Masanori Iwase

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Stroke topography in diabetic and nondiabetic patients by magnetic resonance imaging
    M Iwase
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Diabetes Res Clin Pract 42:109-16. 1998
  2. pmc Association between sleep duration and urinary albumin excretion in patients with type 2 diabetes: the Fukuoka diabetes registry
    Toshiaki Ohkuma
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Fukuoka, Japan
    PLoS ONE 8:e78968. 2013
  3. pmc Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry
    Hiroki Fujii
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Nutr J 12:159. 2013
  4. ncbi request reprint Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Atherosclerosis 196:931-6. 2008
  5. ncbi request reprint Islet hyperperfusion during prediabetic phase in OLETF rats, a model of type 2 diabetes
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes 51:2530-5. 2002
  6. ncbi request reprint Effect of exogenous cholecystokinin on islet blood flow in anesthetized rats
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, 812 8582, Fukuoka, Japan
    Regul Pept 116:87-93. 2003
  7. doi request reprint Withdrawal of pioglitazone in patients with type 2 diabetes mellitus
    M Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Clin Pharm Ther 35:401-8. 2010
  8. doi request reprint Angiotensin II type 1 receptor antagonists prevent glucose-induced increases in islet blood flow in rats
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Scand J Clin Lab Invest 69:145-50. 2009
  9. ncbi request reprint Pancreatic islet blood flow in conscious rats during hyperglycemia and hypoglycemia
    M Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Am J Physiol Regul Integr Comp Physiol 280:R1601-5. 2001
  10. ncbi request reprint Altered postural regulation of foot skin oxygenation and blood flow in patients with type 2 diabetes mellitus
    M Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Exp Clin Endocrinol Diabetes 115:444-7. 2007

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Stroke topography in diabetic and nondiabetic patients by magnetic resonance imaging
    M Iwase
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Diabetes Res Clin Pract 42:109-16. 1998
    ..The present study demonstrated that infratentorial infarcts were more common in elderly diabetic patients, suggesting the vulnerability of vertebrobasilar circulation in diabetes...
  2. pmc Association between sleep duration and urinary albumin excretion in patients with type 2 diabetes: the Fukuoka diabetes registry
    Toshiaki Ohkuma
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Fukuoka, Japan
    PLoS ONE 8:e78968. 2013
    ..The objective of the present study was to examine the relationship between sleep duration and albuminuria in type 2 diabetic patients...
  3. pmc Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry
    Hiroki Fujii
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Nutr J 12:159. 2013
    ..We investigated the association between dietary fiber intake and obesity, glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese type 2 diabetic patients...
  4. ncbi request reprint Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Atherosclerosis 196:931-6. 2008
    ..Simvastatin treatment reduced serum Lp-PLA(2) and lyso-PC content in LDL. Our findings suggest that Lp-PLA(2) has the proatherogenic activity by contributing to the production of lyso-PC in circulating LDL...
  5. ncbi request reprint Islet hyperperfusion during prediabetic phase in OLETF rats, a model of type 2 diabetes
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes 51:2530-5. 2002
    ..Our results indicate that hyperperfusion is present during the preobese and prediabetic phase in our type 2 diabetes rats...
  6. ncbi request reprint Effect of exogenous cholecystokinin on islet blood flow in anesthetized rats
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, 812 8582, Fukuoka, Japan
    Regul Pept 116:87-93. 2003
    ..Our results demonstrated that exogenous CCK is a potent vasodilator of exocrine as well as islet vasculature via CCK-A receptors, and that such action is mediated by a NO-dependent mechanism rather than by vagal mechanisms...
  7. doi request reprint Withdrawal of pioglitazone in patients with type 2 diabetes mellitus
    M Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Clin Pharm Ther 35:401-8. 2010
    ..We studied the effects of withdrawal of pioglitazone after 3-month treatment on glucose, lipid and high-molecular weight (HMW) adiponectin levels as well as liver function in patients with type 2 diabetes mellitus...
  8. doi request reprint Angiotensin II type 1 receptor antagonists prevent glucose-induced increases in islet blood flow in rats
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Scand J Clin Lab Invest 69:145-50. 2009
    ....
  9. ncbi request reprint Pancreatic islet blood flow in conscious rats during hyperglycemia and hypoglycemia
    M Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Am J Physiol Regul Integr Comp Physiol 280:R1601-5. 2001
    ..This result suggests that prevention of hypoglycemia-induced increase in islet perfusion may be mediated, at least in part, by a cholinergic, vagal muscarinic mechanism...
  10. ncbi request reprint Altered postural regulation of foot skin oxygenation and blood flow in patients with type 2 diabetes mellitus
    M Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Exp Clin Endocrinol Diabetes 115:444-7. 2007
    ..We studied changes in foot skin oxygenation and blood flow during postural changes in patients with type 2 diabetes mellitus...
  11. doi request reprint Nateglinide may increase high-molecular weight adiponectin in type 2 diabetic patients with hypoadiponectinemia
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Diabetes Res Clin Pract 82:e19-22. 2008
    ..Nateglinide may ameliorate hypoadiponectinemia as well as postprandial hyperglycemia in patients with type 2 diabetes mellitus...
  12. ncbi request reprint Nateglinide, a non-sulfonylurea rapid insulin secretagogue, increases pancreatic islet blood flow in rats
    Masanori Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Eur J Pharmacol 518:243-50. 2005
    ..Our results indicated that nateglinide acutely increased islet blood flow at least in part through a nitric oxide-dependent mechanism...
  13. doi request reprint Serum high-molecular weight adiponectin is related to early postprandial glycemic increases and gastric emptying in patients with type 2 diabetes mellitus
    M Iwase
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Metab Res Rev 25:344-50. 2009
    ..The aim of the present study is to investigate the clinical determinants of postprandial glycemia and lipemia, especially serum high-molecular weight adiponectin...
  14. ncbi request reprint Atherogenic role of lysophosphatidylcholine in low-density lipoprotein modified by phospholipase A2 and in diabetic patients: protection by nitric oxide donor
    Kazuo Sonoki
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Metabolism 52:308-14. 2003
    ..Our results suggest that lyso-PC contents in LDL play an important role in atherogenesis under diabetic condition, which could be prevented by increased availability of vascular NO...
  15. doi request reprint Impaired insulin secretion by diphenyleneiodium associated with perturbation of cytosolic Ca2+ dynamics in pancreatic beta-cells
    Hirofumi Imoto
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Endocrinology 149:5391-400. 2008
    ..1 or 1.0 microm H2O2 exogenously. Our results showed that DPI impairment of insulin secretion involved altered Ca2+ signaling, suggesting that NADPH oxidase may modulate Ca2+ signaling in beta-cells...
  16. pmc Impact of metabolic syndrome compared with impaired fasting glucose on the development of type 2 diabetes in a general Japanese population: the Hisayama study
    Naoko Mukai
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Care 32:2288-93. 2009
    ..We examined whether metabolic syndrome predicts incident type 2 diabetes more effectively than impaired fasting glucose (IFG) in a general Japanese population...
  17. doi request reprint Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population
    Yasufumi Doi
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Clin Endocrinol Metab 93:3425-9. 2008
    ..1 mmol/liter, the gold standard diagnostic criterion, in a general Japanese population...
  18. doi request reprint Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Stroke 40:1187-94. 2009
    ..The current criteria of metabolic syndrome (MetS) are not based on evidence derived from prospective studies on cardiovascular disease (CVD)...
  19. doi request reprint Impact of glucose tolerance status on development of ischemic stroke and coronary heart disease in a general Japanese population: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Stroke 41:203-9. 2010
    ..Few studies have shown the association between glucose tolerance status defined by a 75-g oral glucose tolerance test and the development of different types of cardiovascular disease...
  20. ncbi request reprint Liver enzymes as a predictor for incident diabetes in a Japanese population: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Obesity (Silver Spring) 15:1841-50. 2007
    ..We studied the relationship between liver enzymes and the development of diabetes in a general Japanese population...
  21. ncbi request reprint Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using 13C-octanoic acid breath test
    Sakae Nohara
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Diabetes Complications 20:295-301. 2006
    ..Because the pathogenesis of delayed gastric emptying is multifactorial in diabetic patients, the recently developed OBT is useful for studying gastric emptying in various clinical settings of diabetic patients...
  22. doi request reprint Association between glucose tolerance level and cancer death in a general Japanese population: the Hisayama Study
    Yoichiro Hirakawa
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Epidemiol 176:856-64. 2012
    ..These findings suggest that both prediabetic hyperglycemia and diabetes are significant risk factors for cancer death in the general Japanese population...
  23. ncbi request reprint U-shaped association of sleep duration with metabolic syndrome and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry
    Toshiaki Ohkuma
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Fukuoka, Japan
    Metabolism 63:484-91. 2014
    ..The objective of the present study was to examine the associations of sleep duration with metabolic syndrome and insulin resistance, a major pathophysiologic feature of metabolic syndrome, in patients with type 2 diabetes...
  24. ncbi request reprint Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: The Hisayama Study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes 56:2829-33. 2007
    ..2 and diabetes has been reported in Caucasians but not in Asians. We examined this issue in follow-up and cross-sectional studies in a general Japanese population...
  25. pmc Impact of sleep duration on obesity and the glycemic level in patients with type 2 diabetes: the Fukuoka Diabetes Registry
    Toshiaki Ohkuma
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Care 36:611-7. 2013
    ..The objective of the current study was to examine the relationship between sleep duration, obesity, and the glycemic level in type 2 diabetic patients...
  26. doi request reprint N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 31:2997-3003. 2011
    ..Few studies have examined the association between natriuretic peptides and the incidence of cardiovascular disease (CVD) in Asian populations...
  27. ncbi request reprint Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population: the Hisayama Study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes Care 28:2497-500. 2005
    ..We examined the association between high-sensitivity C-reactive protein (CRP) levels and the development of diabetes in a general Japanese population...
  28. ncbi request reprint Relations of lysophosphatidylcholine in low-density lipoprotein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in patients with type 2 diabetes mellitus
    Kazuo Sonoki
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes Res Clin Pract 86:117-23. 2009
    ..We studied the relations of lysophosphatidylcholine (lyso-PC) in LDL with serum lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), paraoxonase and homocysteine thiolactonase (HTLase) activities in patients with type 2 diabetes mellitus...
  29. ncbi request reprint Expression of secretory phospholipase A 2 in insulitis of human transplanted pancreas and its insulinotropic effect on isolated rat islets
    Miwako Ishida-Oku
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Islets 2:274-7. 2010
    ..Although sPLA 2 induced insulin secretion in vitro probably via the production of lysophospholipid, the significance of this enzyme expression in insulitis remains elusive...
  30. ncbi request reprint Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling
    Yuji Uchizono
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka City 812 8582, Japan
    Endocrinology 145:2264-72. 2004
    ..However, tacrolimus-induced impaired insulin secretion was reversed 3 d after removal of the drug. Our study demonstrated that tacrolimus impairs insulin secretion at multiple steps in stimulus-secretion coupling...
  31. pmc Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Care 36:98-100. 2013
    ..To examine, for the first time, the association between a novel inflammatory cytokine, angiopoietin-like protein (ANGPTL) 2, and the development of type 2 diabetes (T2DM)...
  32. ncbi request reprint Rapid intracellular acidification and cell death by H2O2 and alloxan in pancreatic beta cells
    Udai Nakamura
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Free Radic Biol Med 40:2047-55. 2006
    ....
  33. ncbi request reprint PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose
    Maki Ueta
    Department of Medicine and Clinical Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Kidney Int 65:961-71. 2004
    ....
  34. ncbi request reprint Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells
    Kazuo Sonoki
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Eur J Pharmacol 475:139-47. 2003
    ..Although the mechanisms of anti-atherogenic effects of the two drugs on glycoxidized LDL are different, both dilazep and fenofibric acid could potentially prevent atherosclerosis in diabetes mellitus...
  35. pmc Impact of leisure-time physical activity on glycemic control and cardiovascular risk factors in Japanese patients with type 2 diabetes mellitus: the fukuoka diabetes registry
    Shinako Kaizu
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 9:e98768. 2014
    ..We studied associations between LTPA and glycemia and cardiovascular risk factors in Japanese type 2 diabetic patients...
  36. ncbi request reprint Overt diabetes mellitus in a patient with combined primary aldosteronism and Cushing's syndrome
    Nobuhiro Sasaki
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Intern Med 45:1237-42. 2006
    ..A solitary left aldosterone- and cortisol-producing adrenal tumor was diagnosed. We described a rare case of overt diabetes mellitus in a patient with combined primary aldosteronism and Cushing's syndrome...
  37. ncbi request reprint Expression of isoforms of NADPH oxidase components in rat pancreatic islets
    Yuji Uchizono
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Life Sci 80:133-9. 2006
    ..Our results suggest that the functional significance of NADPH oxidase in insulin secretion may merit further investigation...
  38. ncbi request reprint Glycoxidized low-density lipoprotein enhances monocyte chemoattractant protein-1 mRNA expression in human umbilical vein endothelial cells: relation to lysophosphatidylcholine contents and inhibition by nitric oxide donor
    Kazuo Sonoki
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Metabolism 51:1135-42. 2002
    ..Our results suggest that LDL modified by glycation and oxidation may contribute to the development of accelerated atherosclerosis in the presence of diabetes, a process that may be prevented by increased vascular NO availability...
  39. ncbi request reprint Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography
    Yuko Ohta
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Hypertens 23:1905-11. 2005
    ..We evaluated the relationship between these indices and pulse wave velocity (PWV), a measure of arterial stiffness, which reflects atherosclerosis, and determined whether renal RI and PI differ depending on the underlying renal disease...
  40. ncbi request reprint Usefulness of brachial-ankle pulse wave velocity measurement: correlation with abdominal aortic calcification
    Udai Nakamura
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertens Res 26:163-7. 2003
    ..Our results indicate that baPWV is useful for estimating aortic damage and could be a potentially useful predictor of vascular morbidity and mortality...
  41. ncbi request reprint Relationship between C-reactive protein and glucose levels in community-dwelling subjects without diabetes: the Hisayama Study
    Yasufumi Doi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes Care 28:1211-3. 2005
  42. ncbi request reprint Orthostatic hypertension in patients with type 2 diabetes
    M Yoshinari
    Department of Endocrinology and Metabolism, National Fukuoka Higashi Hospital, Koga, Fukuoka, Japan
    Diabetes Care 24:1783-6. 2001
    ..The prevalence and clinical importance of orthostatic hypertension (OHT) in diabetic patients has not been elucidated, in contrast to orthostatic hypotension, which is occasionally found in diabetic patients with autonomic neuropathy...
  43. ncbi request reprint Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) expresses in rat mesangial cells and PPARgamma agonists modulate its differentiation
    T Asano
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3 1 1, Higashi ku, 812 8586, Fukuoka, Japan
    Biochim Biophys Acta 1497:148-54. 2000
    ..These results indicate that PPARgamma1 is expressing in rat mesangial cells, and PPARgamma1 activation with its agonists modulates the proliferation and differentiation of cultured rat mesangial cells...
  44. ncbi request reprint Lysophosphatidylcholine molecular species in low density lipoprotein of type 2 diabetes
    A h Shi
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Horm Metab Res 31:283-6. 1999
    ..60+/-2.61 mg vs 2.53+/1.15 mg, respectively, p < 0.05). The LPC molecular species may participate in the atherogenicity of LDL in patients with Type 2 diabetes...
  45. ncbi request reprint Effect of gemfibrozil on serum levels of prostacyclin and precursor fatty acids in hyperlipidemic patients with Type 2 diabetes
    M Yoshinari
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi, Fukuoka, Japan
    Diabetes Res Clin Pract 42:149-54. 1998
    ..Thus, gemfibrozil did not affect the synthesis of prostacyclin in spite of the reduction of precursor fatty acids in diabetic and non-diabetic patients...
  46. ncbi request reprint Probucol reduces lysophosphatidylcholines in low-density lipoprotein
    M Yoshinari
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Eur J Clin Pharmacol 55:787-92. 2000
    ..Lysophosphatidylcholine (LPC) in low-density lipoprotein (LDL) comes into notice as an important atherogenic substance...
  47. ncbi request reprint Smoking cessation and glycaemic control in type 2 diabetic patients
    K Iino
    Department of Internal Medicine, Fukuoka Red Cross Hospital, Fukuoka, Japan
    Diabetes Obes Metab 6:181-6. 2004
    ..To elucidate the relationship between glycaemic control, blood pressure and body-weight change after smoking cessation in type 2 diabetic patients...
  48. ncbi request reprint Reduced tissue oxygenation and its reversibility by glycemic control in diabetic patients
    K Iino
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka City, Japan
    Diabetes Res Clin Pract 34:163-8. 1997
    ..These findings suggest that tissue oxygenation in diabetic patients was deteriorated in relation to hyperglycemia and was reversed with glycemic control. Improvement of Pa(O2) might contribute partly to the increase of TcP(O2)...
  49. doi request reprint A case of recurrent type 1 diabetes mellitus with insulitis of transplanted pancreas in simultaneous pancreas-kidney transplantation from cardiac death donor
    M Ishida-Oku
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetologia 53:341-5. 2010
    ..Unexpectedly, we found insulitis in the transplanted pancreas and characterised the insulitis...
  50. doi request reprint Histologic studies of islets of Langerhans in transplanted pancreata from marginal donors in Japan
    M Ishida-Oku
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Transplant Proc 42:1819-21. 2010
    ..Transplanted pancreata from marginal donors showed preserved beta cells and function despite diffuse oxidative changes...
  51. ncbi request reprint Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese
    Hajime Nawata
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Hum Genet 49:629-34. 2004
    ..These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12...
  52. ncbi request reprint The atypical antipsychotic clozapine impairs insulin secretion by inhibiting glucose metabolism and distal steps in rat pancreatic islets
    N Sasaki
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka, Japan
    Diabetologia 49:2930-8. 2006
    ..We investigated the long-term effects of culturing isolated rat pancreatic islets with atypical antipsychotic clozapine...
  53. ncbi request reprint Suppression of the renin-angiotensin system induced by streptozotocin treatment in neonatal spontaneously hypertensive rats
    Y Takata
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Jpn Circ J 54:192-200. 1990
    ..Urinary aldosterone excretion rate was not altered by neonatal STZ treatment. In conclusion, a decrease in MAP in SHR with neonatal STZ treatment may be attributed to the suppressed pressor activity of RAS...
  54. pmc Secretory PLA2 inhibitor indoxam suppresses LDL modification and associated inflammatory responses in TNFalpha-stimulated human endothelial cells
    K Sonoki
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 153:1399-408. 2008
    ..We investigated the effects of the indole analogue indoxam on low-density lipoprotein (LDL) modification by sPLA2 enzymes of different types and on the associated inflammatory responses in human umbilical vein endothelial cells (HUVEC)...
  55. ncbi request reprint Neuronal histamine release elicited by hyperthermia mediates tracheal dilation and pressor response
    M Kanamaru
    Department of Physiology, Showa University School of Medicine, Shinagawa-ku, Tokyo 142-8555, Japan
    Am J Physiol Regul Integr Comp Physiol 280:R1748-54. 2001
    ..Brain histaminergic neurons play important roles in tracheal tone and peripheral vascular tone via H(1) receptors in the RVLM and homeostasis on body temperature...
  56. ncbi request reprint Cardiac functional and structural alterations induced by endotoxin in rats: importance of platelet-activating factor
    M Iwase
    Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan
    Crit Care Med 29:609-17. 2001
    ..Pretreatment with a PAF antagonist reduced LPS-induced alterations. PAF may play a pivotal role during the initial phase of LPS-induced cardiovascular responses...
  57. ncbi request reprint Biphasic changes in left ventricular end-diastolic pressure during dynamic exercise in patients with nonobstructive hypertrophic cardiomyopathy
    Y Takeichi
    Cardiovascular Division, Nagoya University, Graduate School of Medicine, Japan
    J Am Coll Cardiol 38:335-43. 2001
    ..CONCLUSIONS: The biphasic changes in LVEDP seen during exercise may be related to improved coronary microcirculation in response to beta-adrenergic stimulation in patients with mild to moderate HCM...
  58. ncbi request reprint Lack of temperature-induced polypnea in histamine H1 receptor-deficient mice
    M Izumizaki
    Department of Physiology, School of Medicine, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Neurosci Lett 284:139-42. 2000
    ..These results indicate that central histamine contributes to an increase in respiratory frequency due to a reduction in expiratory time through histamine H1 receptors when body temperature is raised...
  59. ncbi request reprint Smt3, a SUMO-1 homolog, is conjugated to Cdc3, a component of septin rings at the mother-bud neck in budding yeast
    Y Takahashi
    Graduate School of Science, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113, Japan
    Biochem Biophys Res Commun 259:582-7. 1999
    ..Around the time of cytokinesis the Cdc3-Smt3 conjugate disappeared. We discuss the biological significance of this Smt3 conjugation to a septin component...
  60. ncbi request reprint Bite force, occlusal contact area and masticatory efficiency before and after orthognathic surgical correction of mandibular prognathism
    M Iwase
    Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan
    Int J Oral Maxillofac Surg 35:1102-7. 2006
    ..These results suggest that further adjustment of occlusion and mechanical advantage should be considered before the end of treatment...
  61. ncbi request reprint Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice
    K Ishiguro
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan
    J Biol Chem 276:47483-8. 2001
    ..These results indicate that syndecan-4 could be involved in prevention of endotoxin shock, at least partly through the inhibitory action of transforming growth factor-beta1 on IL-1beta production...
  62. ncbi request reprint Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro
    M Iwase
    Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan
    Hum Exp Toxicol 25:715-21. 2006
    ..Furthermore, it was shown that the effects of organic solvents on CYP3A activity are substrate-dependent. The present study also shows that methanol had little effect on either substrate...