Masayuki Yoshikawa

Summary

Affiliation: Kyoto Pharmaceutical University
Country: Japan

Publications

  1. ncbi request reprint Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, 607 8412, Kyoto, Japan
    Bioorg Med Chem 10:1547-54. 2002
  2. pmc Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes
    Li Kun Han
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide, Kumamoto 862 8502, Japan
    BMC Complement Altern Med 5:9. 2005
  3. ncbi request reprint Antidiabetogenic activity of oleanolic acid glycosides from medicinal foodstuffs
    M Yoshikawa
    Kyoto Pharmacetutical University, Japan
    Biofactors 13:231-7. 2000
  4. ncbi request reprint Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    J Nutr 132:1819-24. 2002
  5. ncbi request reprint New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    J Nat Prod 65:1151-5. 2002
  6. ncbi request reprint Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 13:1045-9. 2003
  7. ncbi request reprint Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 66:922-7. 2003
  8. ncbi request reprint New amides and gastroprotective constituents from the fruit of Piper chaba
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto, Japan
    Planta Med 70:152-9. 2004
  9. ncbi request reprint Bioactive saponins and glycosides. XXV. Acylated oleanane-type triterpene saponins from the seeds of tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 55:57-63. 2007
  10. ncbi request reprint Bioactive saponins and glycosides. XXIII. Triterpene saponins with gastroprotective effect from the seeds of Camellia sinensis--theasaponins E3, E4, E5, E6, and E7
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Japan
    Chem Pharm Bull (Tokyo) 53:1559-64. 2005

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, 607 8412, Kyoto, Japan
    Bioorg Med Chem 10:1547-54. 2002
    ....
  2. pmc Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes
    Li Kun Han
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide, Kumamoto 862 8502, Japan
    BMC Complement Altern Med 5:9. 2005
    ..Obesity is closely associated with life-style-related diseases. This study was performed to clarify whether chikusetsusaponins prevent obesity induced in mice by a high-fat diet for 9 weeks...
  3. ncbi request reprint Antidiabetogenic activity of oleanolic acid glycosides from medicinal foodstuffs
    M Yoshikawa
    Kyoto Pharmacetutical University, Japan
    Biofactors 13:231-7. 2000
    ..Furthermore, oleanolic acid glycosides were suggested to suppress the gastric emptying by stimulating the release and/or production of dopamine to act through dopamine2 receptors, which in turn causes the release of prostaglandins...
  4. ncbi request reprint Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    J Nutr 132:1819-24. 2002
    ..01). In conclusion, polyphenolic compounds may be involved in the antiobesity effects of SRHW in rats through inhibition of fat metabolizing enzymes (PL, LPL and GPDH) and enhanced lipolysis...
  5. ncbi request reprint New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    J Nat Prod 65:1151-5. 2002
    ..The flavonol glycosides and prunose I were found to inhibit aldose reductase, while prunoses I and II inhibited platelet aggregation induced by thrombin...
  6. ncbi request reprint Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 13:1045-9. 2003
    ..Anastatins A and B were found to show hepatoprotective effects on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes and their activities were stronger than those of related flavonoids and commercial silybin...
  7. ncbi request reprint Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 66:922-7. 2003
    ..The principal dammarane-type triterpene saponins from the roots and flower buds of Panax notoginseng were found to show potent hepatoprotective effects...
  8. ncbi request reprint New amides and gastroprotective constituents from the fruit of Piper chaba
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto, Japan
    Planta Med 70:152-9. 2004
    ..o., while 5, 7, 8, 10, 12, and 13 also significantly inhibited indomethacin-induced gastric lesions at the same dose...
  9. ncbi request reprint Bioactive saponins and glycosides. XXV. Acylated oleanane-type triterpene saponins from the seeds of tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 55:57-63. 2007
    ..The structures of 1-7 were elucidated on the basis of chemical and physicochemical evidence...
  10. ncbi request reprint Bioactive saponins and glycosides. XXIII. Triterpene saponins with gastroprotective effect from the seeds of Camellia sinensis--theasaponins E3, E4, E5, E6, and E7
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Japan
    Chem Pharm Bull (Tokyo) 53:1559-64. 2005
    ....
  11. ncbi request reprint Hepatoprotective and antioxidative properties of Salacia reticulata: preventive effects of phenolic constituents on CCl4-induced liver injury in mice
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 25:72-6. 2002
    ..These results suggest that the antioxidative activity of the principal phenolic compounds is involved in the hepatoprotective activity of S. reticulata...
  12. ncbi request reprint Bioactive saponins and glycosides. XIX. Notoginseng (3): immunological adjuvant activity of notoginsenosides and related saponins: structures of notoginsenosides-L, -M, and -N from the roots of Panax notoginseng (Burk.) F. H. Chen
    M Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 49:1452-6. 2001
    ....
  13. ncbi request reprint Medicinal flowers. III. Marigold. (1): hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis
    M Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 49:863-70. 2001
    ..Some structure-activity relationships are discussed...
  14. ncbi request reprint Medicinal flowers. II. Inhibitors of nitric oxide production and absolute stereostructures of five new germacrane-type sesquiterpenes, kikkanols D, D monoacetate, E, F, and F monoacetate from the flowers of Chrysanthemum indicum L
    M Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 48:651-6. 2000
    ....
  15. ncbi request reprint Saponins of plants of Panax species collected in Central Nepal, and their chemotaxonomical significance. III
    O Tanaka
    Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, Japan
    Chem Pharm Bull (Tokyo) 48:889-92. 2000
    ..Based on the present and previous studies, medicinal evaluation and chemogeographical correlation of Himalayan Panax spp. are discussed...
  16. ncbi request reprint Medicinal foodstuffs. XVIII. Phytoestrogens from the aerial part of Petroselinum crispum MIll. (Parsley) and structures of 6"-acetylapiin and a new monoterpene glycoside, petroside
    M Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Japan
    Chem Pharm Bull (Tokyo) 48:1039-44. 2000
    ..61 microM) and genistein (0.60 microM). The methanolic extract of parsley, apiin, and apigenin restored the uterus weight in ovariectomized mice when orally administered for consecutive 7 days...
  17. ncbi request reprint Bioactive saponins and glycosides. XVI. Nortriterpene oligoglycosides with gastroprotective activity from the fresh leaves of Euptelea polyandra Sieb. et Zucc. (1): structures of Eupteleasaponins I, II, III, IV, V, and V acetate
    M Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Japan
    Chem Pharm Bull (Tokyo) 48:1045-50. 2000
    ....
  18. ncbi request reprint Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 14:7468-75. 2006
    ..In addition, principal constituents, kankanoside F, kankanose, echinacoside, acteoside, and cistanoside F, showed vasorelaxant activity, and several structural requirements for the activity were clarified...
  19. ncbi request reprint Bioactive constituents of Chinese natural medicines. V. Radical scavenging effect of Moutan Cortex. (1): Absolute stereostructures of two monoterpenes, paeonisuffrone and paeonisuffral
    M Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 48:1327-31. 2000
    ..Their absolute stereostructures were elucidated on the basis of chemical and physiochemical evidence, which included the application of a modified Mosher's method and lipase catalyzed debenzoylation reaction...
  20. ncbi request reprint Alcohol absorption inhibitors from bay leaf (Laurus nobilis): structure-requirements of sesquiterpenes for the activity
    M Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Bioorg Med Chem 8:2071-7. 2000
    ..In addition, the acute toxicities of 1 and 2 in a single oral administration were found to be lower than that of 12...
  21. ncbi request reprint Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 14:456-63. 2006
    ..Furthermore, hyuganin A, anomalin, and isopteryxin inhibited the decrease in cell viability by TNF-alpha in L929 cells...
  22. ncbi request reprint Bioactive constituents from Chinese natural medicines. XXIII. Absolute structures of new megastigmane glycosides, sedumosides A(4), A(5), A(6), H, and I, and hepatoprotective megastigmanes from Sedum sarmentosum
    Kiyofumi Ninomiya
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:1185-91. 2007
    ..Among them, sedumoside F(1) (IC(50)=47 microM), (3S,5R,6S,9R)-megastigmane-3,9-diol (61 microM), and myrsinionosides A (52 microM) and D (62 microM) were found to show the strong hepatoprotective activity...
  23. doi request reprint Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 18:2038-42. 2008
    ..5-10 mg/kg (p.o.) in D-GalN/LPS-treated mice, and this inhibitory effect was suggested to depend on the reduced sensitivity of hepatocytes to TNF-alpha...
  24. ncbi request reprint Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium
    Seikou Nakamura
    Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1704-9. 2008
    ..In addition, the principal constituents, coronaririn C and 15-hydroxylabda-8(17),11,13-trien-16,15-olide, displayed hepatoprotective effects, which were stronger than that of the hepatoprotective agent, silybin...
  25. ncbi request reprint Structures of acetylated oleanane-type triterpene saponins, rarasaponins IV, V, and VI, and anti-hyperlipidemic constituents from the pericarps of Sapindus rarak
    Yasunobu Asao
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    Chem Pharm Bull (Tokyo) 57:198-203. 2009
    ....
  26. ncbi request reprint Bioactive constituents from chinese natural medicines. XXIX. Monoterpene and monoterpene glycosides from the roots of Rhodiola sachalinensis
    Xuezheng Li
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:612-5. 2008
    ..The absolute stereostructures of new monoterpenes were elucidated on the basis of chemical and physicochemical evidence including the application of the modified Mosher's method...
  27. ncbi request reprint Bioactive constituents from chinese natural medicines. XXIV. Hypoglycemic effects of Sinocrassula indica in sugar-loaded rats and genetically diabetic KK-A(y) mice and structures of new acylated flavonol glycosides, sinocrassosides A(1), A(2), B(1), and B
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:1308-15. 2007
    ..The absolute stereostructures of the four new compounds were elucidated on the basis of chemical and physicochemical evidence...
  28. ncbi request reprint Bioactive constituents from Chinese natural medicines. XIV. New glycosides of beta-carboline-type alkaloid, neolignan, and phenylpropanoid from Stellaria dichotoma L. var. lanceolata and their antiallergic activities
    Toshio Morikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 52:1194-9. 2004
    ..These findings suggest that dichotomoside D is more effective against the late-phase reactions in type I allergy than in the immediate phase...
  29. ncbi request reprint Medicinal flowers. XXII. Structures of chakasaponins V and VI, chakanoside I, and chakaflavonoside A from flower buds of Chinese tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1297-303. 2008
    ..O. KUNTZE]. The chemical structures of those new glycosides were elucidated on the basis of chemical and physicochemical evidence...
  30. ncbi request reprint Medicinal flowers. XXI. Structures of perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:559-68. 2008
    ..The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence...
  31. doi request reprint Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells
    Souichi Nakashima
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 18:2337-45. 2010
    ....
  32. ncbi request reprint Bioactive saponins and glycosides. XXVIII. New triterpene saponins, foliatheasaponins I, II, III, IV, and V, from Tencha (the leaves of Camellia sinensis)
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:293-8. 2007
    ..Among the new saponins, foliatheasaponins II and III, were found to inhibit release of beta-hexosaminidase, as a marker of antigen-induced degranulation, in RBL-2H3 cells...
  33. ncbi request reprint Gastroprotective effects of phenylpropanoids from the rhizomes of Alpinia galanga in rats: structural requirements and mode of action
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Eur J Pharmacol 471:59-67. 2003
    ..These findings suggest that endogenous prostaglandins and sulfhydryl compounds are involved in the protective effect of 1'S-1'-acetoxychavicol acetate...
  34. ncbi request reprint [Biological activities of Salacia chinensis originating in Thailand: the quality evaluation guided by alpha-glucosidase inhibitory activity]
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Yakugaku Zasshi 123:871-80. 2003
    ..reticulata. In addition, we isolated the principal alpha-glucosidase inhibitor, salacinol, from the stems of S. chinensis and examined alpha-glucosidase inhibitory activities of eleven samples of S. chinensis collected in Thailand...
  35. ncbi request reprint Absolute structures of new megastigmane glycosides, foliasalaciosides E(1), E(2), E(3), F, G, H, and I from the leaves of Salacia chinensis
    Yi Zhang
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:547-53. 2008
    ..collected in Thailand. The absolute stereostructures of the new compounds were characterized on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method...
  36. doi request reprint Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B
    Seikou Nakamura
    Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Kyoto 607 8412, Japan
    Bioorg Med Chem 21:1043-9. 2013
    ..The principal alkaloid constituents were found to display potent melanogenesis inhibitory activity. The structural requirements of the carbazole alkaloids for melanogenesis inhibitory activity were discussed...
  37. ncbi request reprint Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 66:86-91. 2003
    ..In addition, the principal diarylheptanoid constituents were found to exhibit inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages...
  38. ncbi request reprint Reinvestigation of absolute stereostructure of (-)-rosiridol: structures of monoterpene glycosides, rosiridin, rosiridosides A, B, and C, from Rhodiola sachalinensis
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:695-700. 2008
    ....
  39. ncbi request reprint Bioactive constituents from Chinese natural medicines. XI. inhibitors on NO production and degranulation in RBL-2H3 from Rubia yunnanensis: structures of rubianosides II, III, and IV, rubianol-g, and rubianthraquinone
    Jing Tao
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 51:654-62. 2003
    ..In addition, an anthraquinone constituent, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, was found to show inhibitory effects on the release of beta-hexosaminidase in RBL-2H3 cells...
  40. ncbi request reprint Medicinal flowers. XXXVIII. structures of acylated sucroses and inhibitory effects of constituents on aldose reducatase from the flower buds of Prunus mume
    Katsuyoshi Fujimoto
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 61:445-51. 2013
    ..mume, were shown to substantially inhibit aldose reductase. In particular, mumeic acid-A was found to exhibit a potent inhibitory effect [IC50=0.4 µm]...
  41. ncbi request reprint Structure-activity relationships of 1'S-1'-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 15:1949-53. 2005
    ..4) The substitution of acetyl groups with propionyl or methyl groups reduced the activity. (5) Lengthening of the carbon chain between the 1'- and 2'-positions reduced the activity...
  42. ncbi request reprint Monoterpene constituents from Cistanche tubulosa--chemical structures of kankanosides A-E and kankanol-
    Haihui Xie
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 54:669-75. 2006
    ..WIGHT (Orobanchaceae) together with 16 known compounds. The structures of these new compounds (1-6) were determined on the basis of the chemical and physicochemical evidence...
  43. ncbi request reprint Carnosic acid, a new class of lipid absorption inhibitor from sage
    Kiyofumi Ninomiya
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 14:1943-6. 2004
    ..o.). Furthermore, carnosic acid (20 mg/kg/day, p.o.) reduced the gain of body weight and the accumulation of epididymal fat weight in high fat diet-fed mice after 14 days...
  44. ncbi request reprint Inhibitors of nitric oxide production from the flowers of Angelica furcijuga: structures of hyuganosides IV and V
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Kyoto
    Chem Pharm Bull (Tokyo) 53:387-92. 2005
    ..Among them, 3'-angeloyl-cis-khellactone (IC(50)=82 microM), (S)-(-)-oxypeucedanin (57 microM), imperatorin (60 microM), isoepoxypteryxin (53 microM), and isopteryxin (8.8 microM) showed inhibitory activity...
  45. ncbi request reprint Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Japan
    Chem Pharm Bull (Tokyo) 52:494-7. 2004
    ..Nigellamines were found to lower triglyceride levels in primary cultured mouse hepatocytes, and in particular, the activity of nigellamine A(5) was equivalent to that of the hypolipidemic agent, clofibrate...
  46. ncbi request reprint Medicinal flowers. XVI. New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:1034-8. 2007
    ..Ginsenoside Rd (protopanaxadiol 3,20-O-bisdesmoside) exhibited inhibitory effects on ethanol- and indomethacin-induced gastric mucosal lesions in rats...
  47. ncbi request reprint Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 55:308-16. 2007
    ..In addition, the principal steroid saponin, dioscin (13), inhibited the increase of serum glucose levels in sucrose-loaded rats at a dose of 50 mg/kg, p.o...
  48. ncbi request reprint Bioactive constituents from Chinese natural medicines. XV. Inhibitory effect on aldose reductase and structures of Saussureosides A and B from Saussurea medusa
    Haihui Xie
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 53:1416-22. 2005
    ..In addition, some isolates were found to show an inhibitory effect on aldose reductase...
  49. ncbi request reprint Medicinal flowers. XXXIII. Anti-hyperlipidemic and anti-hyperglycemic effects of chakasaponins I-III and structure of chakasaponin IV from flower buds of Chinese tea plant (Camellia sinensis)
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 60:674-80. 2012
    ..In addition, the chemical structure of a new acylated oleanane-type triterpene oligoglycoside, chakasaponin IV, was elucidated on the basis of chemical and physicochemical evidence...
  50. ncbi request reprint Medicinal flowers. XXXVI.1) Acylated oleanane-type triterpene saponins with inhibitory effects on melanogenesis from the flower buds of Chinese Camellia japonica
    Seikou Nakamura
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    Chem Pharm Bull (Tokyo) 60:752-8. 2012
    ..The inhibitory effects of the triterpene oligoglycoside constituents on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells were investigated...
  51. ncbi request reprint Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: involvement of glucagon-like peptide-1
    Ghazi Mohamed Eisa Hussein
    Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 34:1849-55. 2011
    ..These findings suggest that mate may induce anorexic effects by direct induction of satiety and by stimulation of GLP-1 secretion and modulation of serum leptin levels...
  52. ncbi request reprint Cucurbitane-type triterpenes with anti-proliferative effects on U937 cells from an egyptian natural medicine, Bryonia cretica: structures of new triterpene glycosides, bryoniaosides A and B
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 58:747-51. 2010
    ..2 and 16 nM after 72 h, and their IC(50) values were equivalent to that of camptothecin. An alpha,beta-conjugated ketone moiety at the 22-24-positions and an acetoxy group at the 25-position are essential for the strong activity...
  53. ncbi request reprint Brazilian natural medicines. IV. New noroleanane-type triterpene and ecdysterone-type sterol glycosides and melanogenesis inhibitors from the roots of Pfaffia glomerata
    Seikou Nakamura
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 58:690-5. 2010
    ..The inhibitory effects were stronger than that of reference compound, arbutin (IC(50)=174 microM)...
  54. ncbi request reprint Characterization of new sweet triterpene saponins from Albizia myriophylla
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 65:1638-42. 2002
    ..In addition, when sensory tests were performed on sweetness, albiziasaponin B (2), with a carbonyl group at the C-30 position, was found to show a potent sweetness intensity relative to sucrose (600 times)...
  55. ncbi request reprint Antidiabetogenic constituents from the Thai traditional medicine Cotylelobium melanoxylon
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 57:487-94. 2009
    ..In addition, vaticanols A, E, and/or G inhibited the enzyme activities of rat intestinal alpha-glucosidase, porcine pancreatic lipase, and rat lens aldose reductase...
  56. ncbi request reprint Medicinal Flowers. XXVI. structures of acylated oleanane-type triterpene oligoglycosides, yuchasaponins A, B, C, and D, from the flower buds of Camellia oleifera-gastroprotective, aldose reductase inhibitory, and radical scavenging effects-
    Sachiko Sugimoto
    Kyoto Pharmaceutical University, Yamashitaa ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 57:269-75. 2009
    ....
  57. ncbi request reprint Brazilian natural medicines. III. structures of triterpene oligoglycosides and lipase inhibitors from mate, leaves of ilex paraguariensis
    Sachiko Sugimoto
    Kyoto Pharmaceutical University, Yamashina ku, Kyoto 607 8412, Japan
    Chem Pharm Bull (Tokyo) 57:257-61. 2009
    ..The chemical structures of new oligoglycosides were elucidated on the basis of chemical and physicochemical evidence. Several constituents showed inhibitory activities on pancreatic lipase...
  58. ncbi request reprint Structures of new sesquiterpenes from Curcuma comosa
    Fengming Xu
    Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1710-6. 2008
    ..Their structures were elucidated on the basis of chemical and physicochemical evidence...
  59. ncbi request reprint Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action
    Hiroshi Shimoda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 13:223-8. 2003
    ..In addition, inhibition of gastric emptying was shown to be partly involved in anti-hyperlipidemic activity...
  60. doi request reprint Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Biodivers 6:903-15. 2009
    ..Compounds 1-3 showed accelerating effects on gastrointestinal transit in mice and inhibitory effects against porcine pancreatic lipase (IC(50)=150-530 microM)...
  61. ncbi request reprint Absolute stereostructures of new arborinane-type triterpenoids and inhibitors of nitric oxide production from Rubia yunnanensis
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    J Nat Prod 66:638-45. 2003
    ..The effects of the isolated constituents on nitric oxide production in lipopolysaccharide-activated macrophages were examined, and several triterpenes were found to show inhibitory activity...
  62. ncbi request reprint Antiallergic principles from Alpinia galanga: structural requirements of phenylpropanoids for inhibition of degranulation and release of TNF-alpha and IL-4 in RBL-2H3 cells
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 13:3197-202. 2003
    ....
  63. ncbi request reprint Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 68:1360-5. 2005
    ..Floratheasaponins (1-3) showed inhibitory effects on serum triglyceride elevation, with their activities being more potent than those of theasaponins E1 (4) and E2 (5) obtained previously from the seeds of C. sinensis...
  64. ncbi request reprint Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Phytomedicine 15:177-84. 2008
    ..In addition, the profile of gene expression by thunberginol B was similar to that by luteolin, a natural flavone with a potent anti-allergic effect...
  65. doi request reprint Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    J Nat Prod 71:828-35. 2008
    ..Among these saponins, perennisosides I (1) and II (2) showed inhibitory effects on serum triglyceride elevation at doses of 25-50 mg/kg, po...
  66. ncbi request reprint Structures of new monoterpenes from Thai herbal medicine Curcuma comosa
    Seikou Nakamura
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:1604-6. 2008
    ..Their structures were elucidated on the basis of chemical and physicochemical evidence...
  67. ncbi request reprint Bioactive constituents from Chinese natural medicines. XXVIII. Chemical structures of acyclic alcohol glycosides from the roots of Rhodiola crenulata
    Seikou Nakamura
    Kyoto Pharmaceutical University, Kyoto, Japan
    Chem Pharm Bull (Tokyo) 56:536-40. 2008
    ..The chemical structures of new constituents were elucidated on the basis of chemical and physicochemical evidence...
  68. ncbi request reprint Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis
    Toshio Morikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Nat Prod 66:1191-6. 2003
    ..In addition, six constituents, 3beta,22beta-dihydroxyolean-12-en-29-oic acid, tingenone, tingenine B, regeol A, triptocalline A, and mangiferin, were found to show an inhibitory effect on rat lens aldose reductase...
  69. ncbi request reprint Medicinal flowers. I. Aldose reductase inhibitors and three new eudesmane-type sesquiterpenes, kikkanols A, B, and C, from the flowers of Chrysanthemum indicum L
    M Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 47:340-5. 1999
    ..The structures of kikkanols A, B, and C were elucidated on the basis of chemical and physicochemical evidence, which included application of the modified Mosher's method...
  70. ncbi request reprint Inhibitors from rhubarb on lipopolysaccharide-induced nitric oxide production in macrophages: structural requirements of stilbenes for the activity
    T Kageura
    Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan
    Bioorg Med Chem 9:1887-93. 2001
    ..Furthermore, the active stilbenes (rhapontigenin, piceatannol, and resveratrol) did not inhibit inducible NO synthase activity, but they inhibited nuclear factor-kappa B activation following expression of inducible NO synthase...
  71. ncbi request reprint Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides
    H Matsuda
    Kyoto Pharmaceutical University, Japan
    Bioorg Med Chem 9:41-50. 2001
    ..O2-. In addition, several stilbenes with both the 3-hydroxyl and 4'-methoxyl groups inhibited xanthine oxidase...