Research Topics
Genomes and Genes
| Takahiko HoriuchiSummaryAffiliation: Kyushu University Country: Japan Publications
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Detail Information
Publications
Clinical and radiographic evaluation of total hip arthroplasties using porous tantalum modular acetabular components: 5-year follow-up of clinical trialYasuharu Nakashima
Department of Orthopaedic Surgery, Kyushu University, 1 3 3 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
Mod Rheumatol 23:112-8. 2013..We present here 5-years follow-up report of a multicenter clinical trial of total hip arthroplasties (THA) with porous tantalum modular acetabular component (modular PTC)...- Clinical evaluation of tocilizumab for patients with active rheumatoid arthritis refractory to anti-TNF biologics: tocilizumab in combination with methotrexateYasuharu Nakashima
Department of Orthopaedic Surgery, Kyushu University, Higashi ku, Fukuoka, Japan
Mod Rheumatol 20:343-52. 2010..Based on these results, we conclude that TCZ is able to significantly alleviate disease symptoms in a wide range of patients with RA in a normal clinical context... - Transtrochanteric rotational osteotomy for late-onset Legg-Calve-Perthes diseaseYasuharu Nakashima
Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan
J Pediatr Orthop 31:S223-8. 2011..The purpose of this study was to evaluate the long-term clinical results of the transtrochanteric rotational osteotomy for the patients with LCPD onset at more than 9 years of age... - Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese populationChikako Kiyohara
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
J Rheumatol 36:2195-203. 2009..Along with environmental factors such as smoking, both polymorphisms may modulate an individual's susceptibility to SLE. We investigated these relationships in a case-control study to evaluate risk factors for SLE among Japanese women... - Cigarette smoking, alcohol consumption, and risk of systemic lupus erythematosus: a case-control study in a Japanese populationChikako Kiyohara
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Rheumatol 39:1363-70. 2012..Cigarette smoking may be associated with increased risk of systemic lupus erythematosus (SLE), whereas the role of alcohol consumption is unknown. We examined the association between SLE risk and smoking or drinking... - Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infectionsYasutaka Kimoto
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Rheumatology (Oxford) 49:1346-53. 2010..Identification of the association of killer cell immunoglobulin-like receptor (KIR) genes with SLE and accompanying infections... 
Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese populationChikako Kiyohara
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
BMC Cancer 11:459. 2011..We examined if smoking or alcohol consumption modify associations between MTHFR polymorphisms and lung cancer risk...
Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese populationChikako Kiyohara
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Oncol Rep 23:1361-8. 2010..Our findings indicate the possible association of the Glu allele of the TP53BP1 Asp353Glu polymorphism with lower risk of lung cancer especially among the Pro allele carriers of the TP53 Arg72Pro polymorphism...- Mechanisms for cytotoxic effects of anti-tumor necrosis factor agents on transmembrane tumor necrosis factor alpha-expressing cells: comparison among infliximab, etanercept, and adalimumabHiroki Mitoma
Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Arthritis Rheum 58:1248-57. 2008..We undertook this study to understand the different clinical effects of these anti-TNFalpha agents by analyzing their biologic activities on transmembrane TNFalpha... - Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE: findings from the KYSS studyTakahiko Horiuchi
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Rheumatology (Oxford) 48:1045-9. 2009..These three genes are involved in the generation of reactive oxygen species (ROS), which play a critical role for autoimmune diseases... - Prevalence of and risk factors for low bone mineral density in Japanese female patients with systemic lupus erythematosusMakio Furukawa
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Rheumatol Int 31:365-76. 2011..A history of high-dose oral corticosteroids was associated with the preservation of BMD at the lumbar spine, however, further study is needed considering the limited sample size... - Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese populationChikako Kiyohara
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Japan
J Thorac Oncol 7:954-62. 2012..Several components of overall lung carcinogenesis, carcinogen metabolic and DNA repair pathways may be involved in individual genetic susceptibility to lung cancer... - Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cellsHiroshi Tsukamoto
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Rheumatology (Oxford) 50:944-52. 2011..The aim of this study is to evaluate the mechanism of long-term effect of autologous haematopoietic stem cell transplantation (ASCT) in treatment of SSc... - IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese populationChikako Kiyohara
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
J Thorac Oncol 5:299-304. 2010..Interleukin 1B (IL1B) is involved in pulmonary inflammation induced by environmental or occupational toxins. Chronic inflammation has been implicated in the development of lung cancer... - Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysisJunji Otsuka
Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Arthritis Rheum 50:871-81. 2004..To investigate whether polymorphism(s) or mutation(s) in the hematopoietic cell-specific Lyn substrate 1 (HS1) gene are involved in the pathogenesis of systemic lupus erythematosus (SLE)... - CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cellsHiroaki Niiro
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Blood 119:2263-73. 2012..Together, these results suggest that CIN85 is required for Cbl-mediated regulation of BCR signaling and for downstream events such as survival, growth, and differentiation of human B cells... - Correlation between pretreatment or follow-up CT findings and therapeutic effect of autologous peripheral blood stem cell transplantation for interstitial pneumonia associated with systemic sclerosisHidetake Yabuuchi
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Eur J Radiol 79:e74-9. 2011.... - Cigarette smoking, N-acetyltransferase 2 polymorphisms and systemic lupus erythematosus in a Japanese populationC Kiyohara
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Lupus 18:630-8. 2009..50, 95% CI = 0.12-0.88), compared with the NAT2 rapid acetylator genotype and no history of smoking. This study suggests that, in this Japanese population, the NAT2 slow acetylator status may be a determinant in susceptibility to SLE... - Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agentsTakahiko Horiuchi
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Rheumatology (Oxford) 49:1215-28. 2010.... - RP105-lacking B cells from lupus patients are responsible for the production of immunoglobulins and autoantibodiesYuji Kikuchi
Saga Medical School, Saga, Japan
Arthritis Rheum 46:3259-65. 2002..In the present study, we attempted to determine whether RP105-negative B cells obtained from SLE patients would be capable of producing autoantibodies as well as immunoglobulins... - Increased expression of membrane TNF-alpha on activated peripheral CD8+ T cells in systemic lupus erythematosusTakahiko Horiuchi
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
Int J Mol Med 17:875-9. 2006..038). Membrane TNF-alpha-bearing CD8+ T cells from SLE patients displayed cytotoxic activity against L929 cells. It is possible that membrane TNF-alpha may be involved in the increased apoptosis and the generation of autoantigens in SLE... - Molecular bases for human complement C7 polymorphisms, C7*3 and C7*4Takahiko Horiuchi
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
Biochem Biophys Res Commun 298:450-5. 2002..We present genetic bases for this C7 polymorphism, which we determined using polymerase chain reaction (PCR)-based genotyping, a simple and accurate method suitable for large-scale studies... - Novel mutations in TNFRSF1A in patients with typical tumor necrosis factor receptor-associated periodic syndrome and with systemic lupus erythematosus in JapaneseTakahiko Horiuchi
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
Int J Mol Med 14:813-8. 2004..A larger scale of study will clarify whether these two mutations, T61I and R104Q, are associated with chronic inflammatory disorders, such as SLE, or not... - Molecular analysis of a novel hereditary C3 deficiency with systemic lupus erythematosusHiroshi Tsukamoto
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
Biochem Biophys Res Commun 330:298-304. 2005..These data indicate that a novel AG-->GG 3'-splice acceptor site mutation in intron 38 caused aberrant splicing of exon 39, resulting in defective secretion of C3... - Hereditary angioedema in Japan: genetic analysis of 13 unrelated casesTetsuro Yamamoto
Yamamoto Clinic, Fukuoka, Japan
Am J Med Sci 343:210-4. 2012..Thus, the authors researched the genetic and clinical characteristics of Japanese patients with HAE... - The relationship between the daily dosage of the carbapenem meropenem (MEPM) and MEPM-resistant Pseudomonas aeruginosaShin ichi Harashima
Department of Clinical Research, Hara Doi Hospital, Fukuoka, Japan
J Infect Chemother 14:219-22. 2008..aeruginosa in a hospital ward, and there were no side effects... - Guideline for hereditary angioedema (HAE) 2010 by the Japanese Association for Complement Research - secondary publicationTakahiko Horiuchi
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Allergol Int 61:559-62. 2012..This is a 2010 year version and will be updated according to any pertinent medical advancements... - Successful treatment of rapidly progressive interstitial pneumonia with autologous peripheral blood stem cell transplantation in a patient with dermatomyositisKensuke Oryoji
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka, Japan
Clin Rheumatol 24:637-40. 2005..This improvement was confirmed by diminished interstitial shadows on chest X-ray and computed tomography scans. Eighteen months after transplantation, the patient is doing well without symptoms and signs of interstitial pneumonia... - A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysisTakahiko Horiuchi
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Ann Rheum Dis 66:320-4. 2007.... - Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alphaHiroki Mitoma
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Gastroenterology 128:376-92. 2005..To clarify this difference in clinical efficacy, we investigated reverse signaling through transmembrane TNF-alpha (mTNF) by these 2 anti-TNF agents... - Reconstitution of HLA-A*2402-restricted cytomegalovirus-specific T-cells following stem cell transplantationHisashi Gondo
Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
Int J Hematol 80:441-8. 2004.... - Systemic vasculitis associated with alphal-antitrypsin deficiencyYasushi Takii
Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka
Intern Med 42:619-23. 2003..This serious genetic defect severely affects the balance between a protease and a protease inhibitor at the pathological site...