Hajime Yoshifuji

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Amelioration of experimental arthritis by a calpain-inhibitory compound: regulation of cytokine production by E-64-d in vivo and in vitro
    Hajime Yoshifuji
    Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Int Immunol 17:1327-36. 2005
  2. ncbi request reprint Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies
    Hajime Yoshifuji
    Kyoto University, Graduate School of Medicine, Department of Rheumatology and Clinical Immunology, Japan
    Autoimmunity 39:233-41. 2006
  3. doi request reprint The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody
    Ran Nakashima
    Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Rheumatology (Oxford) 49:433-40. 2010
  4. doi request reprint Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4
    Kosaku Murakami
    Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    FEBS Lett 586:319-24. 2012
  5. doi request reprint NEFA/nucleobindin-2 is a target autoantigen of the anti-Wa antibody and is associated with transfer RNA
    Yoshitaka Imura
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Mod Rheumatol 22:685-94. 2012
  6. doi request reprint Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases
    Kosuke Tanaka
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 59:107-9. 2014
  7. pmc Correlation of antinuclear antibody and anti-double-stranded DNA antibody with clinical response to infliximab in patients with rheumatoid arthritis: a retrospective clinical study
    Naoichiro Yukawa
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Arthritis Res Ther 13:R213. 2011
  8. pmc Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals
    Mikiko Iguchi-Hashimoto
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e27020. 2011
  9. pmc Neutrophils are essential as a source of IL-17 in the effector phase of arthritis
    Masaki Katayama
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS ONE 8:e62231. 2013
  10. ncbi request reprint Ameliorative effects of follistatin-related protein/TSC-36/FSTL1 on joint inflammation in a mouse model of arthritis
    Daisuke Kawabata
    Kyoto University Graduate School of Medicine, Kyoto, Japan
    Arthritis Rheum 50:660-8. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Amelioration of experimental arthritis by a calpain-inhibitory compound: regulation of cytokine production by E-64-d in vivo and in vitro
    Hajime Yoshifuji
    Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Int Immunol 17:1327-36. 2005
    ..These results suggest the key roles of calpain in the pathophysiology of arthritis and that calpain-inhibitory compounds might be applicable to the treatment of arthritic diseases such as RA...
  2. ncbi request reprint Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies
    Hajime Yoshifuji
    Kyoto University, Graduate School of Medicine, Department of Rheumatology and Clinical Immunology, Japan
    Autoimmunity 39:233-41. 2006
    ..In conclusion, screening of anti-ARS may be useful to predict late-onset myopathy in ILD-preceding patients and to predict the clinical course of ILD in PM/DM patients...
  3. doi request reprint The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody
    Ran Nakashima
    Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Rheumatology (Oxford) 49:433-40. 2010
    ..We assessed the clinical significance of the anti-CADM-140 antibody and then investigated the autoantigen recognized by the anti-CADM-140 antibody...
  4. doi request reprint Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4
    Kosaku Murakami
    Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    FEBS Lett 586:319-24. 2012
    ..Moreover, similar to lipopolysaccharide (LPS), FRP induced tolerance to the second LPS stimulation. FRP has the function of evoking innate immune responses as one of the endogenous TLR4 agonists...
  5. doi request reprint NEFA/nucleobindin-2 is a target autoantigen of the anti-Wa antibody and is associated with transfer RNA
    Yoshitaka Imura
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Mod Rheumatol 22:685-94. 2012
    ..The anti-Wa antibody found in systemic sclerosis patients reacts with a transfer RNA (tRNA)-associated 48-kDa protein and immunoprecipitates several tRNAs. We investigated the Wa antigen and its binding to tRNA species...
  6. doi request reprint Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases
    Kosuke Tanaka
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 59:107-9. 2014
    ..0038). Those who are carrying at least one copy of the A allele displayed decreased mean concentration of TAC by 31.0% compared with subjects with GG genotype. Rs776746 is associated with concentrations of TAC in patients with CTD. ..
  7. pmc Correlation of antinuclear antibody and anti-double-stranded DNA antibody with clinical response to infliximab in patients with rheumatoid arthritis: a retrospective clinical study
    Naoichiro Yukawa
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Arthritis Res Ther 13:R213. 2011
    ....
  8. pmc Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals
    Mikiko Iguchi-Hashimoto
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e27020. 2011
    ..Thus, this strategy may prove viable as a candidate treatment for inflammatory diseases such as RA...
  9. pmc Neutrophils are essential as a source of IL-17 in the effector phase of arthritis
    Masaki Katayama
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS ONE 8:e62231. 2013
    ..However, the role of IL-17 in the T cell-independent effector phase has not fully been examined. We investigated whether IL-17 is involved in the effector phase of arthritis by using K/BxN serum-induced arthritis model...
  10. ncbi request reprint Ameliorative effects of follistatin-related protein/TSC-36/FSTL1 on joint inflammation in a mouse model of arthritis
    Daisuke Kawabata
    Kyoto University Graduate School of Medicine, Kyoto, Japan
    Arthritis Rheum 50:660-8. 2004
    ..To clarify the in vivo function of follistatin-related protein (FRP)/TSC-36/FSTL1 in rheumatoid arthritis (RA), we investigated the roles of FRP in a mouse model of arthritis...
  11. doi request reprint Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis
    Yoshinaga Ito
    Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Arthritis Rheum 60:2294-303. 2009
    ..The involvement of IL-17-producing gamma/delta T cells in SKG mice with autoimmune arthritis and patients with rheumatoid arthritis (RA) was also investigated...
  12. ncbi request reprint Severe subcutaneous generalized edema in a patient with dermatomyositis
    Yoshinaga Ito
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Mod Rheumatol 17:171-3. 2007
    ..We conclude that subcutaneous generalized edema can occur during the course of DM/PM, and subcutaneous vasculopathy may be involved in the pathogenesis of DM/PM...
  13. pmc Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population
    Chikashi Terao
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan Electronic address
    Am J Hum Genet 93:289-97. 2013
    ....
  14. pmc Inverse association between air pressure and rheumatoid arthritis synovitis
    Chikashi Terao
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 9:e85376. 2014
    ..Standardized multiple linear regression analysis revealed these associations were independent from humidity and temperature. Our findings suggest that air pressure is inversely associated with synovitis in patients with RA...
  15. doi request reprint A case of Behçet's disease developing after poststreptococcal acute glomerulonephritis
    Yuichiro Kitai
    Department of Rheumatology and Clinical Immunology, Osaka Red Cross Hospital, Hudegasaki Cho 5 30, Ten noji ku, Osaka, 543 8555, Japan
    Mod Rheumatol 23:1221-5. 2013
    ..Treatment with oral prednisolone (20 mg/day) resulted in the remarkable disappearance of these symptoms. These findings support the hypothesis that Streptococcus pyogenes may be an etiologic factor of BD...
  16. pmc Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance
    Kazuhiro Kiyama
    Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Kyoto 606 8507, Japan
    Arthritis Res Ther 14:R86. 2012
    ..Here we analyzed the serum levels of BAFF and APRIL and their respective clinical associations in patients with an immunoglobulin (Ig) G4-related disease (IgG4-RD)...
  17. pmc Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database
    Chikashi Terao
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e59341. 2013
    ..We confirmed the symmetric joint involvement in RA. Our results suggested that RA synovitis can be classified into subgroups and that several different mechanisms may underlie the pathophysiology in RA synovitis...
  18. ncbi request reprint Successful treatment of a patient with refractory adult Still's disease by tacrolimus
    Kosaku Murakami
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Mod Rheumatol 17:167-70. 2007
    ..Tacrolimus may be one of the drugs for the ASD patients refractory to the conventional treatments including TNF inhibitors...
  19. ncbi request reprint Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significance
    Tsuneyo Mimori
    Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Curr Opin Rheumatol 19:523-9. 2007
    ..This review examines recent progress in myositis-specific autoantibodies, particularly in their clinical significance and pathophysiological roles...
  20. doi request reprint Association of Takayasu arteritis with HLA-B 67:01 and two amino acids in HLA-B protein
    Chikashi Terao
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Rheumatology (Oxford) 52:1769-74. 2013
    ..We performed genetic association studies to determine independent HLA-B susceptibility alleles other than HLA-B 52:01 and to identify important amino acids of HLA-B protein in TAK susceptibility...
  21. ncbi request reprint Clinical features and treatment of multicentric castleman's disease : a retrospective study of 21 Japanese patients at a single institute
    Hiroshi Kawabata
    Department of Hematology and Oncology Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Clin Exp Hematop 53:69-77. 2013
    ..A nationwide survey is required to further clarify the epidemiology, clinical features, and optimal treatment strategies of MCD in Japan...
  22. ncbi request reprint Recent advances in Takayasu arteritis
    Chikashi Terao
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Rheum Dis 17:238-47. 2014
    ..The recent accumulation of research data should improve understanding of the basic pathophysiology of TAK and lead to better management of patients with TAK. ..
  23. ncbi request reprint [A case of dermatomyositis associated with different types of cancers at intervals of six years]
    Mikiko Hashimoto
    Shizuoka General Hospital
    Nihon Rinsho Meneki Gakkai Kaishi 27:427-30. 2004
    ..We report this rare and interesting case to consider the etiology of cancer-associated myositis as a paraneoplastic syndrome, since the two cancers have different histological types...