Yasuaki Hata

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. doi request reprint Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Jpn J Ophthalmol 52:16-23. 2008
  2. doi request reprint Antiangiogenic mechanisms of simvastatin in retinal endothelial cells
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Graefes Arch Clin Exp Ophthalmol 248:667-73. 2010
  3. ncbi request reprint Preclinical investigation of fluorometholone acetate as a potential new adjuvant during vitreous surgery
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Graefes Arch Clin Exp Ophthalmol 245:1019-25. 2007
  4. doi request reprint Vascular endothelial growth factor expression by hyalocytes and its regulation by glucocorticoid
    Y Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Ophthalmol 92:1540-4. 2008
  5. ncbi request reprint [Preventive strategy for the treatment of diabetic vitreoretinopathy]
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Nihon Ganka Gakkai Zasshi 113:379-401; discussion 402. 2009
  6. ncbi request reprint Biocompatibility of brilliant blue G in a rat model of subretinal injection
    Akifumi Ueno
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 27:499-504. 2007
  7. pmc Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins
    Shuhei Kawahara
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Diabetes 57:2784-93. 2008
  8. ncbi request reprint Preclinical investigation of internal limiting membrane staining and peeling using intravitreal brilliant blue G
    Hiroshi Enaida
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 26:623-30. 2006
  9. ncbi request reprint Intracellular events in retinal glial cells exposed to ICG and BBG
    Shuhei Kawahara
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 48:4426-32. 2007
  10. ncbi request reprint Functional role of Egr-1 mediating VEGF-induced tissue factor expression in the retinal capillary endothelium
    Yukio Sassa
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, 812 8582 Japan
    Graefes Arch Clin Exp Ophthalmol 240:1003-10. 2002

Collaborators

Detail Information

Publications51

  1. doi request reprint Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Jpn J Ophthalmol 52:16-23. 2008
    ..In this study, we addressed the therapeutic potential of fasudil, a potent Rho-kinase inhibitor, for VEGF-elicited angiogenesis and also for the intracellular signalings induced by VEGF...
  2. doi request reprint Antiangiogenic mechanisms of simvastatin in retinal endothelial cells
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Graefes Arch Clin Exp Ophthalmol 248:667-73. 2010
    ..While statins have an anti-angiogenic property, their underlying mechanisms are not fully understood. We investigated intracellular mechanisms of simvastatin-mediated reduction in VEGF-induced signalings...
  3. ncbi request reprint Preclinical investigation of fluorometholone acetate as a potential new adjuvant during vitreous surgery
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Graefes Arch Clin Exp Ophthalmol 245:1019-25. 2007
    ..To examine the effects of intravitreal fluorometholone acetate (FMT) on the morphology and function of the retina and to investigate its possible use for vitreous surgery...
  4. doi request reprint Vascular endothelial growth factor expression by hyalocytes and its regulation by glucocorticoid
    Y Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Ophthalmol 92:1540-4. 2008
    ..The authors investigated the effect of hypoxia, TNF-alpha and dexamethasone on vascular endothelial growth factor (VEGF) expression by cultured hyalocytes...
  5. ncbi request reprint [Preventive strategy for the treatment of diabetic vitreoretinopathy]
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Nihon Ganka Gakkai Zasshi 113:379-401; discussion 402. 2009
    ....
  6. ncbi request reprint Biocompatibility of brilliant blue G in a rat model of subretinal injection
    Akifumi Ueno
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 27:499-504. 2007
    ..To evaluate the toxicity of brilliant blue G (BBG) compared with those of indocyanine green (ICG) and trypan blue (TB) in a rat model of subretinal injection...
  7. pmc Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins
    Shuhei Kawahara
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Diabetes 57:2784-93. 2008
    ..Novel pharmaceutical approaches are thus urgently needed for the management of these vision-threatening diseases. In the current study, we investigated the inhibitory effects of statins on the progression of PVDs...
  8. ncbi request reprint Preclinical investigation of internal limiting membrane staining and peeling using intravitreal brilliant blue G
    Hiroshi Enaida
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 26:623-30. 2006
    ..To investigate the effects of intravitreal brilliant blue G (BBG) on the morphology and functions of the retina and its possible use for staining and peeling of the internal limiting membrane (ILM)...
  9. ncbi request reprint Intracellular events in retinal glial cells exposed to ICG and BBG
    Shuhei Kawahara
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 48:4426-32. 2007
    ..To investigate the intracellular events in retinal glial cells exposed to indocyanine green (ICG) and brilliant blue G (BBG)...
  10. ncbi request reprint Functional role of Egr-1 mediating VEGF-induced tissue factor expression in the retinal capillary endothelium
    Yukio Sassa
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, 812 8582 Japan
    Graefes Arch Clin Exp Ophthalmol 240:1003-10. 2002
    ..To investigate the causal relationship between VEGF and tissue factor (TF) expression, and its intracellular signaling in the retinal capillary endothelium both in vitro and in vivo...
  11. doi request reprint Histopathology of neovascular tissue from eyes with proliferative diabetic retinopathy after intravitreal bevacizumab injection
    Ri ichiro Kohno
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Ophthalmol 150:223-229.e1. 2010
    ..To examine the histopathologic effect of a single intravitreal injection of bevacizumab on newly formed vessels in eyes with proliferative diabetic retinopathy (PDR)...
  12. ncbi request reprint Functional characteristics of connective tissue growth factor on vitreoretinal cells
    Takeshi Kita
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Diabetes 56:1421-8. 2007
    ..Whereas CTGF might have no direct effects or minimal effects, if any, on retinal neovascularization, it is possible that CTGF has indirect effects by modulating the expression of VEGF...
  13. ncbi request reprint Functional properties of hyalocytes under PDGF-rich conditions
    Yoshihiro Noda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 45:2107-14. 2004
    ..To investigate the functional properties and intracellular signaling of hyalocytes under platelet-derived growth factor (PDGF)-rich conditions...
  14. ncbi request reprint Critical role of the Rho-kinase pathway in TGF-beta2-dependent collagen gel contraction by retinal pigment epithelial cells
    Muneki Miura
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Exp Eye Res 82:849-59. 2006
    ....
  15. pmc Role of TGF-beta in proliferative vitreoretinal diseases and ROCK as a therapeutic target
    Takeshi Kita
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 105:17504-9. 2008
    ..ROCK, a key downstream mediator of TGF-beta and other factors might become a unique therapeutic target in the treatment of proliferative vitreoretinal diseases...
  16. ncbi request reprint Fibrinogen stimulates in vitro angiogenesis by choroidal endothelial cells via autocrine VEGF
    Satomi Shiose
    Department of Ophthalmology of the Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, 812 8582 Fukuoka, Japan
    Graefes Arch Clin Exp Ophthalmol 242:777-83. 2004
    ..The purpose of this study is to investigate the effect of fibrinogen on angiogenesis in vitro formed by cultured bovine choroidal endothelial cells (BCECs) and the involvement of vascular endothelial growth factor (VEGF) in this mechanism...
  17. ncbi request reprint Evaluating adjunctive surgical procedures during vitrectomy for diabetic macular edema
    Yasutaka Mochizuki
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Retina 26:143-8. 2006
    ..To evaluate the long-term outcomes of adjunctive surgical procedures during pars plana vitrectomy (PPV) for the treatment of diabetic macular edema (DME)...
  18. ncbi request reprint Triamcinolone acetonide-assisted pars plana vitrectomy improves residual posterior vitreous hyaloid removal: ultrastructural analysis of the inner limiting membrane
    Hiroyoshi Matsumoto
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 27:174-9. 2007
    ....
  19. ncbi request reprint Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor
    Takeshi Kita
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes 56:231-8. 2007
    ..Hyalocytes may be a possible source of CTGF and thus might play a role in vitreoretinal interface diseases. Furthermore, Rho kinase inhibitors might have therapeutic potential to control fibrotic disorders in the eye...
  20. ncbi request reprint Reduced incidence of intraoperative complications in a multicenter controlled clinical trial of triamcinolone in vitrectomy
    Keita Yamakiri
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan
    Ophthalmology 114:289-96. 2007
    ..To evaluate the benefits and potential complications of using triamcinolone acetonide (TA) in pars plana vitrectomy (PPV)...
  21. doi request reprint Role of tumour necrosis factor-α (TNFα) in the functional properties of hyalocytes
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Br J Ophthalmol 95:261-5. 2011
    ..Recently, our studies have indicated that hyalocytes contribute to the pathogenesis of these diseases. However, the impact of TNFα on the functional properties of hyalocytes is unknown...
  22. ncbi request reprint Cellular migration associated with macular hole: a new method for comprehensive bird's-eye analysis of the internal limiting membrane
    Toshio Hisatomi
    Department of Ophthalmology and Morphology Core, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arch Ophthalmol 124:1005-11. 2006
    ..To elucidate the pathogenesis of macular hole formation, focusing in particular on the possible role of cellular migration on the cortical vitreous and internal limiting membrane (ILM) around the macular hole...
  23. ncbi request reprint Suppression of experimental choroidal neovascularization utilizing KDR selective receptor tyrosine kinase inhibitor
    Atsunobu Takeda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, 812 8582 Fukuoka, Japan
    Graefes Arch Clin Exp Ophthalmol 241:765-72. 2003
    ....
  24. ncbi request reprint Brilliant blue G selectively stains the internal limiting membrane/brilliant blue G-assisted membrane peeling
    Hiroshi Enaida
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 26:631-6. 2006
    ..To report the use of the dye brilliant blue G (BBG) for staining of the internal limiting membrane (ILM) during macular hole (MH) and epiretinal membrane (ERM) surgery...
  25. doi request reprint Anatomical findings of vitreoretinal interface in eyes with asteroid hyalosis
    Yasutaka Mochizuki
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Graefes Arch Clin Exp Ophthalmol 247:1173-7. 2009
    ..To investigate the anatomical features of vitreoretinal interface in eyes with asteroid hyalosis (AH) with optical coherence tomography (OCT) and intravitreal triamcinolone acetonide (TA) during vitreous surgery...
  26. pmc Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases
    Takeru Yoshimura
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 4:e8158. 2009
    ..Major three factors: IL-6, IL-8, and MCP-1 were strongly correlated with each other indicating a common pathway involved in inflammation process in vitreoretinal diseases...
  27. ncbi request reprint The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytes
    Kumiko Hirayama
    Departments of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 45:3896-903. 2004
    ..To investigate the involvement of the Rho-kinase pathway in collagen gel contraction by hyalocytes...
  28. doi request reprint Equivalent tamponade by room air as compared with SF(6) after macular hole surgery
    Yuhei Hasegawa
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Graefes Arch Clin Exp Ophthalmol 247:1455-9. 2009
    ..To evaluate the effect of tamponade by room air after vitrectomy for the treatment of idiopathic macular hole (MH)...
  29. ncbi request reprint Staining ability and biocompatibility of brilliant blue G: preclinical study of brilliant blue G as an adjunct for capsular staining
    Toshio Hisatomi
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arch Ophthalmol 124:514-9. 2006
    ..To evaluate the effectiveness and biocompatibility of brilliant blue G (BBG) for capsular visualization for continuous curvilinear capsulorrhexis...
  30. pmc Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage
    Ryoichi Arita
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diabetes 58:215-26. 2009
    ..Involvement of the Rho/Rho kinase (ROCK) pathway in diabetic microvasculopathy and therapeutic potential of fasudil, a selective ROCK inhibitor, are investigated...
  31. pmc Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis
    Shintaro Nakao
    Department of Ophthalmology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Pathol 171:1058-65. 2007
    ....
  32. doi request reprint Prevalence and systemic risk factors for retinal vein occlusion in a general Japanese population: the Hisayama study
    Miho Yasuda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 51:3205-9. 2010
    ..To examine the prevalence of retinal vein occlusion (RVO) and its systemic relevant factors in a general Japanese population aged 40 years or older...
  33. ncbi request reprint A new method for comprehensive bird's-eye analysis of the surgically excised internal limiting membrane
    Toshio Hisatomi
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Ophthalmol 139:1121-2. 2005
    ..To investigate the role of cells and extracellular matrix on the internal limiting membrane (ILM), we demonstrated a new method for a comprehensive bird's-eye analysis of surgically excised ILM...
  34. ncbi request reprint Possible benefits of triamcinolone-assisted pars plana vitrectomy for retinal diseases
    Hiroshi Enaida
    Department of Ophthlamology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Retina 23:764-70. 2003
    ..To study the advantages and complications of triamcinolone acetonide (TA)-assisted pars plana vitrectomy (PPV) for various retinal diseases...
  35. doi request reprint Retinitis pigmentosa associated with asteroid hyalosis
    Yasuhiro Ikeda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 30:1278-81. 2010
    ..Asteroid hyalosis is considered not to cause decreased vision or any other visual symptoms except in rare cases. There have been a few reports of AH in patients with retinitis pigmentosa (RP)...
  36. ncbi request reprint Incidence of acute endophthalmitis after triamcinolone-assisted pars plana vitrectomy
    Taiji Sakamoto
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Science, Sakaragaoka 8 35 1, Kagoshima 890 8520, Japan
    Am J Ophthalmol 138:137-8. 2004
    ..To report the incidence of acute endophthalmitis after triamcinolone acetonide-assisted pars plana vitrectomy (PPV)...
  37. ncbi request reprint Critical role of photoreceptor apoptosis in functional damage after retinal detachment
    Toshio Hisatomi
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Curr Eye Res 24:161-72. 2002
    ..To investigate the relation between retinal function and apoptosis, we studied photoreceptor apoptosis in experimental retinal detachment (RD)...
  38. doi request reprint An early "reopening" case of idiopathic macular hole; supportive usefulness of fundus autofluorescence
    Mitsuru Arima
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Graefes Arch Clin Exp Ophthalmol 247:711-4. 2009
    ..We report a case of early reopening of anatomically closed MH, 2 days after release from face-down positioning where FAF abnormalities proceeded OCT findings...
  39. ncbi request reprint [Pathology of diabetic retinopathy]
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University
    Nihon Rinsho 63:165-70. 2005
  40. ncbi request reprint [Chronic complications due to diabetes mellitus: Pathology of diabetic retinopathy]
    Yasuaki Hata
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University
    Nihon Rinsho 60:155-61. 2002
  41. ncbi request reprint Visualization of the Cloquet canal during triamcinolone-assisted vitrectomy
    Hiroshi Enaida
    Department of Ophthalmology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Arch Ophthalmol 122:1564-5. 2004
  42. ncbi request reprint Bifunctional properties of peroxisome proliferator-activated receptor gamma1 in KDR gene regulation mediated via interaction with both Sp1 and Sp3
    Yukio Sassa
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Diabetes 53:1222-9. 2004
    ..In conclusion, PPARgamma1 has bifunctional properties in the regulation of KDR gene expression mediated via interaction with both Sp1 and Sp3...
  43. ncbi request reprint Expression of matrix metalloproteinases and their inhibitors in experimental retinal ischemia-reperfusion injury in rats
    Xu Zhang
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Exp Eye Res 74:577-84. 2002
    ..These results suggest that MMP-2 and MMP-9 may play an important role in the pathomechanism of retinal ischemic injury...
  44. ncbi request reprint Interleukin-18 regulates pathological intraocular neovascularization
    Hong Qiao
    Ophthalmology, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Leukoc Biol 81:1012-21. 2007
    ..We therefore concluded that IL-18 regulates pathogenic retinal NV by promoting its regression rather than inhibiting its development. This suggests some useful, new approaches to treating retinopathy in humans...
  45. ncbi request reprint Retinal capillary hemangioma managed by transpupillary thermotherapy
    Yasutaka Mochizuki
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 24:981-4. 2004
  46. doi request reprint Nine-year incidence and risk factors for age-related macular degeneration in a defined Japanese population the Hisayama study
    Miho Yasuda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ophthalmology 116:2135-40. 2009
    ..To estimate the 9-year incidence and risk factors for age-related macular degeneration (AMD) in a general Japanese population...
  47. ncbi request reprint Lipemia retinalis: low-density lipoprotein apheresis improved the appearance of retinal vessels in a patient with type 5 hyperlipoproteinemia
    Yukio Sassa
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Retina 25:803-4. 2005
  48. ncbi request reprint Neovascularization in the anterior segment of the rabbit eye by experimental anterior ischemia
    Akihiko Tawara
    Department of Ophthalmology, University of Occupational and Environmental Health, Japan
    Graefes Arch Clin Exp Ophthalmol 240:144-53. 2002
    ..To investigate the effects of anterior ischemia accompanied by neither retinal nor choroidal ischemia on the anterior segment of the eye...
  49. pmc ROCK as a Therapeutic Target of Diabetic Retinopathy
    Ryoichi Arita
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Ophthalmol 2010:175163. 2010
    ..Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed...
  50. pmc Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factor
    Yukio Sassa
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Ophthalmol 4:275-83. 2010
    ..Physicians are waiting for new guidelines for the management of AMD and the results of current and upcoming trials systematically addressing these issues will be expected to provide it...
  51. ncbi request reprint Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways
    Izumi Suzuma
    Research Division and Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:1047-57. 2002
    ..This mechanism may play a role in the well documented association of concomitant hypertension with clinical exacerbation of neovascularization and vascular permeability...