Nobuaki Egashira

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. doi request reprint Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Psychopharmacology (Berl) 226:295-305. 2013
  2. ncbi request reprint N-acetyl-L-cysteine inhibits marble-burying behavior in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Japan
    J Pharmacol Sci 119:97-101. 2012
  3. doi request reprint Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Pharmacol Biochem Behav 99:52-8. 2011
  4. ncbi request reprint Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: possible involvement of GABA(A)-benzodiazepine receptor complex
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    J Pharmacol Sci 116:316-20. 2011
  5. doi request reprint Involvement of opioid system in cognitive deficits induced by ∆⁹-tetrahydrocannabinol in rats
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Psychopharmacology (Berl) 219:1111-8. 2012
  6. ncbi request reprint Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka and Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Eur J Pharmacol 563:149-54. 2007
  7. ncbi request reprint Schizandrin reverses memory impairment in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Phytother Res 22:49-52. 2008
  8. ncbi request reprint Theanine prevents memory impairment induced by repeated cerebral ischemia in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Phytother Res 22:65-8. 2008
  9. doi request reprint Depression-like behavior and reduced plasma testosterone levels in the senescence-accelerated mouse
    Nobuaki Egashira
    Department of Neuropharmacology, Fukuoka University, Fukuoka 814 0180, Japan
    Behav Brain Res 209:142-7. 2010
  10. ncbi request reprint Mexiletine reverses oxaliplatin-induced neuropathic pain in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Japan
    J Pharmacol Sci 112:473-6. 2010

Collaborators

Detail Information

Publications96

  1. doi request reprint Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Psychopharmacology (Berl) 226:295-305. 2013
    ..Marble-burying behavior is a pharmacological model for study of OCD...
  2. ncbi request reprint N-acetyl-L-cysteine inhibits marble-burying behavior in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Japan
    J Pharmacol Sci 119:97-101. 2012
    ..o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD...
  3. doi request reprint Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Pharmacol Biochem Behav 99:52-8. 2011
    ..o.) reversed inhibition of head-twitch response by NBQX and URB597. These findings indicated that endocannabinoid and glutamatergic systems participate in the mechanism of action of DOI to induce head-twitch response...
  4. ncbi request reprint Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: possible involvement of GABA(A)-benzodiazepine receptor complex
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    J Pharmacol Sci 116:316-20. 2011
    ..p.), but not WAY100635. These findings suggest that the GABA(A)-benzodiazepine receptor complex, but not 5-HT(1A) receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation...
  5. doi request reprint Involvement of opioid system in cognitive deficits induced by ∆⁹-tetrahydrocannabinol in rats
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Psychopharmacology (Berl) 219:1111-8. 2012
    ..1 mg/kg), suggesting that the effect of THC is mediated through cannabinoid CB(1) receptors...
  6. ncbi request reprint Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka and Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Eur J Pharmacol 563:149-54. 2007
    ....
  7. ncbi request reprint Schizandrin reverses memory impairment in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Phytother Res 22:49-52. 2008
    ..Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits...
  8. ncbi request reprint Theanine prevents memory impairment induced by repeated cerebral ischemia in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Phytother Res 22:65-8. 2008
    ..These results suggest that theanine prevents memory impairment induced by repeated cerebral ischemia, in part by protecting against neuronal cell death, and that it might be useful for preventing cerebrovascular disease...
  9. doi request reprint Depression-like behavior and reduced plasma testosterone levels in the senescence-accelerated mouse
    Nobuaki Egashira
    Department of Neuropharmacology, Fukuoka University, Fukuoka 814 0180, Japan
    Behav Brain Res 209:142-7. 2010
    ..The results of the present study indicate that testosterone may play an important role in the depression-like behavior in SAMP10...
  10. ncbi request reprint Mexiletine reverses oxaliplatin-induced neuropathic pain in rats
    Nobuaki Egashira
    Department of Pharmacy, Kyushu University Hospital, Japan
    J Pharmacol Sci 112:473-6. 2010
    ..p., twice a week). Lidocaine (30, but not 3 and 10, mg/kg, i.p.) also significantly relieved both pain behaviors. These results suggest that mexiletine may be effective in relieving the oxaliplatin-induced neuropathic pain clinically...
  11. ncbi request reprint Calcium-channel antagonists inhibit marble-burying behavior in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 108:140-3. 2008
    ..p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior...
  12. ncbi request reprint New topics in vasopressin receptors and approach to novel drugs: role of the vasopressin receptor in psychological and cognitive functions
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 109:44-9. 2009
    ..Moreover, V1aR KO mice exhibited reduced anxiety-like behavior and impairment of spatial learning. These results suggest that V1aR and V1bR play an important role in psychological and cognitive functions...
  13. doi request reprint Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Eur J Pharmacol 592:103-8. 2008
    ..These findings suggest that aripiprazole may be a useful drug for the treatment of obsessive-compulsive disorder, and that aripiprazole inhibits the marble-burying behavior via 5-HT1A receptor-independent mechanisms...
  14. doi request reprint Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Eur J Pharmacol 589:117-21. 2008
    ..WAY100635 (1 mg/kg) also reversed the reduction effect of citalopram (10 mg/kg). These findings suggest that the 5-HT(1A) receptors are involved in THC-induced enhancement of immobility...
  15. ncbi request reprint Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka 814 0180, Japan
    Neuropharmacology 52:1079-87. 2007
    ..It is to be hoped that cannabidiol will have a palliative action and open new therapeutic possibilities for treating cerebrovascular disorders...
  16. doi request reprint Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Neuropharmacology 55:1280-6. 2008
    ..Cannabidiol will open new therapeutic possibilities for post-ischemic injury via HMGB1-inhibiting mechanism...
  17. ncbi request reprint Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Neurochem 102:1488-96. 2007
    ....
  18. ncbi request reprint Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats
    Takuya Watanabe
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Fukuoka, Japan
    J Pharmacol Sci 106:84-91. 2008
    ..This model may be useful for developing new drugs for the treatment of early-phase Alzheimer's disease...
  19. doi request reprint Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease
    Takuya Watanabe
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 1249:222-8. 2009
    ..Measuring ACh release in this model might be a useful index for the screening of new drugs to treat the early-phase of Alzheimer's disease...
  20. ncbi request reprint Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka City, Fukuoka, Japan
    Brain Res 1188:157-64. 2008
    ..These findings may contribute in setting the basis for interaction of cannabinoids and to find a cannabinoid mechanism in central nervous system...
  21. doi request reprint Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, and Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1516-20. 2008
    ....
  22. ncbi request reprint Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: involvement of 5-HT1A receptors in the dorsal hippocampus in rats
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 1069:54-62. 2006
    ..These findings suggest that 5-HT1A receptors in the DH play an important role in the mechanisms underlying the 8-OH-DPAT-induced impairment of spatial memory in rats...
  23. ncbi request reprint Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Neuropsychopharmacology 30:1996-2005. 2005
    ..The results of the present study indicate that V1bR may be involved in the regulation of PPI of the startle reflex. The V1bR has been considered an important molecular target for the development of antipsychotic drugs...
  24. doi request reprint Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Eur J Pharmacol 586:164-70. 2008
    ..By contrast, amantadine (30 mg/kg, i.p.) did not affect prepulse inhibition. These findings suggest that amantadine could be a useful drug for the treatment of OCD...
  25. ncbi request reprint Antipsychotics improve Delta9-tetrahydrocannabinol-induced impairment of the prepulse inhibition of the startle reflex in mice
    Hiroshi Nagai
    Department of Psychiatry, Fukuoka University School of Medicine, Fukuoka 814 0180, Japan
    Pharmacol Biochem Behav 84:330-6. 2006
    ..These results suggest that dopaminergic hyperfunction in the nucleus accumbens may be involved in THC-induced PPI deficits...
  26. ncbi request reprint Characteristics of behavioral abnormalities in alpha1d-adrenoceptors deficient mice
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka 814 0180, Japan
    Behav Brain Res 152:365-73. 2004
    ....
  27. ncbi request reprint Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    J Pharmacol Sci 109:424-30. 2009
    ..These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area...
  28. ncbi request reprint Delta9-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in rats
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Fukuoka 814 0180, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:499-506. 2008
    ..Therefore, olanzapine could attenuate the acute short-term and working memory deficits induced by cannabis...
  29. ncbi request reprint Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 104:329-34. 2007
    ..These results suggest that in this repeated cerebral ischemia model, the 4-oxo group and the 2,3-double bond in the C ring of rutin and quercetin are related to their neuroprotective action...
  30. doi request reprint Prevention of oxaliplatin-induced mechanical allodynia and neurodegeneration by neurotropin in the rat model
    Takehiro Kawashiri
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Eur J Pain 15:344-50. 2011
    ....
  31. ncbi request reprint Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder
    Michihiko Matsushita
    Department of Psychiatry, Fukuoka University School of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    J Pharmacol Sci 99:154-9. 2005
    ..These findings suggest that perospirone may exhibit anti-OCD activity in clinical use and that 5-HT(1A)-receptor agonistic activity may be involved in the inhibition of marble-burying behavior by perospirone...
  32. ncbi request reprint Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Pharmacol Biochem Behav 83:161-7. 2006
    ..Taken together these findings suggest that low dose citalopram is useful for the treatment of memory deficits and consciousness disturbance...
  33. ncbi request reprint Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka, Japan
    Life Sci 80:1466-71. 2007
    ....
  34. ncbi request reprint Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka, University, 8 19 1, Nanakuma, Fukuoka 814 0180, Japan
    Eur J Pharmacol 550:117-22. 2006
    ..On the other hand, WAY100635 (0.3 and 1 mg/kg, i.p.) enhanced the catalepsy-like immobilization induced by THC (6 mg/kg, i.p.). These findings suggest that the 5-HT(1A) receptors are involved in THC-induced catalepsy-like immobilization...
  35. ncbi request reprint Effectiveness and safety of antiemetic aprepitant in Japanese patients receiving high-dose chemotherapy prior to autologous hematopoietic stem cell transplantation
    Mayako Uchida
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Biol Pharm Bull 36:819-24. 2013
    ..In conclusion, the results of this study suggest that the addition of aprepitant to granisetron can improve the antiemetic effect without increasing ADEs in patients receiving high-dose chemotherapy prior to auto-PBSCT...
  36. ncbi request reprint Protective effect of buckwheat polyphenols against long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 94:393-402. 2004
    ..These results suggested that BWP might ameliorate spatial memory impairment by inhibiting glutamate release and the delayed generation of NO(x)(-) in rats subjected to repeated cerebral ischemia...
  37. ncbi request reprint Protective effect of Toki-shakuyaku-san on amyloid beta25-35-induced neuronal damage in cultured rat cortical neurons
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Phytother Res 19:450-3. 2005
    ..These results suggest that TSS has a protective effect against Abeta25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD...
  38. ncbi request reprint Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma Jonan ku, Fukuoka University, Fukuoka 814 0180, Japan
    Behav Brain Res 178:123-7. 2007
    ....
  39. doi request reprint Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka, 814 0180 Japan
    Stroke 39:951-8. 2008
    ..However, the cerebroprotective mechanism of minocycline remains unclear. In the present study, we investigated that mechanism of minocycline in a murine model of 4-hour middle cerebral artery (MCA) occlusion...
  40. ncbi request reprint Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Phytother Res 21:126-9. 2007
    ..Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits...
  41. ncbi request reprint Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 995:131-9. 2004
    ..YM-90K could provide neuroprotective activity and improve the spatial memory impaired by repeated ischemia...
  42. ncbi request reprint Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka, 814 0180, Japan
    Neuroreport 15:2381-5. 2004
    ....
  43. ncbi request reprint Post-ischemic treatment with toki-shakuyaku-san (tang-gui-shao-yao-san) prevents the impairment of spatial memory induced by repeated cerebral ischemia in rats
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University Fukuoka 814 0180, Japan
    Am J Chin Med 33:475-89. 2005
    ..These results suggested that the TSS has neuroprotective action which may be indirectly mediated by the AMPA receptor, and TSS may be beneficial for the treatment of cerebrovascular dementia...
  44. ncbi request reprint Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka City, Fukuoka, Japan
    Stroke 36:1077-82. 2005
    ..Cannabidiol has been reported to be a neuroprotectant, but the neuroprotective mechanism of cannabidiol remains unclear. We studied the neuroprotective mechanism of cannabidiol in 4-hour middle cerebral artery (MCA) occlusion mice...
  45. ncbi request reprint 2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 105:361-6. 2007
    ..p.). Thus, on the basis of these results, it appears that 5-HT(2A)-receptor mechanisms might be responsible for the inhibitory effect of DOI on THC-induced catalepsy-like immobilization...
  46. ncbi request reprint Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Brain Res 1097:216-23. 2006
    ..These findings suggest that ischemia is an important factor facilitating the symptoms of Alzheimer's disease, and this model may be useful for developing new drugs for the treatment of Alzheimer's disease...
  47. ncbi request reprint Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    J Pharmacol Sci 93:188-96. 2003
    ..Nilvadipine may have a neuroprotective effect and could be a useful pharmacotherapeutic agent for cerebrovascular dementia...
  48. ncbi request reprint Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Biol Pharm Bull 30:698-701. 2007
    ..These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD)...
  49. ncbi request reprint Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Pharmacol Sci 105:211-4. 2007
    ..These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABA(A) receptors...
  50. ncbi request reprint The serotonin1A receptor agonist 8-OHDPAT reverses delta 9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats
    Keiichrio Inui
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Neurotox Res 6:153-8. 2004
    ..These findings suggest that low doses of 8-OHDPAT may improve delta9-tetrahydrocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus...
  51. doi request reprint Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury
    Takaaki Yamada
    Department of Pharmacy, Kyushu University Hospital, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Free Radic Biol Med 52:1285-93. 2012
    ..These results indicate that an activation of p38 MAPK by oxidative stress is involved in the epirubicin-induced endothelial cell injury...
  52. ncbi request reprint Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 814 0180, Fukuoka, Japan
    Life Sci 72:397-407. 2002
    ..These findings suggest that inhibition of the cholinergic pathway by reduced acetylcholine release is one of the means by which Delta9-tetrahydrocannabinol impairs spatial memory in the 8-arm radial maze...
  53. ncbi request reprint V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurosci Lett 356:195-8. 2004
    ..Moreover, OPC-21268, a selective V1aR antagonist, impaired spatial memory in the eight-arm radial maze in WT mice characterized by an increased number of errors. These results suggest that the V1aR controls spatial memory in mice...
  54. ncbi request reprint Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Fukuoka 814 0180, Japan
    Brain Res 1059:7-12. 2005
    ..These results suggest that R406W Tg mice exhibit changes in depression-related behavior involving serotonergic neurons and provide an animal model for investigating AD with depression...
  55. doi request reprint Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia
    Fengling Pu
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Nat Med 64:167-74. 2010
    ..These data suggest neuroprotection with KGKR requires continuous pre-ischemic treatment, and that the mechanisms of protection may be involved in inhibiting the glutamatergic receptors of the post-synaptic neurons...
  56. pmc Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats
    Yuki Mihara
    Department of Pharmacy, Kyushu University Hospital, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Pain 7:8. 2011
    ..In the present study, we investigated the involvement of NR2B-containing N-methyl-D-aspartate (NMDA) receptors in oxaliplatin-induced mechanical allodynia in rats...
  57. pmc L type Ca²+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats
    Takehiro Kawashiri
    Department of Pharmacy, Kyushu University Hospital, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Pain 8:7. 2012
    ..In the present study, we examined the effects of Ca²⁺ channel blockers on oxaliplatin-induced cold hyperalgesia in rats...
  58. pmc Inhibition of Ca2+/calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in rats
    Masafumi Shirahama
    Department of Pharmacy, Kyushu University Hospital, Higashi ku, Fukuoka, Japan
    Mol Pain 8:26. 2012
    ....
  59. ncbi request reprint Role of 5-hydroxytryptamine2C receptors in marble-burying behavior in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Biol Pharm Bull 35:376-9. 2012
    ..Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT(2C) receptors play a role in marble-burying behavior in mice...
  60. ncbi request reprint Repeated cerebral ischemia induced hippocampal cell death and impairments of spatial cognition in the rat
    Eun hee Chung
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814 0180, Japan
    Life Sci 72:609-19. 2002
    ..The repeated cerebral ischemia model which produces cell death and ACh dysfunction in the hippocampus is thought to be useful for evaluating new drugs for the treatment of cerebrovascular dementia...
  61. ncbi request reprint Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia
    Keiichi Irie
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 814 0180, Fukuoka, Japan
    Life Sci 72:621-9. 2002
    ..These results suggest that spatial memory impairment at 7 days after repeated ischemia may be related to apoptosis in hippocampal CA1 cells...
  62. ncbi request reprint Hypoxia-ischemic insult in neonatal rats induced slowly progressive brain damage related to memory impairment
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka 814 0180 Japan
    Neurosci Lett 376:194-9. 2005
    ....
  63. ncbi request reprint Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats
    Kenichi Mishima
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka 814 0180, Japan
    Behav Brain Res 151:209-17. 2004
    ..These outcomes clearly show that temperature regulation during HI insult plays an important role in the induction of behavioral and histological changes following neonatal HI insult in rats...
  64. doi request reprint Pemirolast reduces cisplatin-induced kaolin intake in rats
    Yoko Tatsushima
    Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan
    Eur J Pharmacol 661:57-62. 2011
    ..These results suggest that substance P is involved in cisplatin-induced kaolin intake in rats, and pemirolast reduces kaolin intake by inhibition of substance P release...
  65. ncbi request reprint Ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats
    Katsunori Iwasaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurotox Res 6:299-309. 2004
    ....
  66. doi request reprint Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents
    Soichiro Ushio
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Eur J Cancer 48:1407-13. 2012
    ....
  67. doi request reprint Oxaliplatin-induced neuropathy in the rat: involvement of oxalate in cold hyperalgesia but not mechanical allodynia
    Mariko Sakurai
    Department of Pharmacy, Kyushu University Hospital, Higashi ku, Fukuoka, Japan
    Pain 147:165-74. 2009
    ..These findings suggest the involvement of oxalate in oxaliplatin-induced cold hyperalgesia but not mechanical allodynia, and usefulness of prophylactic treatments with calcium and magnesium on the acute peripheral neuropathy...
  68. ncbi request reprint Involvement of 5-hydroxytryptamine neuronal system in Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory
    Nobuaki Egashira
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Eur J Pharmacol 445:221-9. 2002
    ..These results suggest that the 5-HT neuronal system may be involved in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory...
  69. ncbi request reprint Protective effects of amino acids against gabexate mesilate-induced cell injury in porcine aorta endothelial cells
    Tomoko Aki
    Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan
    J Pharmacol Sci 107:238-45. 2008
    ..These findings suggest that Gly exerts protection against GM-induced cellular membrane injury, and several amino acids such as Gly may be useful for prophylaxis of the GM-induced severe vascular injury...
  70. ncbi request reprint Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress
    Kazunori Sano
    Advanced Materials Institute, Fukuoka University, 8 19 1 Nanakuma, Fukuoka, 814 0180, Japan
    Biol Pharm Bull 32:2065-7. 2009
    ..This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB(1) receptor, thereby increasing the risk of depression...
  71. doi request reprint Role of oxidative stress in vinorelbine-induced vascular endothelial cell injury
    Takaaki Yamada
    Department of Pharmacy, Kyushu University Hospital, Fukuoka 812 8582, Japan
    Free Radic Biol Med 48:120-7. 2010
    ..These results clearly demonstrate that VNR induces oxidative stress by depleting intracellular GSH and increasing ROS production in PAECs, and oxidative stress plays an important role in the VNR-induced cell injury...
  72. ncbi request reprint Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABA(A) - Benzodiazepine Receptor Complex
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    J Pharmacol Sci 116:316-20. 2011
    ..p.), but not WAY100635. These findings suggest that the GABA(A) - benzodiazepine receptor complex, but not 5-HT(1A) receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation...
  73. ncbi request reprint High-cholesterol feeding aggravates cerebral infarction via decreasing the CB1 receptor
    Kazuhide Hayakawa
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka 814 0180, Japan
    Neurosci Lett 414:183-7. 2007
    ....
  74. ncbi request reprint Intracerebral microinjections of delta 9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats
    Nobuaki Egashira
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814 0180, Japan
    Brain Res 952:239-45. 2002
    ..These results suggest that DH and VH may be important brain sites for the delta(9)-THC-induced impairment of spatial memory...
  75. ncbi request reprint Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice
    Kenta Umeda
    Department of Neuropharmacology Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Eur J Pharmacol 553:157-62. 2006
    ..3 mg/kg, s.c.), lithium carbonate exacerbated the dizocilpine-induced disruption. These results suggest that valproate, carbamazepine and lithium carbonate reverse the disruption of prepulse inhibition through the dopaminergic system...
  76. doi request reprint Involvement of substance P in peripheral neuropathy induced by paclitaxel but not oxaliplatin
    Yoko Tatsushima
    Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan
    J Pharmacol Exp Ther 337:226-35. 2011
    ..Oxaliplatin, by contrast, did not increase the release of substance P. These results suggest that substance P is involved in paclitaxel-induced neuropathy, and the mechanism of its action is clearly different from that of oxaliplatin...
  77. ncbi request reprint Timing of expression of blood coagulation abnormality in patients treated with warfarin and s-1 concomitantly
    Takaaki Yamada
    Department of Pharmacy, Kyushu University Hospital, Maidashi, Higashi ku, Fukuoka, Japan
    Yakugaku Zasshi 130:955-60. 2010
    ..These results suggest that the careful monitoring of the blood coagulation ability is necessary in all patients receiving warfarin and S-1 concomitantly...
  78. pmc Amphotericin B-induced renal tubular cell injury is mediated by Na+ Influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2+ concentration
    Takahisa Yano
    Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan
    Antimicrob Agents Chemother 53:1420-6. 2009
    ....
  79. ncbi request reprint Characteristics of gabexate mesilate-induced cell injury in porcine aorta endothelial cells
    Tomoko Aki
    Department of Pharmacy, Kyushu University Hospital, Japan
    J Pharmacol Sci 106:415-22. 2008
    ..0 mM)-treated cells. Surprisingly, GM (2.0 mM) immediately increased cellular uptake of propidium iodine. These findings suggest that GM induces necrotic cell death via injury of the cell membrane...
  80. ncbi request reprint Neuroprotective effect of gamma-glutamylethylamide (theanine) on cerebral infarction in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurosci Lett 363:58-61. 2004
    ..These results suggest that theanine directly provides neuroprotection against focal cerebral ischemia and may be clinically useful for preventing cerebral infarction...
  81. ncbi request reprint Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin
    Takahisa Yano
    Department of Pharmacy, Kyushu University Hospital, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Apoptosis 12:1901-9. 2007
    ....
  82. doi request reprint Combined treatment with L-carnitine and a pan-caspase inhibitor effectively reverses amiodarone-induced injury in cultured human lung epithelial cells
    Takahisa Yano
    Department of Pharmacy, Kyushu University Hospital, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Apoptosis 13:543-52. 2008
    ..These finding suggest that different intracellular events operate to cause apoptosis and necrosis after exposure of pulmonary epithelial cells to amiodarone...
  83. ncbi request reprint Impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with changes in the hippocampal cholinergic and noradrenergic contents
    Takashi Egawa
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, Japan
    Behav Brain Res 129:31-9. 2002
    ..These results suggest that the impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with dysfunction of the hippocampal cholinergic and noradrenergic systems...
  84. ncbi request reprint Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats
    Shinji Katsuragi
    Department of Obstetrics and Gynecology, Miyazaki Medical College, Kiyotake cho, Miyazaki, Japan
    Am J Obstet Gynecol 192:1028-37. 2005
    ..We examined the effect of glial cell line-derived neurotrophic factors on long-term learning and memory impairment and morphological changes up to 18 weeks after hypoxic-ischemic stress in neonatal rats...
  85. ncbi request reprint Effect of Toki-shakuyaku-san on acetylcholine level and blood flow in dorsal hippocampus of intact and twice-repeated ischemic rats
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Kinikli, Denizli 20070, Turkey
    Phytother Res 21:291-4. 2007
    ..TSS also increased ACh in ischemic rats but to a lesser extent than in intact rats. These results could suggest that TSS-increased ACh and blood flow in DH may contribute in the cognition improving property of TSS...
  86. ncbi request reprint Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice
    Fujio Umehara
    Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka 8 35 1, Kagoshima, Japan
    Behav Brain Res 174:167-73. 2006
    ..These behavioral abnormalities of Dhh KO male mice may be due to lower testosterone levels with abnormal development of the testes caused by Dhh-null mutation...
  87. ncbi request reprint Comparison of single- and repeated-ischemia-induced changes in expression of flip and flop splice variants of AMPA receptor subtypes GluR1 and GluR2 in the rats hippocampus CA1 subregion
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Turkey
    J Pharmacol Sci 103:83-91. 2007
    ..These results reveal the differential effects of the SI and RI on memory and expression of the AMPARs subunits GluR1 and GluR2 and their flip and flop variants in the CA1...
  88. ncbi request reprint Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy
    Jesmin I Noor
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Stroke 36:2468-74. 2005
    ..We examined the effect of edaravone on the optimal duration of treatment, the long-term effect on the brain, and the effect on learning and memory disability in a rat model of neonatal hypoxic-ischemic encephalopathy...
  89. ncbi request reprint Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale, University, Denizli, Turkey
    Life Sci 75:1967-78. 2004
    ..These results suggest that direct inhibition of PARP and caspase-3, but not of caspase-1, prevents apoptosis and improves spatial memory impaired by repeated ischemia...
  90. ncbi request reprint Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    J Pharmacol Sci 96:33-41. 2004
    ..The improving effect of TSS is produced greatly by the Toki component, the activity of which was greatly produced by the fraction extracted by butanol...
  91. ncbi request reprint Dexamethasone prevents long-lasting learning impairment following a combination of lipopolysaccharide and hypoxia-ischemia in neonatal rats
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Am J Obstet Gynecol 192:719-26. 2005
    ....
  92. ncbi request reprint Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki 889 16, Japan
    Am J Obstet Gynecol 191:2132-41. 2004
    ..We assessed the long-term effects of perinatal hypoxia-ischemia and endotoxin on attention and short- and long-term memory in neonatal rats with the use of behavioral tasks and brain histologic results...
  93. ncbi request reprint Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats
    Izzettin Hatip-Al-Khatib
    Division of Internal Medicine, Department of Pharmacology, Faculty of Medicine, Pamukkale University, Denizli 20070, Turkey
    Brain Res 1012:169-76. 2004
    ..On the other hand, the fast and specific effect of TAK-147 may be useful for cure of early stages of Alzheimer's disease (AD)...
  94. pmc Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats
    Izzettin Hatip-Al-Khatib
    Department of Pharmacology, Division of Internal Medicine, Faculty of Medicine, Pamukkale University, Kinikli, Denizli 20070, Turkey
    Br J Pharmacol 145:1035-44. 2005
    ....
  95. pmc Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation
    Tetsuro Murakami
    Department of Neurology, Neuroscience, Biophysiological Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558 Japan
    Am J Pathol 169:1365-75. 2006
    ..These transgenic mice may aid therapeutic development for FTDP-17 and other diseases featuring accumulations of four-repeat tau, such as Alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy...
  96. ncbi request reprint Rehabilitative training tasks improve spatial learning impairment in the water maze following hypoxic-ischemic insult in neonatal rats
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Kihara, Japan
    Pediatr Res 59:61-5. 2006
    ..Rehabilitative training tasks prevented the neonatal HI-induced late-onset slowly progressive learning and memory disability...