Research Topics
Genomes and Genes
| Dongchon KangSummaryAffiliation: Kyushu University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytesNobuhiro Suematsu
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Circulation 107:1418-23. 2003..CONCLUSIONS: The intimate link between TNF-alpha, ROS, and mtDNA damage might play an important role in myocardial remodeling and failure...- Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancerDongchon Kang
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
Curr Med Chem 12:429-41. 2005..In this review, we focus on ROS and chemical damage of mitochondrial DNA in common diseases... - Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functionsDongchon Kang
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
Mitochondrion 7:39-44. 2007..TFAM may play a crucial role in maintaining mitochondrial DNA as a main component of the nucleoid... - [Oxidative damage, maintenance, and higher structure of mitochondrial DNA]Dongchon Kang
Tanpakushitsu Kakusan Koso 50:316-21. 2005 - [Nucleo-mitochondrial interactions]Dongchon Kang
Tanpakushitsu Kakusan Koso 50:1872-4. 2005 - [Integrity of mitochondrial genome in somatic cells: genetic information and its quantity]Dongchon Kang
Tanpakushitsu Kakusan Koso 50:1737-41. 2005 - Mitochondrial oxidative stress and mitochondrial DNADongchon Kang
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Clin Chem Lab Med 41:1281-8. 2003..Cumulative damage of mitochondrial DNA is implicated in the aging process and in the progression of such common diseases as diabetes, cancer, and heart failure... - Mitochondrial DNA in somatic cells: a promising target of routine clinical testsDongchon Kang
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Clin Biochem 38:685-95. 2005..In this review, we focus on maintenance of mitochondrial DNA in somatic cells and its clinical importance... - Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple rolesDongchon Kang
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Ann N Y Acad Sci 1042:101-8. 2005..The effects of TFAM in these aspects are intimately related to each other and to function as a whole for the purpose of maintenance of mtDNA... 
Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in miceYoshinori Hayashi
Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Neurosci 28:8624-34. 2008..Together, an overexpression of TFAM is therefore considered to ameliorate age-dependent impairment of the brain functions through the prevention of oxidative stress and mitochondrial dysfunctions in microglia...- Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarctionMasaki Ikeuchi
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Circulation 112:683-90. 2005..Myocardial mtDNA copy number and TFAM expression both decreased in cardiac failure. However, the functional significance of TFAM has not been established in this disease state... - Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factorsYujiro Uchida
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Int J Antimicrob Agents 35:444-50. 2010..coli recently became prevalent at least in East Asia and suggest that this might become a public health problem because the strains may acquire resistance to other antimicrobial agents... - PDIP38 associates with proteins constituting the mitochondrial DNA nucleoidXiaoli Cheng
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582
J Biochem 138:673-8. 2005..PDIP38 associates with the nucleoid components and could be involved in the metabolism of mitochondrial DNA... - The C-terminal tail of mitochondrial transcription factor a markedly strengthens its general binding to DNAKippei Ohgaki
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
J Biochem 141:201-11. 2007..Thus, the C-terminal tail of TFAM is important for the strong general binding to mtDNA. This strong DNA-binding conferred by the C-tail may play an important role in the nucleoid structure... 
p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding abilityMikako Yagi
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Nucleic Acids Res 40:9717-37. 2012..Co-immunoprecipitation revealed the close association of p32 with the mitoribosome. We propose that p32 is required for functional mitoribosome formation to synthesize proteins within mitochondria...- Human mitochondrial DNA is packaged with TFAMTanfis Istiaq Alam
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Nucleic Acids Res 31:1640-5. 2003..Based on the fact that TFAM is abundant enough to wrap mtDNA entirely, these results suggest that human mtDNA is packaged with TFAM... - DNA conformation-dependent activities of human mitochondrial RNA polymeraseAtsushi Fukuoh
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
Genes Cells 14:1029-42. 2009..We suggest that these properties of POLRMT could explain the characteristic features of mammalian mtDNA transcription and replication... - Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteinsShinya Matsumoto
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Mitochondrion 12:391-8. 2012..The RNA-binding protein Y-box binding protein-1 is localized at the mitochondrial outer membrane and bound to the OXPHOS mRNAs. Our findings offer new insight into mitochondrial co-translational import in human cells... - Arg 901 in the AE1 C-terminal tail is involved in conformational change but not in substrate bindingShinya Takazaki
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Fukuoka, Japan
Biochim Biophys Acta 1818:658-65. 2012..These results suggested that the increased hydrophobicity of the C-terminal region around Arg 901 leads to inefficient conformational change by the newly produced hydrophobic interaction... - Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeastYusuke Kurihara
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
J Biol Chem 287:3265-72. 2012..Mitophagy contributes to this process by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production... - Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNATomotake Kanki
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Mol Cell Biol 24:9823-34. 2004..Thus, the mtDNA amount is finely correlated with the amount of TFAM but not with the transcription level. We discuss an architectural role for TFAM in the maintenance of mtDNA in addition to its role in transcription activation... - Mitochondrial nucleoid and transcription factor ATomotake Kanki
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan
Ann N Y Acad Sci 1011:61-8. 2004..TFAM is tightly associated with mtDNA as a main component of the nucleoid... - Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNAShinya Matsumoto
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
Biochem J 443:573-84. 2012..Taken together, our findings suggest that YB-1 is a critical factor for translation that may control OXPHOS activity... - ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardationTakeshi Uchiumi
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Nucleic Acids Res 38:5554-68. 2010..These results suggest that ERAL1 is localized in a small subunit of the mitochondrial ribosome, plays an important role in the small ribosomal constitution, and is also involved in cell viability... - Methods for assessing binding of mitochondrial transcription factor A (TFAM) to DNAAtsushi Fukuoh
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Methods Mol Biol 554:87-101. 2009..Thus, TFAM may play a crucial role in maintaining mitochondrial DNA as a main component of the nucleoid (or more appropriately mitochromosome)... - 1-Methyl-4-phenylpyridinium ion, a toxin that can cause parkinsonism, alters branched structures of DNAMitsutoshi Iwaasa
Department of Neurosurgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan
J Neurochem 82:30-7. 2002..This conversion is reversed by 1 mM Mg(2+), as is the resolution of the D-loops or cruciform DNA. These observations suggest that the junction structure of mitochondrial D- and R-loops is affected by MPP+... - [Maintenance of mitochondrial DNA in somatic cells: diseases and aging]Dongchon Kang
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences
Fukuoka Igaku Zasshi 97:351-7. 2006 - Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replicationMayumi Okamaoto
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan
Curr Genet 43:364-70. 2003..This close association of ditercalinium chloride with mitochondrial DNA may contribute to the mitochondrial DNA-depleting activity... - Phosphorylation of Serine 114 on Atg32 mediates mitophagyYoshimasa Aoki
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
Mol Biol Cell 22:3206-17. 2011..We also found that Hog1 and Pbs2, which are involved in the osmoregulatory signal transduction cascade, are related to Atg32 phosphorylation and mitophagy... - [Microbiological and clinical features of nine cases with nocardial infections]Yukiko Maki
Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812 8582, Japan
Rinsho Byori 59:213-8. 2011..These data suggested the identification of Nocardia to the species level and susceptibility testing were important for diagnosis as infectious diseases and treatments... - The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signalYasunari Sakai
Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
J Mol Med (Berl) 84:660-70. 2006..The cellular fractionation revealed that MTH1a(Met83) was localized in the mitochondria to the same extent as was MTH1d(Val83). However, the mitochondrial translocation of MTH1d(Met83) was less efficient than that of MTH1d(Val83)... - Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patientsJingxian Fang
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
Biosci Rep 32:631-9. 2012.... - Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding proteinChihiro Takamatsu
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
EMBO Rep 3:451-6. 2002..Hence, mtSSB functions in both stabilization and resolution. We propose that TFAM and mtSSB are cooperatively involved in stabilizing D-loops and in the maintenance of mtDNA... - Mammalian mitochondrial endonuclease G. Digestion of R-loops and localization in intermembrane spaceTakashi Ohsato
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Eur J Biochem 269:5765-70. 2002.... - Mutation of His 834 in human anion exchanger 1 affects substrate bindingShinya Takazaki
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Biochim Biophys Acta 1798:903-8. 2010..These data suggest that His 834 is critically important for the efficient binding of sulfate anion, but not for the conformational change induced by substrate binding... - Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytesTakeo Fujino
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Mitochondrion 12:449-58. 2012..rhTFAM attenuated subsequent morphological hypertrophy of myocytes as well. rhTFAM would be an attractive molecule in attenuating cardiac pathological hypertrophy... - The role of TFAM-associated proteins in mitochondrial RNA metabolismTakeshi Uchiumi
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Fukuoka, Japan
Biochim Biophys Acta 1820:565-70. 2012..Mitochondrial transcription factor A (TFAM), which was cloned as a transcription factor for mitochondrial DNA, is critical for forming this higher structure and for maintenance of mtDNA... - A simple search of TM segments in polytopic membrane protein using matrix-assisted laser desorption ionization time-of-flight mass spectrometryYoshito Abe
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Protein Pept Lett 13:761-7. 2006..The method can be applied to other polytopic membrane proteins in erythrocyte membrane... - High-sensitivity detection of the A3243G mutation of mitochondrial DNA by a combination of allele-specific PCR and peptide nucleic acid-directed PCR clampingMichiyo Urata
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
Clin Chem 50:2045-51. 2004..06% heteroplasmy, suggesting that 0.1% is diagnostically significant. CONCLUSIONS: PNA maintains the specificity of allele-specific PCR over a wide range of conditions, which is important for routine clinical testing... - Monitoring mitophagy in yeast: the Om45-GFP processing assayTomotake Kanki
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Autophagy 5:1186-9. 2009..Following the uptake of mitochondria into the vacuole, Om45-GFP is degraded, releasing the intact form of GFP, which is detected by immunoblotting. Therefore, the amount of free GFP reflects the level of mitophagy... - Affinity purification of antibodies by using Ni2+-resins on which inclusion body-forming proteins are immobilizedWorawan Chumpia
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan
Protein Expr Purif 32:147-50. 2003..Taking advantage of this feature, we have successfully purified antigen-specific antibodies by directly using Ni(2+)-resins onto which denatured proteins are bound... - Fulminant sepsis/meningitis due to Haemophilus influenzae in a protein C-deficient heterozygote treated with activated protein C therapyMasataka Ishimura
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
Eur J Pediatr 168:673-7. 2009..The monitoring of plasma protein C activity and sufficient administration of activated protein C product could improve the outcome of severe sepsis in children... - Thromboembolic complications in splenectomized patients with dominantly inherited beta-thalassemiaShouichi Ohga
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Acta Haematol 120:31-5. 2008 - Maintenance of mitochondrial DNA integrity: repair and degradationDongchon Kang
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Curr Genet 41:311-22. 2002..In addition to DNA repair, the degradation of damaged mtDNA may be tolerated because there are multiple copies of mtDNA molecules in a cell... - Mitochondrial disease: maintenance of mitochondrial genome and molecular diagnosticsDongchon Kang
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan
Adv Clin Chem 42:217-54. 2006..In this chapter, we focus on maintenance of mtDNA in somatic cells, its clinical importance, and recent developments of molecular tests... - Genomic cloning and promoter analysis of a mouse anion exchanger 3 (AE3) geneMitsutoshi Iwaasa
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Department of Nuerosurgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan
DNA Seq 13:251-5. 2002.... - Platelet contamination causes large variation as well as overestimation of mitochondrial DNA content of peripheral blood mononuclear cellsMichiyo Urata
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi Higashi ku, Fukuoka, Japan
Ann Clin Biochem 45:513-4. 2008..Recently, the copy number of leukocyte mtDNA has been considered to serve as a biomarker to monitor or chase such diseases. Therefore, reproducible mtDNA measurement is required... - Geographic distribution of fluoroquinolone-resistant Escherichia coli strains in AsiaYujiro Uchida
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Int J Antimicrob Agents 35:387-91. 2010..These data suggest that the increase in FQ-resistant E. coli strains is mainly generated by mutations in the QRDR in each geographical area rather than through intercontinental spread... - Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomyRie Amamoto
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Cancer Sci 102:639-47. 2011..These data suggest that p32 is critical for prostate cancer cell proliferation and may be a novel marker of clinical progression in prostate cancer... - The physiological role of mitophagy: new insights into phosphorylation eventsYuko Hirota
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Int J Cell Biol 2012:354914. 2012..In this paper, we describe the molecular processes and regulatory mechanisms of mitophagy in yeast and mammalian cells... - [Distributions and spreads of antimicrobial drug-resistant microorganisms in Saga prefecture]Makiko Kiyosuke
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812 8582, Japan
Rinsho Byori 59:226-35. 2011..Investigations of distribution of drug-resistant organisms in not only each hospitals but also in the first and the second medical areas are important for controls of healthcare-associated infections and antibiotic prescriptions... - [Approach for prevention of medical test malpractice using ISO 15189]Yuzo Kayamori
Department of Clinical Laboratory and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812 8582, Japan
Rinsho Byori 58:839-46. 2010..We introduced practices for quality improvement and prevention of medical test malpractice proposed by the ISO committee of our medical laboratory and describe these practices in this report... - Identification of oxidized methionine sites in erythrocyte membrane protein by liquid chromatography/electrospray ionization mass spectrometry peptide mappingChunyan Li
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Biochemistry 45:12117-24. 2006.... - Decreased maternal protein S activity is associated with fetal growth restrictionSatoshi Hojo
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
Thromb Res 123:55-9. 2008..Protein S (PS) activity has been shown to decrease during normal pregnancy. The aim of this study was to determine any correlation between decreased maternal PS activity and fetal growth restriction (FGR)... - [ISO 15189 accreditation acquisition and the procedure]Yuzo Kayamori
Department of Clinical Chemistry and, Laboratory Medicine, Kyushu University Hospital, Fukuoka 812 8582, Japan
Rinsho Byori 57:146-55. 2009..In this report, we summarize the process via which our laboratory was awarded this ISO and the situation in which we passed two surveillances... - MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicityKosuke Kajitani
Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
J Neurosci 26:1688-98. 2006.... - Synergistic enhancement of TRAIL- and tumor necrosis factor alpha-induced cell death by a phenoxazine derivativeKeiichi Hara
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Mol Cancer Ther 4:1121-7. 2005..Considering that both TRAIL and Phx-1 have only marginal cytotoxicity to most normal cells, Phx-1 may provide an ideal combination for cancer therapy with TRAIL... - Protein S and protein C gene mutations in Japanese deep vein thrombosis patientsSachiko Kinoshita
Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, 3 1 1 Maedashi Fukuoka 812 8582, Japan
Clin Biochem 38:908-15. 2005..Hitherto, the constitutional background of Japanese thrombotic patients has never been systematically examined. We have performed a systematic investigation to determine pathogenesis for deep vein thrombosis in a Japanese population... - Development of a new measurement method for serum calcium with chlorophosphonazo-IIIEisaku Hokazono
Department of Health Sciences, Division of Biological Science and Technology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Ann Clin Biochem 46:296-301. 2009..The present method showed better linearity and reagent stability compared with the oCPC method... - P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNAYoichiro Yoshida
Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu Fukuoka 807 8555, Japan
Cancer Res 63:3729-34. 2003..Binding of mtTFA to cisplatin-modified DNA was significantly enhanced by p53, whereas binding to oxidized DNA was inhibited. Our findings suggest that the interaction of p53 with mtTFA may play an important role in apoptosis... - Acute loss of transcription factor E2F1 induces mitochondrial biogenesis in HeLa cellsYuya Goto
Department of Life Sciences, Meiji University Graduate School of Agriculture, Tama ku, Kawasaki, Kanagawa 214 8571, Japan
J Cell Physiol 209:923-34. 2006..Taken together, these data demonstrate a novel physiological aspect of E2F1 in human cancer cells, where activated mitochondrial biogenesis occurs as a consequence of the acute loss of E2F1... - Inhibitory effect of coenzyme Q on eukaryotic DNA polymerase gamma and DNA topoisomerase II activities on the growth of a human cancer cell lineYuko Yonezawa
Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University, Nishi-ku, Kobe, Hyogo 651-2180
Cancer Sci 97:716-23. 2006..The cells were halted at S phase and G1 phase in the cell cycle, and suppressed mitochondrial proliferation. From these results, the relationship between the inhibition of pol gamma/topo II and cancer cell growth by CoQ is discussed... - The regulation of DNAse activities in subcellular compartments of activated thymocytesTakuya Nagata
Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
Immunology 105:399-406. 2002..These results demonstrate that TCR engagement of thymocytes induces caspase-3-dependent activation of CAD localized in both cytosol and microsome, leading to DNA fragmentation in harmony...