Ikuo Ikeda

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. pmc The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Cardiovasc Disord 3:4. 2003
  2. ncbi request reprint Cholesterol esterase bound to intestinal brush border membranes does not accelerate incorporation of micellar cholesterol into absorptive cells
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 67:2381-7. 2003
  3. ncbi request reprint Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812 8581, Japan
    J Nutr 135:155-9. 2005
  4. ncbi request reprint Cholesterol esterase accelerates intestinal cholesterol absorption
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1571:34-44. 2002
  5. ncbi request reprint Reduced hepatic triglyceride secretion in rats fed docosahexaenoic acid-rich fish oil suppresses postprandial hypertriglyceridemia
    I Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School Kyushu University, Fukuoka, 812 8581 Japan
    J Nutr 131:1159-64. 2001
  6. ncbi request reprint Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats
    I Ikeda
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Lipids 33:897-904. 1998
  7. ncbi request reprint Effects of triolein or oleic acid on lymphatic recovery of docosahexaenoic acid given as ethyl ester and their intramolecular distribution in lymph triglyceride of rats
    I Ikeda
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Lipids 32:949-52. 1997
  8. ncbi request reprint Effect of a liver X receptor agonist on deposition and lymphatic absorption of plant sterols in stroke-prone spontaneously hypertensive rats having a mutation in ATP-binding cassette transporter G5
    Tadateru Hamada
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 75:2359-63. 2011
  9. ncbi request reprint Missense mutation in Abcg5 in SHRSP rats does not accelerate intestinal absorption of plant sterols: comparison with Wistar rats
    Tadateru Hamada
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 73:361-5. 2009
  10. ncbi request reprint Missense mutation of Abcg5 in stroke-prone spontaneously hypertensive rats does not influence lymphatic sitosterol absorption regardless of the dose: comparison with Wistar rats
    Tadateru Hamada
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 73:2777-8. 2009

Collaborators

Detail Information

Publications41

  1. pmc The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Cardiovasc Disord 3:4. 2003
    ..These genes are organized in a head-to-head configuration at the STSL locus on human chromosome 2p21...
  2. ncbi request reprint Cholesterol esterase bound to intestinal brush border membranes does not accelerate incorporation of micellar cholesterol into absorptive cells
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 67:2381-7. 2003
    ..The results suggest that the accelerated incorporation of micellar cholesterol by cholesterol esterase into absorptive cells is not mediated by the enzyme bound to the brush border membranes...
  3. ncbi request reprint Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812 8581, Japan
    J Nutr 135:155-9. 2005
    ..Because postprandial hypertriacylglycerolemia is a risk factor for coronary heart disease, our results suggest that catechins with a galloyl moiety may prevent this disease...
  4. ncbi request reprint Cholesterol esterase accelerates intestinal cholesterol absorption
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1571:34-44. 2002
    ..This may be a major cause of the acceleration of cholesterol absorption by cholesterol esterase...
  5. ncbi request reprint Reduced hepatic triglyceride secretion in rats fed docosahexaenoic acid-rich fish oil suppresses postprandial hypertriglyceridemia
    I Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School Kyushu University, Fukuoka, 812 8581 Japan
    J Nutr 131:1159-64. 2001
    ..These observations strongly support the hypothesis that in rats, the principal cause of the suppression of postprandial hypertriglyceridemia by fish oil is the depression of triglyceride secretion from the liver...
  6. ncbi request reprint Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats
    I Ikeda
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Lipids 33:897-904. 1998
    ..These results showed that the main effects in rats of the different intramolecular distributions of EPA and DHA in dietary fats were on arachidonic acid content in tissue phospholipids and on platelet TXA2 production...
  7. ncbi request reprint Effects of triolein or oleic acid on lymphatic recovery of docosahexaenoic acid given as ethyl ester and their intramolecular distribution in lymph triglyceride of rats
    I Ikeda
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Lipids 32:949-52. 1997
    ..Oleic acid given as free acid or triolein with ethyl DHA was a major fatty acid at the 2-position. Intramolecular distribution of DHA and oleic acid in lymph triglyceride was similar when ethyl DHA was given with oleic acid or triolein...
  8. ncbi request reprint Effect of a liver X receptor agonist on deposition and lymphatic absorption of plant sterols in stroke-prone spontaneously hypertensive rats having a mutation in ATP-binding cassette transporter G5
    Tadateru Hamada
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 75:2359-63. 2011
    ..These results suggest that the plant sterol deposition in SHRSPs was not necessarily caused by the increased absorption of plant sterols...
  9. ncbi request reprint Missense mutation in Abcg5 in SHRSP rats does not accelerate intestinal absorption of plant sterols: comparison with Wistar rats
    Tadateru Hamada
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 73:361-5. 2009
    ..These observations suggest that a mutation in Abcg5 does not greatly influence intestinal absorption of plant sterols in SHRSP rats, at least in comparison with Wistar rats...
  10. ncbi request reprint Missense mutation of Abcg5 in stroke-prone spontaneously hypertensive rats does not influence lymphatic sitosterol absorption regardless of the dose: comparison with Wistar rats
    Tadateru Hamada
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 73:2777-8. 2009
    ..The results suggest that the mutation of Abcg5 in SHRSPs, compared with Wistar rats, did not influence the ability for intestinal sitosterol absorption regardless of the dose...
  11. ncbi request reprint Solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats
    Tadateru Hamada
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812 8581, Japan
    Lipids 41:551-6. 2006
    ..These observations strongly suggest that both solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats...
  12. ncbi request reprint Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812 8581, Japan
    J Agric Food Chem 51:7303-7. 2003
    ..Compounds 7 and 8 were more effective to precipitate cholesterol than 3 and 4, respectively. These observations strongly suggest that heat-epimerized catechins may be more hypocholesterolemic than tea catechins...
  13. ncbi request reprint Comparison of effects of dietary unesterified and esterified plant sterols on cholesterol absorption in rats
    Makoto Kobayashi
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka, Japan
    J Nutr Sci Vitaminol (Tokyo) 54:210-4. 2008
    ....
  14. ncbi request reprint Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 69:1049-53. 2005
    ....
  15. ncbi request reprint Hydrolysis of micellar phosphatidylcholine accelerates cholesterol absorption in rats and Caco-2 cells
    Tadateru Hamada
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812 8581, Japan
    Biosci Biotechnol Biochem 69:1726-32. 2005
    ..These results strongly suggest that the release of monomer cholesterol from bile salt micelles is accelerated by hydrolysis of PC in bile salt micelles and hence that cholesterol absorption is enhanced...
  16. ncbi request reprint Phytosterol oxidation products are absorbed in the intestinal lymphatics in rats but do not accelerate atherosclerosis in apolipoprotein E-deficient mice
    Hiroko Tomoyori
    Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka 812 8681, Japan
    J Nutr 134:1690-6. 2004
    ..These results indicate that exogenous oxyphytosterols are well-absorbed and accumulate in the body, but do not promote the development of atherosclerosis in apo E-deficient mice...
  17. ncbi request reprint Dietary 5-campestenone (campest-5-en-3-one) enhances fatty acid oxidation in perfused rat liver
    Shizuka Tamaru
    Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:127-33. 2006
    ..These results suggest that dietary 5-campestenone exerts its hypotriglyceridemic effect, at least, in part through an enhanced metabolism of endogenous and exogenous fatty acids to oxidation at the expense of esterification in rat liver...
  18. ncbi request reprint LXR agonist increases the lymph HDL transport in rats by promoting reciprocally intestinal ABCA1 and apo A-I mRNA levels
    Masao Sato
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812 8581, Japan
    Lipids 43:125-31. 2008
    ..The LXR agonist stimulated in vivo the synthesis of nascent HDL by increasing reciprocally the mRNA for ABCAI and apo A-I in the intestine, thereby contributing to an increase in the circulating HDL...
  19. ncbi request reprint Effects of dietary defatted squid on cholesterol metabolism and hepatic lipogenesis in rats
    K Tanaka
    Laboratory of Nutrition Chemistry, Siebold University of Nagasaki, Nishisonogi Gun, Japan
    Lipids 36:461-6. 2001
    ..The fraction also induces a triglyceride-lowering activity in the liver by decreasing hepatic lipogenesis...
  20. ncbi request reprint Concentration of serum lipids and aortic lesion size in female and male apo E-deficient mice fed docosahexaenoic acid
    Y Adan
    Department of Food Science and Technology, Faculty of Agriculture 46 09, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 63:309-13. 1999
    ....
  21. ncbi request reprint Effects of feeding oyster, Crassostrea gigas, on serum and liver lipid levels in rats
    Kazunari Tanaka
    Laboratory of Nutrition Chemistry, Siebold University of Nagasaki, Nagasaki 851 2195, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:100-6. 2003
    ..Our results suggest that the feeding of oysters exerts a more potent hypolipidemic activity than soybean protein, and the effect may be ascribed to both lipid and non-lipid fractions in oyster...
  22. ncbi request reprint Lymphatic absorption and deposition of various plant sterols in stroke-prone spontaneously hypertensive rats, a strain having a mutation in ATP binding cassette transporter G5
    Tadateru Hamada
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Lipids 42:241-8. 2007
    ..Lipids 41:551-556, 2006). These observations suggest that differential absorption of various plant sterols is kept in SHRSP in spite of a mutation in Abcg5...
  23. ncbi request reprint Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats
    Hiroko Tomoyori
    Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 66:828-34. 2002
    ..It therefore remains to be determined which oxysterol was responsible for the triacyglycerol transport...
  24. ncbi request reprint Effect of dietary seal and fish oils on lipid metabolism in hamsters
    H Yoshida
    Division of Food and Nutrition, Nakamura Gakuen Junior College, Fukuoka, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:242-7. 2001
    ..These results showed that different intramolecular distribution of n-3 PUFAs influenced glycerolipid metabolism and arachidonic acid content in serum and liver phospholipids of hamsters...
  25. ncbi request reprint Oxysterol regulation of estrogen receptor alpha-mediated gene expression in a transcriptional activation assay system using HeLa cells
    Hiroyoshi Sato
    Laboratory of Nutrition Chemistry, Faculty of Bioresources and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka 812 8581, Japan
    Biosci Biotechnol Biochem 68:1790-3. 2004
    ..These compounds were not estrogenic in estrogen receptor-negative HeLa cells...
  26. ncbi request reprint Application of the random arbitrary primed polymerase chain reaction differential display method to isolate genes of cholesterol metabolism-related proteins from rat liver
    M Sato
    Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 64:1058-60. 2000
    ..These results indicate that RAP-PCR DD is an appropriate alternative to RT-PCR DD for isolating the genes involved in hypercholesterolemia...
  27. ncbi request reprint Tocotrienol levels in various tissues of Sprague-Dawley rats after intragastric administration of tocotrienols
    Masaaki Okabe
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 66:1768-71. 2002
    ..These results suggest that the distribution and metabolism of T3 in the rat vary considerably among different tissues...
  28. ncbi request reprint Mechanisms of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats
    I Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Metabolism 50:1361-8. 2001
    ..These strains of rats may be suitable models for studying mechanisms of differential absorption of various sterols...
  29. ncbi request reprint Intestinal absorbability of wheat allergens, subunits of a wheat alpha-amylase inhibitor, expressed by bacteria
    M Kusaba-Nakayama
    Division of Bioresource and Bioenvironmental Sciences, Graduate School, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 65:2448-55. 2001
    ..Accordingly, the intestinal absorption of these three proteins in the form present in wheat should be evaluated...
  30. ncbi request reprint Effects of highly purified structured lipids containing medium-chain fatty acids and linoleic acid on lipid profiles in rats
    Jun ichi Nagata
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
    Biosci Biotechnol Biochem 67:1937-43. 2003
    ..These results indicate that the feeding of highly purified L-M-L types could effectively improve serum and liver lipid profiles and that M-L-M types may be a preferable substrate for the pancreas and contribute to energy supply in rats...
  31. ncbi request reprint Multifunctional effects of green tea catechins on prevention of the metabolic syndrome
    Ikuo Ikeda
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Scicence, Tohoku University, Sendai, Japan
    Asia Pac J Clin Nutr 17:273-4. 2008
    ....
  32. ncbi request reprint Heat-epimerized tea catechins have the same cholesterol-lowering activity as green tea catechins in cholesterol-fed rats
    Makoto Kobayashi
    Central Research Institute, ITO EN, Ltd, Shizuoka, Japan
    Biosci Biotechnol Biochem 69:2455-8. 2005
    ..There was no differential effect between the two catechin preparations...
  33. ncbi request reprint Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters
    Shizuko Tachibana
    Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 71:1886-95. 2007
    ..These results indicate that ABCG5/G8, unlike ABCA1, together with bile acids should participate in sterol efflux on the apical surface of Caco-2 cells...
  34. ncbi request reprint Suppression of postprandial hypertriglyceridemia in rats and mice by oolong tea polymerized polyphenols
    Yoshiko Toyoda-Ono
    Suntory Institute for Health Care Science, Osaka, Japan
    Biosci Biotechnol Biochem 71:971-6. 2007
    ..These results suggest that OTPP is responsible for the suppression of hypertriglyceridemia by ingestion of oolong tea...
  35. ncbi request reprint Comparison of the lymphatic transport of radiolabeled 1,3-dioleoylglycerol and trioleoylglycerol in rats
    Teruyoshi Yanagita
    Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840 8502, Japan
    Lipids 39:827-32. 2004
    ..The possibility that the slower lymphatic transport of DAG contributes to the anti-obesity action observed in the feeding of 1,3-DAG cannot be excluded...
  36. ncbi request reprint Slow absorption of conjugated linoleic acid in rat intestines, and similar absorption rates of 9c,11t-conjugated linoleic acid and 10t,12c-conjugated linoleic acid
    Tsuyoshi Tsuzuki
    Department of Food Management, School of Food, Agricultural and Environmental Sciences, Miyagi University, Sendai, Japan
    Biosci Biotechnol Biochem 71:2034-40. 2007
    ....
  37. ncbi request reprint Effect of sesaminol on plasma and tissue alpha-tocopherol and alpha-tocotrienol concentrations in rats fed a vitamin E concentrate rich in tocotrienols
    Kanae Yamashita
    Department of Food and Nutrition, Sugiyama Jogakuen University, Nagoya, Japan
    Lipids 37:351-8. 2002
    ..1 and 2). However, the sesaminol-induced increases of a-tocopherol and a-tocotrienol concentrations in plasma and tissue were not caused by their enhanced absorption since sesaminol did not enhance their absorption...
  38. ncbi request reprint Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid
    Tsuyoshi Tsuzuki
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Nutr 136:2153-9. 2006
    ..05). These results indicated that alpha-ESA and PA are slowly absorbed in rat intestine, and a portion of these fatty acids is quickly converted to 9Z11E-CLA...
  39. ncbi request reprint Decrease in plasma low-density lipoprotein cholesterol, apolipoprotein B, cholesteryl ester transfer protein, and oxidized low-density lipoprotein by plant stanol ester-containing spread: a randomized, placebo-controlled trial
    Yasuhiko Homma
    Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan
    Nutrition 19:369-74. 2003
    ..The assessment of safety was also made...
  40. ncbi request reprint Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats
    Ikuo Ikeda
    Laboratory of Food and Biomolecular Science, Department of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amemiyamachi, Aoba ku, Sendai 981 8555, Japan
    Biochim Biophys Acta 1760:800-7. 2006
    ..These observations suggest a possibility that campestenone has an ability to prevent coronary heart disease by improving obesity and abnormality of lipid metabolism...
  41. ncbi request reprint Lymphatic absorption of structured triacylglycerols, 1(3)-stearoyl-2,3 (1)-dilinoleoylglycerol and 2-linoleoyl-1,3-distearoylglycerol in rats
    Takashi Yagi
    Research and Development Center, Showa Sangyoo Co Ltd, Hinode, Funabashi 273 0015, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:446-8. 2004
    ..Recoveries of stearic acid from SLL, SLS and the randomly esterified triacylglycerol were 88.49%, 68.3% and 101%. respectively...