Dongchon Kang

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes
    Nobuhiro Suematsu
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 107:1418-23. 2003
  2. ncbi request reprint Mitochondrial DNA in somatic cells: a promising target of routine clinical tests
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Clin Biochem 38:685-95. 2005
  3. ncbi request reprint [Oxidative damage, maintenance, and higher structure of mitochondrial DNA]
    Dongchon Kang
    Tanpakushitsu Kakusan Koso 50:316-21. 2005
  4. ncbi request reprint Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Ann N Y Acad Sci 1042:101-8. 2005
  5. ncbi request reprint Mitochondrial oxidative stress and mitochondrial DNA
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Chem Lab Med 41:1281-8. 2003
  6. ncbi request reprint [Integrity of mitochondrial genome in somatic cells: genetic information and its quantity]
    Dongchon Kang
    Tanpakushitsu Kakusan Koso 50:1737-41. 2005
  7. ncbi request reprint [Nucleo-mitochondrial interactions]
    Dongchon Kang
    Tanpakushitsu Kakusan Koso 50:1872-4. 2005
  8. ncbi request reprint Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Mitochondrion 7:39-44. 2007
  9. ncbi request reprint Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancer
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Curr Med Chem 12:429-41. 2005
  10. doi request reprint Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice
    Yoshinori Hayashi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 28:8624-34. 2008

Detail Information

Publications66

  1. ncbi request reprint Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes
    Nobuhiro Suematsu
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 107:1418-23. 2003
    ..We thus investigated whether the direct exposure of cardiac myocytes to TNF-alpha and Ang II in vitro could induce mtDNA damage via production of ROS...
  2. ncbi request reprint Mitochondrial DNA in somatic cells: a promising target of routine clinical tests
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Clin Biochem 38:685-95. 2005
    ..In this review, we focus on maintenance of mitochondrial DNA in somatic cells and its clinical importance...
  3. ncbi request reprint [Oxidative damage, maintenance, and higher structure of mitochondrial DNA]
    Dongchon Kang
    Tanpakushitsu Kakusan Koso 50:316-21. 2005
  4. ncbi request reprint Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Ann N Y Acad Sci 1042:101-8. 2005
    ..The effects of TFAM in these aspects are intimately related to each other and to function as a whole for the purpose of maintenance of mtDNA...
  5. ncbi request reprint Mitochondrial oxidative stress and mitochondrial DNA
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Chem Lab Med 41:1281-8. 2003
    ..Cumulative damage of mitochondrial DNA is implicated in the aging process and in the progression of such common diseases as diabetes, cancer, and heart failure...
  6. ncbi request reprint [Integrity of mitochondrial genome in somatic cells: genetic information and its quantity]
    Dongchon Kang
    Tanpakushitsu Kakusan Koso 50:1737-41. 2005
  7. ncbi request reprint [Nucleo-mitochondrial interactions]
    Dongchon Kang
    Tanpakushitsu Kakusan Koso 50:1872-4. 2005
  8. ncbi request reprint Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Mitochondrion 7:39-44. 2007
    ..TFAM may play a crucial role in maintaining mitochondrial DNA as a main component of the nucleoid...
  9. ncbi request reprint Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancer
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Curr Med Chem 12:429-41. 2005
    ..In this review, we focus on ROS and chemical damage of mitochondrial DNA in common diseases...
  10. doi request reprint Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice
    Yoshinori Hayashi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 28:8624-34. 2008
    ..Together, an overexpression of TFAM is therefore considered to ameliorate age-dependent impairment of the brain functions through the prevention of oxidative stress and mitochondrial dysfunctions in microglia...
  11. ncbi request reprint Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction
    Masaki Ikeuchi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 112:683-90. 2005
    ..Myocardial mtDNA copy number and TFAM expression both decreased in cardiac failure. However, the functional significance of TFAM has not been established in this disease state...
  12. doi request reprint Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors
    Yujiro Uchida
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Int J Antimicrob Agents 35:444-50. 2010
    ..coli recently became prevalent at least in East Asia and suggest that this might become a public health problem because the strains may acquire resistance to other antimicrobial agents...
  13. ncbi request reprint PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid
    Xiaoli Cheng
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582
    J Biochem 138:673-8. 2005
    ..PDIP38 associates with the nucleoid components and could be involved in the metabolism of mitochondrial DNA...
  14. ncbi request reprint The C-terminal tail of mitochondrial transcription factor a markedly strengthens its general binding to DNA
    Kippei Ohgaki
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Biochem 141:201-11. 2007
    ..Thus, the C-terminal tail of TFAM is important for the strong general binding to mtDNA. This strong DNA-binding conferred by the C-tail may play an important role in the nucleoid structure...
  15. pmc p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability
    Mikako Yagi
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nucleic Acids Res 40:9717-37. 2012
    ..Co-immunoprecipitation revealed the close association of p32 with the mitoribosome. We propose that p32 is required for functional mitoribosome formation to synthesize proteins within mitochondria...
  16. pmc Human mitochondrial DNA is packaged with TFAM
    Tanfis Istiaq Alam
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nucleic Acids Res 31:1640-5. 2003
    ..Based on the fact that TFAM is abundant enough to wrap mtDNA entirely, these results suggest that human mtDNA is packaged with TFAM...
  17. doi request reprint DNA conformation-dependent activities of human mitochondrial RNA polymerase
    Atsushi Fukuoh
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Genes Cells 14:1029-42. 2009
    ..We suggest that these properties of POLRMT could explain the characteristic features of mammalian mtDNA transcription and replication...
  18. doi request reprint Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins
    Shinya Matsumoto
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mitochondrion 12:391-8. 2012
    ..The RNA-binding protein Y-box binding protein-1 is localized at the mitochondrial outer membrane and bound to the OXPHOS mRNAs. Our findings offer new insight into mitochondrial co-translational import in human cells...
  19. doi request reprint Arg 901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding
    Shinya Takazaki
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1818:658-65. 2012
    ..These results suggested that the increased hydrophobicity of the C-terminal region around Arg 901 leads to inefficient conformational change by the newly produced hydrophobic interaction...
  20. pmc Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast
    Yusuke Kurihara
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    J Biol Chem 287:3265-72. 2012
    ..Mitophagy contributes to this process by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production...
  21. pmc Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA
    Tomotake Kanki
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Cell Biol 24:9823-34. 2004
    ..Thus, the mtDNA amount is finely correlated with the amount of TFAM but not with the transcription level. We discuss an architectural role for TFAM in the maintenance of mtDNA in addition to its role in transcription activation...
  22. ncbi request reprint Mitochondrial nucleoid and transcription factor A
    Tomotake Kanki
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Ann N Y Acad Sci 1011:61-8. 2004
    ..TFAM is tightly associated with mtDNA as a main component of the nucleoid...
  23. doi request reprint Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA
    Shinya Matsumoto
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Biochem J 443:573-84. 2012
    ..Taken together, our findings suggest that YB-1 is a critical factor for translation that may control OXPHOS activity...
  24. pmc ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation
    Takeshi Uchiumi
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nucleic Acids Res 38:5554-68. 2010
    ..These results suggest that ERAL1 is localized in a small subunit of the mitochondrial ribosome, plays an important role in the small ribosomal constitution, and is also involved in cell viability...
  25. pmc Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients
    Jingxian Fang
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Biosci Rep 32:631-9. 2012
    ....
  26. ncbi request reprint 1-Methyl-4-phenylpyridinium ion, a toxin that can cause parkinsonism, alters branched structures of DNA
    Mitsutoshi Iwaasa
    Department of Neurosurgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan
    J Neurochem 82:30-7. 2002
    ..This conversion is reversed by 1 mM Mg(2+), as is the resolution of the D-loops or cruciform DNA. These observations suggest that the junction structure of mitochondrial D- and R-loops is affected by MPP+...
  27. ncbi request reprint [Maintenance of mitochondrial DNA in somatic cells: diseases and aging]
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences
    Fukuoka Igaku Zasshi 97:351-7. 2006
  28. doi request reprint Methods for assessing binding of mitochondrial transcription factor A (TFAM) to DNA
    Atsushi Fukuoh
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Methods Mol Biol 554:87-101. 2009
    ..Thus, TFAM may play a crucial role in maintaining mitochondrial DNA as a main component of the nucleoid (or more appropriately mitochromosome)...
  29. ncbi request reprint Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication
    Mayumi Okamaoto
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, 812 8582 Fukuoka, Japan
    Curr Genet 43:364-70. 2003
    ..This close association of ditercalinium chloride with mitochondrial DNA may contribute to the mitochondrial DNA-depleting activity...
  30. ncbi request reprint [Microbiological and clinical features of nine cases with nocardial infections]
    Yukiko Maki
    Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Rinsho Byori 59:213-8. 2011
    ..These data suggested the identification of Nocardia to the species level and susceptibility testing were important for diagnosis as infectious diseases and treatments...
  31. pmc Phosphorylation of Serine 114 on Atg32 mediates mitophagy
    Yoshimasa Aoki
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Mol Biol Cell 22:3206-17. 2011
    ..We also found that Hog1 and Pbs2, which are involved in the osmoregulatory signal transduction cascade, are related to Atg32 phosphorylation and mitophagy...
  32. ncbi request reprint The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal
    Yasunari Sakai
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Mol Med (Berl) 84:660-70. 2006
    ..The cellular fractionation revealed that MTH1a(Met83) was localized in the mitochondria to the same extent as was MTH1d(Val83). However, the mitochondrial translocation of MTH1d(Met83) was less efficient than that of MTH1d(Val83)...
  33. pmc Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein
    Chihiro Takamatsu
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    EMBO Rep 3:451-6. 2002
    ..Hence, mtSSB functions in both stabilization and resolution. We propose that TFAM and mtSSB are cooperatively involved in stabilizing D-loops and in the maintenance of mtDNA...
  34. doi request reprint Mutation of His 834 in human anion exchanger 1 affects substrate binding
    Shinya Takazaki
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochim Biophys Acta 1798:903-8. 2010
    ..These data suggest that His 834 is critically important for the efficient binding of sulfate anion, but not for the conformational change induced by substrate binding...
  35. ncbi request reprint Mammalian mitochondrial endonuclease G. Digestion of R-loops and localization in intermembrane space
    Takashi Ohsato
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Eur J Biochem 269:5765-70. 2002
    ....
  36. doi request reprint Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome
    Takeshi Uchiumi
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Hepatol Res 43:569-75. 2013
    ..No MRP2 protein was expressed from HEK293 cells transfected with an R1310X-containing construct. This compound heterozygous mutation of the MRP2 gene causes dysfunction of the MRP2 protein and the hyperbilirubinemia seen in DJS...
  37. doi request reprint The role of TFAM-associated proteins in mitochondrial RNA metabolism
    Takeshi Uchiumi
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1820:565-70. 2012
    ..Mitochondrial transcription factor A (TFAM), which was cloned as a transcription factor for mitochondrial DNA, is critical for forming this higher structure and for maintenance of mtDNA...
  38. doi request reprint Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes
    Takeo Fujino
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mitochondrion 12:449-58. 2012
    ..rhTFAM attenuated subsequent morphological hypertrophy of myocytes as well. rhTFAM would be an attractive molecule in attenuating cardiac pathological hypertrophy...
  39. doi request reprint Fulminant sepsis/meningitis due to Haemophilus influenzae in a protein C-deficient heterozygote treated with activated protein C therapy
    Masataka Ishimura
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Eur J Pediatr 168:673-7. 2009
    ..The monitoring of plasma protein C activity and sufficient administration of activated protein C product could improve the outcome of severe sepsis in children...
  40. ncbi request reprint Maintenance of mitochondrial DNA integrity: repair and degradation
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Curr Genet 41:311-22. 2002
    ..In addition to DNA repair, the degradation of damaged mtDNA may be tolerated because there are multiple copies of mtDNA molecules in a cell...
  41. ncbi request reprint High-sensitivity detection of the A3243G mutation of mitochondrial DNA by a combination of allele-specific PCR and peptide nucleic acid-directed PCR clamping
    Michiyo Urata
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
    Clin Chem 50:2045-51. 2004
    ..We aimed to develop a routinely available PCR method for quantitative detection of low-level heteroplasmy of the A3243G mutation...
  42. ncbi request reprint A simple search of TM segments in polytopic membrane protein using matrix-assisted laser desorption ionization time-of-flight mass spectrometry
    Yoshito Abe
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Protein Pept Lett 13:761-7. 2006
    ..The method can be applied to other polytopic membrane proteins in erythrocyte membrane...
  43. ncbi request reprint Affinity purification of antibodies by using Ni2+-resins on which inclusion body-forming proteins are immobilized
    Worawan Chumpia
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Protein Expr Purif 32:147-50. 2003
    ..Taking advantage of this feature, we have successfully purified antigen-specific antibodies by directly using Ni(2+)-resins onto which denatured proteins are bound...
  44. pmc Monitoring mitophagy in yeast: the Om45-GFP processing assay
    Tomotake Kanki
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Autophagy 5:1186-9. 2009
    ..Following the uptake of mitochondria into the vacuole, Om45-GFP is degraded, releasing the intact form of GFP, which is detected by immunoblotting. Therefore, the amount of free GFP reflects the level of mitophagy...
  45. doi request reprint Thromboembolic complications in splenectomized patients with dominantly inherited beta-thalassemia
    Shouichi Ohga
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Acta Haematol 120:31-5. 2008
  46. ncbi request reprint Mitochondrial disease: maintenance of mitochondrial genome and molecular diagnostics
    Dongchon Kang
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Adv Clin Chem 42:217-54. 2006
    ..In this chapter, we focus on maintenance of mtDNA in somatic cells, its clinical importance, and recent developments of molecular tests...
  47. ncbi request reprint Genomic cloning and promoter analysis of a mouse anion exchanger 3 (AE3) gene
    Mitsutoshi Iwaasa
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Department of Nuerosurgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan
    DNA Seq 13:251-5. 2002
    ....
  48. doi request reprint Platelet contamination causes large variation as well as overestimation of mitochondrial DNA content of peripheral blood mononuclear cells
    Michiyo Urata
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi Higashi ku, Fukuoka, Japan
    Ann Clin Biochem 45:513-4. 2008
    ..Recently, the copy number of leukocyte mtDNA has been considered to serve as a biomarker to monitor or chase such diseases. Therefore, reproducible mtDNA measurement is required...
  49. doi request reprint Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy
    Rie Amamoto
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 102:639-47. 2011
    ..These data suggest that p32 is critical for prostate cancer cell proliferation and may be a novel marker of clinical progression in prostate cancer...
  50. doi request reprint Geographic distribution of fluoroquinolone-resistant Escherichia coli strains in Asia
    Yujiro Uchida
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Int J Antimicrob Agents 35:387-91. 2010
    ..These data suggest that the increase in FQ-resistant E. coli strains is mainly generated by mutations in the QRDR in each geographical area rather than through intercontinental spread...
  51. doi request reprint Protein C deficiency as the major cause of thrombophilias in childhood
    Shouichi Ohga
    Department of Perinatal and Pediatric Medicine, Kyushu University, Fukuoka, Japan
    Pediatr Int 55:267-71. 2013
    ..The molecular epidemiology of thrombosis in Asian children would provide a clue to establish the early intervention and optimal anticoagulant therapy in pediatric PC deficiency...
  52. pmc The physiological role of mitophagy: new insights into phosphorylation events
    Yuko Hirota
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Cell Biol 2012:354914. 2012
    ..In this paper, we describe the molecular processes and regulatory mechanisms of mitophagy in yeast and mammalian cells...
  53. ncbi request reprint [Approach for prevention of medical test malpractice using ISO 15189]
    Yuzo Kayamori
    Department of Clinical Laboratory and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Rinsho Byori 58:839-46. 2010
    ..We introduced practices for quality improvement and prevention of medical test malpractice proposed by the ISO committee of our medical laboratory and describe these practices in this report...
  54. ncbi request reprint [Distributions and spreads of antimicrobial drug-resistant microorganisms in Saga prefecture]
    Makiko Kiyosuke
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Rinsho Byori 59:226-35. 2011
    ..Investigations of distribution of drug-resistant organisms in not only each hospitals but also in the first and the second medical areas are important for controls of healthcare-associated infections and antibiotic prescriptions...
  55. ncbi request reprint Protein S and protein C gene mutations in Japanese deep vein thrombosis patients
    Sachiko Kinoshita
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 3 1 1 Maedashi Fukuoka 812 8582, Japan
    Clin Biochem 38:908-15. 2005
    ..Hitherto, the constitutional background of Japanese thrombotic patients has never been systematically examined. We have performed a systematic investigation to determine pathogenesis for deep vein thrombosis in a Japanese population...
  56. ncbi request reprint [ISO 15189 accreditation acquisition and the procedure]
    Yuzo Kayamori
    Department of Clinical Chemistry and, Laboratory Medicine, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Rinsho Byori 57:146-55. 2009
    ..In this report, we summarize the process via which our laboratory was awarded this ISO and the situation in which we passed two surveillances...
  57. doi request reprint Decreased maternal protein S activity is associated with fetal growth restriction
    Satoshi Hojo
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Thromb Res 123:55-9. 2008
    ..Protein S (PS) activity has been shown to decrease during normal pregnancy. The aim of this study was to determine any correlation between decreased maternal PS activity and fetal growth restriction (FGR)...
  58. ncbi request reprint MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity
    Kosuke Kajitani
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 26:1688-98. 2006
    ....
  59. ncbi request reprint Identification of oxidized methionine sites in erythrocyte membrane protein by liquid chromatography/electrospray ionization mass spectrometry peptide mapping
    Chunyan Li
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochemistry 45:12117-24. 2006
    ....
  60. ncbi request reprint Synergistic enhancement of TRAIL- and tumor necrosis factor alpha-induced cell death by a phenoxazine derivative
    Keiichi Hara
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Mol Cancer Ther 4:1121-7. 2005
    ..Considering that both TRAIL and Phx-1 have only marginal cytotoxicity to most normal cells, Phx-1 may provide an ideal combination for cancer therapy with TRAIL...
  61. ncbi request reprint [The functional and pathological analysis of mitochondrial protein p32]
    Takeshi Uchiumi
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Rinsho Byori 61:493-500. 2013
    ..These data suggest that p32 is critical for prostate cancer cell proliferation and may be a novel marker of clinical progression in prostate cancer...
  62. doi request reprint Development of a new measurement method for serum calcium with chlorophosphonazo-III
    Eisaku Hokazono
    Department of Health Sciences, Division of Biological Science and Technology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Ann Clin Biochem 46:296-301. 2009
    ..The present method showed better linearity and reagent stability compared with the oCPC method...
  63. ncbi request reprint P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA
    Yoichiro Yoshida
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu Fukuoka 807 8555, Japan
    Cancer Res 63:3729-34. 2003
    ..Binding of mtTFA to cisplatin-modified DNA was significantly enhanced by p53, whereas binding to oxidized DNA was inhibited. Our findings suggest that the interaction of p53 with mtTFA may play an important role in apoptosis...
  64. ncbi request reprint Acute loss of transcription factor E2F1 induces mitochondrial biogenesis in HeLa cells
    Yuya Goto
    Department of Life Sciences, Meiji University Graduate School of Agriculture, Tama ku, Kawasaki, Kanagawa 214 8571, Japan
    J Cell Physiol 209:923-34. 2006
    ..Taken together, these data demonstrate a novel physiological aspect of E2F1 in human cancer cells, where activated mitochondrial biogenesis occurs as a consequence of the acute loss of E2F1...
  65. ncbi request reprint Inhibitory effect of coenzyme Q on eukaryotic DNA polymerase gamma and DNA topoisomerase II activities on the growth of a human cancer cell line
    Yuko Yonezawa
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180
    Cancer Sci 97:716-23. 2006
    ..The cells were halted at S phase and G1 phase in the cell cycle, and suppressed mitochondrial proliferation. From these results, the relationship between the inhibition of pol gamma/topo II and cancer cell growth by CoQ is discussed...
  66. pmc The regulation of DNAse activities in subcellular compartments of activated thymocytes
    Takuya Nagata
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Immunology 105:399-406. 2002
    ..These results demonstrate that TCR engagement of thymocytes induces caspase-3-dependent activation of CAD localized in both cytosol and microsome, leading to DNA fragmentation in harmony...