Research Topics
Genomes and GenesSpecies | Yuji IshiiSummaryAffiliation: Kyushu University Country: Japan Publications
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Publications
Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidationYuji Ishii
Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
Drug Metab Dispos 32:1057-60. 2004..Hetero-oligomer formation of UGT2B21 and UGT2B22 may act by fine-tuning the catalytic glucuronidation of chloramphenicol...- Suppression of carbonic anhydrase III mRNA level by an aryl hydrocarbon receptor ligand in primary cultured hepatocytes of ratYuji Ishii
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Biol Pharm Bull 28:1087-90. 2005.... - Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complexYuji Ishii
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Drug Metab Pharmacokinet 22:367-76. 2007..Thus, CYP2C11/13 could associate with UGTs, but the affinity is assumed to be weaker than that of CYP2B/3As. These results suggest that there is isoform specificity in the interaction between P450s and UGTs... 
Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behaviorTomoki Takeda
Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Pharmacol Exp Ther 329:1091-9. 2009..These results demonstrate that TCDD disrupts steroidogenesis in fetuses by targeting pituitary gonadotropin production and imprints demasculinization in males and defeminization in females in terms of their copulatory behavior...- Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitaryJunko Taketoh
Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Life Sci 80:1259-67. 2007.... - [Effect on the expression of testicular steroidogenic enzymes in fetal mouse by maternal exposure to TCDD]Junpei Mutoh
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Fukuoka Igaku Zasshi 98:203-7. 2007..In addition, the data obtained suggest that the suppression of fetal testicular steroidogenic enzymes is, at least, one of the key mechanisms for impaired sex behavior induced by dioxin... - Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive modeShuso Takeda
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Drug Metab Dispos 34:1277-82. 2006.... - Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4Shuso Takeda
Graduate School of Pharmaceutical Sciences, Kyushu University; Fukuoka 812-8582, Japan
Biol Pharm Bull 28:2026-7. 2005..These results suggest that CYP1A2 and CYP2C9 have ability to modify UGT2B7 function. However, the mechanism(s) underlying the modulation of UGT2B7 function by these P450s seems to differ from that by CYP3A4... - Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4Shuso Takeda
Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Mol Pharmacol 67:665-72. 2005..This study provides the first evidence that P450 is not only involved in oxidation of drugs but also modulates the function of UGTs... - Modulation of UDP-glucuronosyltransferase activity by protein-protein associationYuji Ishii
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Drug Metab Rev 42:145-58. 2010..In this review, we summarize these interactions and discuss their relevance to UGT function... - [Possible candidates for the compound which is expected to attenuate dioxin toxicity]Yuji Ishii
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Fukuoka Igaku Zasshi 96:204-13. 2005..Prior to the application of these compounds to Yusho patients, the limitation and possibility of these candidate compounds are seemed to be further studied... - Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesisYuki Matsumoto
Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
J Toxicol Sci 35:365-73. 2010..These results demonstrate a possibility that TCDD may reduce the metabolic activity of the hypothalamus in a fetus-specific fashion, resulting in the reduced synthesis of gonadotropins... - Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interactionShuso Takeda
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Mol Pharmacol 75:956-64. 2009.... - Attenuation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by resveratrol: a comparative study with different routes of administrationTakumi Ishida
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Biol Pharm Bull 32:876-81. 2009..These data suggest that 1) oral resveratrol is attractive candidate as an agent capable of combating dioxin toxicity and 2) increasing the bioavailability of this polyphenol enhances its protective effect... 
Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxinTomoki Takeda
Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
J Biol Chem 287:18440-50. 2012..These results strongly suggest that the increased deacetylation of histone owing to HDAC induction plays a critical role in the TCDD-induced reduction in LHβ in the fetal pituitary...- 2,3,7,8-tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitariesTomoki Takeda
Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
J Toxicol Sci 36:221-9. 2011..These results suggest that TCDD reduces gonadotropin biosynthesis via damage to GnRH-stimulated PKC and PKA signaling in a β-subunit- and fetal age-specific manner... - 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced change in intestinal function and pathology: evidence for the involvement of arylhydrocarbon receptor-mediated alteration of glucose transportationTakumi Ishida
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Toxicol Appl Pharmacol 205:89-97. 2005..The data provided here also suggest that AhR is involved in the mechanism of SGLT1 induction... - Activation of morphine glucuronidation by fatty acyl-CoAs and its plasticity: a comparative study in humans and rodents including chimeric mice carrying human liverArief Nurrochmad
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
Drug Metab Pharmacokinet 25:262-73. 2010..The function of UGT appears to be dynamically changed depending on the cellular acyl-CoA level in many species... - [The effect of maternal exposure to dioxin on fetal steroidogenesis in the steroidogenic organs]Tomoki Takeda
Graduate School of Pharmaceutical Sciences, Kyushu University
Fukuoka Igaku Zasshi 102:159-66. 2011..Thus, the mechanism whereby TCDD exerts its endocrine-disrupting properties is considered to differ, at least partially, between male and female fetuses... - Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acidTakayuki Koga
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
PLoS ONE 7:e40322. 2012.... - Modulation of UDP-glucuronosyltransferase activity by endogenous compoundsYuji Ishii
Kyushu University, Fukuoka, Japan
Drug Metab Pharmacokinet 25:134-48. 2010..Further, we have also suggested that adenine and related compounds are endogenous allosteric inhibitors of UGT. In this review, we summarize the endogenous modulators of UGT and discuss their relevance to UGT function... - Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanismYoshio Nishimura
Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Biochim Biophys Acta 1770:1557-66. 2007..These results suggest that (1) a number of cellular nucleotides present within the endoplasmic reticulum regulate UGT function; and (2) these substances bind to a common allosteric site on UGT to reduce catalytic function... - Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferasesKazuharu Okamura
Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Biochem Biophys Res Commun 345:1649-56. 2006..These results suggest that: (1) acyl-CoAs play a role as an endogenous activator of UGTs, and (2) a sulfhydryl group is required for the activation of UGT by physiological concentrations of acyl-CoAs... - Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in ratsJunpei Mutoh
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Endocrinology 147:927-36. 2006..Taken together, these results demonstrate that TCDD impairs steroidogenesis in the fetus by targeting pituitary gonadotropins... - Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteinsTakumi Ishida
Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Environ Toxicol Pharmacol 26:348-54. 2008..Based on the evidence obtained, it appears that proteasome inhibition results in a reduction in the expression of AhR-regulated proteins... - Functional protein-protein interaction of drug metabolizing enzymesYuji Ishii
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Front Biosci 10:887-95. 2005..In this review, we summarize the interaction between drug metabolizing enzymes and discuss its impact on their function... - Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brainHideyuki Yamada
Laboratory of Molecular Life Science, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
J Toxicol Sci 28:395-401. 2003..These results suggest that endogenous morphine is converted to its 6-glucuronide, a more highly analgesic substance than the parent compound, to suppress effectively pain symptoms in humans... - [The accelerated excretion of 2,3,4,7,8-pentachlorodibenzofuran by Cholebine]Takumi Ishida
Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582
Fukuoka Igaku Zasshi 100:210-6. 2009..This is because no binding of Cholebine to 14C-PenCDF was detected. These results suggest that Cholebine has little effect on the reabsorption of dioxin, whereas it reduces substantially the first absorption of dioxin... - ATP Serves as an Endogenous Inhibitor of UDP-Glucuronosyltransferase (UGT): A New Insight into the Latency of UGTYuji Ishii
Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Drug Metab Dispos 40:2081-9. 2012..Therefore, Gefitinib inhibits UGT1A9 at the common ATP-binding site shared with ATP and AMP. Releasing adenine nucleotide from the ER is suggested to be one of the mechanisms that explain the "latency" of UGT... - Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcoholsYuji Ishii
Graduate School of Pharmaceutical Sciences, Kyushu University, University 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Biol Pharm Bull 35:1811-7. 2012..These results demonstrate that dietary and supplementary monoterpenoid alcohols modify the pharmacokinetics and pharmacodynamics of morphine through inhibition of UGT2B7... - Reduction of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, geranylgeranylacetoneTakumi Ishida
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Biol Pharm Bull 27:1397-402. 2004..These data suggest that GGA exhibits a protective effect against some forms of dioxin toxicity by a mechanism without involving inhibition of arylhydrocarbon receptor activation... - Cytochrome P450 1A1 (CYP1A1) inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase (UGT) activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats: possible involvement of UGT-P450 interactiKen-ichiro Taura
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Biol Pharm Bull 27:56-60. 2004..It is likely that P450 functions as a substrate transporter for some isoforms of UGT via possible interactions between UGT and P450... - Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanismHideyuki Yamada
Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Curr Drug Metab 7:397-409. 2006.... - Glucuronidation and the UDP-glucuronosyltransferases in health and diseasePeter G Wells
Faculty of Pharmacy and Department of Pharmacology, University of Toronto, Ontario, Canada
Drug Metab Dispos 32:281-90. 2004.... - A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenolTakashi Umemura
Division of Pathology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Toxicol Sci 90:111-9. 2006..These data suggest that Nrf2 plays a key role in prevention of PCP-induced oxidative stress and cell proliferation... - Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta miceYuichi Kuroiwa
Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
Arch Toxicol 81:63-9. 2007..These results suggest that genotoxicity, including oxidative DNA damage, is not involved in mouse hepatocarcinogenesis by FLU, which might rather solely exert tumor-promoting effects in the liver... - Induction of characteristic hepatocyte proliferative lesion with dietary exposure of Wistar Hannover rats to tocotrienol for 1 yearMasako Tasaki
Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Toxicology 250:143-50. 2008..Based on the present data demonstrating nodular liver lesions only at the high dose of both sexes, we conclude that the no-observed-adverse-effect level (NOAEL) is 0.4% (303 mg/kg/day for males, and 472 mg/kg/day for females)... - Hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactorYuji Ishii
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
World J Gastroenterol 14:2740-7. 2008..To examine the efficacy of the radial flow bioreactor (RFB) as an extracorporeal bioartificial liver (BAL) and the reconstruction of liver organoids using embryonic pig liver cells...