Hideo Kanaide

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Measurement of [Ca²⁺]i in smooth muscle strips using front-surface fluorimetry
    Hideo Kanaide
    International University of Health and Welfare, Fukuoka, Japan
    Methods Mol Biol 937:207-16. 2013
  2. ncbi request reprint Ca2+ sensitization in contraction of human bladder smooth muscle
    Ryosuke Takahashi
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Urol 172:748-52. 2004
  3. ncbi request reprint Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery
    Noriko Shiga
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ Res 96:1014-21. 2005
  4. doi request reprint Enhanced contractile response of the basilar artery to platelet-derived growth factor in subarachnoid hemorrhage
    Yoshihisa Maeda
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Stroke 40:591-6. 2009
  5. ncbi request reprint Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells
    Tatsuya Yufu
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 25:1506-11. 2005
  6. doi request reprint Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas
    Murasaki Aman
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Vasc Res 47:494-506. 2010
  7. pmc Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries
    Jun Maki
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 159:919-27. 2010
  8. ncbi request reprint Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells
    Katsuya Hirano
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Exp Ther 322:668-77. 2007
  9. ncbi request reprint RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate
    Ryosuke Takahashi
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurourol Urodyn 26:547-51. 2007
  10. ncbi request reprint Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage
    Yasutoshi Kai
    Professor, Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Stroke 38:3259-65. 2007

Collaborators

  • Katsuya Hirano
  • Junji Nishimura
  • Narihito Seki
  • Tomio Sasaki
  • Mayumi Hirano
  • Ryosuke Takahashi
  • Jun Maki
  • Murasaki Aman
  • Seiji Naito
  • Yoshihisa Maeda
  • Dan Bi
  • Sumio Hoka
  • Yasutoshi Kai
  • Tatsuya Yufu
  • Noriko Shiga
  • Yuichiro Kikkawa
  • Katsuharu Kameda
  • Takakazu Yunoki
  • Toshihisa Tomoda
  • Hitoo Nakano
  • Naohisa Niiro
  • Hajime Nawata
  • Yukihide Iwamoto

Detail Information

Publications22

  1. ncbi request reprint Measurement of [Ca²⁺]i in smooth muscle strips using front-surface fluorimetry
    Hideo Kanaide
    International University of Health and Welfare, Fukuoka, Japan
    Methods Mol Biol 937:207-16. 2013
    ..The protocol gives our practice for the loading of the Ca(2+) indicators in various smooth muscle tissues...
  2. ncbi request reprint Ca2+ sensitization in contraction of human bladder smooth muscle
    Ryosuke Takahashi
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Urol 172:748-52. 2004
    ..The role of Ca2+ sensitization in the contraction of human bladder urinary smooth muscle (UBSM) was investigated...
  3. ncbi request reprint Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery
    Noriko Shiga
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ Res 96:1014-21. 2005
    ..Simvastatin and TATHA-RB significantly upregulated eNOS in the rabbit mesenteric artery. The present study provides the first evidence that RhoA plays a physiological role in suppressing NO production in in situ endothelial cells...
  4. doi request reprint Enhanced contractile response of the basilar artery to platelet-derived growth factor in subarachnoid hemorrhage
    Yoshihisa Maeda
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Stroke 40:591-6. 2009
    ..The level of platelet-derived growth factor (PDGF) in cerebrospinal fluid is elevated in subarachnoid hemorrhage (SAH). Therefore, the contractile effect of PDGF on the basilar artery was examined in SAH...
  5. ncbi request reprint Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells
    Tatsuya Yufu
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 25:1506-11. 2005
    ..Protease-activated receptor-1 (PAR1) mediates the thrombin-induced proliferation and hypertrophy of vascular smooth muscle cells. A role of Rac1 in the regulation of PAR1 expression was investigated...
  6. doi request reprint Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas
    Murasaki Aman
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Vasc Res 47:494-506. 2010
    ..The effects of oxidative stress on the vascular responsiveness to the agonists of proteinase-activated receptors (PARs) were investigated...
  7. pmc Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries
    Jun Maki
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 159:919-27. 2010
    ..Thrombin may thus play an important role in the pathogenesis and pathophysiology of PAH. Hence, we investigated the contractile effects of thrombin and its mechanism in pulmonary artery...
  8. ncbi request reprint Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells
    Katsuya Hirano
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Exp Ther 322:668-77. 2007
    ..PAR(4) preferably activates Galpha(i/o) and induced NO production in a manner mostly independent of Ca(2+) but dependent on the PI3K/Akt pathway, whereas PAR(1) activates both the Ca(2+)-dependent and -independent mechanisms...
  9. ncbi request reprint RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate
    Ryosuke Takahashi
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurourol Urodyn 26:547-51. 2007
    ..In the present study, we examined the functional role of RhoA/Rho kinase (ROCK), one of the major intracellular molecules involved in smooth muscle contraction, in the contraction of the human prostate...
  10. ncbi request reprint Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage
    Yasutoshi Kai
    Professor, Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Stroke 38:3259-65. 2007
    ..Its pathogenesis still remains elusive, and effective therapeutic strategies are yet to be established. We investigated the role of proteinase-activated receptor-1 (PAR1) in the hypercontractile state in SAH...
  11. doi request reprint Involvement of reactive oxygen species in thrombin-induced pulmonary vasoconstriction
    Jun Maki
    Research Institute of Angiocardiology, Kyushu University, Higashi ku, Fukuoka, Japan
    Am J Respir Crit Care Med 182:1435-44. 2010
    ..Thrombin may thus play an important role in the pathogenesis and pathophysiology of pulmonary arterial hypertension...
  12. ncbi request reprint Contractile properties of the cultured vascular smooth muscle cells: the crucial role played by RhoA in the regulation of contractility
    Dan Bi
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ Res 96:890-7. 2005
    ..The expression level of RhoA thus plays a crucial role in regulating the contractility of cultured VSMCs...
  13. ncbi request reprint Modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle
    Ryosuke Takahashi
    Division of Molecular Cardiology, Research Institute of Angiocardiology and Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Urol 169:2412-6. 2003
    ..We examined the role of the modulation of Ca2+ sensitivity for regulating the contractility of corpus cavernosum smooth muscle...
  14. ncbi request reprint Rac1-dependent transcriptional up-regulation of p27Kip1 by homophilic cell-cell contact in vascular endothelial cells
    Mayumi Hirano
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Biochim Biophys Acta 1773:1500-10. 2007
    ..The present study thus demonstrated for the first time that the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells...
  15. ncbi request reprint Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca2+ sensitivity in an intact coronary artery
    Katsuya Hirano
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 24:464-9. 2004
    ..The region of the 110 kDa regulatory subunit (MYPT1) of smooth muscle myosin phosphatase involved in the regulation of contraction was determined under physiological conditions...
  16. ncbi request reprint [Changes in the contractility of the NIH3T3 fibroblast induced by the over-expression of CPI-17]
    Junji Nishimura
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Nihon Yakurigaku Zasshi 122:43P-45P. 2003
    ..The limited expression of CPI-17 to SMC may explain the previous observation that the effects of PKC stimulation were quite different in SMC from those of other cell types...
  17. ncbi request reprint Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry
    Hideo Kanaide
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Methods Mol Biol 312:251-9. 2006
  18. pmc Enhancement of trypsin-induced contraction by in vivo treatment with 17beta-estradiol and progesterone in rat myometrium
    Murasaki Aman
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Br J Pharmacol 146:425-34. 2005
    ..A novel type of receptor, other than PAR1, PAR2 or PAR4, is suggested to mediate the trypsin-induced contraction as in the case of the pregnant rat myometrium...
  19. ncbi request reprint Physiology and pathophysiology of proteinase-activated receptors (PARs): regulation of the expression of PARs
    Katsuya Hirano
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 97:31-7. 2005
    ..The transcription factors and the regulatory elements in the promoter regions, and the proteins that interact with the receptors and thereby regulate their trafficking and desensitization are the main problems that need to be elucidated...
  20. ncbi request reprint Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain
    Katusya Hirano
    Division of Molecular Cardiology, Research Institute ofAngiocardiology, Graduate School of Medical Sciences, Kyushu University Maidashi, Higashi ku, Fukuoka, Japan
    Mol Cell Biochem 248:105-14. 2003
    ..In the preliminary study, we succeeded in introducing a fragment of MYPT1 into the arterial strips, and found enhancement of contraction...
  21. pmc The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum
    Ryosuke Takahashi
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Br J Pharmacol 137:845-54. 2002
    ....
  22. ncbi request reprint Role of protease-activated receptors in the vascular system
    Katsuya Hirano
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Atheroscler Thromb 10:211-25. 2003
    ..Understanding the functional role of PARs in the vascular system can thus help in the development of new strategies for the prevention and therapy of vascular diseases...