Naohisa Yoshida

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. ncbi request reprint Prevention of colonic spasm using L-menthol in colonoscopic examination
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Int J Colorectal Dis 29:579-83. 2014
  2. doi request reprint The ability of a novel blue laser imaging system for the diagnosis of invasion depth of colorectal neoplasms
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    J Gastroenterol 49:73-80. 2014
  3. doi request reprint Multicenter study of endoscopic mucosal resection using 0.13% hyaluronic acid solution of colorectal polyps less than 20 mm in size
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Colorectal Dis 28:985-91. 2013
  4. doi request reprint Possibility of ex vivo animal training model for colorectal endoscopic submucosal dissection
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Int J Colorectal Dis 28:49-56. 2013
  5. doi request reprint Endoscopic mucosal resection with 0.13% hyaluronic acid solution for colorectal polyps less than 20 mm: a randomized controlled trial
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Gastroenterol Hepatol 27:1377-83. 2012
  6. doi request reprint The detection of surface patterns by flexible spectral imaging color enhancement without magnification for diagnosis of colorectal polyps
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Colorectal Dis 27:605-11. 2012
  7. pmc Safe procedure in endoscopic submucosal dissection for colorectal tumors focused on preventing complications
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    World J Gastroenterol 16:1688-95. 2010
  8. doi request reprint Endoscopic submucosal dissection for colorectal tumors: technical difficulties and rate of perforation
    N Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602 8566, Japan
    Endoscopy 41:758-61. 2009
  9. doi request reprint Outcome of endoscopic submucosal dissection for colorectal tumors in elderly people
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Colorectal Dis 25:455-61. 2010
  10. ncbi request reprint Ileal mucosa-associated lymphoid tissue lymphoma showing several ulcer scars detected using double-balloon endoscopy
    N Yoshida
    Dept of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Endoscopy 36:1022-4. 2004

Detail Information

Publications58

  1. ncbi request reprint Prevention of colonic spasm using L-menthol in colonoscopic examination
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Int J Colorectal Dis 29:579-83. 2014
    ..The detailed efficacy of intraluminal L-menthol for preventing colonic spasm is not known. The aim of this study was to evaluate the effectiveness of L-menthol in preventing colonic spasm during colonoscopy...
  2. doi request reprint The ability of a novel blue laser imaging system for the diagnosis of invasion depth of colorectal neoplasms
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    J Gastroenterol 49:73-80. 2014
    ..The aim of this study was to evaluate BLI magnification in comparison with narrow-band imaging (NBI) magnification for the diagnosis of colorectal neoplasms...
  3. doi request reprint Multicenter study of endoscopic mucosal resection using 0.13% hyaluronic acid solution of colorectal polyps less than 20 mm in size
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Colorectal Dis 28:985-91. 2013
    ..Endoscopic mucosal resection (EMR) of colorectal polyps should be curative and safe. This study aimed to determine the efficacy and safety of colorectal EMR using 0.13% hyaluronic acid (HA) solution...
  4. doi request reprint Possibility of ex vivo animal training model for colorectal endoscopic submucosal dissection
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Int J Colorectal Dis 28:49-56. 2013
    ....
  5. doi request reprint Endoscopic mucosal resection with 0.13% hyaluronic acid solution for colorectal polyps less than 20 mm: a randomized controlled trial
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Gastroenterol Hepatol 27:1377-83. 2012
    ..The objective of this study is to determine the efficacy of 0.13% hyaluronic acid (HA) solution for high and sustained mucosal elevation during colorectal EMR...
  6. doi request reprint The detection of surface patterns by flexible spectral imaging color enhancement without magnification for diagnosis of colorectal polyps
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Colorectal Dis 27:605-11. 2012
    ..Resolution of FICE has recently been improved. We evaluated diagnostic accuracy for neoplastic and non-neoplastic colorectal polyp differentiation with detection of surface patterns by FICE without magnification...
  7. pmc Safe procedure in endoscopic submucosal dissection for colorectal tumors focused on preventing complications
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    World J Gastroenterol 16:1688-95. 2010
    ..In this review, we describe safe procedures in ESD to prevent complications, the complications of ESD and their management...
  8. doi request reprint Endoscopic submucosal dissection for colorectal tumors: technical difficulties and rate of perforation
    N Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602 8566, Japan
    Endoscopy 41:758-61. 2009
    ..These aspects of ESD are thoroughly analyzed in our retrospective study...
  9. doi request reprint Outcome of endoscopic submucosal dissection for colorectal tumors in elderly people
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Colorectal Dis 25:455-61. 2010
    ..Our study investigated whether ESD was suitable for elderly people with large colorectal tumors in terms of its invasiveness...
  10. ncbi request reprint Ileal mucosa-associated lymphoid tissue lymphoma showing several ulcer scars detected using double-balloon endoscopy
    N Yoshida
    Dept of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Endoscopy 36:1022-4. 2004
    ..Based on these findings, the lesion was diagnosed as a marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue. Eighteen months after surgery, the patient was still in complete remission...
  11. doi request reprint Efficacy of hyaluronic acid in endoscopic mucosal resection of colorectal tumors
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto, Japan
    J Gastroenterol Hepatol 26:286-91. 2011
    ..In the present study, we assessed the appropriate concentration of HA for EMR...
  12. doi request reprint Efficacy of magnifying endoscopy with flexible spectral imaging color enhancement in the diagnosis of colorectal tumors
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Gastroenterol 46:65-72. 2011
    ..We evaluated and compared FICE magnification to narrow-band imaging (NBI) magnification...
  13. pmc Efficient hemostatic method for endoscopic submucosal dissection of colorectal tumors
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    World J Gastroenterol 16:4180-6. 2010
    ..To evaluate a new hemostatic method using hemostatic forceps to prevent perforation and perioperative hemorrhage during colonic endoscopic submucosal dissection (ESD)...
  14. ncbi request reprint Cytogenetic and clinicopathological characterization by fluorescence in situ hybridization on paraffin-embedded tissue sections of twenty-six cases with malignant lymphoma of small intestine
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Scand J Gastroenterol 41:212-22. 2006
    ....
  15. ncbi request reprint Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model
    Ken Inoue
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    Biol Pharm Bull 34:1659-65. 2011
    ..These findings suggest that DKT reduces intestinal fibrosis associated with decreasing expression of HSP47 and collagen content in the intestine...
  16. doi request reprint Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Gastroenterol Hepatol 27:70-5. 2012
    ..However, the precise pathogenesis and therapeutic strategy have not been fully revealed. The aim of the present study was to determine the upregulated proteins in the small intestine exposed to indomethacin...
  17. ncbi request reprint Pulmonary relapse of non-Hodgkin's lymphoma in bilateral upper lobes
    Yoshiko Fujimoto
    Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Intern Med 45:971-3. 2006
    ..Thus, TBLB proved to be essential for the diagnosis of the lung involvement of non-Hodgkin's lymphoma (NHL)...
  18. doi request reprint Role of tumor necrosis factor-α in the pathogenesis of indomethacin-induced small intestinal injury in mice
    Kohei Fukumoto
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Int J Mol Med 27:353-9. 2011
    ..TNF-α plays an important role in the pathogenesis of indomethacin-induced small intestinal damage. These results suggest that TNF-α could become a new therapeutic target for NSAID-induced small intestinal damage...
  19. ncbi request reprint Successful endoscopic hemostasis for gastric arterial bleeding due to invasion of malignant lymphoma
    Kenichi Nomura
    Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kamigyo ku, Kyoto 602 0841, Japan
    World J Gastroenterol 11:4285-6. 2005
    ..Since gastric bleeding causes significant mortality, endoscopic hemostasis should be considered as first-line treatment for ML patients who were treated with chemotherapy...
  20. ncbi request reprint Ability of a novel blue laser imaging system for the diagnosis of colorectal polyps
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Dig Endosc 26:250-8. 2014
    ..The aim of the present study was to evaluate the utility of BLI for the diagnosis of colorectal polyps...
  21. ncbi request reprint Anti-inflammatory Effects of Carbon Monoxide-Releasing Molecule on Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice
    Wataru Fukuda
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Dig Dis Sci 59:1142-51. 2014
    ..Here, we assessed the effects of a novel water-soluble CO-releasing molecule, CORM-3, on trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice...
  22. ncbi request reprint Pseudomembranous colitis presenting as acute colonic obstruction without diarrhea in a patient with gastric Burkitt lymphoma
    Kenichi Nomura
    Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 0841, Japan
    World J Gastroenterol 11:2681-3. 2005
    ..Physicians should take into account the possibility of bowel obstruction due to PMC occurring in patients undergoing chemotherapy and perform emergency colonoscopy examination of suspected cases...
  23. ncbi request reprint New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic Acid
    Kazuhiko Uchiyama
    Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    PLoS ONE 9:e95080. 2014
    ..In this study, single nucleotide polymorphisms (SNPs) related to differential gene expression affecting AZA drug metabolism in combination therapy with 5-ASA were examined...
  24. ncbi request reprint Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy
    Sawako Taji
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    World J Gastroenterol 11:89-93. 2005
    ....
  25. ncbi request reprint Severe cytomegalovirus enterocolitis after standard chemotherapy for non-Hodgkin's lymphoma
    Kenichi Nomura
    Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Scand J Gastroenterol 40:604-6. 2005
    ..Octreotide may therefore be an effective agent for severe colitis...
  26. ncbi request reprint Small bowel non-Hodgkin's lymphoma remaining in complete remission by surgical resection and adjuvant rituximab therapy
    Kenichi Nomura
    Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
    World J Gastroenterol 11:4443-4. 2005
    ..Rituximab was administered as adjuvant therapy at weekly doses of 375 mg/m2. Four cycles were performed every 6 mo and he remained CR. Rituximab may be effective as adjuvant therapy...
  27. ncbi request reprint An additional segment at 1p36 derived from der(18)t(14;18) in patients with diffuse large B-cell lymphomas transformed from follicular lymphoma
    Kenichi Nomura
    Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kyoto, 602 8566, Japan
    Ann Hematol 84:474-6. 2005
    ....
  28. doi request reprint Evaluation of autofluorescence colonoscopy for diagnosis of superficial colorectal neoplastic lesions
    Ken Inoue
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kamigyo ku, Kyoto, Japan
    Int J Colorectal Dis 25:811-6. 2010
    ..This study was designed to assess the potential usefulness of AF colonoscopy for evaluating superficial colorectal neoplastic lesions...
  29. doi request reprint Reduced small-intestinal injury induced by indomethacin in interleukin-17A-deficient mice
    Shinya Yamada
    Department of Molecular Gastroenterology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 26:398-404. 2011
    ..To define the role of IL-17A in small intestinal injury and inflammation, we studied the effects of indomethacin administration in mice with targeted deletions of the IL-17A gene...
  30. ncbi request reprint MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid
    Munehiro Kugai
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cell Physiol Biochem 32:942-50. 2013
    ..We assessed the involvement of Multi Drug Resistance (MDR) 1 in intestinal epithelial cell injury caused by aspirin using MDR1 gene-transfected Caco2 cells...
  31. ncbi request reprint [The technique and indication of endoscopic mucosal resection and endoscopic submucosal dissection]
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
    Nihon Rinsho 72:97-101. 2014
    ..Two knives such as a tip-typed knife and a scissor type are used for safe ESD procedure. In this review, we have demonstrated the efficacies of EMR and ESD for early colorectal cancers...
  32. doi request reprint L-menthol improves adenoma detection rate during colonoscopy: a randomized trial
    Ken Inoue
    Department of Molecular Gastroenterology and Hepatology, North Medical Center Kyoto Prefectural University of Medicine, Kyoto, Japan
    Endoscopy 46:196-202. 2014
    ..The aim of this study was to evaluate the efficacy of L-menthol spray as an antiperistaltic agent and its effect on adenoma detection...
  33. doi request reprint Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer
    Takeshi Ishikawa
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan Department of Cancer ImmunoCell Regulation, Kyoto Prefectural University of Medicine, Kyoto, Japan
    PLoS ONE 9:e83786. 2014
    ..In this phase I clinical trial, we build on these prior results by assessing the safety and efficacy of FN-CH296 stimulated T cell therapy in patients with advanced cancer...
  34. doi request reprint Relationship between circulating cytokine levels and physical or psychological functioning in patients with advanced cancer
    Takeshi Ishikawa
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Biochem 45:207-11. 2012
    ..To investigate the relation between functional impairments of cancer patients and circulating cytokines using a multiplex technique...
  35. ncbi request reprint Graft-versus-host disease confined solely to intestine after allogeneic peripheral blood stem cells transplantation in a patient with chronic myelogenous leukemia
    Kenichi Nomura
    Molocular Hematology and Oncology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kawaramachi Hirokoji Kamigyo ku 602 0841 Kyoto Japan
    Hematology 9:131-3. 2004
    ..Acute GVHD involving only the intestine has rarely been described but when using HLA-mismatched PBSCs, acute GVHD may occur severely and atypically...
  36. ncbi request reprint Lack of evidence for leukocyte maternal microchimerism in primary biliary cirrhosis
    Kenichi Nomura
    Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
    World J Gastroenterol 10:2415-6. 2004
    ..Maternal microchimerism has not been investigated until now. The current study aimed to clear either maternal microchimerism was involved in the pathogenesis of PBC or not...
  37. ncbi request reprint Successful treatment with rifampin for fulminant antibiotics-associated colitis in a patient with non-Hodgkin's lymphoma
    Kenichi Nomura
    Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
    World J Gastroenterol 10:765-6. 2004
    ..After administration of rifampin, fever alleviated and diarrhea was improved. Because AAC may result in significant mortality, patients with refractory or fulminant AAC should be treated with oral rifampin from outset...
  38. doi request reprint Phase II trial of combined regional hyperthermia and gemcitabine for locally advanced or metastatic pancreatic cancer
    Takeshi Ishikawa
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hyperthermia 28:597-604. 2012
    ..We conducted this phase II study to evaluate the efficacy and safety of regional hyperthermia combined with gemcitabine for the treatment of unresectable advanced pancreatic cancer...
  39. pmc Image-enhanced endoscopy for diagnosis of colorectal tumors in view of endoscopic treatment
    Naohisa Yoshida
    Naohisa Yoshida, Nobuaki Yagi, Yuji Naito, Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602 8566, Japan
    World J Gastrointest Endosc 4:545-55. 2012
    ..AFI light comprises a blue light for emitting and a green light for hemoglobin absorption. The aim of this review is to highlight the efficacy of IEE for diagnosis of colorectal tumors for endoscopic treatment...
  40. pmc Importance of histological evaluation in endoscopic resection of early colorectal cancer
    Naohisa Yoshida
    Naohisa Yoshida, Yuji Naito, Nobuaki Yagi, Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602 8566, Japan
    World J Gastrointest Pathophysiol 3:51-9. 2012
    ..Precise histopathological evaluation of these lesions should be performed in order to determine the necessity of additional therapy, including surgical resection...
  41. ncbi request reprint Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma
    Naohisa Yoshida
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602 8566, Japan
    World J Gastroenterol 10:2602-4. 2004
    ..T-FISH method is useful for the detection of a monoclonality of atypical lymphocytes in an SMT of the gastrointestinal tract, and particularly for the detection of chromosomal translocations specific to lymphoma subtypes...
  42. ncbi request reprint Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease
    Masahide Hamaguchi
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    World J Gastroenterol 13:1579-84. 2007
    ..To clarify whether nonalcoholic fatty liver disease (NAFLD) increases the risk of cardiovascular disease...
  43. ncbi request reprint Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease
    N Yoshida
    Molecular Gastroenterology and Hepatology, Department of Legal Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Scand J Gastroenterol 39:816-22. 2004
    ..In this study, we examined the expression of mRNA for interleukin (IL)-8, a potent chemokine for neutrophils, in the esophageal mucosa of patients with GERD and compared the results with their endoscopic findings and symptoms...
  44. ncbi request reprint An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice
    Y Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, 602 8566, Kyoto, Kawaramachi Hirokoji, Japan
    Inflamm Res 53:462-8. 2004
    ..A dextran sulfate sodium (DSS) colitis model was established to examine the effects of MMP inhibition, by an orally active MMP inhibitor ONO-4847, on colonic inflammation...
  45. pmc Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice
    R Ito
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Exp Immunol 146:330-8. 2006
    ..The present results demonstrate clearly that IFN-gamma plays indispensable roles in the initiation of DSS colitis, and some chemokines are produced in an IFN-gamma-dependent fashion...
  46. ncbi request reprint Frequent silencing of RUNX3 in esophageal squamous cell carcinomas is associated with radioresistance and poor prognosis
    C Sakakura
    Dept of Surgery and Regenerative Medicine, Div of Surgery and Physiology of the Digestive System, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi, Kamigyo ku, Kyoto 602 8566, Japan
    Oncogene 26:5927-38. 2007
    ..Examination of RUNX3 expression in pretreatment specimens may predict radiosensitivity, and induction of RUNX3 expression may increase tumor radiosensitivity...
  47. ncbi request reprint Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells
    N Yoshida
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Mol Med 19:335-40. 2007
    ....
  48. ncbi request reprint A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins
    T Nishikawa
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Hepatol 44:1074-82. 2006
    ..A major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), has previously been shown to induce cell-cycle arrest and apoptosis in various cancers. However, little is known about its effects on hepatocellular carcinomas (HCCs)...
  49. ncbi request reprint Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors
    O Handa
    Department of Biomedical Safety Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokouji, Kamigyo ku, Kyoto, Japan, 602 8566
    Inflamm Res 55:476-80. 2006
    ....
  50. ncbi request reprint Cytokine genetic adjuvant facilitates prophylactic intravascular DNA vaccine against acute and latent herpes simplex virus infection in mice
    F D Cui
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Gene Ther 12:160-8. 2005
    ..These results strongly suggest potential usefulness of Th1 cytokine genes as effective molecular adjuvants that facilitate specific humoral as well as cellular immune responses elicited by intravascular molecular vaccination...
  51. ncbi request reprint Interferon treatment improves survival in chronic hepatitis C patients showing biochemical as well as virological responses by preventing liver-related death
    A Kasahara
    Department of General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Viral Hepat 11:148-56. 2004
    ..Hence interferon treatment improved survival in chronic hepatitis C patients showing a biochemical as well as a virological response by preventing liver-related deaths...
  52. pmc Regression of idiopathic thrombocytopenic purpura after endoscopic mucosal resection of gastric mucosa associated lymphoid tissue lymphoma
    M Noda
    Department of Gastroenterology, Kyoto Prefectural Yosanoumi Hospital, Otokoyama 481, Iwataki cho, Yosa gun, Kyoto 629 2261, Japan
    Gut 53:1698-700. 2004
    ..We suggest that while some cases of thrombocytopenic purpura may be induced by H pylori, others may be due to an autoreactive antibody produced by MALT lymphoma B cells...
  53. ncbi request reprint Autoimmune hepatitis in a patient with systemic lupus erythematosus
    M Iwai
    Kyoto Prefectural University of Medicine, Kamikyo, Kyoto 602 8566, Japan
    Clin Rheumatol 22:234-6. 2003
    ..Our case suggested invalidity of AIH score among patients of SLE, and liver histology should be inferred most important at present to make a differential diagnosis of lupus hepatitis or AIH in patients with SLE...
  54. ncbi request reprint The effect of rebamipide on Helicobacter pylori extract-mediated changes of gene expression in gastric epithelial cells
    N Yoshida
    Molecular Gastroenterology and Hepatology and Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Aliment Pharmacol Ther 18:63-75. 2003
    ..pylori-stimulation through the attenuated activation of nuclear factor-kappaB (NF-kappaB)...
  55. ncbi request reprint High expression of transgenes mediated by hybrid retroviral vectors in hepatocytes: comparison of promoters from murine retroviruses in vitro and in vivo
    N Ohnishi
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Gene Ther 9:303-6. 2002
    ..Thus, FMEV-type vectors may represent a novel type of vectors for human gene therapy with hepatocytes...