Daisuke Harada

Summary

Affiliation: Kyowa Hakko Kogyo Co
Country: Japan

Publications

  1. ncbi request reprint Analyses of a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application
    Daisuke Harada
    Department of Allergy Research, Kyowa Hakko Kogyo Co, Ltd, Sunto gun, Sizuoka 411 8731, Japan
    J Dermatol Sci 37:159-67. 2005
  2. ncbi request reprint Effect of orally administered rolipram, a phosphodiesterase 4 inhibitor, on a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application
    Daisuke Harada
    Department of Allergy Research, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd 1188 Shimotogari, Nagaizumi cho, Sunto gun, Sizuoka 411 8731, Japan
    Eur J Pharmacol 532:128-37. 2006
  3. doi request reprint Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models
    Daisuke Harada
    Department of Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Sizuoka 411 8731, Japan
    Int Immunopharmacol 9:55-62. 2009
  4. ncbi request reprint Pharmacological characterization of itch-associated response induced by repeated application of oxazolone in mice
    Yukihito Tsukumo
    Pharmacological Research Laboratories, Kyowa Hakko Kirin Co, Ltd, Nagaizumi cho, Shizuoka, Japan
    J Pharmacol Sci 113:255-62. 2010
  5. ncbi request reprint Staphylococcus aureus peptidoglycan stimulates granulocyte macrophage colony-stimulating factor production from human epidermal keratinocytes via mitogen-activated protein kinases
    Masahiro Matsubara
    Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka 411 8731, Japan
    FEBS Lett 566:195-200. 2004
  6. ncbi request reprint [Recent development of new drugs for the treatment of allergic diseases]
    Kenji Ohmori
    Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, Suntogun, Shizuoka, Japan
    Nihon Yakurigaku Zasshi 123:335-48. 2004
  7. doi request reprint Curative effects of phosphodiesterase 4 inhibitors cilomilast, roflumilast, and rolipram in dermatitis mouse model
    Daisuke Harada
    J Dermatol Sci 51:215-9. 2008
  8. ncbi request reprint Association of clinical features with mutation of TECTA in a family with autosomal dominant hearing loss
    Satoshi Iwasaki
    Department of Otolaryngology, Hamamatsu University School of Medicine, Hamamatsu City, Japan
    Arch Otolaryngol Head Neck Surg 128:913-7. 2002
  9. ncbi request reprint Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1
    Daisuke Harada
    Department of Pediatrics, Okayama University, Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Bone 41:273-81. 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Analyses of a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application
    Daisuke Harada
    Department of Allergy Research, Kyowa Hakko Kogyo Co, Ltd, Sunto gun, Sizuoka 411 8731, Japan
    J Dermatol Sci 37:159-67. 2005
    ..The model of chronic dermatitis caused by repeated application of hapten is frequently used as a tool for assessment of the efficacy of a compound or the elucidation of chronic dermatitis...
  2. ncbi request reprint Effect of orally administered rolipram, a phosphodiesterase 4 inhibitor, on a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application
    Daisuke Harada
    Department of Allergy Research, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd 1188 Shimotogari, Nagaizumi cho, Sunto gun, Sizuoka 411 8731, Japan
    Eur J Pharmacol 532:128-37. 2006
    ..The present results suggest that the PDE4 inhibitor is a promising oral medicine for the treatment of chronic skin inflammatory diseases...
  3. doi request reprint Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models
    Daisuke Harada
    Department of Pharmacological Research Laboratories, Research Division, Kyowa Hakko Kirin Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Sizuoka 411 8731, Japan
    Int Immunopharmacol 9:55-62. 2009
    ..Furthermore, KF66490 produced less potent emetic effects than the first generation PDE4 inhibitor, rolipram. The present results suggest that KF66490 has excellent potential as an oral medicine for the treatment of atopic dermatitis...
  4. ncbi request reprint Pharmacological characterization of itch-associated response induced by repeated application of oxazolone in mice
    Yukihito Tsukumo
    Pharmacological Research Laboratories, Kyowa Hakko Kirin Co, Ltd, Nagaizumi cho, Shizuoka, Japan
    J Pharmacol Sci 113:255-62. 2010
    ..These results suggest that leukotriene B(4) receptor and M(3) muscarinic acetylcholine receptor are involved in the itch-associated response induced by repeated application of oxazolone in mice...
  5. ncbi request reprint Staphylococcus aureus peptidoglycan stimulates granulocyte macrophage colony-stimulating factor production from human epidermal keratinocytes via mitogen-activated protein kinases
    Masahiro Matsubara
    Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka 411 8731, Japan
    FEBS Lett 566:195-200. 2004
    ..These results suggested that PGN of S. aureus directly exacerbates inflammation of inflammatory skin disease...
  6. ncbi request reprint [Recent development of new drugs for the treatment of allergic diseases]
    Kenji Ohmori
    Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, Suntogun, Shizuoka, Japan
    Nihon Yakurigaku Zasshi 123:335-48. 2004
    ..Most of these new agents are aimed to inhibit various components of allergic inflammation. The future use of allergic disease therapies hold great promise and excitement...
  7. doi request reprint Curative effects of phosphodiesterase 4 inhibitors cilomilast, roflumilast, and rolipram in dermatitis mouse model
    Daisuke Harada
    J Dermatol Sci 51:215-9. 2008
  8. ncbi request reprint Association of clinical features with mutation of TECTA in a family with autosomal dominant hearing loss
    Satoshi Iwasaki
    Department of Otolaryngology, Hamamatsu University School of Medicine, Hamamatsu City, Japan
    Arch Otolaryngol Head Neck Surg 128:913-7. 2002
    ..Nonsyndromic hearing impairment caused by TECTA mutations has been reported in Austrian, Belgian, Swedish, French, and Lebanese families. The phenotypes and genotypes were different among these families...
  9. ncbi request reprint Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1
    Daisuke Harada
    Department of Pediatrics, Okayama University, Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Bone 41:273-81. 2007
    ..DN-PLCgamma reduced the apoptosis of ATDC5 cells expressing TDII-FGFR3, but over-expression of both DN-PLCgamma and STAT1-C induced apoptosis. Therefore, we conclude that a PLCgamma-STAT1 pathway mediates apoptotic signaling by FGFR3...