M Harada

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Heat shock proteins and the antitumor T cell response
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Biotherapy 10:229-35. 1998
  2. ncbi request reprint Systemic administration of interleukin-12 can restore the anti-tumor potential of B16 melanoma-draining lymph node cells impaired at a late tumor-bearing state
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Int J Cancer 75:400-5. 1998
  3. ncbi request reprint Characterization of B16 melanoma-specific cytotoxic T lymphocytes
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Immunol Immunother 47:198-204. 1998
  4. ncbi request reprint Oral administration of PSK can improve the impaired anti-tumor CD4+ T-cell response in gut-associated lymphoid tissue (GALT) of specific-pathogen-free mice
    M Harada
    Department of Virology, Kyushu University, Fukuoka, Japan
    Int J Cancer 70:362-72. 1997
  5. ncbi request reprint Human thymic epithelial cells maintain long-term survival of clonogenic myeloid and erythroid progenitor cells in vitro
    K Takenaka
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Haematol 111:363-70. 2000
  6. ncbi request reprint Immunosuppressive activity of cloned natural killer (NK1.1+) T cells established from murine tumor-infiltrating lymphocytes
    K Tamada
    Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    J Immunol 158:4846-54. 1997
  7. ncbi request reprint Role of the endogenous production of interleukin 12 in immunotherapy
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Res 58:3073-7. 1998
  8. ncbi request reprint Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice
    S Shimizu
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Rheumatology (Oxford) 43:1121-8. 2004
  9. doi request reprint A dose-escalation study of rituximab for treatment of systemic lupus erythematosus and Evans' syndrome: immunological analysis of B cells, T cells and cytokines
    Y Tamimoto
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Rheumatology (Oxford) 47:821-7. 2008
  10. doi request reprint Long-term outcomes of autologous PBSCT for peripheral T-cell lymphoma: retrospective analysis of the experience of the Fukuoka BMT group
    A Numata
    Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
    Bone Marrow Transplant 45:311-6. 2010

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Heat shock proteins and the antitumor T cell response
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Biotherapy 10:229-35. 1998
    ..These lines of evidence therefore indicate that HSP may be potentially promising target molecules for antitumor T cell immunotherapy...
  2. ncbi request reprint Systemic administration of interleukin-12 can restore the anti-tumor potential of B16 melanoma-draining lymph node cells impaired at a late tumor-bearing state
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Int J Cancer 75:400-5. 1998
    ....
  3. ncbi request reprint Characterization of B16 melanoma-specific cytotoxic T lymphocytes
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Immunol Immunother 47:198-204. 1998
    ..Overall, these results indicate that the Tc1-type Vbeta11+ AB1 cells exert an antitumor activity against syngeneic B16 melanoma through recognition of TRP-2(181-188) peptide in an H-2Kb-restricted manner...
  4. ncbi request reprint Oral administration of PSK can improve the impaired anti-tumor CD4+ T-cell response in gut-associated lymphoid tissue (GALT) of specific-pathogen-free mice
    M Harada
    Department of Virology, Kyushu University, Fukuoka, Japan
    Int J Cancer 70:362-72. 1997
    ..Overall, these results indicate that the p.o. administration of PSK can improve the impaired anti-tumor CD4+ T-cell response in GALT, mainly through a suppression of TGF-beta production and a restoration of IFN-gamma production...
  5. ncbi request reprint Human thymic epithelial cells maintain long-term survival of clonogenic myeloid and erythroid progenitor cells in vitro
    K Takenaka
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Haematol 111:363-70. 2000
    ..Our results suggest that thymic cortical epithelial cells have the ability to support not only the differentiation of haematopoietic cells, but also long-term survival of clonogenic myeloid/erythroid progenitor cells...
  6. ncbi request reprint Immunosuppressive activity of cloned natural killer (NK1.1+) T cells established from murine tumor-infiltrating lymphocytes
    K Tamada
    Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    J Immunol 158:4846-54. 1997
    ..Collectively, these findings demonstrate that NK1.1+ T cells in TIL show immunosuppressive activity in the antitumor immune response through the production of TGF-beta and the preferential cytolysis of B7-expressing cells...
  7. ncbi request reprint Role of the endogenous production of interleukin 12 in immunotherapy
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Res 58:3073-7. 1998
    ....
  8. ncbi request reprint Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice
    S Shimizu
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Rheumatology (Oxford) 43:1121-8. 2004
    ..The aim of this study was to examine whether anti-MCP-1 gene therapy inhibits the progression of nephritis in MRL/lpr mice...
  9. doi request reprint A dose-escalation study of rituximab for treatment of systemic lupus erythematosus and Evans' syndrome: immunological analysis of B cells, T cells and cytokines
    Y Tamimoto
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Rheumatology (Oxford) 47:821-7. 2008
    ..We performed a dose-escalation study for treatment of Japanese patients with autoimmune diseases including eight with SLE and one with Evans' syndrome...
  10. doi request reprint Long-term outcomes of autologous PBSCT for peripheral T-cell lymphoma: retrospective analysis of the experience of the Fukuoka BMT group
    A Numata
    Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
    Bone Marrow Transplant 45:311-6. 2010
    ..4% vs 27.3%, P=0.046). HDCT supported by auto-SCT may therefore be effective as consolidation in CR for PTCL treatment...
  11. doi request reprint Infectious complications in patients receiving autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases
    K Kohno
    Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Transpl Infect Dis 11:318-23. 2009
    ..Because the risk for infections approaches that seen in allogeneic transplant recipients, infection surveillance, diagnostic workup, and prophylactic strategies similar to those applicable to allogeneic recipients are warranted...
  12. ncbi request reprint Melanoma-Reactive CD8+ T cells recognize a novel tumor antigen expressed in a wide variety of tumor types
    M Harada
    Kurume University School of Medicine, Fukuoka, Japan
    J Immunother 24:323-33. 2001
    ..Thus, AIM-2 may represent a potential target for the development of vaccines in patients bearing tumors of a variety of histologies...
  13. doi request reprint Role of autotransplantation in the treatment of acute promyelocytic leukemia patients in remission: Fukuoka BMT Group observations and a literature review
    T Kamimura
    Department of Hematology, Harasanshin Hospital, Fukuoka, Japan
    Bone Marrow Transplant 46:820-6. 2011
    ..We review previous reports and discuss the role of autotransplantation in the treatment of APL patients in CR...
  14. ncbi request reprint Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis
    H Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Lupus 13:165-7. 2004
    ..In this study we assessed the significance of the MCP-1 gene in determination of the histological phenotype in lupus nephritis. There was no association between the risk of DPGN and the MCP-1 gene genotype...
  15. pmc Evidence of the extrathymic development of tyrosinase-related protein-2-recognizing CD8+ T cells with low avidity
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Immunology 104:67-74. 2001
    ..Overall, these results suggest that low avidity CD8+ T cells recognizing TRP-2 can be developed extrathymically...
  16. ncbi request reprint The antitumor effect induced by local injections with interleukin-2 is diminished by combing with a local injection with mitomycin C
    T Li
    Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Immunopharmacol Immunotoxicol 18:497-509. 1996
    ....
  17. ncbi request reprint Identification of Lck-derived peptides capable of inducing HLA-A2-restricted and tumor-specific CTLs in cancer patients with distant metastases
    N Imai
    Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Int J Cancer 94:237-42. 2001
    ..Overall, the Lck(246-254) and Lck(422-430) peptides could be useful for specific immunotherapy of HLA-A2(+) cancer patients, especially with distant metastases...
  18. ncbi request reprint Cidofovir for treating adenoviral hemorrhagic cystitis in hematopoietic stem cell transplant recipients
    K Nagafuji
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Bone Marrow Transplant 34:909-14. 2004
    ..CDV proved effective in treating AdV HC in transplant patients. However, CDV at 1 mg/kg/day given three times weekly failed to prevent breakthrough infection with CMV and HSV in some patients...
  19. pmc Circulating immunoglobulin-bound transforming growth factor beta at a late tumour-bearing stage impairs antigen-specific responses of CD4+ T cells
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8482, Japan
    Clin Exp Immunol 128:204-12. 2002
    ..Taken together, these results suggest that circulating IgG-bound TGF- is, at least in part, responsible for the impaired responses of CD4+ T cells at the late tumour-bearing stage by suppressing antigen uptake/ processing by APC...
  20. ncbi request reprint Concomitant immunity against tumor development is enhanced by the oral administration of a kampo medicine, Hochu-ekki-to (TJ-41: Bu-Zhong-Yi-Qi-Tang)
    M Harada
    Department of Virology and Immunology, Kyushu University, Fukuoka, Japan
    Immunopharmacol Immunotoxicol 17:687-703. 1995
    ..These results indicate that the oral administration of TJ-41 into the tumor bearing mice may thus be able to enhance concomitant antitumor immunity through the augmentation of the cytostatic activity...
  21. ncbi request reprint Aclarubicin induces differentiation of leukemic progenitors in myelodysplastic syndrome cooperating with granulocyte colony-stimulating factor
    K Akashi
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Leuk Res 24:243-8. 2000
    ....
  22. ncbi request reprint Sonographic diagnosis of venocclusive disease of the liver and danazol therapy for autoimmune thrombocytopenia in an autologous marrow transplant patient
    E Matsuishi
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka
    Jpn J Clin Oncol 20:188-92. 1990
    ..Accordingly, danazol can be used as an alternative to prednisolone for the treatment of autoimmune thrombocytopenia after bone marrow transplantation...
  23. ncbi request reprint Multiple autoimmune haemopoietic disorders and insidious clonal proliferation of large granular lymphocytes
    K Akashi
    First Department of Internal Medicine, Kyushu University, Fukuoka, Japan
    Br J Haematol 107:670-3. 1999
    ..Accordingly, an undetectable level of proliferation of a clonal LGL population could cause various autoimmune haemopoietic disorders...
  24. doi request reprint Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus
    H Miyagawa
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Rheumatology (Oxford) 47:158-64. 2008
    ..Identification of the genes responsible for systemic lupus erythematosus (SLE)...
  25. ncbi request reprint Association of MBL gene polymorphisms with major bacterial infection in patients treated with high-dose chemotherapy and autologous PBSCT
    T Horiuchi
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Genes Immun 6:162-6. 2005
    ..2, almost the same in seven different areas of Japan. This common occurrence suggests that MBL deficiency may play an important role in the clinical settings of immunosuppression...
  26. doi request reprint CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL
    Y Kong
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Leukemia 22:1207-13. 2008
    ..Recapitulation of patient B-ALL in NOD/SCID/IL2rgamma(null) recipients provides a powerful tool for directly studying leukemogenesis and for developing therapeutic strategies...
  27. ncbi request reprint Effects of G-CSF, GM-CSF, and IL-5 on nuclear segmentation of neutrophils and eosinophils in congenital or acquired Pelger-Huët anomaly
    T Teshima
    First Department of Internal Medicine, Kyushu University, Fukuoka, Japan
    Exp Hematol 19:322-5. 1991
    ..These results suggest that G-CSF plays some role in the nuclear development of neutrophils, whereas IL-5 may not have such an effect on eosinophil maturation in the individual cases studied...
  28. ncbi request reprint Allogeneic peripheral blood stem cell transplantation from two- or three-loci-mismatched related donors in adult Japanese patients with high-risk hematologic malignancies
    S Yamasaki
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Bone Marrow Transplant 33:279-89. 2004
    ..Although the number of patients is small, our data suggest that transplant-related problems, particularly infectious complications, are major obstacles to the success of this therapy...
  29. ncbi request reprint FLT3 mutations in normal karyotype acute myeloid leukemia in first complete remission treated with autologous peripheral blood stem cell transplantation
    G Yoshimoto
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Bone Marrow Transplant 36:977-83. 2005
    ..Myeloablative chemotherapy supported by auto-PBSCT may overcome any poor prognostic implications of FLT3 mutations...
  30. ncbi request reprint Rituximab does not compromise the mobilization and engraftment of autologous peripheral blood stem cells in diffuse-large B-cell lymphoma
    K Kamezaki
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Bone Marrow Transplant 39:523-7. 2007
    ..Larger studies are required to determine the impact of rituximab on the mobilization and function of PBSC as well as whether a survival advantage exists in patients who undergo auto-PBSCT with rituximab...
  31. pmc Identification of parathyroid hormone-related protein-derived peptides immunogenic in human histocompatibility leukocyte antigen-A24+ prostate cancer patients
    A Yao
    Department of Immunology, Kurume University School of Medicine, Fukuoka, Japan
    Br J Cancer 91:287-96. 2004
    ..These results indicate that the PTHrP could be a promising target molecule for specific immunotherapy of HLA-A24(+) prostate cancer patients with metastases...
  32. ncbi request reprint Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice
    N Kawano
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan
    Leukemia 19:1384-90. 2005
    ..Taken together, the NOD/SCID/beta2m(null) newborn system is useful to understand kinetics, metastasis, and disease progression of ATL in vivo...
  33. ncbi request reprint Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors
    Y Nonaka
    Department of Immunology, Kurume University School of Medicine, Fukuoka, Japan
    Tissue Antigens 60:319-27. 2002
    ..These results indicate that these two ARF4L peptides could be targets for immunotherapy of HLA-A2+ patients with brain tumors...
  34. ncbi request reprint Demonstration of reversed flow in segmental branches of the portal vein with hand-held color Doppler ultrasonography after hematopoietic stem cell transplantation
    M Hashiguchi
    Second Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Bone Marrow Transplant 36:1071-5. 2005
    ..Monitoring for reversed portal flow with color Doppler ultrasonography may be a useful tool for the early diagnosis of VOD, and may improve prognosis by allowing early initiation of treatment...
  35. ncbi request reprint A familial case of hyper-IgM immunodeficiency
    R Iwakiri
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan
    Acta Haematol 88:50-4. 1992
    ..From these observations, it is suggested that it is a rare case of autosomal dominant or polygenal inheritance of hyper-IgM immunodeficiency...
  36. ncbi request reprint The c-kit molecule and the surface immunophenotype of human acute leukemia
    A Kubota
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Leuk Lymphoma 14:421-8. 1994
    ..On such cells, expression of the c-kit molecule may have a functional role and be related to the maturation process...
  37. doi request reprint Long-term outcomes after hematopoietic SCT for adult T-cell leukemia/lymphoma: results of prospective trials
    I Choi
    Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan
    Bone Marrow Transplant 46:116-8. 2011
    ..This is the first report to clarify the long-term outcomes after RIC for ATLL patients...
  38. ncbi request reprint Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha
    K Karube
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Ann Oncol 17:110-6. 2006
    ..In contrast, only few cases were positive for IL-11Ralpha in B cell lymphoma, diffuse large cell lymphoma and follicular lymphoma. This is the first analysis report of tissue HRS cells with cDNA microarray technique...
  39. pmc The emergence of non-cytolytic NK1.1+ T cells in the long-term culture of murine tumour-infiltrating lymphocytes: a possible role of transforming growth factor-beta
    K Tamada
    Department of Immunology, Kyushu University, Fukuoka, Japan
    Immunology 89:627-35. 1996
    ..TGF-beta could be an autocrine growth factor for NKL1.1+ T cells and thereby induce non-cytolytic NK1.1+ T cells in the long-term culture of TIL...
  40. ncbi request reprint Use of an in vitro immunoselected tumor line to identify shared melanoma antigens recognized by HLA-A*0201-restricted T cells
    M Harada
    Department of Virology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Res 61:1089-94. 2001
    ....
  41. ncbi request reprint Development of rheumatoid arthritis following autologous peripheral blood stem cell transplantation
    R Imamura
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Bone Marrow Transplant 30:527-9. 2002
    ..However, the patient developed RA 40 days after transplantation. Our experience suggests that the systemic autoimmune disease, RA, may occur in patients with predisposing factors after autologous PBSCT...
  42. ncbi request reprint Influence of transplanted dose of CD56+ cells on development of graft-versus-host disease in patients receiving G-CSF-mobilized peripheral blood progenitor cells from HLA-identical sibling donors
    S Yamasaki
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Bone Marrow Transplant 32:505-10. 2003
    ..00001; 95% CI <0.00001-0.053; P=0.0083). These results suggest that CD56+ cells in G-PBPC allografts from HLA-identical sibling donors may play an important role in preventing the development of GVHD...
  43. ncbi request reprint Alterations in tight junctions differ between primary biliary cirrhosis and primary sclerosing cholangitis
    S Sakisaka
    Third Department of Medicine, Fukuoka University School of Medicine, Fukuoka, Japan
    Hepatology 33:1460-8. 2001
    ....
  44. ncbi request reprint Genetically determined interferon-gamma production influences the histological phenotype of lupus nephritis
    K Miyake
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Rheumatology (Oxford) 41:518-24. 2002
    ..To clarify whether the interferon-gamma (IFN-gamma) gene (IFNG) is associated with the histological phenotype of lupus nephritis...
  45. pmc Involvement of Na+-Ca2+ exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice
    E Karashima
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 150:434-44. 2007
    ..We thus investigated the involvement of NCX in the mechanism for the forskolin-induced vaso-relaxation, using wild type (WT) and transgenic (TG) mice that specifically over-express NCX1.3 in smooth muscle...
  46. ncbi request reprint Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations
    S Nagafuchi
    Department of Medical Science and Technology, School of Medicine, Kyushu University, Fukuoka, Japan
    J Intern Med 261:605-10. 2007
    ..Thus, not only candidiasis but also HSV infection should receive more attention in patients with APECED, with treatment being administered accordingly...
  47. ncbi request reprint Endothelial nitric oxide synthase gene is positively associated with essential hypertension
    Y Miyamoto
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Hypertension 32:3-8. 1998
    ..In conclusion, the Glu298Asp missense variant was significantly associated with essential hypertension, which suggests that it is a genetic susceptibility factor for essential hypertension...
  48. ncbi request reprint Clinical impact of graft-versus-host disease against leukemias not in remission at the time of allogeneic hematopoietic stem cell transplantation from related donors. The Japan Society for Hematopoietic Cell Transplantation Working Party
    I Kataoka
    Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, Tsukiji, Chuo Ku, Tokyo, Japan
    Bone Marrow Transplant 34:711-9. 2004
    ..Our results suggest that treatment for grade II acute GVHD may need to be attenuated in transplant for refractory leukemias...
  49. ncbi request reprint Transforming growth factor-beta(2) polymorphisms are associated with childhood atopic asthma
    K Hatsushika
    Department of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    Clin Exp Allergy 37:1165-74. 2007
    ..Recent studies suggest that TGF-beta(2) is a predominant isoform expressed in severe asthma and it is also associated with airway remodelling...
  50. ncbi request reprint Lack of association between T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and essential hypertension
    N Kajiyama
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Hypertens Res 23:561-5. 2000
    ....
  51. pmc A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease
    H Tsukamoto
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Ann Rheum Dis 65:508-14. 2006
    ....
  52. ncbi request reprint Comparison between reduced intensity and conventional myeloablative allogeneic stem-cell transplantation in patients with hematologic malignancies aged between 50 and 59 years
    R Kojima
    Hematopoietic Stem Cell Transplantation Unit, The National Cancer Center Hospital, and Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Japan
    Bone Marrow Transplant 36:667-74. 2005
    ..The low relapse rates following RIST suggest a strong antitumor activity through allogeneic immunity...
  53. ncbi request reprint Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population
    A Kokaze
    Department of Public Health, Kyorin University School of Medicine, Shinkawa Mitaka shi, Tokyo, Japan
    J Hum Hypertens 18:41-5. 2004
    ..These results suggest that mt5178 A/C (=ND2-237 Met/Leu) polymorphism may influence both diastolic blood pressure in Japanese women and the blood-pressure-increasing effect of drinking in Japanese men...
  54. ncbi request reprint MEFV mutation analysis of familial Mediterranean fever in Japan
    N Tomiyama
    Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, Nishihara, Okinawa, Japan
    Clin Exp Rheumatol 26:13-7. 2008
    ..We studied FMF patients and their relatives to examine the clinical and genetic features of this disease in the Japanese population...
  55. ncbi request reprint Association between IL-4 genotype and IL-4 production in the Japanese population
    H Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Genes Immun 3:107-9. 2002
    ..These results make it likely that IL-4 genotype could influence the type of immune response...
  56. ncbi request reprint Plasma stromal cell-derived factor-1 during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization
    T Kozuka
    Second Deparment of Internal Medicine, Okayama University Medical School, Okayama, Japan
    Bone Marrow Transplant 31:651-4. 2003
    ..Further studies of a possible additive effect of granulocyte colony-stimulating factor and stromal cell-derived factor-1 are warranted...
  57. ncbi request reprint Detection of cardiovascular risk factors by indices of obesity obtained from anthropometry and dual-energy X-ray absorptiometry in Japanese individuals
    H Ito
    Fukuoka Health Promotion Foundation, Japan
    Int J Obes Relat Metab Disord 27:232-7. 2003
    ..To determine the cut-off points of indices of obesity for detecting hypertension, dyslipidemia and diabetes mellitus in Japanese individuals...
  58. ncbi request reprint Mismatch of minor histocompatibility antigen contributes to a graft-versus-leukemia effect rather than to acute GVHD, resulting in long-term survival after HLA-identical stem cell transplantation in Japan
    T Katagiri
    Faculty of Health Science, Kanazawa University School of Medicine, 13 1 Takara machi, Kanazawa City 920 8641, Japan
    Bone Marrow Transplant 38:681-6. 2006
    ..03). Our data suggest that incompatibility of CD62L, CD31 codon 563 and CD31 codon 125 contributes to a graft-versus-leukemia effect rather than to GVHD, resulting in prolonged survival after HLA-identical SCT...
  59. ncbi request reprint A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus
    T Koyama
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Rheumatology (Oxford) 42:980-5. 2003
    ..We investigated the association of gene polymorphisms in APRIL, a new member of the TNF family, with systemic lupus erythematosus...
  60. ncbi request reprint Excess accumulation of body fat is related to dyslipidemia in normal-weight subjects
    H Ito
    Fukuoka Health Promotion Foundation, Fukuoka, Japan
    Int J Obes Relat Metab Disord 28:242-7. 2004
    ..To assess the relationship of fat mass (FM) and its distribution to hypertension and dyslipidemia in normal-weight Japanese individuals...
  61. ncbi request reprint Hepatic graft-versus-host disease presenting as an acute hepatitis after allogeneic peripheral blood stem cell transplantation
    N Fujii
    Department of Internal Medicine II, Okayama University Medical School, Okayama, Japan
    Bone Marrow Transplant 27:1007-10. 2001
    ..These findings indicate that acute hepatic GVHD may present as acute hepatitis and this should be included in the differential diagnosis for patients with increased aminotransferases after allogeneic stem cell transplantation...
  62. doi request reprint Allo-SCT using reduced-intensity conditioning against advanced pancreatic cancer: a Japanese survey
    Y Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Omiya ku, Saitama City, Saitama, Japan
    Bone Marrow Transplant 42:99-103. 2008
    ..Patients who developed chronic GVHD tended to survive longer than those who did not. These findings support the investigation of a novel treatment strategy to enhance the immunological effect against pancreatic cancer...
  63. pmc A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
    H Asahina
    First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Br J Cancer 95:998-1004. 2006
    ..7-11.1 months). The median overall survival time has not yet been reached. Most of the toxicities were mild. This study showed that gefitinib is very active and well tolerated as first-line therapy for advanced NSCLC with EGFR mutations...
  64. ncbi request reprint Mechanism of NKT cell-mediated transplant tolerance
    X Jiang
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama City, Kanagawa 230 0045, Japan
    Am J Transplant 7:1482-90. 2007
    ....
  65. ncbi request reprint cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats
    M Ishikawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Japan
    Biochem Biophys Res Commun 219:377-81. 1996
    ....
  66. ncbi request reprint Onchocerca eberhardi n. sp. (Nematoda: Filarioidea) from sika deer in Japan; relationships between species parasitic in cervids and bovids in the Holarctic region
    S Uni
    Department of Medical Zoology, Osaka City University Medical School, Osaka 545 8585, Japan
    Parasite 14:199-211. 2007
    ....
  67. doi request reprint Diffusion tensor imaging in patients with Creutzfeldt-Jakob disease
    K Fujita
    J Neurol Neurosurg Psychiatry 79:1304-6. 2008
  68. ncbi request reprint Two novel gene mutations in type I antithrombin deficiency
    K Niiya
    Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School, Japan
    Int J Hematol 74:469-72. 2001
    ..The 2 mutations found in this study are novel. The use of PCR and the sequencing of the PCR product subclones has simplified and confirmed the detection and characterization of the various AT mutations...
  69. ncbi request reprint Salacia oblonga root decreases cardiac hypertrophy in Zucker diabetic fatty rats: inhibition of cardiac expression of angiotensin II type 1 receptor
    T H Huang
    Faculty of Pharmacy, University of Sydney, Australia
    Diabetes Obes Metab 10:574-85. 2008
    ....
  70. ncbi request reprint [Clinical study of itraconazole for systemic fungal infections complicated with hematological malignancies--multicenter cooperative study. West-Japan Systemic Fungal Infection Study Group]
    H Shiku
    Osaka Medical Center for Cancer and Cardiovascular Diseases
    Kansenshogaku Zasshi 72:1208-18. 1998
    ..6%), and itraconazole may have been associated with them. As a conclusion, itraconazole proved to be effective and safe on SFI developed in patients with various hematological malignancies...
  71. ncbi request reprint Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors
    T Yoshida
    Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Kurume, Japan
    Oncogene 25:6056-66. 2006
    ..These data indicate that the reduction of Spred expression in HCC is one of the causes of the acquisition of malignant features. Thus, Spred could be not only a novel prognostic factor but also a new therapeutic target for human HCC...
  72. ncbi request reprint Recurrence of ovarian endometrioma after laparoscopic excision
    K Koga
    Department of Obstetrics and Gynecology, University of Tokyo, Japan
    Hum Reprod 21:2171-4. 2006
    ..To analyse risk factors that influence the recurrence of endometrioma after laparoscopic excision...
  73. ncbi request reprint Merits of duplicate LAN cabling in hospitals
    E Hanada
    Department of Medical Information Science, Kyushu University Hospital, Japan
    J Med Syst 25:367-71. 2001
    ..Herein, we show the merits of separate cable installation...
  74. ncbi request reprint Life-threatening bleeding and acquired factor V deficiency associated with primary systemic amyloidosis
    Y Emori
    Second Department of Medicine, Okayama University Medical School, Japan
    Blood Coagul Fibrinolysis 13:555-9. 2002
    ..Perivascular amyloid deposition and factor V deficiency are both thought to be the cause of the severe hemorrhagic tendency seen in this patient...
  75. ncbi request reprint Clonal expansion of limited T cell clonotypes in affected muscle from a patient with post-transplant polymyositis
    K Kojima
    The Second Department of Medicine and the Second Department of Pathology, Okayama University Medical School, Okayama, Japan
    Bone Marrow Transplant 30:467-70. 2002
    ..Taken together, T cells expanded in the muscle, possibly stimulated by limited kinds of antigens, may drive myositis...
  76. ncbi request reprint High-dose chemotherapy and autologous peripheral blood stem cell transplantation for treatment of unspecified peripheral T-cell lymphoma presented with hepatosplenomegaly and hypercytokinemia syndrome: report of three cases
    J Tsuchiyama
    First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi 1 754, Niigata 951, Japan
    Ann Hematol 81:588-92. 2002
    ..Our observations suggest that auto-PBSCT following HDCT may be an effective and safe therapeutic modality for high-risk PTCL-US patients characterized by hepatosplenomegaly and cytokine-induced syndrome...
  77. ncbi request reprint Synergistic effects of pegylated recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor on mobilization of hematopoietic progenitor and stem cells with long-term repopulating ability into peripheral blood i
    K Honda
    Department of Internal Medicine II, Okayama University Medical School, Okayama, Japan
    Bone Marrow Transplant 28:329-34. 2001
    ..Our data suggest that cytokine-induced pathways for PBPC mobilization may be different between PEG-rHuMGDF and rhG-CSF and indicate that PEG-rHuMGDF alone or the combination with rhG-CSF may be useful in effective PBPC mobilization...
  78. ncbi request reprint Molecular characterization of the ERGIC-53 gene in two Japanese patients with combined factor V-factor VIII deficiency
    H Dansako
    Department of Medicine, University of Okayama, Japan
    Ann Hematol 80:292-4. 2001
    ....
  79. pmc Phase I/II study of docetaxel and cisplatin with concurrent thoracic radiation therapy for locally advanced non-small-cell lung cancer
    K Kiura
    Second Department of Internal Medicine, Okayama University Medical School, Okayama, Japan
    Br J Cancer 89:795-802. 2003
    ....
  80. ncbi request reprint Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation
    T Mori
    Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Bone Marrow Transplant 33:431-4. 2004
    ..8 x 10(4) copies/ml plasma). We conclude that CMV antigenemia testing has limited value in prediction or early diagnosis of CMV-GI disease, and that real-time PCR could have a more diagnostic significance...
  81. ncbi request reprint Chromosome analysis after ex vivo expansion of CD34(+) cells from human cord blood
    Y Katayama
    Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1079, 10029, USA, New York, NY, USA
    Cancer Genet Cytogenet 125:161-2. 2001
    ..This observation suggests that multifactor supported expansion of cord blood cells may not induce karyotypic abnormality, although a limited number of ex vivo expanded cells were tested...
  82. ncbi request reprint Compound heterozygosity for alpha-1-antitrypsin (S(iiyama) and QO(clayton)) in an Oriental patient
    N Miyahara
    Department of Internal Medicine, Respiratory Disease Center, National Sanyo Hospital, Ube, Yamaguchi
    Intern Med 40:336-40. 2001
    ....
  83. ncbi request reprint Evans' syndrome following autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma
    K Kamezaki
    Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan
    Clin Lab Haematol 26:291-3. 2004
    ..She developed Evans' syndrome, the association of immune thrombocytopenia and autoimmune hemolytic anemia, 49 days after transplantation. Multiple autoimmune disorders may occur concurrently after autologous PBSCT...
  84. ncbi request reprint Giant negative T waves during interferon therapy in a patient with chronic hepatitis C
    T Fujiwara
    Second Department of Medicine, Okayama University Medical School
    Intern Med 40:105-9. 2001
    ..Cardiovascular toxicity should be carefully monitored during IFN-alpha therapy even in patients with minor cardiac disease, such as premature ventricular contracture (PVC) and mild hypertension...
  85. ncbi request reprint Autoimmune thrombocytopenia with clonal expansion of CD8-positive T cells after autologous peripheral blood stem cell transplantation for diffuse large B-cell lymphoma
    T Isobe
    Bone Marrow Transplant 35:315-6. 2005
  86. pmc Raised serum APRIL levels in patients with systemic lupus erythematosus
    T Koyama
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Ann Rheum Dis 64:1065-7. 2005
    ..To determine whether serum levels of a proliferation-inducing ligand (APRIL) are raised in patients with systemic lupus erythematosus (SLE) and correlate with autoantibody titres or disease activity, or both...
  87. ncbi request reprint Human herpesvirus-6 encephalitis followed by severe acute GVHD after a stem cell transplant from a microchimeric non-inherited maternal antigen (NIMA)-mismatched sibling
    T Muta
    Bone Marrow Transplant 35:411-3. 2005
  88. ncbi request reprint Inhibition of tumor metastasis by adoptive transfer of IL-12-activated Valpha14 NKT cells
    T Shin
    CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST, Department of Molecular Immunology, Graduate School of Medicine, Chiba University 1-8-1 Inohana, Chuo-ku, Chiba, Japan
    Int J Cancer 91:523-8. 2001
    ..Moreover, our studies have suggested the involvement of direct cytotoxic mechanisms rather than cytokine-mediated immune responses at the effector phase of the Valpha14 NKT cell-mediated anti-tumor activity...
  89. pmc Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity
    K M Fukasawa
    Department of Oral Biochemistry, Matsumoto Dental University, Shiojiri, Nagano, 399 0781, Japan
    Biochem J 339:497-502. 1999
    ..However, these mutants, Y408F, N409S and NE409-410SS also did not possess any epoxide hydrolase activity. We concluded that Ap B is an M1-family zinc metallopeptidase without epoxide hydrolase activity...
  90. ncbi request reprint Monitoring of cytomegalovirus reactivation after allogeneic stem cell transplantation: comparison of an antigenemia assay and quantitative real-time polymerase chain reaction
    K Yakushiji
    Second Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan
    Bone Marrow Transplant 29:599-606. 2002
    ..Although PCR is more sensitive than antigenemia, both tests are useful in the early detection of CMV after allogeneic stem cell transplantation...