Hiderou Yoshida

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Cell Biol 172:565-75. 2006
  2. ncbi request reprint [Cytoplasmic mRNA splicing]
    Hiderou Yoshida
    Tanpakushitsu Kakusan Koso 51:863-70. 2006
  3. ncbi request reprint XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 8502, Japan
    Cell Struct Funct 31:117-25. 2006
  4. ncbi request reprint ER stress and diseases
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    FEBS J 274:630-58. 2007
  5. ncbi request reprint Unconventional splicing of XBP-1 mRNA in the unfolded protein response
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan, PRESTO SORST, Japan Science and Technology Agency, Kyoto, Japan
    Antioxid Redox Signal 9:2323-33. 2007
  6. ncbi request reprint pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Cell Struct Funct 34:1-10. 2009
  7. doi request reprint ER stress response, peroxisome proliferation, mitochondrial unfolded protein response and Golgi stress response
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    IUBMB Life 61:871-9. 2009
  8. pmc Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation
    Yukako Oda
    Department of Molecular and Cellular Biology Institute for Frontier Medical Sciences, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Cell Biol 172:383-93. 2006
  9. ncbi request reprint Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
    Keisuke Yamamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Dev Cell 13:365-76. 2007
  10. ncbi request reprint Analysis of ATF6 activation in Site-2 protease-deficient Chinese hamster ovary cells
    Satomi Nadanaka
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 8502, Japan
    Cell Struct Funct 31:109-16. 2006

Collaborators

Detail Information

Publications30

  1. pmc pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Cell Biol 172:565-75. 2006
    ..Thus, pXBP1(U) is a negative feedback regulator of pXBP1(S), which shuts off the transcription of target genes during the recovery phase of ER stress...
  2. ncbi request reprint [Cytoplasmic mRNA splicing]
    Hiderou Yoshida
    Tanpakushitsu Kakusan Koso 51:863-70. 2006
  3. ncbi request reprint XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 8502, Japan
    Cell Struct Funct 31:117-25. 2006
    ..We concluded that ATF6-mediated induction of XBP1 mRNA is important to the production of pXBP1(S), activation of XBP1-target genes, and protection of cells from ER stress...
  4. ncbi request reprint ER stress and diseases
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    FEBS J 274:630-58. 2007
    ..In this review, I will summarize recent progress in this field. Molecules that regulate the ER stress response would be potential candidates for drug targets in various conformational diseases...
  5. ncbi request reprint Unconventional splicing of XBP-1 mRNA in the unfolded protein response
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan, PRESTO SORST, Japan Science and Technology Agency, Kyoto, Japan
    Antioxid Redox Signal 9:2323-33. 2007
    ..In this short review, I briefly summarize research on cytoplasmic splicing and focus on current hot topics...
  6. ncbi request reprint pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Cell Struct Funct 34:1-10. 2009
    ..This enhanced degradation is mediated by the degradation domain located at the pXBP1(U)-specific C-terminal end. We conclude that pXBP1(U) functions as a negative regulator of the UPR-specific transcription factors ATF6 and pXBP1(S)...
  7. doi request reprint ER stress response, peroxisome proliferation, mitochondrial unfolded protein response and Golgi stress response
    Hiderou Yoshida
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    IUBMB Life 61:871-9. 2009
    ..The functional capacity of the Golgi apparatus may be regulated by the mechanism of the Golgi stress response. These observations strongly suggest the existence of an elaborate network of organelle autoregulation in eukaryotic cells...
  8. pmc Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation
    Yukako Oda
    Department of Molecular and Cellular Biology Institute for Frontier Medical Sciences, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Cell Biol 172:383-93. 2006
    ..These findings indicate that Derlin-2 and -3 provide the missing link between EDEM and p97 in the process of degrading misfolded glycoproteins...
  9. ncbi request reprint Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
    Keisuke Yamamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Dev Cell 13:365-76. 2007
    ..These results demonstrate that ATF6alpha functions as a critical regulator of ER quality control proteins in mammalian cells, in marked contrast to worm and fly cells in which IRE1 is responsible...
  10. ncbi request reprint Analysis of ATF6 activation in Site-2 protease-deficient Chinese hamster ovary cells
    Satomi Nadanaka
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 8502, Japan
    Cell Struct Funct 31:109-16. 2006
    ..M19 cells showed inefficient secretion of a model protein. These results suggest that Rip-mediated activation of ATF6 is important for the homeostasis of the ER in not only ER-stressed but also unstressed cells...
  11. ncbi request reprint Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II
    Keisuke Yamamoto
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
    J Biochem 136:343-50. 2004
    ..Accordingly, the induction of Herp mRNA was diminished in the absence of XBP1 whereas that of BiP mRNA was not affected. These results may help in understanding the role of Herp in the quality control system in the ER...
  12. ncbi request reprint Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation
    Satomi Nadanaka
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 8502, Japan
    Cell Struct Funct 31:127-34. 2006
    ..Importantly, reduction of disulfide bridges and transport of reduced monomer occurred in response to glucose starvation. We conclude that ER stress-induced reduction of ATF6 represents a general feature of the ATF6 activation process...
  13. pmc Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum
    Satomi Nadanaka
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Mol Biol Cell 15:2537-48. 2004
    ....
  14. pmc Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds
    Keisuke Yamamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    J Biochem 144:477-86. 2008
    ..The presence of UPR element II to which XBP1 but not ATF6 directly binds explains at least in part the dependency of HRD1 induction on the IRE1-XBP1 pathway...
  15. doi request reprint Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response
    Aya Uemura
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    J Cell Sci 122:2877-86. 2009
    ..From these observations, we concluded that unconventional splicing of XBP1 mRNA occurs predominantly in the cytoplasm...
  16. pmc Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress
    Satomi Nadanaka
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 8502, Japan
    Mol Cell Biol 27:1027-43. 2007
    ..This mechanism ensures the strictness of regulation, in that the cell can only process ATF6 which has experienced the changes in the ER...
  17. ncbi request reprint UBC9 regulates the stability of XBP1, a key transcription factor controlling the ER stress response
    Aya Uemura
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Cell Struct Funct 38:67-79. 2013
    ..From these observations, we concluded that UBC9 is a novel regulator of the mammalian ER stress response...
  18. ncbi request reprint A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6
    Tetsuya Okada
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8304, Japan
    J Biol Chem 278:31024-32. 2003
    ..These results indicate that the transport of ATF6 from the ER to the Golgi apparatus and that from the Golgi apparatus to the nucleus are distinct steps that can be distinguished by treatment with AEBSF...
  19. ncbi request reprint A time-dependent phase shift in the mammalian unfolded protein response
    Hiderou Yoshida
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8304, Japan
    Dev Cell 4:265-71. 2003
    ....
  20. ncbi request reprint ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum
    Yusuke Adachi
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Cell Struct Funct 33:75-89. 2008
    ..Based on these results, we propose that ATF6 is a transcription factor specialized in the regulation of ER quality control proteins...
  21. ncbi request reprint The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells
    Jun ichi Nozaki
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8397, Japan
    Genes Cells 9:261-70. 2004
    ..These results indicate that this cell line is subject to continuous ER stress and that the Ins2 C96Y mutation induces the expression of ER chaperones through the activation of ATF6 and XBP1...
  22. pmc Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
    Tetsuya Okada
    Graduate School of Biostudies, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8304, Japan
    Biochem J 366:585-94. 2002
    ..Thus we propose that mammalian cells have evolved a strategy to cope with ER stress different from that of yeast cells...
  23. ncbi request reprint Novel cis-acting element GASE regulates transcriptional induction by the Golgi stress response
    Masaya Oku
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    Cell Struct Funct 36:1-12. 2011
    ..These results suggest that mammalian cells have the Golgi stress response, and that GASE regulates transcriptional induction involved in the Golgi stress response...
  24. ncbi request reprint [Multiphase defense system in mammalian unfolded protein response]
    Hiderou Yoshida
    Tanpakushitsu Kakusan Koso 48:1248-55. 2003
  25. pmc Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress
    Zhi Ming Huang
    Pathology Service, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Mol Cell Biol 25:7522-33. 2005
    ..Thus, the hepatitis B virus S promoter responds to a novel, cell type-restricted transcriptional pathway downstream of IRE1-alpha and XBP1...
  26. ncbi request reprint Dysfunction of the unfolded protein response during global brain ischemia and reperfusion
    Rita Kumar
    Department of Emergency Medicine, Wayne State University, Detroit, Michigan, U S A
    J Cereb Blood Flow Metab 23:462-71. 2003
    ..As other studies have shown evidence for ER stress after brain ischemia and reperfusion, the failure of the UPR may play a significant role in reperfusion neuronal death...
  27. ncbi request reprint [Molecular biology of the ER stress response]
    Hiderou Yoshida
    PRESTO, Japan Science and Technology Agency
    Seikagaku 76:617-30. 2004
  28. ncbi request reprint The fusion oncoprotein PML-RARalpha induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress
    Md Matiullah Khan
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 279:11814-24. 2004
    ..Overexpression of N-CoR induces the differentiation of APL-derived NB4 cells, suggesting that the low levels of N-CoR in the nucleus may contribute at least partly to PML-RARalpha-mediated leukemogenesis...
  29. pmc IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
    Kyungho Lee
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Genes Dev 16:452-66. 2002
    ..Both processing of ATF6 and IRE1alpha-mediated splicing of XBP1 mRNA are required for full activation of the UPR...
  30. ncbi request reprint XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
    Lorenzo Romero-Ramirez
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5152, USA
    Cancer Res 64:5943-7. 2004
    ..Taken together, these studies directly implicate XBP1 as an essential survival factor for hypoxic stress and tumor growth...