
  7. doi request reprint Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT1 receptor in the brainstem
    T Kishi
    Department of Advanced Therapeutics forCardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Conf Proc IEEE Eng Med Biol Soc 2011:1969-72. 2011
    ..These results suggest that experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT(1) receptor in the brain, especially in hypertension...
  8. doi request reprint Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Exp Hypertens 33:240-5. 2011
    ..These results suggest that calorie restriction inhibits SNA via anti-oxidant effect in the RVLM of obesity-induced obesity rats...
  9. doi request reprint Atorvastatin might improve ventricular electrostability and decelerate the deterioration of renal function in patients with heart failure and diabetes mellitus
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Higashi ku, Fukuoka, Japan
    J Cardiol 53:341-8. 2009
    ..However, it remains unknown how statins impact pathophysiology of heart failure with diabetes mellitus. The aim of this study was to investigate the effects of atorvastatin on pathophysiology of heart failure with diabetes mellitus...
  10. doi request reprint Cilnidipine inhibits the sympathetic nerve activity and improves baroreflex sensitivity in patients with hypertension
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University, Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Clin Exp Hypertens 31:241-9. 2009
    ....
  11. doi request reprint Atorvastatin improves the impaired baroreflex sensitivity via anti-oxidant effect in the rostral ventrolateral medulla of SHRSP
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Clin Exp Hypertens 31:698-704. 2009
    ..These results suggest that atorvastatin improves the impaired BRS in SHRSP via its anti-oxidant effect in the RVLM of SHRSP...
  12. ncbi request reprint Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress
    Yoshikuni Kimura
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Circ Res 96:252-60. 2005
    ..These results suggest that overexpression of iNOS in the RVLM increases blood pressure via activation of the sympathetic nervous system, which is mediated by an increase in oxidative stress...
  13. doi request reprint Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats
    Satomi Konno
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiovasc Pharmacol 52:555-60. 2008
    ....
  14. ncbi request reprint Overexpression of eNOS in brain stem reduces enhanced sympathetic drive in mice with myocardial infarction
    Koji Sakai
    Dept of Cardiovascular Medicine, Kyushu Univ Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 289:H2159-66. 2005
    ....
  15. ncbi request reprint Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Circulation 109:2357-62. 2004
    ....
  16. ncbi request reprint Sympathoinhibition caused by orally administered telmisartan through inhibition of the AT₁ receptor in the rostral ventrolateral medulla of hypertensive rats
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertens Res 35:940-6. 2012
    ....
  17. ncbi request reprint Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension
    Koji Ito
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Circ Res 92:1337-43. 2003
    ....
  18. doi request reprint High salt intake enhances blood pressure increase during development of hypertension via oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats
    Yasuaki Koga
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Japan
    Hypertens Res 31:2075-83. 2008
    ..These responses are mediated by increased ROS generation that is probably due to upregulation of AT(1)R/NAD(P)H oxidase in the RVLM. (Hypertens Res 2008; 31: 2075-2083)...
  19. ncbi request reprint Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition
    Koji Ito
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Hypertension 43:156-62. 2004
    ..These results indicate that activation of the Rho/Rho-kinase pathway in the NTS contributes to neurogenic hypertension caused by chronic NO synthase inhibition...
  20. ncbi request reprint Inhibition of Rac1-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats
    Masatsugu Nozoe
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Maidashi, Higashi ku, Fukuoka, Japan
    Hypertension 50:62-8. 2007
    ....
  21. ncbi request reprint Reduction of nitric oxide-mediated γ-amino butyric acid release in rostral ventrolateral medulla is involved in superoxide-induced sympathoexcitation of hypertensive rats
    Keisuke Shinohara
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Circ J 76:2814-21. 2012
    ..In this study, we investigated whether or not NO-mediated GABA release is involved in superoxide-induced sympathoexcitation in the RVLM of hypertensive rats...
  22. ncbi request reprint Combination therapy of olmesartan and azelnidipine inhibits sympathetic activity associated with reducing oxidative stress in the brain of hypertensive rats
    Keisuke Shinohara
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Exp Hypertens 34:456-62. 2012
    ..Furthermore, the antioxidant effect in the brainstem and the sympathoinhibitory effect of OLM/AZ combination may be greater than those of CAN/AM combination treatment...
  23. ncbi request reprint Inhibition of oxidative stress in rostral ventrolateral medulla improves impaired baroreflex sensitivity in stroke-prone spontaneously hypertensive rats
    Kiyohiro Ogawa
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
    Int Heart J 53:193-8. 2012
    ..In contrast, in the AdLacZ-transfected SHRSP, atropine did not decrease BRS. These results suggest that chronic reduction of ROS in the local RVLM improves the impaired BRS in SHRSP through inhibition of the sympathetic component...
  24. doi request reprint Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Exp Hypertens 30:3-11. 2008
    ..These results suggest that atorvastatin reduces oxidative stress in the RVLM of SHRSP, which might contribute to the sympatho-inhibitory effects of atorvastatin in SHRSP...
  25. ncbi request reprint Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertension 41:255-60. 2003
    ..These results indicate that an increase in NO production in the RVLM improves the impaired baroreflex control of HR in SHRSP and that these effects may have resulted from a cardiac sympathoinhibitory effect of NO in the RVLM of SHRSP...
  26. ncbi request reprint Enhanced depressor response to endothelial nitric oxide synthase gene transfer into the nucleus tractus solitarii of spontaneously hypertensive rats
    Yoshitaka Hirooka
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertens Res 26:325-31. 2003
    ..An abnormality of the L-arginine-NO pathway in the NTS may be related to the hypertensive mechanism(s) of SHR...
  27. ncbi request reprint Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitric oxide synthases in stroke-prone spontaneously hypertensive rats
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Hypertens 21:379-86. 2003
    ..The aim of this study was thus to examine the effects of atorvastatin on blood pressure, sympathetic nerve activity, and the expression of NOS in stroke-prone spontaneously hypertensive rats (SHRSP) as well as in Wistar-Kyoto (WKY) rats...
  28. ncbi request reprint Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Circulation 111:2741-7. 2005
    ..The aim of the present study was to examine whether Rho-kinase is involved in the peripheral circulation abnormalities of HF in humans with the Rho-kinase inhibitor fasudil...
  29. doi request reprint Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostral ventrolateral medulla
    Masatsugu Nozoe
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Hypertens 26:2176-84. 2008
    ..It is not clear, however, whether mitochondria-derived ROS in the central nervous system also participate in sympathoexcitation...
  30. doi request reprint Angiotensin II receptor blockers improve endothelial dysfunction associated with sympathetic hyperactivity in metabolic syndrome
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Hypertens 30:1646-55. 2012
    ..We investigated whether treatment with angiotensin II type 1 receptor blockers (ARBs) improves endothelial and autonomic function in patients with MetS...
  31. doi request reprint Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method
    Shuichiro Araki
    Department of Cardiovascular Medicine, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Hypertens Res 32:1091-6. 2009
    ..These findings indicate that olmesartan has anti-oxidative property in the brain without stimulating reflex-mediated sympathetic activity in SHRSP...
  32. doi request reprint Sympathoinhibitory effects of telmisartan through the reduction of oxidative stress in the rostral ventrolateral medulla of obesity-induced hypertensive rats
    Satomi Konno
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Hypertens 30:1992-9. 2012
    ..The aim of the present study was to determine whether oral administration of an AT1R blocker (ARB) inhibits SNS activity via antioxidative effects in the RVLM of rats with dietary-induced obesity...
  33. doi request reprint Sympathoinhibition induced by centrally administered atorvastatin is associated with alteration of NAD(P)H and Mn superoxide dismutase activity in rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiovasc Pharmacol 55:184-90. 2010
    ..Our findings suggest that centrally administered atorvastatin decreases SNA and is associated with decreasing NAD(P)H oxidase activity and upregulation of Mn-SOD activity in the RVLM of SHRSP, leading to suppressing oxidative stress...
  34. ncbi request reprint Reduced nitric oxide synthase in the brainstem contributes to enhanced sympathetic drive in rats with heart failure
    Yoshitaka Hirooka
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiovasc Pharmacol 42:S111-5. 2003
    ..These results suggest that reduced nNOS expression in the NTS and the RVLM, and the resulting reduced NO production of these sites, contribute to the enhanced sympathetic drive in HF...
  35. doi request reprint Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats
    Yoshikuni Kimura
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Clin Exp Hypertens 31:281-6. 2009
    ..Bilateral microinjection of aminoguanidine into the RVLM dose-dependently decreased BP and heart rate in SHR, but not in WKY. These findings suggest that iNOS expression in the RVLM of SHR contributes to increase BP...
  36. doi request reprint Brain AT1 receptor activates the sympathetic nervous system through toll-like receptor 4 in mice with heart failure
    Kiyohiro Ogawa
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiovasc Pharmacol 58:543-9. 2011
    ..These results suggest that activation of the TLR4 via AT1R in the brainstem contributes to the sympathoexcitation probably due to the inflammation in the brain of the myocardial infarction-induced HF...
  37. doi request reprint Role of angiotensin-(1-7) in rostral ventrolateral medulla in blood pressure regulation via sympathetic nerve activity in Wistar-Kyoto and spontaneous hypertensive rats
    Toshiaki Nakagaki
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Exp Hypertens 33:223-30. 2011
    ..Our results suggest that endogenous Ang-(1-7) in the RVLM contributes to maintain AP and renal sympathetic nerve activity both in SHR and WKY and that its activity might be enhanced in SHR...
  38. doi request reprint Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertension 55:291-7. 2010
    ....
  39. doi request reprint Different role of oxidative stress in paraventricular nucleus and rostral ventrolateral medulla in cardiovascular regulation in awake spontaneously hypertensive rats
    Masaaki Nishihara
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Higashi ku, Fukuoka, Japan
    J Hypertens 30:1758-65. 2012
    ..We investigated the relative contribution of oxidative stress in the PVN and RVLM of SHR in blood pressure (BP) regulation...
  40. ncbi request reprint Vitamin C improves attenuated angiotensin II-induced endothelium-dependent vasodilation in human forearm vessels
    Yoshitaka Hirooka
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertens Res 26:953-9. 2003
    ..Thus, angiotensin II likely attenuates endothelium-dependent vasodilation via an increase of superoxide anion production in the human forearm in vivo...
  41. ncbi request reprint Statin therapy may prevent restenosis after successful coronary intervention, independent of lipid-lowering effect and CRP level
    Tohru Yamawaki
    Division of Cardiovascular Medicine, Aso Iizuka Hospital, Fukuoka, Japan
    Fukuoka Igaku Zasshi 98:260-9. 2007
    ..As statins have the anti-atherosclerotic pleiotropic effects, we retrospectively examined the effects of statins on restenosis after percutaneous coronary intervention (PCI)...
  42. pmc Partially silencing brain toll-like receptor 4 prevents in part left ventricular remodeling with sympathoinhibition in rats with myocardial infarction-induced heart failure
    Kiyohiro Ogawa
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
    PLoS ONE 8:e69053. 2013
    ..The purpose of the present study was to examine whether silencing brain TLR4 could prevent LV remodeling with sympathoinhibition in MI-induced heart failure...
  43. doi request reprint Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats
    Masaaki Nishihara
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Hypertens 30:97-106. 2012
    ....
  44. doi request reprint Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension
    Yoshitaka Hirooka
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Am J Physiol Regul Integr Comp Physiol 300:R818-26. 2011
    ..Together, the evidence indicates that an imbalance of NO and ROS in the CNS plays a pivotal role in the pathogenesis of hypertension...
  45. ncbi request reprint Percutaneous coronary arterial thrombectomy for acute myocardial infarction reduces no-reflow phenomenon and protects against left ventricular remodeling related to the proximal left anterior descending and right coronary artery
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Aso Iizuka Hospital, Fukuoka, Japan
    Int Heart J 48:287-302. 2007
    ....
  46. doi request reprint Moxonidine-induced central sympathoinhibition improves prognosis in rats with hypertensive heart failure
    Nobuhiro Honda
    aDepartment of Cardiovascular Medicine bDepartment of Advanced Cardiovascular Regulation and Therapeutics cDepartment of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences dDepartment of Bio Functional Science, Graduate School of Pharmaceutical Sciences eInnovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan
    J Hypertens 31:2300-8; discussion 2308. 2013
    ..In the present study, we investigated the effects of central sympathoinhibition by intracerebral infusion of moxonidine on survival in a rat model of hypertensive heart failure and the possible mechanisms involved...
  47. ncbi request reprint Effect of overproduction of nitric oxide in the brain stem on the cardiovascular response in conscious rats
    Yoshitaka Hirooka
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiovasc Pharmacol 41:S119-26. 2003
    ....
  48. ncbi request reprint Elevated serum C-reactive protein levels as a predictive indicator for subsequent renal impairment in patients with acute heart failure
    Yoshihiro Fukumoto
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Tohoku J Exp Med 213:361-8. 2007
    ..In conclsion, higher serum levels of CRP could predict the subsequent renal impairment in patients admitted with the worsening of HF symptoms...
  49. ncbi request reprint Oxidative stress and central cardiovascular regulation. - Pathogenesis of hypertension and therapeutic aspects -
    Yoshitaka Hirooka
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Circ J 74:827-35. 2010
    ..The aim of the present review is to describe the contribution of oxidative stress in the brain to the neural mechanisms that underlie hypertension, and discuss evidence that brain oxidative stress is a potential therapeutic target...
  50. ncbi request reprint Role of endothelium-derived hyperpolarizing factor in human forearm circulation
    Kosuke Inokuchi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Hypertension 42:919-24. 2003
    ..128, 0.256, 0.512, and 1.024 mg/min, n=8). These results suggest that EDHF contributes substantially to basal forearm vascular resistance, as well as to forearm vasodilatation evoked by substance P and bradykinin in humans in vivo...
  51. ncbi request reprint Regulation of the sympathetic nervous system by nitric oxide and oxidative stress in the rostral ventrolateral medulla: 2012 Academic Conference Award from the Japanese Society of Hypertension
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertens Res 36:845-51. 2013
    ..In conclusion, our studies suggest that the increase in AT1R-induced oxidative stress and/or the decrease in NO in the RVLM mainly cause sympathoexcitation in hypertension. ..
  52. ncbi request reprint Cardiovascular effects of overexpression of endothelial nitric oxide synthase in the rostral ventrolateral medulla in stroke-prone spontaneously hypertensive rats
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertension 39:264-8. 2002
    ....
  53. ncbi request reprint Fatal case of amiodarone-induced acute respiratory distress syndrome in a patient with severe left ventricular dysfunction due to extensive anterior acute myocardial infarction
    Yoshihiro Fukumoto
    Division of Cardiovascular Medicine, Aso Iizuka Hospital, Fukuoka, Japan
    Fukuoka Igaku Zasshi 97:37-41. 2006
    ..It is sometimes difficult to diagnose congestive heart failure or amiodarone-induced pulmonary infiltrates in patients with severe left ventricular dysfunction...
  54. doi request reprint Striking volume intolerance is induced by mimicking arterial baroreflex failure in normal left ventricular function
    Kouta Funakoshi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Card Fail 20:53-9. 2014
    ....
  55. ncbi request reprint Histopathological multiple recanalized lesion is critical element of outcome after pulmonary thromboendarterectomy
    Kazuya Hosokawa
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Int Heart J 52:377-81. 2011
    ..Histopathological study may be a potent diagnostic strategy for accurately predicting surgical outcome in the early perioperative period...
  56. ncbi request reprint Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease
    Yoshihiro Fukumoto
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Coron Artery Dis 17:63-70. 2006
    ..We have recently demonstrated that shock wave therapy effectively induces neovascularization and improves myocardial ischemia in a porcine model in vivo...
  57. ncbi request reprint Case of isolated thoracic aortic aneurysm as a manifestation of undiscovered giant cell arteritis
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 97:358-65. 2006
    ..In cases of the thoracic aortic aneurysms with unknown etiology, there is a possibility that GCA is the cause of the aortic aneurysm...
  58. doi request reprint Telmisartan reduces mortality and left ventricular hypertrophy with sympathoinhibition in rats with hypertension and heart failure
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Am J Hypertens 27:260-7. 2014
    ..The aim of this study was to determine whether TLM improves survival in rats with hypertension and heart failure...
  59. ncbi request reprint [Endothelin receptor antagonist]
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
    Nihon Rinsho 66:2152-6. 2008
    ..Recent many trials suggested that endothelin receptor antagonist, bosentan, caused good results in idiopathic PAH and PAH associated with chronic thromboembolism, collagen diseases, and congenital heart diseases...
  60. ncbi request reprint Baroreflex sensitivity might predict responders to milrinone in patients with heart failure
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Higashi ku, Fukuoka, Japan
    Int Heart J 51:411-5. 2010
    ..94 and 0.93, respectively. BRS might be useful for identifying potential responders to milrinone in patients with blood pressure-preserved "wet and cold" heart failure...
  61. pmc Sympathoexcitation associated with Renin-Angiotensin system in metabolic syndrome
    Takuya Kishi
    Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Hypertens 2013:406897. 2013
    ..In conclusion, SNS activation associated with RAS activation in the brain should be the target of the treatment, and ARBs could have the potential benefit on SNS activation in patients with MetS...
  62. ncbi request reprint [Abnormal peripheral circulation in patients with heart failure]
    Takuya Kishi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
    Nihon Rinsho 65:316-20. 2007