Y Iwasa

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint [Cancer initiation as mini-evolution]
    Yoh Iwasa
    Tanpakushitsu Kakusan Koso 50:1962-9. 2005
  2. pmc The evolution of X-linked genomic imprinting
    Y Iwasa
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan
    Genetics 158:1801-9. 2001
  3. pmc Evolution of resistance during clonal expansion
    Yoh Iwasa
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan
    Genetics 172:2557-66. 2006
  4. ncbi request reprint Evolutionary dynamics of invasion and escape
    Yoh Iwasa
    Department of Biology, Faculty of Sciences, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    J Theor Biol 226:205-14. 2004
  5. ncbi request reprint Population genetics of tumor suppressor genes
    Yoh Iwasa
    Department of Biology, Faculty of Sciences, Kyushu University, Hakozoki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    J Theor Biol 233:15-23. 2005
  6. pmc Stochastic tunnels in evolutionary dynamics
    Yoh Iwasa
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan
    Genetics 166:1571-9. 2004
  7. ncbi request reprint Some basic properties of immune selection
    Yoh Iwasa
    Department of Biology, Faculty of Sciences, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    J Theor Biol 229:179-88. 2004
  8. ncbi request reprint Good parent and good genes models of handicap evolution
    Y Iwasa
    Faculty of Science, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 200:97-109. 1999
  9. ncbi request reprint Distance between AER and ZPA is defined by feed-forward loop and is stabilized by their feedback loop in vertebrate limb bud
    Tsuyoshi Hirashima
    Department of Biology, Faculty of Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Bull Math Biol 70:438-59. 2008
  10. ncbi request reprint Extinction risk of a density-dependent population estimated from a time series of population size
    H Hakoyama
    Department of Biology, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 204:337-59. 2000

Detail Information

Publications93

  1. ncbi request reprint [Cancer initiation as mini-evolution]
    Yoh Iwasa
    Tanpakushitsu Kakusan Koso 50:1962-9. 2005
  2. pmc The evolution of X-linked genomic imprinting
    Y Iwasa
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan
    Genetics 158:1801-9. 2001
    ..Experimental evidence concerning X-imprinting in mouse and human is interpreted in the light of these predictions and is shown to be far more easily explained by sex-specific selection...
  3. pmc Evolution of resistance during clonal expansion
    Yoh Iwasa
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan
    Genetics 172:2557-66. 2006
    ..Hence a tumor subject to high rates of apoptosis will show a higher incidence of resistance than expected on its detection size only...
  4. ncbi request reprint Evolutionary dynamics of invasion and escape
    Yoh Iwasa
    Department of Biology, Faculty of Sciences, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    J Theor Biol 226:205-14. 2004
    ..We develop a general theory, based on multitype branching processes, to describe the evolutionary dynamics of invasion and escape...
  5. ncbi request reprint Population genetics of tumor suppressor genes
    Yoh Iwasa
    Department of Biology, Faculty of Sciences, Kyushu University, Hakozoki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    J Theor Biol 233:15-23. 2005
    ..The inactivation of the first and of the second allele can occur at equal or different rates. Our calculations provide insights into basic aspects of population genetics determining cancer initiation and progression...
  6. pmc Stochastic tunnels in evolutionary dynamics
    Yoh Iwasa
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan
    Genetics 166:1571-9. 2004
    ..Although our theory is developed for cancer genetics, stochastic tunnels are general phenomena that could arise in many circumstances...
  7. ncbi request reprint Some basic properties of immune selection
    Yoh Iwasa
    Department of Biology, Faculty of Sciences, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    J Theor Biol 229:179-88. 2004
    ..Therefore, appropriate cross-reactive immunity can lead to a viral evolution within a host which limits the extent of the disease...
  8. ncbi request reprint Good parent and good genes models of handicap evolution
    Y Iwasa
    Faculty of Science, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 200:97-109. 1999
    ..However, we predict that the handicap process is often strong enough to lead to a stable equilibrium. This leads to the conclusion that cyclic evolution is less likely to occur for handicap than Fisherian traits...
  9. ncbi request reprint Distance between AER and ZPA is defined by feed-forward loop and is stabilized by their feedback loop in vertebrate limb bud
    Tsuyoshi Hirashima
    Department of Biology, Faculty of Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Bull Math Biol 70:438-59. 2008
    ..Furthermore, sensitivity analysis shows that there exists the optimal feedback strength where the robustness is the most improved...
  10. ncbi request reprint Extinction risk of a density-dependent population estimated from a time series of population size
    H Hakoyama
    Department of Biology, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 204:337-59. 2000
    ..We illustrate the method using data for a freshwater fish, Japanese crucian carp (Carassius auratus subsp.) in Lake Biwa, in which the growth rate and environmental noise of crucian carp are estimated using fishery records...
  11. ncbi request reprint Sex specific X chromosome expression caused by genomic imprinting
    Y Iwasa
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 197:487-95. 1999
    ..The hypothesis offers a good explanation of the existing data on X-imprinted genes...
  12. pmc The evolution of genomic imprinting
    A Mochizuki
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Genetics 144:1283-95. 1996
    ..We show however that deleterious mutations in the coding region of the gene create selection against imprinting...
  13. ncbi request reprint Cell-cell adhesion in limb-formation, estimated from photographs of cell sorting experiments based on a spatial stochastic model
    A Mochizuki
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Dev Dyn 211:204-14. 1998
    ..This result can be explained both by the stage-specific change in adhesion molecules and by a linear increase (or decrease) in the amount of adhesion molecules on cell surface...
  14. ncbi request reprint Self-organization of the vascular system in plant leaves: inter-dependent dynamics of auxin flux and carrier proteins
    Francois G Feugier
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 236:366-75. 2005
    ..These results suggest that canalization is a good candidate for describing plant vein pattern formation...
  15. ncbi request reprint Virus evolution within patients increases pathogenicity
    Yoh Iwasa
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 232:17-26. 2005
    ..Thus, in general, virus evolution makes things worse. An idea for combating HIV infection, however, is constructing a virus mutant that could outcompete the existing infection without being pathogenic itself...
  16. ncbi request reprint How canalization can make loops: a new model of reticulated leaf vascular pattern formation
    Francois G Feugier
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 243:235-44. 2006
    ..We explore several alternative functional forms for the flux bifurcator affecting the reallocation of efflux carriers and examine parameter dependence of the resulting vein pattern...
  17. ncbi request reprint Direction of regeneration waves in grid-based models for forest dynamics
    Robert Schlicht
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 242:363-71. 2006
    ..We apply this to several grid-based models for forest dynamics which are evaluated analytically or by simulation. The results reveal a clear distinction of the models which earlier studies were not able to detect...
  18. ncbi request reprint The leading eight: social norms that can maintain cooperation by indirect reciprocity
    Hisashi Ohtsuki
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 239:435-44. 2006
    ..Second, we prove the two basic properties of the leading eight, which give a quantitative evaluation of the ESS condition and the level of cooperation maintained at the ESS...
  19. ncbi request reprint Temperature compensation in circadian clock models
    Gen Kurosawa
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka shi, Fukuoka 812 8581, Japan
    J Theor Biol 233:453-68. 2005
    ..A strong temperature sensitivity of degradation of PER proteins and/or temperature-sensitive alternative splicing of per gene, known for Drosophila, can be mechanisms for the temperature compensation of circadian clock...
  20. ncbi request reprint How should we define goodness?--reputation dynamics in indirect reciprocity
    Hisashi Ohtsuki
    Department of Biology, Faculty of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    J Theor Biol 231:107-20. 2004
    ..In addition, we believe that the formalism of reputation dynamics gives general insights into the way social information is generated, handled, and transmitted in animal societies...
  21. ncbi request reprint Optimal growth pattern of defensive organs: the diversity of shell growth among mollusks
    Takahiro Irie
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Am Nat 165:238-49. 2005
    ..This result explains the observation that many tropical gastropods with thickened shell lips spend their vulnerable juvenile phase in sheltered habitats...
  22. ncbi request reprint Multiple-year optimization of conservation effort and monitoring effort for a fluctuating population
    Hiroyuki Yokomizo
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 230:157-71. 2004
    ..However, if the population is endangered, both types of effort become smaller when the conservation period increases...
  23. doi request reprint Dynamic modeling of branching morphogenesis of ureteric bud in early kidney development
    Tsuyoshi Hirashima
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan
    J Theor Biol 259:58-66. 2009
    ..These are consistent with experimental observations in different morphological anomalies of mutants. We show that the different branching patterns are accurately predicted by growth-chemotaxis ratio...
  24. ncbi request reprint Global analyses of evolutionary dynamics and exhaustive search for social norms that maintain cooperation by reputation
    Hisashi Ohtsuki
    Faculty of Sciences, Department of Biology, Kyushu University, 6 10 1 Hakozaki, Fukuoka 812 8581, Japan
    J Theor Biol 244:518-31. 2007
    ..Also, we study the model in which private reputation errors exist to a small extent. In this case, we find the stable coexistence of unconditional and conditional cooperators under the three norms...
  25. ncbi request reprint Probability of resistance evolution for exponentially growing virus in the host
    Hiroshi Haeno
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 246:323-31. 2007
    ..The risk of resistance is smaller when more cells are newly infected by viral particles from a single infected cell if the viral growth rate is the same...
  26. doi request reprint Pollinator coupling can induce synchronized flowering in different plant species
    Yuuya Tachiki
    Department of Biology, Faculty of Science, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    J Theor Biol 267:153-63. 2010
    ..We demonstrate mathematically that co-flowering of different species occurs under a much narrower range of circumstances than intraspecific co-flowering...
  27. doi request reprint Optimal seasonal schedules and the relative dominance of heteromorphic and isomorphic life cycles in macroalgae
    Kazuhiro Bessho
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 267:201-12. 2010
    ..These predictions are consistent with the observed distribution patterns of the two life cycles in macroalgae...
  28. pmc Evolution towards oscillation or stability in a predator-prey system
    Akihiko Mougi
    Department of Biology, Faculty of Sciences, Kyushu University, Hakozaki, Fukuoka, Japan
    Proc Biol Sci 277:3163-71. 2010
    ..Our results predict that populations and traits in host-parasite systems are more likely than those in prey-predator systems to show large-amplitude oscillations...
  29. pmc Random cell movement promotes synchronization of the segmentation clock
    Koichiro Uriu
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Proc Natl Acad Sci U S A 107:4979-84. 2010
    ..Finally, we discuss that the enhancement of synchronization by random cell movement occurs in several different models for the oscillation of segmentation clock genes...
  30. doi request reprint Optimal number of regulatory T cells
    Koichi Saeki
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 263:210-8. 2010
    ..We also examine the separate regulation of the abundances of regulatory T cells for different self-antigens, comparing it with the situation in which they are constrained to be equal...
  31. doi request reprint Mechanisms for split localization of Fgf10 expression in early lung development
    Tsuyoshi Hirashima
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan
    Dev Dyn 238:2813-22. 2009
    ..Fgf10 expression has a single peak when a length between the tip of lung bud and the lung border is large. When the length is small, Fgf10 expression has two peaks, whose location depends on the curvature of lung border...
  32. doi request reprint Global mutations and local mutations have very different effects on evolution, illustrated by mixed strategies of asymmetric binary games
    Takashi Uehara
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 262:223-31. 2010
    ..When common local mutations and rare global mutations occur simultaneously, the evolutionary outcome is controlled by the latter...
  33. doi request reprint Synchronized oscillation of the segmentation clock gene in vertebrate development
    Koichiro Uriu
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Math Biol 61:207-29. 2010
    ..From statistical study of a model with randomly generated parameters, we revealed how the likelihood that the system generates stable synchronized oscillation depends on the rate of each reaction in the gene-protein kinetics...
  34. doi request reprint Traveling wave formation in vertebrate segmentation
    Koichiro Uriu
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 257:385-96. 2009
    ..Based on this result, we derive a mathematical formula for how the peak of gene expression moves along the pre-somitic mesoderm...
  35. doi request reprint Estimating the spatiotemporal pattern of volumetric growth rate from fate maps in chick limb development
    Yoshihiro Morishita
    PRESTO, Japan Science and Technology Agency, 4 1 8 Honcho Kawaguchi, Saitama, Japan
    Dev Dyn 238:415-22. 2009
    ..5 times as fast as in the distal region (within approximately 100 microm from the limb tip) than in the proximal region...
  36. pmc Growth based morphogenesis of vertebrate limb bud
    Yoshihiro Morishita
    PRESTO, Japan Science and Technology Agency, 4 1 8 Honcho Kawaguchi, Saitama, Japan
    Bull Math Biol 70:1957-78. 2008
    ..We believe that the ideas shown in the present paper are useful for the morphogenesis of other organs...
  37. doi request reprint Spatial heterogeneity of mortality and temporal fluctuation in fertility promote coexistence but not vice versa: a random-community approach
    Soyoka Muko
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 253:593-600. 2008
    ....
  38. doi request reprint Advantage of having regulatory T cells requires localized suppression of immune reactions
    Koichi Saeki
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 260:392-401. 2009
    ..This requires regulatory T cells to stop circulating once they are activated by their own target self-antigens...
  39. ncbi request reprint Single-class orbits in nonlinear Leslie matrix models for semelparous populations
    Ryusuke Kon
    Department of Biology, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    J Math Biol 55:781-802. 2007
    ..Conversely, if intra-class competition is severe, the single-class state is repelling. Numerical investigations show that all classes do not necessarily coexist even if the single-class state is repelling...
  40. ncbi request reprint Turing pattern formation with two kinds of cells and a diffusive chemical
    Koichiro Uriu
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, 812 8581, Japan
    Bull Math Biol 69:2515-36. 2007
    ..In the two-dimensional model, we study the condition for spot, stripe or reversed spot pattern to emerge (pattern selection). We discuss heuristic criteria for the pattern selection...
  41. doi request reprint Coevolution of phenotypic plasticity in predator and prey: why are inducible offenses rarer than inducible defenses?
    Akihiko Mougi
    Department of Biology, Kyushu University, Higashi ku, Fukuoka 812 8581, Japan
    Evolution 65:1079-87. 2011
    ..Reciprocal phenotypic plasticity may be widespread in nature but may have been overlooked by field studies because offensive phenotypes are rare and inconspicuous...
  42. ncbi request reprint Forest gap dynamics and the Ising model
    Robert Schlicht
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka shi, Kyushu 812 8581, Japan
    J Theor Biol 230:65-75. 2004
    ..The spatial pattern of the original forest data deviates significantly from the Ising model. We examine whether a larger sampling distance or the removal of the effects of the topography can reduce this deviation...
  43. ncbi request reprint Incomplete mixing promotes species coexistence in a lottery model with permanent spatial heterogeneity
    Soyoka Muko
    Department of Biology, Faculty of Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka Ken, Fukuoka shi 812 8581, Japan
    Theor Popul Biol 64:359-68. 2003
    ..the dynamics when larval migration and competition among adults are symmetric between habitats, and (3). the case with unidirectional migration. The coexistence of competitors is more likely to occur when larval migration is weak...
  44. ncbi request reprint Conservation effort and assessment of population size in fluctuating environments
    Hiroyuki Yokomizo
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 224:167-82. 2003
    ..3) We subsequently discuss the cases where the cue accuracy can be improved by assessment of the population. We study the optimal level of the assessment effort and discuss its dependence on various parameters...
  45. ncbi request reprint Optimal choice between feedforward and feedback control in gene expression to cope with unpredictable danger
    Emi Shudo
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 223:149-60. 2003
    ..All the HSP are produced by feedforward control when the maximum is close to the mean of denatured protein abundance conditional on the heat-shock intensity...
  46. ncbi request reprint Possibility of tissue separation caused by cell adhesion
    Ryohji Takano
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 221:459-74. 2003
    ....
  47. ncbi request reprint Difference in the retinal cone mosaic pattern between zebrafish and medaka: cell-rearrangement model
    Shusaku Tohya
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 221:289-300. 2003
    ..We also developed theoretical analysis of the parameter ranges for the row mosaic and the square mosaic to have higher total adhesion than alternative spatial patterns...
  48. ncbi request reprint Optimal conservation effort for a population in a stochastic environment
    Hiroyuki Yokomizo
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 220:215-31. 2003
    ..The recommended policy should depend critically on the choice of the criterion to optimize, which shows the importance of theoretical study of the relationship in performing proper decision making in conservation practice...
  49. ncbi request reprint Saturation of enzyme kinetics in circadian clock models
    Gen Kurosawa
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Biol Rhythms 17:568-77. 2002
    ..In the experimental measurements of enzyme kinetics and in published circadian clock simulators, in-loop reaction steps have a small saturation index whereas branch reaction steps have a large saturation index...
  50. ncbi request reprint Optimal defense strategy: storage vs. new production
    Emi Shudo
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 219:309-23. 2002
    ..When infection size is much smaller than the expected size, some of the stored proteins may stay unused...
  51. ncbi request reprint Directionality of stripes formed by anisotropic reaction-diffusion models
    Hiroto Shoji
    Department of Biology, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 214:549-61. 2002
    ..The transition between these two phases occurs sharply...
  52. ncbi request reprint Stripes, spots, or reversed spots in two-dimensional Turing systems
    Hiroto Shoji
    Mathematical Biology Laboratory, Department of Biology, Kyushu University, 812 8581 Fukuoka shi, Japan
    J Theor Biol 224:339-50. 2003
    ..This observation provides a heuristic argument of how the location of the equilibrium between the constraints leads to pattern selection...
  53. ncbi request reprint Dynamic optimization of host defense, immune memory, and post-infection pathogen levels in mammals
    Emi Shudo
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 228:17-29. 2004
    ..We also discuss the role of immune memory based on the results of the optimal immune reaction...
  54. ncbi request reprint Estimating local interaction from spatiotemporal forest data, and Monte Carlo bias correction
    Akiko Satake
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 226:225-35. 2004
    ..The use of MCBC estimates, suggesting a strong interaction between sites, improved this discrepancy...
  55. pmc Evolutionary dynamics of escape from biomedical intervention
    Yoh Iwasa
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan
    Proc Biol Sci 270:2573-8. 2003
    ..Our theory shows how to estimate the probability of success or failure of biomedical intervention, such as drug treatment and vaccination, against rapidly evolving organisms...
  56. pmc Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases
    D Falush
    Department of Biology, Faculty of Science, Kyushu University, Japan
    Am J Hum Genet 68:373-85. 2001
    ..Ascertainment falls to <50% for individuals with 40 repeats and to <5% for individuals with 36-38 repeats. Clinicians should not assume that HD is rare outside known pedigrees or that most cases have onset at age <50 years...
  57. ncbi request reprint Pollen coupling of forest trees: forming synchronized and periodic reproduction out of chaos
    A Satake
    Department of Biology, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 203:63-84. 2000
    ..This is consistent with the observation that the distinction between mast years and non-mast years is often not clear cut...
  58. ncbi request reprint Origin of directionality in the fish stripe pattern
    Hiroto Shoji
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan
    Dev Dyn 226:627-33. 2003
    ..Scales are the most likely candidate structure for generating anisotropic interactions in skin...
  59. pmc The evolution of two mutations during clonal expansion
    Hiroshi Haeno
    Department of Biology, Kyushu University, Fukuoka, Japan
    Genetics 177:2209-21. 2007
    ..Further, we develop a formula for the expected number of cells carrying both mutations when the final population size is reached. Our theory establishes an understanding of the dynamics of two mutations during clonal expansion...
  60. ncbi request reprint Comparative study of circadian clock models, in search of processes promoting oscillation
    Gen Kurosawa
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan kyushu u ac jp
    J Theor Biol 216:193-208. 2002
    ..We discuss the implications of these results...
  61. ncbi request reprint Comparing risk factors for population extinction
    H Hakoyama
    Department of Biology, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 204:327-36. 2000
    ..This conclusion depends also on the nonlinearity of dose-effect relationship. To illustrate the method, we analyse a freshwater fish, Japanese crucian carp (Carassius auratus subsp.) in Lake Biwa...
  62. ncbi request reprint Formation of cone mosaic of zebrafish retina
    S Tohya
    Faculty of Science, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 200:231-44. 1999
    ..However, the convergence time is shortened considerably if the pre-pattern formation occurs only in a narrow band of morphogenetic cell layer that sweeps from one end of the lattice to the other...
  63. ncbi request reprint Dynamics of marine sessile organisms with space-limited growth and recruitment: application to corals
    S Muko
    Department of Biology, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 210:67-80. 2001
    ..The dominance of tabular corals in exposed sites can be explained either by lower mortality or by faster recruitment than branching corals...
  64. ncbi request reprint Robustness of the signal transduction system of the mammalian JAK/STAT pathway and dimerization steps
    Emi Shudo
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Fukuoka 812 8581, Japan
    J Theor Biol 246:1-9. 2007
    ..We conclude that the observed structure of the JAK/STAT1 pathway is responsible for the robust system behavior...
  65. ncbi request reprint Accuracy of positional information provided by multiple morphogen gradients with correlated noise
    Yoshihiro Morishita
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Phys Rev E Stat Nonlin Soft Matter Phys 79:061905. 2009
    ....
  66. ncbi request reprint Variable timing of reproduction in unpredictable environments: adaption of flood plain plants
    A Satake
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan
    Theor Popul Biol 60:1-15. 2001
    ..In the presence of noise, the ESS distribution of programmed timing of reproduction is discrete...
  67. ncbi request reprint Inducible defense against pathogens and parasites: optimal choice among multiple options
    E Shudo
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, 812 8581, Japan
    J Theor Biol 209:233-47. 2001
    ..We discuss mammalian immunity and the plant chemical defense from the model's viewpoint...
  68. pmc A model for the circadian rhythm of cyanobacteria that maintains oscillation without gene expression
    Gen Kurosawa
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Biophys J 91:2015-23. 2006
    ..Results of this work suggest that KaiA and KaiB strengthen the nonlinearity of KaiC phosphorylation, thereby promoting the circadian rhythm in cyanobacteria...
  69. ncbi request reprint The evolution of a Müllerian mimic in a spatially distributed community
    Mathieu Joron
    Institut des Sciences de l Evolution, Universite de Montpellier, Place Eugene Bataillon, 34095 Montpellier Cedex 05, France
    J Theor Biol 237:87-103. 2005
    ..Local adaptation is predicted in most polymorphic cases. These results are in very good accordance with recent empirical findings on the polymorphic butterflies Heliconius numata and H. cydno...
  70. ncbi request reprint Can chromosomal instability initiate tumorigenesis?
    Franziska Michor
    Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, MA 02138, USA
    Semin Cancer Biol 15:43-9. 2005
    ..If two tumor suppressor genes have to be inactivated in rate-limiting steps, then CIN is likely to emerge before the inactivation of the first tumor suppressor gene...
  71. ncbi request reprint Labyrinthine versus straight-striped patterns generated by two-dimensional Turing systems
    Hiroto Shoji
    Yukawa Institute for Theoretical Physics, Kyoto University, Kyoto 606 8502, Japan
    J Theor Biol 237:104-16. 2005
    ....
  72. ncbi request reprint Somatic selection for and against cancer
    Franziska Michor
    Program in Theoretical Biology and Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 225:377-82. 2003
    ..If both deleterious and advantageous mutations participate in tumor initiation, then we find an intermediate optimum for the compartment size...
  73. ncbi request reprint Extinction risk to herring gull populations from DDT exposure
    Mayuko Nakamaru
    Department of Systems Engineering, Shizuoka University, Hamamatsu, Japan
    Environ Toxicol Chem 21:195-202. 2002
    ..5% when K is 100 (the number of breeding females), and coefficient of variation (CV) = 0.2 (sigma2 = 0.0298) [corrected]. Risk equivalent allows us to compare different risk factors and is useful in mitigation banking...
  74. ncbi request reprint Optimal conservation strategy in fluctuating environments with species interactions: resource-enhancement of the native species versus extermination of the alien species
    Hiroyuki Yokomizo
    The Ecology Centre, School of Integrative Biology, The University of Queensland, St Lucia, QLD 4072, Australia
    J Theor Biol 244:46-58. 2007
    ..We also examine the situation in which the impact of the alien species is uncertain. The optimal extermination effort increases with the uncertainty of this impact except when the cost of extermination is very high...
  75. pmc The linear process of somatic evolution
    Martin A Nowak
    Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:14966-9. 2003
    ..This design can slow down the rate of somatic evolution dramatically and therefore delay the onset of cancer...
  76. ncbi request reprint Extinction risk of a meta-population: aggregation approach
    Hiroshi Hakoyama
    National Research Institute of Fisheries Science, Yokohama 236 8648, Japan
    J Theor Biol 232:203-16. 2005
    ..We conclude that the formula for an unstructured single-population model has good approximation capability and can be applicable in estimating the extinction risk of the structured meta-population model for a limited data set...
  77. ncbi request reprint Dynamics of cancer progression
    Franziska Michor
    Program for Evolutionary Dynamics, Harvard University, One Brattle Square, Cambridge, MA 02138, USA
    Nat Rev Cancer 4:197-205. 2004
  78. ncbi request reprint Dynamics of chronic myeloid leukaemia
    Franziska Michor
    Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 435:1267-70. 2005
    ..We calculate the probability of developing imatinib resistance mutations and estimate the time until detection of resistance. Our model provides the first quantitative insights into the in vivo kinetics of a human cancer...
  79. pmc Evolutionary dynamics of tumor suppressor gene inactivation
    Martin A Nowak
    Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 101:10635-8. 2004
    ..Small lesions without genetic instability can take a very long time to inactivate the next TSG, whereas the same lesions with genetic instability pose a much greater risk for cancer progression...
  80. pmc Genetic addiction: selfish gene's strategy for symbiosis in the genome
    Atsushi Mochizuki
    National Institute for Basic Biology, Okazaki, Japan
    Genetics 172:1309-23. 2006
    ..Our demonstration that genomes can evolve through acquisition of addiction genes has implications for the general question of how a genome can evolve as a community of potentially selfish genes...
  81. ncbi request reprint Dynamics of metastasis suppressor gene inactivation
    Franziska Michor
    Harvard Society of Fellows, Harvard Program for Evolutionary Dynamics, Cambridge, MA 02138, USA
    J Theor Biol 241:676-89. 2006
    ..Most metastases-causing mutations will be present in all (or most) cells in the main tumor...
  82. pmc A symmetry of fixation times in evoultionary dynamics
    Christine Taylor
    Program for Evolutionary Dynamics, Department of Mathematics, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 243:245-51. 2006
    ..This does not hold for Wright-Fisher models, nor when the mutants start from multiple copies...
  83. ncbi request reprint Evolution of resistance to cancer therapy
    Franziska Michor
    Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, MA 02138, USA
    Curr Pharm Des 12:261-71. 2006
    ..We apply the general model to evolution of resistance of cancer cells and discuss examples for diverse mechanisms of resistance. Our theory shows how to estimate the probability of success for any treatment regimen...
  84. pmc Genetic instability and clonal expansion
    Martin A Nowak
    Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 241:26-32. 2006
    ....
  85. ncbi request reprint Environmental risk evaluation of chemicals: achievements of the project and seeds for future--development of metrics for evaluating risks
    Junko Nakanishi
    Research Center for Chemical Risk Management, National Institute of Advanced Industrial Science and Technology, Onogawa 16 1, AIST West, Tsukuba, Ibaraki 305 8569, Japan
    Chemosphere 53:389-98. 2003
    ..Protocols for estimating human health risks and ecological risks are illustrated...
  86. ncbi request reprint Coupled ecological-social dynamics in a forested landscape: spatial interactions and information flow
    Akiko Satake
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    J Theor Biol 246:695-707. 2007
    ..Our results highlight the importance of institutional arrangements that encourage a long-term perspective and increased information flow among landowners in order to achieve successful forest management...
  87. pmc Patterns of cell division and the risk of cancer
    Steven A Frank
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697 2525, USA
    Genetics 163:1527-32. 2003
    ....
  88. ncbi request reprint Local regulation of homeostasis favors chromosomal instability
    Franziska Michor
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Curr Biol 13:581-4. 2003
    ..Thus, small compartments protect against mutations in tumor suppressor genes or oncogenes but promote the emergence of genetic instability...
  89. pmc The fastest evolutionary trajectory
    Arne Traulsen
    Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 249:617-23. 2007
    ..We discuss deviations for large mutation rates and including back mutations. For very large mutation rates, the optimum fitness landscape is flat and has a single peak at type B...
  90. ncbi request reprint Stochastic dynamics of metastasis formation
    Franziska Michor
    Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 240:521-30. 2006
    ..Our theory shows how to calculate the expected number of metastases that are formed by a tumor...
  91. ncbi request reprint The coevolution of altruism and punishment: role of the selfish punisher
    Mayuko Nakamaru
    Department of Value and Decision Science, Graduate School of Decision Science and Technology, Tokyo Institute of Technology, 2 12 1, O Okayama, Meguro ku, Tokyo, 152 8552, Japan
    J Theor Biol 240:475-88. 2006
    ..These results can be understood that punishment is a form of spite behavior, paying a cost to reduce the fitness of the opponents, and that different models give different magnitude of advantage to spite behavior...
  92. ncbi request reprint Extinction risk to bird populations caused by DDT exposure
    Mayuko Nakamaru
    Department of Systems Engineering, Shizuoka University, Hamamatsu 432 8561, Japan
    Chemosphere 53:377-87. 2003
    ..The risk equivalent can be used in mitigation banking...
  93. ncbi request reprint Coexistence of a sexual and an unisexual form stabilized by parasites
    Hiroshi Hakoyama
    Hokkaido National Fisheries Research Institute, Katsurakoi 116, Kushiro 085 0802, Japan
    J Theor Biol 226:185-94. 2004
    ..We conclude that parasitism is a promising candidate mechanism for the coexistence of unisexual complexes...