Yuji Ishii

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Drug Metab Dispos 32:1057-60. 2004
  2. ncbi request reprint Suppression of carbonic anhydrase III mRNA level by an aryl hydrocarbon receptor ligand in primary cultured hepatocytes of rat
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biol Pharm Bull 28:1087-90. 2005
  3. doi request reprint Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior
    Tomoki Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Pharmacol Exp Ther 329:1091-9. 2009
  4. ncbi request reprint Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metab Pharmacokinet 22:367-76. 2007
  5. ncbi request reprint Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitary
    Junko Taketoh
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Life Sci 80:1259-67. 2007
  6. pmc Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid
    Takayuki Koga
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e40322. 2012
  7. ncbi request reprint Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4
    Shuso Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University Fukuoka 812 8582, Japan
    Biol Pharm Bull 28:2026-7. 2005
  8. ncbi request reprint [Effect on the expression of testicular steroidogenic enzymes in fetal mouse by maternal exposure to TCDD]
    Junpei Mutoh
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 98:203-7. 2007
  9. ncbi request reprint Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4
    Shuso Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Pharmacol 67:665-72. 2005
  10. ncbi request reprint Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode
    Shuso Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Drug Metab Dispos 34:1277-82. 2006

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Drug Metab Dispos 32:1057-60. 2004
    ..Hetero-oligomer formation of UGT2B21 and UGT2B22 may act by fine-tuning the catalytic glucuronidation of chloramphenicol...
  2. ncbi request reprint Suppression of carbonic anhydrase III mRNA level by an aryl hydrocarbon receptor ligand in primary cultured hepatocytes of rat
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biol Pharm Bull 28:1087-90. 2005
    ....
  3. doi request reprint Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior
    Tomoki Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Pharmacol Exp Ther 329:1091-9. 2009
    ..These results demonstrate that TCDD disrupts steroidogenesis in fetuses by targeting pituitary gonadotropin production and imprints demasculinization in males and defeminization in females in terms of their copulatory behavior...
  4. ncbi request reprint Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metab Pharmacokinet 22:367-76. 2007
    ..Thus, CYP2C11/13 could associate with UGTs, but the affinity is assumed to be weaker than that of CYP2B/3As. These results suggest that there is isoform specificity in the interaction between P450s and UGTs...
  5. ncbi request reprint Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitary
    Junko Taketoh
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Life Sci 80:1259-67. 2007
    ....
  6. pmc Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid
    Takayuki Koga
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e40322. 2012
    ....
  7. ncbi request reprint Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4
    Shuso Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University Fukuoka 812 8582, Japan
    Biol Pharm Bull 28:2026-7. 2005
    ..These results suggest that CYP1A2 and CYP2C9 have ability to modify UGT2B7 function. However, the mechanism(s) underlying the modulation of UGT2B7 function by these P450s seems to differ from that by CYP3A4...
  8. ncbi request reprint [Effect on the expression of testicular steroidogenic enzymes in fetal mouse by maternal exposure to TCDD]
    Junpei Mutoh
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 98:203-7. 2007
    ..In addition, the data obtained suggest that the suppression of fetal testicular steroidogenic enzymes is, at least, one of the key mechanisms for impaired sex behavior induced by dioxin...
  9. ncbi request reprint Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4
    Shuso Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Pharmacol 67:665-72. 2005
    ..This study provides the first evidence that P450 is not only involved in oxidation of drugs but also modulates the function of UGTs...
  10. ncbi request reprint Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode
    Shuso Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Drug Metab Dispos 34:1277-82. 2006
    ....
  11. doi request reprint Selenium-binding protein 1: its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Sayuri Tsujimoto
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1830:3616-24. 2013
    ..However, the mechanism or likelihood is largely unknown because of the limited information available about the physiological role of Selenbp1...
  12. doi request reprint Modulation of UDP-glucuronosyltransferase activity by protein-protein association
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metab Rev 42:145-58. 2010
    ..In this review, we summarize these interactions and discuss their relevance to UGT function...
  13. ncbi request reprint Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis
    Yuki Matsumoto
    Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    J Toxicol Sci 35:365-73. 2010
    ..These results demonstrate a possibility that TCDD may reduce the metabolic activity of the hypothalamus in a fetus-specific fashion, resulting in the reduced synthesis of gonadotropins...
  14. doi request reprint Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction
    Shuso Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Mol Pharmacol 75:956-64. 2009
    ....
  15. ncbi request reprint Attenuation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by resveratrol: a comparative study with different routes of administration
    Takumi Ishida
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biol Pharm Bull 32:876-81. 2009
    ..These data suggest that 1) oral resveratrol is attractive candidate as an agent capable of combating dioxin toxicity and 2) increasing the bioavailability of this polyphenol enhances its protective effect...
  16. ncbi request reprint [Possible candidates for the compound which is expected to attenuate dioxin toxicity]
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 96:204-13. 2005
    ..Prior to the application of these compounds to Yusho patients, the limitation and possibility of these candidate compounds are seemed to be further studied...
  17. pmc Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxin
    Tomoki Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Biol Chem 287:18440-50. 2012
    ..These results strongly suggest that the increased deacetylation of histone owing to HDAC induction plays a critical role in the TCDD-induced reduction in LHβ in the fetal pituitary...
  18. ncbi request reprint 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced change in intestinal function and pathology: evidence for the involvement of arylhydrocarbon receptor-mediated alteration of glucose transportation
    Takumi Ishida
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Toxicol Appl Pharmacol 205:89-97. 2005
    ..The data provided here also suggest that AhR is involved in the mechanism of SGLT1 induction...
  19. ncbi request reprint Activation of morphine glucuronidation by fatty acyl-CoAs and its plasticity: a comparative study in humans and rodents including chimeric mice carrying human liver
    Arief Nurrochmad
    Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Drug Metab Pharmacokinet 25:262-73. 2010
    ..The function of UGT appears to be dynamically changed depending on the cellular acyl-CoA level in many species...
  20. ncbi request reprint 2,3,7,8-tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries
    Tomoki Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
    J Toxicol Sci 36:221-9. 2011
    ..These results suggest that TCDD reduces gonadotropin biosynthesis via damage to GnRH-stimulated PKC and PKA signaling in a β-subunit- and fetal age-specific manner...
  21. ncbi request reprint [The effect of maternal exposure to dioxin on fetal steroidogenesis in the steroidogenic organs]
    Tomoki Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University
    Fukuoka Igaku Zasshi 102:159-66. 2011
    ..Thus, the mechanism whereby TCDD exerts its endocrine-disrupting properties is considered to differ, at least partially, between male and female fetuses...
  22. ncbi request reprint Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanism
    Yoshio Nishimura
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochim Biophys Acta 1770:1557-66. 2007
    ..These results suggest that (1) a number of cellular nucleotides present within the endoplasmic reticulum regulate UGT function; and (2) these substances bind to a common allosteric site on UGT to reduce catalytic function...
  23. ncbi request reprint Modulation of UDP-glucuronosyltransferase activity by endogenous compounds
    Yuji Ishii
    Kyushu University, Fukuoka, Japan
    Drug Metab Pharmacokinet 25:134-48. 2010
    ..Further, we have also suggested that adenine and related compounds are endogenous allosteric inhibitors of UGT. In this review, we summarize the endogenous modulators of UGT and discuss their relevance to UGT function...
  24. doi request reprint Maternal Exposure to Dioxin Imprints Sexual Immaturity of the Pups through Fixing the Status of the Reduced Expression of Hypothalamic Gonadotropin-Releasing Hormone
    Tomoki Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan T T, M F, Y H, T S, Y I, H Y and Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan M Y, M H
    Mol Pharmacol 85:74-82. 2014
    ....
  25. doi request reprint ATP serves as an endogenous inhibitor of UDP-glucuronosyltransferase (UGT): a new insight into the latency of UGT
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metab Dispos 40:2081-9. 2012
    ..Therefore, Gefitinib inhibits UGT1A9 at the common ATP-binding site shared with ATP and AMP. Releasing adenine nucleotide from the ER is suggested to be one of the mechanisms that explain the "latency" of UGT...
  26. ncbi request reprint Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, University 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biol Pharm Bull 35:1811-7. 2012
    ..These results demonstrate that dietary and supplementary monoterpenoid alcohols modify the pharmacokinetics and pharmacodynamics of morphine through inhibition of UGT2B7...
  27. ncbi request reprint Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases
    Kazuharu Okamura
    Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Biochem Biophys Res Commun 345:1649-56. 2006
    ..These results suggest that: (1) acyl-CoAs play a role as an endogenous activator of UGTs, and (2) a sulfhydryl group is required for the activation of UGT by physiological concentrations of acyl-CoAs...
  28. ncbi request reprint Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats
    Junpei Mutoh
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Endocrinology 147:927-36. 2006
    ..Taken together, these results demonstrate that TCDD impairs steroidogenesis in the fetus by targeting pituitary gonadotropins...
  29. ncbi request reprint Functional protein-protein interaction of drug metabolizing enzymes
    Yuji Ishii
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Front Biosci 10:887-95. 2005
    ..In this review, we summarize the interaction between drug metabolizing enzymes and discuss its impact on their function...
  30. ncbi request reprint Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins
    Takumi Ishida
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Environ Toxicol Pharmacol 26:348-54. 2008
    ..Based on the evidence obtained, it appears that proteasome inhibition results in a reduction in the expression of AhR-regulated proteins...
  31. doi request reprint Alteration of the Function of the UDP-Glucuronosyltransferase 1A Subfamily by Cytochrome P450 3A4: Different Susceptibility for UGT Isoforms and UGT1A1/7 Variants
    Yuji Ishii
    Laboratory of Molecular Life Sciences Y Is, H K, K K, T O, Y Iw, S T, Y M, Y N, N E, H Y and Laboratory of Medicinal Resource Regulation F T, S M, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan S I Tohoku Pharmaceutical University, Sendai, Japan K N Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan Y Y and Department of Clinical Pharmacology, Flinders Medical Centre and Flinders University, Adelaide, Australia P I M
    Drug Metab Dispos 42:229-38. 2014
    ....
  32. ncbi request reprint [The accelerated excretion of 2,3,4,7,8-pentachlorodibenzofuran by Cholebine]
    Takumi Ishida
    Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582
    Fukuoka Igaku Zasshi 100:210-6. 2009
    ..This is because no binding of Cholebine to 14C-PenCDF was detected. These results suggest that Cholebine has little effect on the reabsorption of dioxin, whereas it reduces substantially the first absorption of dioxin...
  33. ncbi request reprint Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain
    Hideyuki Yamada
    Laboratory of Molecular Life Science, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Toxicol Sci 28:395-401. 2003
    ..These results suggest that endogenous morphine is converted to its 6-glucuronide, a more highly analgesic substance than the parent compound, to suppress effectively pain symptoms in humans...
  34. ncbi request reprint Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism
    Hideyuki Yamada
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Curr Drug Metab 7:397-409. 2006
    ....
  35. ncbi request reprint Cytochrome P450 1A1 (CYP1A1) inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase (UGT) activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats: possible involvement of UGT-P450 interacti
    Ken ichiro Taura
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biol Pharm Bull 27:56-60. 2004
    ..It is likely that P450 functions as a substrate transporter for some isoforms of UGT via possible interactions between UGT and P450...
  36. ncbi request reprint Reduction of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, geranylgeranylacetone
    Takumi Ishida
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biol Pharm Bull 27:1397-402. 2004
    ..These data suggest that GGA exhibits a protective effect against some forms of dioxin toxicity by a mechanism without involving inhibition of arylhydrocarbon receptor activation...
  37. ncbi request reprint Glucuronidation and the UDP-glucuronosyltransferases in health and disease
    Peter G Wells
    Faculty of Pharmacy and Department of Pharmacology, University of Toronto, Ontario, Canada
    Drug Metab Dispos 32:281-90. 2004
    ....
  38. ncbi request reprint A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Sci 90:111-9. 2006
    ..These data suggest that Nrf2 plays a key role in prevention of PCP-induced oxidative stress and cell proliferation...
  39. pmc Hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactor
    Yuji Ishii
    Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
    World J Gastroenterol 14:2740-7. 2008
    ..To examine the efficacy of the radial flow bioreactor (RFB) as an extracorporeal bioartificial liver (BAL) and the reconstruction of liver organoids using embryonic pig liver cells...
  40. ncbi request reprint Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Arch Toxicol 81:63-9. 2007
    ..These results suggest that genotoxicity, including oxidative DNA damage, is not involved in mouse hepatocarcinogenesis by FLU, which might rather solely exert tumor-promoting effects in the liver...
  41. doi request reprint Induction of characteristic hepatocyte proliferative lesion with dietary exposure of Wistar Hannover rats to tocotrienol for 1 year
    Masako Tasaki
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 250:143-50. 2008
    ..Based on the present data demonstrating nodular liver lesions only at the high dose of both sexes, we conclude that the no-observed-adverse-effect level (NOAEL) is 0.4% (303 mg/kg/day for males, and 472 mg/kg/day for females)...