Akinori Egashira

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint p53 gene mutations in esophageal squamous cell carcinoma and their relevance to etiology and pathogenesis: results in Japan and comparisons with other countries
    Akinori Egashira
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 98:1152-6. 2007
  2. doi request reprint DNA repair dysfunction in gastrointestinal tract cancers
    Yoshihiko Maehara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 99:451-8. 2008
  3. doi request reprint Loss of p53 in esophageal squamous cell carcinoma and the correlation with survival: analyses of gene mutations, protein expression, and loss of heterozygosity in Japanese patients
    Akinori Egashira
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Surg Oncol 104:169-75. 2011
  4. ncbi request reprint Assessment of predictors of mortality and severity in patients with colorectal perforation
    Akinori Egashira
    Department of Surgery, Fukuoka Higashi Medical Center, Fukuoka, Japan
    Fukuoka Igaku Zasshi 102:56-65. 2011
  5. doi request reprint Phase II study of biweekly docetaxel and S-1 combination therapy for advanced or recurrent gastric cancer
    Yoshihiro Kakeji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncology 77:49-52. 2009
  6. doi request reprint Patterns and time of recurrence after complete resection of esophageal cancer
    Masahiko Sugiyama
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 42:752-8. 2012
  7. doi request reprint Lymph node metastasis from cancer of the esophagogastric junction, and determination of the appropriate nodal dissection
    Yoshihiro Kakeji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 42:351-8. 2012
  8. ncbi request reprint [A randomized controlled trial to evaluate the effect of adjuvant oral fluoropyrimidine derivative therapy after curative resection for stage II/III rectal cancer-adjuvant chemotherapy trial of S-1 for rectal cancer (ACTS-RC):]
    Eiji Oki
    Dept of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gan To Kagaku Ryoho 33:138-43. 2006
  9. doi request reprint Esophagectomy in patients 80 years of age and older with carcinoma of the thoracic esophagus
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Gastroenterol 43:345-51. 2008
  10. doi request reprint Two-stage operation for high-risk patients with thoracic esophageal cancer: an old operation revisited
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 18:2613-21. 2011

Collaborators

Detail Information

Publications47

  1. ncbi request reprint p53 gene mutations in esophageal squamous cell carcinoma and their relevance to etiology and pathogenesis: results in Japan and comparisons with other countries
    Akinori Egashira
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 98:1152-6. 2007
    ..In addition, we observed a peculiar sequence of frameshift mutations. Taken together, these data suggest that this tumor suppressor gene plays a critical role in the multistep carcinogenesis process for esophageal squamous cell cancer...
  2. doi request reprint DNA repair dysfunction in gastrointestinal tract cancers
    Yoshihiko Maehara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 99:451-8. 2008
    ..This review focuses on the function of DNA mismatch repair and oxidative DNA/nucleotide repair among various DNA repair systems in cells, both of which are essentially involved in the carcinogenesis of gastrointestinal tract cancer...
  3. doi request reprint Loss of p53 in esophageal squamous cell carcinoma and the correlation with survival: analyses of gene mutations, protein expression, and loss of heterozygosity in Japanese patients
    Akinori Egashira
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Surg Oncol 104:169-75. 2011
    ..The complexity arises from the different modalities, such as mutation analysis, immunohistochemistry, and the detection of loss of heterozygosity (LOH) at the p53 genomic locus...
  4. ncbi request reprint Assessment of predictors of mortality and severity in patients with colorectal perforation
    Akinori Egashira
    Department of Surgery, Fukuoka Higashi Medical Center, Fukuoka, Japan
    Fukuoka Igaku Zasshi 102:56-65. 2011
    ..In conclusion, CT is necessary for precise diagnosis, and the POSSUM score is helpful for the evaluation of disease mortality and severity...
  5. doi request reprint Phase II study of biweekly docetaxel and S-1 combination therapy for advanced or recurrent gastric cancer
    Yoshihiro Kakeji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncology 77:49-52. 2009
    ..This phase II study evaluated the toxicity and efficacy of a novel dosing schedule of docetaxel and S-1 as treatment for advanced gastric cancer...
  6. doi request reprint Patterns and time of recurrence after complete resection of esophageal cancer
    Masahiko Sugiyama
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 42:752-8. 2012
    ..The purpose of this study is to clarify the characteristics of recurrence in this patient population...
  7. doi request reprint Lymph node metastasis from cancer of the esophagogastric junction, and determination of the appropriate nodal dissection
    Yoshihiro Kakeji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 42:351-8. 2012
    ..Both squamous cell carcinomas and adenocarcinomas can develop in the esophagogastric junction. To clarify the appropriate lymph node dissection range, lymph node metastases from cancers in the esophagogastric junction were investigated...
  8. ncbi request reprint [A randomized controlled trial to evaluate the effect of adjuvant oral fluoropyrimidine derivative therapy after curative resection for stage II/III rectal cancer-adjuvant chemotherapy trial of S-1 for rectal cancer (ACTS-RC):]
    Eiji Oki
    Dept of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gan To Kagaku Ryoho 33:138-43. 2006
    ..We aim to include 400 patients in each of the treatment groups and assume that the registration period will last until 2009...
  9. doi request reprint Esophagectomy in patients 80 years of age and older with carcinoma of the thoracic esophagus
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Gastroenterol 43:345-51. 2008
    ..The purpose of this study was to clarify the indications for an esophagectomy in elderly patients (especially patients over 80 years of age) with esophageal cancer...
  10. doi request reprint Two-stage operation for high-risk patients with thoracic esophageal cancer: an old operation revisited
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 18:2613-21. 2011
    ..An esophagectomy followed by reconstruction for esophageal cancer is a highly aggressive operation. The purpose of this study was to justify a two-stage operation for high-risk patients with esophageal cancer...
  11. ncbi request reprint Clinical significance of cytokeratin positive cells in bone marrow of gastric cancer patients
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Cancer Res Clin Oncol 133:995-1000. 2007
    ..Therefore it does not accurately predict the prognosis or recurrence of the disease...
  12. ncbi request reprint Adenocarcinoma of the esophagogastric junction in Japan
    Manabu Yamamoto
    Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University Fukuoka, Japan
    Hepatogastroenterology 55:103-7. 2008
    ..In particular, the clinical features and prognosis of adenocarcinoma of the esophagogastric junction and the differences between Siewert's type II and III tumors in Japan were evaluated...
  13. doi request reprint The difference in p53 mutations between cancers of the upper and lower gastrointestinal tract
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Digestion 79:33-9. 2009
    ..This study investigated the differences in p53 abnormalities between cancers of the upper and lower gastrointestinal tract...
  14. ncbi request reprint Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Breast Cancer Res Treat 101:249-57. 2007
    ..Our results suggest that simultaneous PTEN LOH and HER2 overexpression enhances Akt activation and may thus lead to a negative PR expression...
  15. doi request reprint Advances in esophageal cancer surgery in Japan: an analysis of 1000 consecutive patients treated at a single institute
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 143:499-508. 2008
    ..The object of this study was to evaluate advances in operative therapy for esophageal cancer in Japan...
  16. doi request reprint Gastric cancer in the reconstructed gastric tube after radical esophagectomy: a single-center experience
    Eiji Oki
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Today 41:966-9. 2011
    ..This study investigated 10 cases of gastric tube cancer in order to clarify the characteristics and the outcome of these patients...
  17. doi request reprint Laparoscopic resection for gastrointestinal stromal tumors in the stomach
    Yoshihiro Kakeji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Surg Today 42:554-8. 2012
    ..This study reviewed the use of laparoscopic surgery for gastric partial resection of GISTs or SMTs that were suspected to be GISTs...
  18. doi request reprint A multicenter phase II clinical study of oxaliplatin, folinic acid, and 5-fluorouracil combination chemotherapy as first-line treatment for advanced colorectal cancer: a Japanese experience
    Hideo Baba
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Surg Today 41:1610-6. 2011
    ....
  19. doi request reprint Clinical significance of salvage esophagectomy for remnant or recurrent cancer following definitive chemoradiotherapy
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Gastroenterol 46:1284-91. 2011
    ..The purpose of this study was to clarify the effect of preoperative chemoradiotherapy (CRT) for esophageal cancer on the postoperative course, and to determine the clinical significance of salvage esophagectomy after definitive CRT...
  20. doi request reprint Pathological prognostic score as a simple criterion to predict outcome in gastric carcinoma
    Tadahiro Nozoe
    Department of Surgery, Fukuoka Higashi Medical Center, Chidori, Koga, Japan
    J Surg Oncol 102:73-6. 2010
    ..The aim of this study was to establish a simple criterion to predict prognosis of patients with gastric carcinoma...
  21. doi request reprint Significance of modified Glasgow prognostic score as a useful indicator for prognosis of patients with gastric carcinoma
    Tadahiro Nozoe
    Department of Surgery, Fukuoka Higashi Medical Center, Koga, Japan
    Am J Surg 201:186-91. 2011
    ..The significance of the Glasgow prognostic score (GPS), an inflammation-based prognostic score, as an indicator of aggressiveness in gastric carcinoma has not been investigated fully...
  22. ncbi request reprint Trastuzumab and breast cancer: developments and current status
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Int J Clin Oncol 11:199-208. 2006
    ..In this review, we describe the developments and current status of trastuzumab-based treatment for breast cancer...
  23. doi request reprint Primary neuroendocrine carcinoma of the breast: report of a case
    Tadahiro Nozoe
    Department of Surgery, Fukuoka Higashi Medical Center, 1 1 1 Chidori, Koga, 811 3195, Japan
    Surg Today 41:829-31. 2011
    ..We herein report the case of a 57-year-old female patient with primary NEC of the breast who underwent a surgical resection and for whom the suitable adjuvant therapy is now being considered...
  24. ncbi request reprint p53 protein accumulation in multiple oesophageal squamous cell carcinoma: relationship to risk factors
    Hiroshi Saeki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncology 62:175-9. 2002
    ..These findings are considered to support the concept of field carcinogenesis of the oesophagus...
  25. ncbi request reprint Deregulation of the Akt pathway in human cancer
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Curr Cancer Drug Targets 8:27-36. 2008
    ..In this review, we describe Akt signaling pathway components and its cellular functions as well as the alterations in human cancers and the therapeutic approaches for targeting the Akt pathway in cancer...
  26. doi request reprint Immunohistochemical expression of epidermal growth factor receptor in breast cancer
    Tadahiro Nozoe
    Department of Surgery, Fukuoka Higashi Medical Center, 1 1 1 Chidori, Koga, Japan
    Breast Cancer 18:37-41. 2011
    ..The aim of the current study was to determine the further significance of immunohistochemical expression of EGFR in breast cancer...
  27. doi request reprint Repair using the pectoralis major muscle flap for anastomotic leakage after esophageal reconstruction via the subcutaneous route
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 147:212-8. 2010
    ..Anastomotic leakage with an intractable cutaneous fistula frequently develops after an esophagectomy and reconstruction via the subcutaneous route...
  28. ncbi request reprint Overexpression of hypoxia-inducible factor 1alpha and p53 is a marker for an unfavorable prognosis in gastric cancer
    Yasushi Sumiyoshi
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka and Department of Surgery, Saga Prefectural Hospital Koseikan, Saga, Japan
    Clin Cancer Res 12:5112-7. 2006
    ..To investigate the effects of the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and p53 on the prognosis of human gastric cancer, the clinicopathologic characteristics of the tumors and the clinical outcome were analyzed...
  29. doi request reprint Successful treatment of acute esophageal necrosis caused by intrathoracic gastric volvulus: report of a case
    Noritaka Matsumoto
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 39:1068-72. 2009
    ..Although a large hiatal hernia is usually a chronic disorder, surgical treatment is recommended, considering the risk of serious complications...
  30. ncbi request reprint [Reoperation for the reconstruction organ necrosis after esophagectomy]
    Akinori Egashira
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Kyobu Geka 66:767-71. 2013
    ..Here, we will summarize the way of diagnosis and treatment for the necrosis of reconstructed organs and present 2 cases of reconstruction organ necrosis (gastric tube and ascending colon) after esophagectomy in our institute. ..
  31. doi request reprint Hepatic aflatoxin B1-DNA adducts and TP53 mutations in patients with hepatocellular carcinoma despite low exposure to aflatoxin B1 in southern Japan
    Ken Shirabe
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Liver Int 31:1366-72. 2011
    ..Mutations in codon 249, exon 7 are a hallmark of AFB1 exposure. Therefore, to clarify the role of AFB1 in hepatocarcinogenesis, we examined AFB1-DNA in liver tissue and sequenced TP53 in Japanese patients with HCC...
  32. ncbi request reprint Neoadjuvant chemoradiotherapy for clinical stage II-III esophageal squamous cell carcinoma
    Hiroshi Saeki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Anticancer Res 31:3073-7. 2011
    ..The clinical significance of neoadjuvant chemoradiotherapy (NACRT) for potentially resectable esophageal squamous cell carcinoma (ESCC) is unclear...
  33. doi request reprint Proctocolectomy for colon cancer associated with ulcerative colitis a few months after living donor liver transplantation for primary sclerosing cholangitis: report of a case
    Takasuke Fukuhara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 39:59-63. 2009
    ..Moreover, surgery, such as radical resection of the colon and rectum should be performed without delay, even shortly after LDLT. To our knowledge, this is the first report of a patient undergoing proctocolectomy after LDLT...
  34. ncbi request reprint Characteristic risk factors in cirrhotic patients for posthepatectomy complications: comparison with noncirrhotic patients
    Shinji Itoh
    Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan
    Am Surg 80:166-70. 2014
    ....
  35. ncbi request reprint [Combination chemotherapy of S-1 plus biweekly docetaxel for advanced and recurrent gastric cancer]
    Ikuo Takahashi
    Dept of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Japan
    Gan To Kagaku Ryoho 33:87-90. 2006
    ..The S-1 +biweekly DOC combination therapy can be a candidate for outpatient chemotherapy for advanced or recurrent gastric cancer...
  36. ncbi request reprint [Development of a molecular target therapy on the basis of global gene analyses of gastrointestinal carcinoma]
    Yoshihiko Maehara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
    Fukuoka Igaku Zasshi 97:30-6. 2006
  37. doi request reprint Epigenetic alterations and their clinical implications in esophageal squamous cell carcinoma
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Gen Thorac Cardiovasc Surg 61:262-9. 2013
    ..Clinical implications of these epigenetic alterations in ESCC will be also discussed...
  38. ncbi request reprint Aberrant hypermethylation of the promoter region of the CHFR gene is rare in primary breast cancer
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Higashi ku, Japan
    Breast Cancer Res Treat 97:199-203. 2006
    ..We observed the hypermethylation of the CHFR promoter region in only one case (0.9%). We herein show that the aberrant hypermethylation of this region is quite a rare event in primary breast carcinoma...
  39. ncbi request reprint MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis
    Katsumi Sakamoto
    Departments of Medical Biophysics and Radiation Biology, Clinical Radiology, and Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi Higashi ku, Fukuoka 812 8582, Japan
    Cancer Res 67:6599-604. 2007
    ....
  40. pmc Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer
    Rintaro Yoshida
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Hum Genet 19:320-5. 2011
    ..Our observations may suggest previously unrecognised complexities in the molecular abnormalities underlying the mutator phenotype in human neoplasms...
  41. ncbi request reprint Results of laparoscopic gastrectomy for early gastric cancer in high-risk patients - estimation of surgical risk of gastrectomy
    Kenichi Koushi
    Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan
    Hepatogastroenterology 60:207-12. 2013
    ..Surgical risk of laparoscopic gastrectomy for gastric cancer in high risk patients was evaluated with E-PASS scoring system...
  42. ncbi request reprint Current topics and the clinical effects of target-based antineoplastic agents
    Yoshihiko Maehara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Int J Clin Oncol 11:164-6. 2006
  43. ncbi request reprint Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes
    Akinori Egashira
    Department of Medical Biophysics and Radiation Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    DNA Repair (Amst) 1:881-93. 2002
    ..These results suggest a possible involvement of multiple anti-mutagenic pathways, including the MTH1 protein and other repair system(s), in mutagenesis caused by the oxidized nucleotides...
  44. ncbi request reprint Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis
    Koshi Araki
    Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Cancer 94:570-5. 2002
    ..However, indications for EMR use in cases of superficial esophageal carcinoma are controversial. The authors evaluated histopathologic risk factors for lymph node metastasis and recurrence...
  45. ncbi request reprint [Molecular target therapy for colonic neoplasms]
    Eiji Oki
    Nihon Naika Gakkai Zasshi 96:289-94. 2007
  46. ncbi request reprint Considerable multiple esophageal carcinoma. Implications of a new clinical entity
    Hiroyuki Kuwano
    Department of General Surgical Science Surgery I, Gunma University, Graduate School of Medicine, Gunma, Japan
    Hepatogastroenterology 51:1713-6. 2004
    ..There have also been some cases with three or more intra-esophageal cancers, however, no detailed clinicopathologic study has yet been performed in the literature...
  47. pmc Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability
    Shinya Oda
    Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka 811 1395, Japan
    Nucleic Acids Res 33:1628-36. 2005
    ..The relationship between MSI and defective mismatch repair may be more complex than hitherto suspected...