Research Topics
Genomes and Genes | Yasuaki HataSummaryAffiliation: Kyushu University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitorYasuaki Hata
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Jpn J Ophthalmol 52:16-23. 2008..In this study, we addressed the therapeutic potential of fasudil, a potent Rho-kinase inhibitor, for VEGF-elicited angiogenesis and also for the intracellular signalings induced by VEGF...- Antiangiogenic mechanisms of simvastatin in retinal endothelial cellsYasuaki Hata
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Graefes Arch Clin Exp Ophthalmol 248:667-73. 2010..While statins have an anti-angiogenic property, their underlying mechanisms are not fully understood. We investigated intracellular mechanisms of simvastatin-mediated reduction in VEGF-induced signalings... 
Preclinical investigation of fluorometholone acetate as a potential new adjuvant during vitreous surgeryYasuaki Hata
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Graefes Arch Clin Exp Ophthalmol 245:1019-25. 2007..To examine the effects of intravitreal fluorometholone acetate (FMT) on the morphology and function of the retina and to investigate its possible use for vitreous surgery...- Vascular endothelial growth factor expression by hyalocytes and its regulation by glucocorticoidY Hata
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Br J Ophthalmol 92:1540-4. 2008..The authors investigated the effect of hypoxia, TNF-alpha and dexamethasone on vascular endothelial growth factor (VEGF) expression by cultured hyalocytes... - [Preventive strategy for the treatment of diabetic vitreoretinopathy]Yasuaki Hata
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Nihon Ganka Gakkai Zasshi 113:379-401; discussion 402. 2009.... - Biocompatibility of brilliant blue G in a rat model of subretinal injectionAkifumi Ueno
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Retina 27:499-504. 2007..To evaluate the toxicity of brilliant blue G (BBG) compared with those of indocyanine green (ICG) and trypan blue (TB) in a rat model of subretinal injection... 
Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statinsShuhei Kawahara
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
Diabetes 57:2784-93. 2008..Novel pharmaceutical approaches are thus urgently needed for the management of these vision-threatening diseases. In the current study, we investigated the inhibitory effects of statins on the progression of PVDs...- Preclinical investigation of internal limiting membrane staining and peeling using intravitreal brilliant blue GHiroshi Enaida
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Retina 26:623-30. 2006..CONCLUSIONS: These results demonstrate that BBG, which has low potential for toxicity, high staining ability, and ease of handling, is a good candidate dye for ILM peeling... - Intracellular events in retinal glial cells exposed to ICG and BBGShuhei Kawahara
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Invest Ophthalmol Vis Sci 48:4426-32. 2007..To investigate the intracellular events in retinal glial cells exposed to indocyanine green (ICG) and brilliant blue G (BBG)... - Functional role of Egr-1 mediating VEGF-induced tissue factor expression in the retinal capillary endotheliumYukio Sassa
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582 Japan
Graefes Arch Clin Exp Ophthalmol 240:1003-10. 2002..01). CONCLUSION: Transcription factor Egr-1, which lies downstream of p44/p42 MAPK, critically mediates VEGF-dependent TF expression in the retinal capillary endothelium... - Histopathology of neovascular tissue from eyes with proliferative diabetic retinopathy after intravitreal bevacizumab injectionRi ichiro Kohno
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Am J Ophthalmol 150:223-229.e1. 2010..To examine the histopathologic effect of a single intravitreal injection of bevacizumab on newly formed vessels in eyes with proliferative diabetic retinopathy (PDR)... - Functional characteristics of connective tissue growth factor on vitreoretinal cellsTakeshi Kita
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
Diabetes 56:1421-8. 2007..Whereas CTGF might have no direct effects or minimal effects, if any, on retinal neovascularization, it is possible that CTGF has indirect effects by modulating the expression of VEGF... - Functional properties of hyalocytes under PDGF-rich conditionsYoshihiro Noda
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Invest Ophthalmol Vis Sci 45:2107-14. 2004.... - Critical role of the Rho-kinase pathway in TGF-beta2-dependent collagen gel contraction by retinal pigment epithelial cellsMuneki Miura
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Exp Eye Res 82:849-59. 2006.... - Role of TGF-beta in proliferative vitreoretinal diseases and ROCK as a therapeutic targetTakeshi Kita
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Proc Natl Acad Sci U S A 105:17504-9. 2008..ROCK, a key downstream mediator of TGF-beta and other factors might become a unique therapeutic target in the treatment of proliferative vitreoretinal diseases... - Fibrinogen stimulates in vitro angiogenesis by choroidal endothelial cells via autocrine VEGFSatomi Shiose
Department of Ophthalmology of the Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, 812 8582 Fukuoka, Japan
Graefes Arch Clin Exp Ophthalmol 242:777-83. 2004..The purpose of this study is to investigate the effect of fibrinogen on angiogenesis in vitro formed by cultured bovine choroidal endothelial cells (BCECs) and the involvement of vascular endothelial growth factor (VEGF) in this mechanism... - Evaluating adjunctive surgical procedures during vitrectomy for diabetic macular edemaYasutaka Mochizuki
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Retina 26:143-8. 2006..450). CONCLUSION: The present study suggests that these 3 PPV approaches do not significantly affect postoperative BCVAs after 18 months of DME treatment... - Triamcinolone acetonide-assisted pars plana vitrectomy improves residual posterior vitreous hyaloid removal: ultrastructural analysis of the inner limiting membraneHiroyoshi Matsumoto
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Retina 27:174-9. 2007.... - Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitorTakeshi Kita
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Diabetes 56:231-8. 2007..Hyalocytes may be a possible source of CTGF and thus might play a role in vitreoretinal interface diseases. Furthermore, Rho kinase inhibitors might have therapeutic potential to control fibrotic disorders in the eye... - Reduced incidence of intraoperative complications in a multicenter controlled clinical trial of triamcinolone in vitrectomyKeita Yamakiri
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan
Ophthalmology 114:289-96. 2007..To evaluate the benefits and potential complications of using triamcinolone acetonide (TA) in pars plana vitrectomy (PPV)... - Role of tumour necrosis factor-α (TNFα) in the functional properties of hyalocytesYasuaki Hata
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
Br J Ophthalmol 95:261-5. 2011..Recently, our studies have indicated that hyalocytes contribute to the pathogenesis of these diseases. However, the impact of TNFα on the functional properties of hyalocytes is unknown... - Cellular migration associated with macular hole: a new method for comprehensive bird's-eye analysis of the internal limiting membraneToshio Hisatomi
Department of Ophthalmology and Morphology Core, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Arch Ophthalmol 124:1005-11. 2006..To elucidate the pathogenesis of macular hole formation, focusing in particular on the possible role of cellular migration on the cortical vitreous and internal limiting membrane (ILM) around the macular hole... - Suppression of experimental choroidal neovascularization utilizing KDR selective receptor tyrosine kinase inhibitorAtsunobu Takeda
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan
Graefes Arch Clin Exp Ophthalmol 241:765-72. 2003.... - Brilliant blue G selectively stains the internal limiting membrane/brilliant blue G-assisted membrane peelingHiroshi Enaida
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Retina 26:631-6. 2006..3 +/- 1.0 months). CONCLUSIONS: BBG selectively stains the ILM. This technique can facilitate the management of MH and ERM surgery without any adverse effects, as was shown in this short-term study... - Anatomical findings of vitreoretinal interface in eyes with asteroid hyalosisYasutaka Mochizuki
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Graefes Arch Clin Exp Ophthalmol 247:1173-7. 2009..To investigate the anatomical features of vitreoretinal interface in eyes with asteroid hyalosis (AH) with optical coherence tomography (OCT) and intravitreal triamcinolone acetonide (TA) during vitreous surgery... - Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseasesTakeru Yoshimura
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
PLoS ONE 4:e8158. 2009..Major three factors: IL-6, IL-8, and MCP-1 were strongly correlated with each other indicating a common pathway involved in inflammation process in vitreoretinal diseases... - The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytesKumiko Hirayama
Departments of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Invest Ophthalmol Vis Sci 45:3896-903. 2004.... - Equivalent tamponade by room air as compared with SF(6) after macular hole surgeryYuhei Hasegawa
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
Graefes Arch Clin Exp Ophthalmol 247:1455-9. 2009..To evaluate the effect of tamponade by room air after vitrectomy for the treatment of idiopathic macular hole (MH)... - Staining ability and biocompatibility of brilliant blue G: preclinical study of brilliant blue G as an adjunct for capsular stainingToshio Hisatomi
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Arch Ophthalmol 124:514-9. 2006..Clinical Relevance The BBG is effective and safe capsular staining for continuous curvilinear capsulorrhexis... - Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damageRyoichi Arita
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Diabetes 58:215-26. 2009..Involvement of the Rho/Rho kinase (ROCK) pathway in diabetic microvasculopathy and therapeutic potential of fasudil, a selective ROCK inhibitor, are investigated... - Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesisShintaro Nakao
Department of Ophthalmology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Am J Pathol 171:1058-65. 2007.... - Prevalence and systemic risk factors for retinal vein occlusion in a general Japanese population: the Hisayama studyMiho Yasuda
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Invest Ophthalmol Vis Sci 51:3205-9. 2010..To examine the prevalence of retinal vein occlusion (RVO) and its systemic relevant factors in a general Japanese population aged 40 years or older... - A new method for comprehensive bird's-eye analysis of the surgically excised internal limiting membraneToshio Hisatomi
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Am J Ophthalmol 139:1121-2. 2005..To investigate the role of cells and extracellular matrix on the internal limiting membrane (ILM), we demonstrated a new method for a comprehensive bird's-eye analysis of surgically excised ILM... - Possible benefits of triamcinolone-assisted pars plana vitrectomy for retinal diseasesHiroshi Enaida
Department of Ophthlamology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Retina 23:764-70. 2003..CONCLUSIONS: Triamcinolone acetonide-assisted PPV appears to be potentially useful to reduce the incidence of reoperation owing to preretinal fibrosis with no serious complications... - Retinitis pigmentosa associated with asteroid hyalosisYasuhiro Ikeda
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Retina 30:1278-81. 2010..Asteroid hyalosis is considered not to cause decreased vision or any other visual symptoms except in rare cases. There have been a few reports of AH in patients with retinitis pigmentosa (RP)... - Incidence of acute endophthalmitis after triamcinolone-assisted pars plana vitrectomyTaiji Sakamoto
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Science, Sakaragaoka 8 35 1, Kagoshima 890 8520, Japan
Am J Ophthalmol 138:137-8. 2004..To report the incidence of acute endophthalmitis after triamcinolone acetonide-assisted pars plana vitrectomy (PPV)... - Critical role of photoreceptor apoptosis in functional damage after retinal detachmentToshio Hisatomi
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Curr Eye Res 24:161-72. 2002.... - An early "reopening" case of idiopathic macular hole; supportive usefulness of fundus autofluorescenceMitsuru Arima
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Graefes Arch Clin Exp Ophthalmol 247:711-4. 2009..We report a case of early reopening of anatomically closed MH, 2 days after release from face-down positioning where FAF abnormalities proceeded OCT findings... - [Pathology of diabetic retinopathy]Yasuaki Hata
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University
Nippon Rinsho 63:165-70. 2005 - [Chronic complications due to diabetes mellitus: Pathology of diabetic retinopathy]Yasuaki Hata
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University
Nippon Rinsho 60:155-61. 2002 - Visualization of the Cloquet canal during triamcinolone-assisted vitrectomyHiroshi Enaida
Department of Ophthalmology, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Arch Ophthalmol 122:1564-5. 2004 - Bifunctional properties of peroxisome proliferator-activated receptor gamma1 in KDR gene regulation mediated via interaction with both Sp1 and Sp3Yukio Sassa
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Diabetes 53:1222-9. 2004..In conclusion, PPARgamma1 has bifunctional properties in the regulation of KDR gene expression mediated via interaction with both Sp1 and Sp3... - Expression of matrix metalloproteinases and their inhibitors in experimental retinal ischemia-reperfusion injury in ratsXu Zhang
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Exp Eye Res 74:577-84. 2002..These results suggest that MMP-2 and MMP-9 may play an important role in the pathomechanism of retinal ischemic injury... - Retinal capillary hemangioma managed by transpupillary thermotherapyYasutaka Mochizuki
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Retina 24:981-4. 2004 - Interleukin-18 regulates pathological intraocular neovascularizationHong Qiao
Ophthalmology, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Leukoc Biol 81:1012-21. 2007..We therefore concluded that IL-18 regulates pathogenic retinal NV by promoting its regression rather than inhibiting its development. This suggests some useful, new approaches to treating retinopathy in humans... - Nine-year incidence and risk factors for age-related macular degeneration in a defined Japanese population the Hisayama studyMiho Yasuda
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Ophthalmology 116:2135-40. 2009..To estimate the 9-year incidence and risk factors for age-related macular degeneration (AMD) in a general Japanese population... - Lipemia retinalis: low-density lipoprotein apheresis improved the appearance of retinal vessels in a patient with type 5 hyperlipoproteinemiaYukio Sassa
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Retina 25:803-4. 2005 - Neovascularization in the anterior segment of the rabbit eye by experimental anterior ischemiaAkihiko Tawara
Department of Ophthalmology, University of Occupational and Environmental Health, Japan
Graefes Arch Clin Exp Ophthalmol 240:144-53. 2002..To investigate the effects of anterior ischemia accompanied by neither retinal nor choroidal ischemia on the anterior segment of the eye... - ROCK as a Therapeutic Target of Diabetic RetinopathyRyoichi Arita
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Ophthalmol 2010:175163. 2010..Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed... - Antiangiogenic drugs in the management of ocular diseases: Focus on antivascular endothelial growth factorYukio Sassa
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Clin Ophthalmol 4:275-83. 2010..Physicians are waiting for new guidelines for the management of AMD and the results of current and upcoming trials systematically addressing these issues will be expected to provide it... - Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathwaysIzumi Suzuma
Research Division and Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
J Biol Chem 277:1047-57. 2002..This mechanism may play a role in the well documented association of concomitant hypertension with clinical exacerbation of neovascularization and vascular permeability...