Toyoshi Inoguchi

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. pmc The role of oxidative stress in the pathogenesis of diabetic vascular complications
    Shuji Sasaki
    Department of Medicine and Regulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Metab J 36:255-61. 2012
  2. ncbi request reprint High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells
    T Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushyu University, Fukuoka, Japan
    Diabetes 49:1939-45. 2000
  3. ncbi request reprint NAD(P)H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome
    Toyoshi Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyusyu University, Japan
    Curr Drug Targets 6:495-501. 2005
  4. ncbi request reprint A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase
    T Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Curr Med Chem 10:1759-64. 2003
  5. ncbi request reprint Altered gap junction activity in cardiovascular tissues of diabetes
    T Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Med Electron Microsc 34:86-91. 2001
  6. ncbi request reprint ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts
    Minako Imamura
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Am J Physiol Endocrinol Metab 283:E775-83. 2002
  7. doi request reprint Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress
    Jing Zheng
    Dept of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyusyu Univ, Fukuoka, Japan
    Am J Physiol Regul Integr Comp Physiol 304:R110-20. 2013
  8. ncbi request reprint Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement
    Hirotaka Tsubouchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Free Radic Biol Med 39:444-52. 2005
  9. doi request reprint Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase
    Masakazu Fujii
    Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Kidney Int 78:905-19. 2010
  10. doi request reprint Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6
    Fumi Sawada
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Metabolism 57:1038-45. 2008

Collaborators

Detail Information

Publications62

  1. pmc The role of oxidative stress in the pathogenesis of diabetic vascular complications
    Shuji Sasaki
    Department of Medicine and Regulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Metab J 36:255-61. 2012
    ....
  2. ncbi request reprint High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells
    T Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushyu University, Fukuoka, Japan
    Diabetes 49:1939-45. 2000
    ..This finding may be involved in the excessive acceleration of atherosclerosis in patients with diabetes and insulin resistance syndrome...
  3. ncbi request reprint NAD(P)H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome
    Toyoshi Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyusyu University, Japan
    Curr Drug Targets 6:495-501. 2005
    ..These results suggest that an NAD(P)H oxidase activation may be a useful therapeutic target for preventing diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome...
  4. ncbi request reprint A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase
    T Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Curr Med Chem 10:1759-64. 2003
    ..In this point of view, the possible new strategy of antioxidative therapy for diabetic vascular complications is discussed in this review...
  5. ncbi request reprint Altered gap junction activity in cardiovascular tissues of diabetes
    T Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Med Electron Microsc 34:86-91. 2001
    ..These results suggest that PKC-dependent impairment of GJIC may lead to various disorders of cardiovascular homeostasis and contribute to cardiovascular dysfunctions associated with diabetes...
  6. ncbi request reprint ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts
    Minako Imamura
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Am J Physiol Endocrinol Metab 283:E775-83. 2002
    ..The detailed molecular mechanisms of ADRP on lipid accumulation remain to be elucidated...
  7. doi request reprint Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress
    Jing Zheng
    Dept of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyusyu Univ, Fukuoka, Japan
    Am J Physiol Regul Integr Comp Physiol 304:R110-20. 2013
    ..In conclusion, oral administration of phycocyanin and phycocyanobilin may offer a novel and feasible therapeutic approach for preventing diabetic nephropathy...
  8. ncbi request reprint Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement
    Hirotaka Tsubouchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Free Radic Biol Med 39:444-52. 2005
    ..In conclusion, pitavastatin attenuated a high glucose-induced and a diabetes-induced oxidative stress in vitro and in vivo. Thus, our data may provide a new insight into antioxidative therapy in diabetes...
  9. doi request reprint Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase
    Masakazu Fujii
    Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Kidney Int 78:905-19. 2010
    ..Collectively, our findings suggest that BIL and BVD may protect against diabetic nephropathy and may lead to novel antioxidant therapies for diabetic nephropathy...
  10. doi request reprint Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6
    Fumi Sawada
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Metabolism 57:1038-45. 2008
    ..Because of the lack of such adverse effects, gliclazide may have a benefit in the preservation of functional beta-cell mass...
  11. pmc Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB
    Tomoaki Inoue
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 286:32045-53. 2011
    ..These results suggest that reduced ATGL expression may influence the atherogenic process in neutral lipid storage diseases and in the insulin-resistant state...
  12. ncbi request reprint Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist
    Mieko Nakayama
    Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 332:927-33. 2005
    ..Angiotensin II-related increased expression of NAD(P)H oxidase may play an important role in increased oxidative stress in islets of Type 2 diabetes. This mechanism may be a novel therapeutic target for preventing beta-cell damage...
  13. ncbi request reprint Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity
    Toshiyo Sonta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Free Radic Biol Med 37:115-23. 2004
    ..These results suggest that vascular NAD(P)H oxidase may be a major source of increased oxidative stress in diabetes and obesity...
  14. ncbi request reprint Adipose differentiation related protein induces lipid accumulation and lipid droplet formation in hepatic stellate cells
    Marie Fukushima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    In Vitro Cell Dev Biol Anim 41:321-4. 2005
    ..LacZ-infected cells. In our in vitro study, ADRP overexpression induced the formation of cytoplasmic lipid droplets in activated HSCs but could not convert other characteristics of the activated form into those of the quiescent form...
  15. ncbi request reprint In vivo imaging of oxidative stress in the kidney of diabetic mice and its normalization by angiotensin II type 1 receptor blocker
    Toshiyo Sonta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 330:415-22. 2005
    ..This technique would be useful as a means of further elucidating the role of oxidative stress in diabetic nephropathy...
  16. ncbi request reprint Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic beta-cell line, MIN6-a role of NAD(P)H oxidase in beta-cells
    Hirotaka Tsubouchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 326:60-5. 2005
    ..This mechanism may be a novel therapeutic target for preventing the progression of beta-cell deterioration...
  17. doi request reprint Impact of metabolic syndrome on the progression of Intima-Media Thickening in Japanese--a follow-up study
    Yuka Matoba
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Diabetes Res Clin Pract 86:e50-3. 2009
    ..Improvement of MetS was related to smaller increases in IMT, especially in females. These findings may suggest a benefit of intervention for MetS, which needs to be confirmed by prospective studies...
  18. ncbi request reprint Evalution of oxidative stress in diabetic animals by in vivo electron spin resonance measurement--role of protein kinase C
    Toshiyo Sonta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Diabetes Res Clin Pract 66:S109-13. 2004
    ..This may contribute to the pathogenesis of diabetic vascular complications...
  19. doi request reprint GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases
    Hari Hendarto
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Metabolism 61:1422-34. 2012
    ..Liraglutide may have a direct beneficial effect on oxidative stress and diabetic nephropathy via a PKA-mediated inhibition of renal NAD(P)H oxidase, independently of a glucose-lowering effect...
  20. doi request reprint Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice
    Tomoaki Inoue
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 438:224-9. 2013
    ..These results suggest that reduced ATGL and CGI-58 expression and increased TG synthesis may exacerbate myocardial steatosis and oxidative stress, thereby promoting cardiac apoptosis in diabetic mice. ..
  21. doi request reprint High prevalence of peripheral arterial disease diagnosed by low ankle-brachial index in Japanese patients with diabetes: the Kyushu Prevention Study for Atherosclerosis
    Yasutaka Maeda
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes Res Clin Pract 82:378-82. 2008
    ..Better diagnostic efforts and more intensive treatments are needed to improve quality of life and the overall prognosis of life in Japanese diabetic patients...
  22. ncbi request reprint Are free radical reactions increased in the diabetic eye?
    Mayumi Yamato
    Department REDOX Medicinal Science, Faculty of Pharmaceutical Sciences, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Antioxid Redox Signal 9:367-73. 2007
    ..This enhanced signal decay was suppressed by the administration of SOD or the pretreatment with aminoguanidine. We demonstrate, for the first time, specific free radical reactions in the eyes of mice with STZ-induced diabetes...
  23. ncbi request reprint Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase
    Toyoshi Inoguchi
    Departments of Medicine and Bioregulatory Science and Molecular and Structure Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Am Soc Nephrol 14:S227-32. 2003
    ..Taken together, these findings strongly suggest that the PKC-dependent activation of NAD(P)H oxidase may be an essential mechanism responsible for increased oxidative stress in diabetes...
  24. ncbi request reprint Maternal high-fat diet induces insulin resistance and deterioration of pancreatic β-cell function in adult offspring with sex differences in mice
    Hisashi Yokomizo
    Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Physiol Endocrinol Metab 306:E1163-75. 2014
    ....
  25. ncbi request reprint Adenovirus-mediated high expression of resistin causes dyslipidemia in mice
    Naoichi Sato
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Endocrinology 146:273-9. 2005
    ..These results suggest that resistin overexpression induces dyslipidemia in mice, which is commonly seen in the insulin-resistant state, partially through enhanced secretion of lipoproteins...
  26. ncbi request reprint High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen-activated protein kinase
    Rie Sugimoto
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Liver Int 25:1018-26. 2005
    ..Oxidative stress is increasingly found in patients with diabetes/hyperglycemia in which conditions reactive oxygen species (ROS) are produced...
  27. doi request reprint Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters
    Yasutaka Maeda
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Physiol Renal Physiol 299:F1328-38. 2010
    ..These findings suggest that chymase offers a new therapeutic target for diabetic nephropathy...
  28. ncbi request reprint Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells
    Naotaka Sekiguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 334:218-22. 2005
    ..Replacing therapy with erythropoietin is often used for correction of renal anemia, but may have potential in preventing atherosclerosis in diabetic patients with end-stage renal failure...
  29. doi request reprint CTLA-4Ig immunotherapy of obesity-induced insulin resistance by manipulation of macrophage polarization in adipose tissues
    Masakazu Fujii
    Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 438:103-9. 2013
    ..This novel mechanism of CTLA-4lg immunotherapy may lead to an ideal anti-obesity/inflammation/insulin resistance agent. ..
  30. ncbi request reprint Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU.1 and AP-1 in macrophages
    Ping Wei
    Division of Clinical Immunology, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    J Biochem 138:399-412. 2005
    ..1/AP-1 complex formation on EMSA. From these results, we concluded that the Ets/AP-1 site is an important cis-acting element that regulates the ADRP gene expression in macrophages...
  31. doi request reprint Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells
    Battsetseg Batchuluun
    Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan Electronic address
    Atherosclerosis 232:156-64. 2014
    ..Thus, we aimed to evaluate the effects of metformin and a GLP-1 analog, liraglutide on high glucose-induced oxidative stress...
  32. ncbi request reprint Optimal cut points of waist circumference for the clinical diagnosis of metabolic syndrome in the Japanese population
    Yuka Matoba
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Care 31:590-2. 2008
  33. ncbi request reprint Effect of erythropoietin on endothelial cell apoptosis induced by high glucose
    Naotaka Sekiguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Diabetes Res Clin Pract 66:S103-7. 2004
    ..These results suggest that reduced production of Epo in patients with end-stage of nephropathy may accelerate diabetic angiopathy and that replacing therapy with Epo might inhibit endothelial cell apoptosis and diabetic angiopathy...
  34. ncbi request reprint Oleic acid-induced ADRP expression requires both AP-1 and PPAR response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells
    Bin Fan
    Division of Clinical Immunology, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    Am J Physiol Endocrinol Metab 297:E112-23. 2009
    ..PYC, a widely used dietary supplement, could be beneficial for the prevention of excessive lipid accumulation such as hepatic steatosis...
  35. ncbi request reprint Association of borderline ankle-brachial index with mortality and the incidence of peripheral artery disease in diabetic patients
    Chiharu Natsuaki
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Atherosclerosis 234:360-5. 2014
    ..This study aimed to investigate the association of ABI with mortality and the incidence of PAD in Japanese diabetic patients...
  36. ncbi request reprint [Role of PKC in the pathogenesis of diabetic vascular complications]
    Toyoshi Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
    Nihon Rinsho 60:67-72. 2002
  37. doi request reprint The lack of the C-terminal domain of adipose triglyceride lipase causes neutral lipid storage disease through impaired interactions with lipid droplets
    Kunihisa Kobayashi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    J Clin Endocrinol Metab 93:2877-84. 2008
    ..The molecular mechanisms by which triglycerides in lipid droplets (LDs) are synthesized, stored, and degraded need to be elucidated...
  38. doi request reprint Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia
    Takahiro A Kato
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Schizophr Res 129:172-82. 2011
    ..Our results imply that aripiprazole may have psychotropic effects by reducing the microglial oxidative reactions and following neuronal reactions, which puts forward a novel therapeutic hypothesis in schizophrenia research...
  39. ncbi request reprint Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan
    Kunihisa Kobayashi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan
    Biochem Biophys Res Commun 335:66-70. 2005
    ..This is a new antiatherogenic property that appears independent of the receptor-mediated hormonal action of adiponectin...
  40. ncbi request reprint Accumulation of 8-hydroxy-2'-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats
    Maiko Kakimoto
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes 51:1588-95. 2002
    ..Our study demonstrated for the first time that oxidative mtDNA damage and subsequent mtDNA deletion may be accumulated in kidney of diabetic rats. This may be involved in the pathogenesis of diabetic nephropathy...
  41. doi request reprint Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women
    Keizo Ohnaka
    Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes Res Clin Pract 88:103-10. 2010
    ....
  42. ncbi request reprint Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction
    T Ide
    Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ Res 88:529-35. 2001
    ..An intimate link among ROS, mtDNA damage, and defects in the electron transport function, which may lead to an additional generation of ROS, might play an important role in the development and progression of LV remodeling and failure...
  43. pmc Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats
    Kosuke Tanaka
    Kosuke Tanaka, Yuko Masaki, Masatake Tanaka, Masayuki Miyazaki, Masaki Kato, Masatoshi Nomura, Kazuhiro Kotoh, Ryoichi Takayanagi, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    World J Gastroenterol 20:2653-63. 2014
    ..To investigate the metabolic changes in skeletal muscle and/or adipose tissue in glucagon-like peptide-1-induced improvement of nonalcoholic fatty liver disease (NAFLD)...
  44. ncbi request reprint Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice
    Shingo Matsumoto
    Laboratory of Bio function Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Free Radic Res 37:767-72. 2003
    ..Hence, the results of this study strongly suggest that superoxide should be generated through the increased XO seen in the diabetic model mice, which may be involved in the pathogenesis of diabetic vascular complications...
  45. ncbi request reprint [Oxidative stress]
    Yasutaka Maeda
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
    Nihon Rinsho 68:814-8. 2010
    ....
  46. ncbi request reprint A Japanese model of disease management
    Naoki Nakashima
    Department of Medical Informatics, Kyushu University Hospital, Japan
    Stud Health Technol Inform 129:1174-8. 2007
    ..Carna promotes periodic medical examinations and quickly provides the result of blood tests to patients. We are conducting a study to assess the medical outcomes and business model. The study will continue until the end of 2007...
  47. ncbi request reprint Greater susceptibility of failing cardiac myocytes to oxygen free radical-mediated injury
    H Tsutsui
    Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 812 8582, Fukuoka, Japan
    Cardiovasc Res 49:103-9. 2001
    ..However, the effects of oxygen radicals on myocyte structure have not been examined in the failing heart...
  48. ncbi request reprint Microdosimetry of epithermal neutron field at the Kyoto University reactor
    Y Onizuka
    School of Health Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Radiat Prot Dosimetry 99:383-5. 2002
    ..Results show good agreement with measurements with the activation method using gold foil. This study demonstrated how microdosimetric parameters change in radiation quality as a function of heavy water depth...
  49. ncbi request reprint Enhanced generation of reactive oxygen species in the limb skeletal muscles from a murine infarct model of heart failure
    H Tsutsui
    Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 104:134-6. 2001
    ..Antioxidant enzyme activities, including superoxide dismutase, catalase, and glutathione peroxidase, were comparable between groups...
  50. ncbi request reprint Effects of ACE inhibition on left ventricular failure and oxidative stress in Dahl salt-sensitive rats
    H Tsutsui
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Cardiovasc Pharmacol 37:725-33. 2001
    ..The progression of LV failure after hypertrophy in high-salt-loaded DS hypertensive rats was associated with increased myocardial ROS, and ACE inhibitor could prevent this transition from compensated hypertrophy to failure...
  51. ncbi request reprint 8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts
    H Tsutsui
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 104:2883-5. 2001
    ..The changes in this defensive system have not yet been examined in failing hearts, in which the generation of ROS increases...
  52. ncbi request reprint A kinetic study of enhancing effect by phenolic compounds on the hydroxyl radical generation during ozonation
    Y H Han
    Department of Bio function Science, Faculty of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi, Fukuoka, Japan
    Water Sci Technol 50:97-102. 2004
    ..0005) exp (60 x [ozone (10(-9) M)]). The equation fitted very well with the experimental results, and the correlation coefficient was larger than 0.98...
  53. ncbi request reprint Therapeutic angiogenesis by ex vivo expanded erythroid progenitor cells
    Shuji Sasaki
    Dept of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu Univ, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 292:H657-65. 2007
    ..Implantation of ECFCs promoted angiogenesis in ischemic limbs by supplying angiogenic cytokines (VEGF and FGF-2), suggesting a possible novel strategy for therapeutic angiogenesis...
  54. ncbi request reprint Development of rapid in vitro assay for oxidative liver injury and its application to 230 chemicals
    S H Kim
    Division of Biophysics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Water Sci Technol 46:337-41. 2002
    ....
  55. pmc Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus
    Ryoichi Takayanagi
    Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Clin Biochem Nutr 48:72-7. 2011
    ..These results suggested that oxidative stress is an exacerbating factor of type 2 diabetes mellitus and that antioxidant therapies are of value to diabetic nephropathy...
  56. ncbi request reprint Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese
    Hajime Nawata
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Hum Genet 49:629-34. 2004
    ..These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12...
  57. ncbi request reprint Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope
    Toshihiko Yanase
    Department of Medicine and Bioregulatory Science, Third Department of Internal Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Am J Hypertens 19:1206-12. 2006
    ..Carotid aver-IMT measurement using the new Intimascope software may provide a more precise and reproducible index of atherosclerosis than does conventional IMT measurement...
  58. ncbi request reprint Lysophosphatidylcholine inhibits the expression of prostacyclin stimulating factor in cultured vascular smooth muscle cells
    Toshihiko Hashimoto
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, 812 8582, Fukuoka, Japan
    J Diabetes Complications 16:81-6. 2002
    ..These results suggest that lysoPC-induced reduction of PSF expression is mediated by PKC activation and is playing a role in the initiation and progression of atherosclerotic lesions...
  59. ncbi request reprint Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages
    Jian Qiu Gu
    Dept of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu Univ, Beppu 874 0838, Japan
    Am J Physiol Endocrinol Metab 295:E1390-400. 2008
    ..In conclusion, TLR4-mediated signals stimulate the ADRP expression in macrophages while PYC antagonizes this process. PYC, a widely used dietary supplement, might be useful for prevention of atherosclerosis...
  60. ncbi request reprint The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides
    A Monji
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Neurochem 77:1425-32. 2001
    ..These results thus suggest that Abeta-associated free radical generation is strongly influenced by the aggregational state of the peptides...
  61. ncbi request reprint The relationship between Abeta-associated free radical generation and Abeta fibril formation revealed by negative stain electron microscopy and thioflavine-T fluorometric assay
    A Monji
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 812 8582, Fukuoka, Japan
    Neurosci Lett 304:65-8. 2001
    ..In conclusion, the present results suggest that Abeta-associated free radical generation is correlated with Abeta fibril formation while its generation is only observed transiently during the process of Abeta fibril formation...
  62. ncbi request reprint A comparative ESR study of some paramagnetic materials as probes for the noninvasive measurement of dissolved oxygen in biological systems
    M Inoue
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 42:2346-8. 1994
    ..In conclusion, active charcoal is suitable as a probe for extracellular oxygen in a system where changes are slow, while nitroxide is a versatile probe for measuring rapidly changing intra- and extra-cellular oxygen concentrations...