Kentaro Yasuchika

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc A transmembrane glycoprotein, gp38, is a novel marker for immature hepatic progenitor cells in fetal mouse livers
    Sayuri Konishi
    Department of Surgery, Graduate School of Medicine Kyoto University, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto, Japan
    In Vitro Cell Dev Biol Anim 47:45-53. 2011
  2. ncbi request reprint Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese nationwide survey
    Iwao Ikai
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer 101:796-802. 2004
  3. ncbi request reprint Results of hepatic resection for hepatocellular carcinoma invading major portal and/or hepatic veins
    Iwao Ikai
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Surg Oncol Clin N Am 12:65-75, ix. 2003
  4. ncbi request reprint Prognostic index for patients with hepatocellular carcinoma combined with tumor thrombosis in the major portal vein
    Iwao Ikai
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Surg 202:431-8. 2006
  5. ncbi request reprint Two populations of Thy1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells
    Naoko Kamo
    Dept of Surgery, Graduate School of Medicine, Kyoto Univ, Shogoin, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G526-34. 2007
  6. ncbi request reprint Purification of adult hepatic progenitor cells using green fluorescent protein (GFP)-transgenic mice and fluorescence-activated cell sorting
    Takahisa Fujikawa
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawara, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatol 39:162-70. 2003
  7. doi request reprint Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma
    Satoru Seo
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Surgery 143:769-77. 2008
  8. ncbi request reprint P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro
    Satoru Seo
    Department of Surgery, Graduate School of Medicine Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Int J Oncol 34:1303-12. 2009
  9. doi request reprint Establishment of a cell line derived from a mouse fetal liver that has the characteristic to promote the hepatic maturation of mouse embryonic stem cells by a coculture method
    Ken Fukumitsu
    Department of Surgery, Graduate School of Medicine Kyoto University, Kyoto, Japan
    Tissue Eng Part A 15:3847-56. 2009
  10. ncbi request reprint Resistance to cisplatin-induced apoptosis via PI3K-dependent survivin expression in a rat hepatoma cell line
    Hiroyuki Asechi
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Oncol 37:89-96. 2010

Detail Information

Publications102 found, 100 shown here

  1. pmc A transmembrane glycoprotein, gp38, is a novel marker for immature hepatic progenitor cells in fetal mouse livers
    Sayuri Konishi
    Department of Surgery, Graduate School of Medicine Kyoto University, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto, Japan
    In Vitro Cell Dev Biol Anim 47:45-53. 2011
    ..Furthermore, Wnt3a had a proliferative effect on the gp38-positive HPCs. In conclusion, the gp38-positive HPCs derived from fetal liver tissue until E13.5 could therefore be candidates for hepatic stem cells in the fetal liver...
  2. ncbi request reprint Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese nationwide survey
    Iwao Ikai
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer 101:796-802. 2004
    ..The objective of this study was to evaluate prognostic predictors for patients with HCC who underwent liver resection in a Japanese nationwide data base...
  3. ncbi request reprint Results of hepatic resection for hepatocellular carcinoma invading major portal and/or hepatic veins
    Iwao Ikai
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Surg Oncol Clin N Am 12:65-75, ix. 2003
    ..The surgical results of 112 patients with HCC invading major portal and/or hepatic veins who underwent hepatic resection between 1985 and 2001 were studied to evaluate the feasibility of hepatic resection as a local treatment...
  4. ncbi request reprint Prognostic index for patients with hepatocellular carcinoma combined with tumor thrombosis in the major portal vein
    Iwao Ikai
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Surg 202:431-8. 2006
    ..This study sought to analyze prognostic factors in patients with hepatocellular carcinoma and tumor thrombosis in the first branch or trunk of the portal vein, and to provide a prognostic index...
  5. ncbi request reprint Two populations of Thy1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells
    Naoko Kamo
    Dept of Surgery, Graduate School of Medicine, Kyoto Univ, Shogoin, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G526-34. 2007
    ..In conclusion, these results suggest that in vitro maturation of HPCs promoted by gp38-positive cells may be opposed by an inhibitory effect of gp38-negative cells, which likely maintain the immature, proliferative state of HPCs...
  6. ncbi request reprint Purification of adult hepatic progenitor cells using green fluorescent protein (GFP)-transgenic mice and fluorescence-activated cell sorting
    Takahisa Fujikawa
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawara, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatol 39:162-70. 2003
    ..However, a lack of detectable definitive markers in viable cells has hindered their primary culture from adult livers...
  7. doi request reprint Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma
    Satoru Seo
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Surgery 143:769-77. 2008
    ..In this study, we investigated the usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) as a marker for lymph node metastasis, P-glycoprotein (P-gp) expression, and recurrence in ICC...
  8. ncbi request reprint P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro
    Satoru Seo
    Department of Surgery, Graduate School of Medicine Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Int J Oncol 34:1303-12. 2009
    ..Collectively, our results show that FDG uptake in HCC is weakly correlated with GLUT-1 expression, and that FDG could be a substrate of P-gp, which may act as an efflux pump to reduce FDG accumulation...
  9. doi request reprint Establishment of a cell line derived from a mouse fetal liver that has the characteristic to promote the hepatic maturation of mouse embryonic stem cells by a coculture method
    Ken Fukumitsu
    Department of Surgery, Graduate School of Medicine Kyoto University, Kyoto, Japan
    Tissue Eng Part A 15:3847-56. 2009
    ..In conclusion, a cell line was established that has the characteristic to promote the hepatic maturation of mouse ESCs and HPCs by a coculture method...
  10. ncbi request reprint Resistance to cisplatin-induced apoptosis via PI3K-dependent survivin expression in a rat hepatoma cell line
    Hiroyuki Asechi
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Oncol 37:89-96. 2010
    ..LY294002 also attenuated survivin expression induced by CDDP. Our results indicate that survivin expression via PI3K contributes to resistance to CDDP-induced apoptosis in a rat hepatoma cell line...
  11. ncbi request reprint Surgical resection of hilar cholangiocarcinoma: analysis of survival and postoperative complications
    Suguru Hasegawa
    Department of Surgery, Kyoto University Hospital, Kyoto, Japan
    World J Surg 31:1256-63. 2007
    ..This study sought to evaluate the efficacy and feasibility of surgical management of hilar bile duct carcinoma, including radical hepatectomy, at a single institution...
  12. ncbi request reprint In vitro differentiation and maturation of mouse embryonic stem cells into hepatocytes
    Takamichi Ishii
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Exp Cell Res 309:68-77. 2005
    ..In conclusion, coculture with Thy1-positive cells in vitro induced the maturation of AFP-producing cells isolated from ES cell cultures into hepatocytes...
  13. ncbi request reprint Commitment of bone marrow cells to hepatic stellate cells in mouse
    Shinji Baba
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawara cho, Shogoin, Sakyo ku, Kyoto City 606 8507, Japan
    J Hepatol 40:255-60. 2004
    ..Recently, several cells found within the liver have been reported to derive from bone marrow (BM). This study sought to examine the commitment of BM cells to hepatic stellate cell (HSC) lineage in mouse liver...
  14. doi request reprint CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury
    Nobuyuki Tamaki
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G498-505. 2008
    ..The results demonstrate an essential role of CHOP in development of liver fibrosis due to cholestatic liver damage...
  15. doi request reprint Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma
    Junji Komori
    Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hepatology 47:888-96. 2008
    ..Moreover, immunostaining for AID was detectable in 16 of 20 bile epithelia in the tissues underlying primary sclerosing cholangitis...
  16. pmc Implication of frequent local ablation therapy for intrahepatic recurrence in prolonged survival of patients with hepatocellular carcinoma undergoing hepatic resection: an analysis of 610 patients over 16 years old
    Kojiro Taura
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ann Surg 244:265-73. 2006
    ..By comparing cohorts in 2 exclusive time frames, the factors that affected the surgical outcomes of patients with hepatocellular carcinoma (HCC) are presented...
  17. doi request reprint Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells
    Keiko Iwaisako
    Department of Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatol 49:768-78. 2008
    ..We disclose the quiescent hepatic stellate cells (HSCs)-specific expression of a septin subunit Sept4 in the liver, and explore the significance of the septin system in liver fibrosis...
  18. ncbi request reprint Discrete breakpoint mapping and shortest region of overlap of chromosome arm 1q gain and 1p loss in human hepatocellular carcinoma detected by semiquantitative microsatellite analysis
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 42:34-43. 2005
    ..32-p36.22, 5.1 Mb). Four known putative tumor-suppressor genes (TP73, RIZ1, NBL1/DAN, and CDKN2C) were outside the SRO, suggesting the presence of other candidate genes with critical roles in hepatocarcinogenesis...
  19. ncbi request reprint Genome-wide semiquantitative microsatellite analysis of human hepatocellular carcinoma: discrete mapping of smallest region of overlap of recurrent chromosomal gains and losses
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Genet Cytogenet 167:57-65. 2006
    ..Although some putative oncogenes or tumor suppressor genes mapped in these SRO may be important, relative copy number changes of numerous other genes may affect pathogenesis of HCC...
  20. ncbi request reprint A modified Japan Integrated Stage score for prognostic assessment in patients with hepatocellular carcinoma
    Iwao Ikai
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Gastroenterol 41:884-92. 2006
    ..This study sought to provide a modified Japan Integrated Stage (m-JIS) score to predict more accurately the survival of patients with HCC...
  21. ncbi request reprint SIAH1 causes growth arrest and apoptosis in hepatoma cells through beta-catenin degradation-dependent and -independent mechanisms
    Hiroshi Yoshibayashi
    Department of Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Oncol Rep 17:549-56. 2007
    ..Further investigations into the mechanisms by which SIAH1 promotes apoptosis and suppresses cell growth should also allow for the discovery of new therapeutic strategies...
  22. doi request reprint A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction
    Masato Narita
    Department of Surgery, Graduate School of Medicine, Kyoto University, Syogoin, Kyoto, Japan
    Ann Surg 249:806-13. 2009
    ..The aim of study was to investigate pharmacological treatment for sinusoidal obstruction syndrome (SOS)...
  23. doi request reprint Comparative study of transplantation of hepatocytes at various differentiation stages into mice with lethal liver damage
    Ryo Kamimura
    Department of Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Cell Transplant 21:2351-62. 2012
    ....
  24. ncbi request reprint Thy1-positive mesenchymal cells promote the maturation of CD49f-positive hepatic progenitor cells in the mouse fetal liver
    Toshitaka Hoppo
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hepatology 39:1362-70. 2004
    ....
  25. ncbi request reprint Improvement of the survival rate by fetal liver cell transplantation in a mice lethal liver failure model
    Takafumi Machimoto
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 84:1233-9. 2007
    ..In this study, we transplanted HPCs into the liver injury model mice to determine whether HPC transplantation may improve the liver dysfunction...
  26. ncbi request reprint Absence of PERV infection in baboons after transgenic porcine liver perfusion
    Ryuta Nishitai
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    J Surg Res 124:45-51. 2005
    ..We evaluated whether PERV is capable of infecting nonhuman primates in vivo after extracorporeal porcine liver perfusion (ECLP)...
  27. ncbi request reprint Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis
    Tadayuki Kou
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Cancer 120:469-76. 2007
    ....
  28. ncbi request reprint Enrichment of hepatic progenitor cells from adult mouse liver
    Hisaya Azuma
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hepatology 37:1385-94. 2003
    ..In conclusion, our methodology allows the enrichment of immature hepatic cells from the normal adult mouse. These cells are capable of growth and maturation along the hepatocyte lineage, indicating that these cells are HPCs...
  29. doi request reprint Preoperative FDG-PET predicts recurrence patterns in hepatocellular carcinoma
    Koji Kitamura
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Ann Surg Oncol 19:156-62. 2012
    ....
  30. doi request reprint Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma
    Takamichi Ishii
    Laboratory of Embryonic Stem Cell Research, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho Shogoin, Sakyo ku, Kyoto, Japan
    Cancer Lett 294:25-34. 2010
    ..AFP and Notch1 expression was observed in clinical intrahepatic cholangiocarcinomas. The AFP-producing cells were suggested to be CSCs. The Notch pathway might play an important role in maintaining the CSC characteristics...
  31. doi request reprint Prophylactic respiratory management after liver resection with bilevel positive airway pressure ventilation: Report of three cases
    Masato Narita
    Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Syogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Surg Today 39:172-4. 2009
    ..Bilevel positive airway pressure ventilation was well tolerated and there were no adverse effects, suggesting its effectiveness for preventing pulmonary complications after hepatectomy...
  32. ncbi request reprint Management of adrenal metastasis from hepatocellular carcinoma
    Hirohito Momoi
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Surg Today 32:1035-41. 2002
    ..This study examines the effectiveness of various treatments for this disease...
  33. ncbi request reprint Transplantation of embryonic stem cell-derived endodermal cells into mice with induced lethal liver damage
    Takamichi Ishii
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Stem Cells 25:3252-60. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  34. doi request reprint Proliferative activity in hepatocellular carcinoma is closely correlated with glucose metabolism but not angiogenesis
    Koji Kitamura
    Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatol 55:846-57. 2011
    ..This study investigated the relationship between tumor proliferative activity and the grade of tumor glucose metabolism or angiogenesis in hepatocellular carcinoma (HCC)...
  35. ncbi request reprint Fluorine-18 fluorodeoxyglucose positron emission tomography predicts tumor differentiation, P-glycoprotein expression, and outcome after resection in hepatocellular carcinoma
    Satoru Seo
    Department of Surgery and Diagnostic Imaging, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Syogoin, Sakyo ku, Kyoto 606 8507, Japan
    Clin Cancer Res 13:427-33. 2007
    ..To investigate the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) for prediction of tumor differentiation, P-glycoprotein (P-gp) expression, and outcome in hepatocellular carcinoma (HCC) patients...
  36. ncbi request reprint Resection for hepatocellular carcinoma with duodenal invasion: report of a case
    Etsuro Hatano
    Department of Gastroenterological Surgery, Kyoto University of Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Hepatogastroenterology 50:1034-6. 2003
    ..This report demonstrated the first case with a hepatocellular carcinoma with duodenal invasion, for which hepatic resection was performed successfully...
  37. ncbi request reprint High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine
    Masaharu Tada
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin Sakyo ku Kyoto, 606 8507, Japan
    J Gene Med 8:1018-26. 2006
    ....
  38. doi request reprint Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics
    Naoya Sasaki
    Department of Surgery, Graduate School of Medicine, Kyoto University, Japan
    Cancer Lett 308:152-61. 2011
    ..The AFP-producing cells were shown to be putative pancreatic cancer stem cells. Furthermore, the expression of ABCA12 appears to be associated with drug resistance...
  39. ncbi request reprint Cholangitis and liver abscess after percutaneous ablation therapy for liver tumors: incidence and risk factors
    Toshiya Shibata
    Department of Diagnostic Imaging and Radiology, Kyoto University Graduate School of Medicine, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    J Vasc Interv Radiol 14:1535-42. 2003
    ..To determine the risk factors of cholangitis and liver abscess occurring after percutaneous ablation therapy for liver tumors...
  40. ncbi request reprint [Comparison of the clinical practice guidelines for hepatocellular carcinoma in Japan and Western countries]
    Iwao Ikai
    Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nihon Geka Gakkai Zasshi 109:343-8. 2008
    ....
  41. doi request reprint Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma
    Hiromitsu Nagata
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Hepatology 49:1944-53. 2009
    ..The specific inhibition of JNK activity by SP600125 suppressed pSmad3L/c-Myc in the damaged hepatocytes and enhanced pSmad3C/p21(WAF1), acting as a tumor suppressor in normal hepatocytes...
  42. ncbi request reprint Establishment of a highly efficient gene transfer system for mouse fetal hepatic progenitor cells
    Kentaro Yasuchika
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan kent kuhp kyotou ac jp
    Hepatology 36:1488-97. 2002
    ..In conclusion, we established a highly efficient in vitro gene transfer system for mouse fetal HPCs using a newly developed isolation and culture system...
  43. ncbi request reprint Influence of coexisting cirrhosis on outcomes after partial hepatic resection for hepatocellular carcinoma fulfilling the Milan criteria: an analysis of 293 patients
    Kojiro Taura
    Department of Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin Sakyo ku, Kyoto City, Kyoto, Japan
    Surgery 142:685-94. 2007
    ..Nevertheless, it remains controversial whether OLT is the best treatment strategy for patients with resectable HCC...
  44. doi request reprint Hepatic differentiation of embryonic stem cells by murine fetal liver mesenchymal cells
    Takamichi Ishii
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Methods Mol Biol 946:469-78. 2013
    ..The ESC-derived hepatocyte-like cells possess hepatic functions, including ammonia removal activity, albumin secretion ability, glycogen synthesis and storage, and cytochrome P450 enzymatic activity...
  45. doi request reprint Early evaluation of transcatheter arterial chemoembolization-refractory hepatocellular carcinoma
    Kenya Yamanaka
    Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Gastroenterol 47:343-6. 2012
    ..This study examined whether evaluating the tumor effect (TE) at 1 week after TACE was useful for predicting refractoriness to TACE...
  46. doi request reprint Prognostic value of (18)F-fluorodeoxyglucose positron emission tomography in patients with extrahepatic bile duct cancer
    Koji Kitamura
    Department of Surgery, Graduate School of Medicine Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatobiliary Pancreat Sci 18:39-46. 2011
    ..In this study, we investigated the prognostic value of FDG-PET in EBDC patients...
  47. ncbi request reprint Comprehensive allelotyping of well-differentiated human hepatocellular carcinoma with semiquantitative determination of chromosomal gain or loss
    Takafumi Nishimura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 35:329-39. 2002
    ..On the other hand, deletions of 13q and 16q were infrequent and were seen only in the most aberrant cases, which suggested that these were late events...
  48. doi request reprint Regulation of basal core promoter activity of human organic cation transporter 1 (OCT1/SLC22A1)
    Moto Kajiwara
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 295:G1211-6. 2008
    ..These findings indicated that both USF1 and USF2 bind to an E-box sequence located in the OCT1 core promoter region and are required for the basal gene expression of this transporter...
  49. doi request reprint Comparative study of cisplatin and epirubicin in transcatheter arterial chemoembolization for hepatocellular carcinoma
    Kenya Yamanaka
    Departments of SurgeryDiagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto UniversityDepartment of Biostatistics, Kyoto University School of Public Health, Kyoto, Japan
    Hepatol Res 41:303-9. 2011
    ..The odds ratio was 4.11 (95% CI = 1.14-17.2). Conclusion:  CDDP may be more effective than EPI in TACE for multiple HCC. A randomized controlled study is needed to clarify the efficacy of CDDP in TACE in patients with multiple HCC...
  50. ncbi request reprint Establishment of the gene-inducible system in primate embryonic stem cell lines
    Keiko Adachi
    Department of Development and Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Stem Cells 24:2566-72. 2006
    ..Such manipulated cells maintained ESC characteristics, and inducible gene expression in both the stem cells and differentiated cells could be reliably controlled by doxycycline administration...
  51. ncbi request reprint Effectiveness of endoscopic nasobiliary drainage for postoperative bile leakage after hepatic resection
    Hiroaki Terajima
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawara cho, Shogoin, Sakyo ku, 606 8507, Kyoto, Japan
    World J Surg 28:782-6. 2004
    ..It is preferable to initiate ENBD as early as possible to shorten the duration of bile leakage and the subsequent hospital stay...
  52. doi request reprint Impact of regulatory polymorphisms in organic anion transporter genes in the human liver
    Masayo Aoki
    Department of Pharmacy, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Pharmacogenet Genomics 19:647-56. 2009
    ..The aim of this study was to evaluate whether genetic polymorphisms are responsible for individual variation in the expression levels of hepatic organic anion transporters...
  53. ncbi request reprint Report of the 17th Nationwide Follow-up Survey of Primary Liver Cancer in Japan
    Iwao Ikai
    The Liver Cancer Study Group of Japan, Kyoto, Japan
    Hepatol Res 37:676-91. 2007
    ..The data obtained in this follow-up survey should contribute to future research and medical practice for primary liver cancer...
  54. ncbi request reprint Hepatic organoid formation in collagen sponge of cells isolated from human liver tissues
    Shinichi Sugimoto
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Japan
    Tissue Eng 11:626-33. 2005
    ..The cells in the collagen sponge actively proliferated and the hepatocytes excreted albumin into the medium. Thus, hepatic organoids could be reconstructed in a collagen sponge by normal human liver cells...
  55. ncbi request reprint Relocation of truncated bid plays an important role in suppression of tumor necrosis factor alpha induced apoptosis in hepatocytes isolated from transgenic mouse
    Tomohiro Shiotani
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    J Surg Res 127:157-63. 2005
    ..This study sought to clarify the relationship between hepatic energy status and TNFalpha-induced hepatocyte apoptosis, using mice transgenic for creatine kinase (CK) expression...
  56. ncbi request reprint Diverse p53 gene aberration in hepatocellular carcinoma detected by dual-color fluorescence in situ hybridization
    Masahiko Kondo
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Gastroenterol Hepatol 19:1066-73. 2004
    ....
  57. ncbi request reprint A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma
    Masayuki Shimoda
    Molecular and Cancer Research Unit, HMRO, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Cancer Res 12:6005-11. 2006
    ..To address the possibility that Prox1 may be involved in the tumorigenesis of hepatocellular carcinoma (HCC), human clinical samples were analyzed...
  58. ncbi request reprint Significance of serum type IV collagen level of hepatectomized patients with chronic liver damage
    Yasuyuki Shimahara
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawaracho, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    World J Surg 26:451-6. 2002
    ..Thus perioperative measurement of the serum type IV collagen levels seemed to be useful for predicting the risk of hepatic resection in patients with chronic liver damage...
  59. ncbi request reprint Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells
    Naoki Koizumi
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Int J Oncol 26:1301-6. 2005
    ..Blocking of PI3K/Akt may thus be helpful for overcoming chemo-resistance of HCC...
  60. ncbi request reprint CT-guided transthoracic percutaneous ethanol injection for hepatocellular carcinoma not detectable with US
    Toshiya Shibata
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    Radiology 223:115-20. 2002
    ..To evaluate the safety and effectiveness of computed tomography (CT)-guided percutaneous ethanol injection (PEI) for the treatment of hepatocellular carcinoma (HCC) not detectable with ultrasonography (US)...
  61. ncbi request reprint Pancreatic arteriovenous malformation with portal hypertension
    Hisahiro Hosogi
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Shogoin, Kyoto 606 8507, Japan
    J Hepatobiliary Pancreat Surg 13:344-6. 2006
    ....
  62. ncbi request reprint Asialo GM1 positive CD8+ T cells induce skin allograft rejection in the absence of the secondary lymphoid organs
    Satoshi Yamanokuchi
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Surg Res 129:57-63. 2005
    ..In this study, we investigated immune responses to skin allografts in splenectomized aly/aly mice, which lack secondary lymphoid organs completely, and examined the effect of anti-asialo GM1 (AsGM1) antibodies on these responses...
  63. ncbi request reprint Contribution of bone marrow cells to liver regeneration after partial hepatectomy in mice
    Hideaki Fujii
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54, Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatol 36:653-9. 2002
    ..We examined whether bone marrow (BM) cells can commit to liver-consisting cells during liver regeneration after partial hepatectomy, using mice transplanted with green fluorescent protein (GFP) positive BM from GFP transgenic mice...
  64. doi request reprint Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma
    Masato Narita
    Department of Surgery, Graduate School of Medicine, Kyoto University, and Department of Diagnostic Pathology, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    J Gastroenterol 44:793-8. 2009
    ..The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC)...
  65. ncbi request reprint Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage
    Hirofumi Suemori
    Laboratory of Embryonic Stem Cell Research, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 345:926-32. 2006
    ..These results provide valuable information that will assist in achieving the goal of the large-scale hES cell culture required for the application of hES cells to disease therapy...
  66. ncbi request reprint Preoperative positron emission tomography with fluorine-18-fluorodeoxyglucose is predictive of prognosis in patients with hepatocellular carcinoma after resection
    Etsuro Hatano
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    World J Surg 30:1736-41. 2006
    ..The standardized uptake values (SUVs) of FDG-positron emission tomography (PET) in high-grade HCCs are significantly higher than those in low-grade HCCs...
  67. ncbi request reprint Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes
    Yuichi Tanaka
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 341:314-9. 2006
    ..Our findings provided the first evidence showing that APOBEC3G is induced by IFN stimulation in human hepatocytes and thus could be involved in host defense mechanisms directed against hepatitis viruses...
  68. ncbi request reprint Single-agent gemcitabine for biliary tract cancers. Study outcomes and systematic review of the literature
    Takayoshi Kiba
    Outpatient Oncology Unit, Kyoto University, Kyoto, Japan
    Oncology 70:358-65. 2006
    ..The aim of this study was to investigate the outcomes of gemcitabine-treated patients with inoperable biliary tract cancers...
  69. ncbi request reprint SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas
    Koichi Matsuo
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 36:283-91. 2003
    ..SIAH1 was significantly downregulated in advanced HCCs, including poorly differentiated tumors, larger tumors, and tumors in advanced stages. These findings suggest that inactivation of SIAH1 plays an important role in HCC progression...
  70. doi request reprint Dai-kenchu-to attenuates rat sinusoidal obstruction syndrome by inhibiting the accumulation of neutrophils in the liver
    Masato Narita
    Department of Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 24:1051-7. 2009
    ..The aim of study was to investigate the pharmacological treatment of SOS using a traditional Japanese medicine, Dai-kenchu-to (DKT)...
  71. ncbi request reprint Primary hepatic carcinoid tumor with metachronous lymph node metastasis after long-term follow up
    Yuji Iimuro
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Gastroenterol Hepatol 17:1119-24. 2002
    ..After lymphadenectomy, the patient is free from recurrence in the regional lymph nodes for more than 1 year. This case is con-sidered to be a primary hepatic carcinoid tumor with metachronous lymph node metastasis...
  72. ncbi request reprint Prognostic impact of multiple allelic losses on metastatic recurrence in hepatocellular carcinoma after curative resection
    Naoshi Nishida
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Oncology 62:141-8. 2002
    ..These findings indicate that accumulation of chromosomal changes is associated with metastatic behavior, and that LOH on 16q was the most useful prognostic indicator for metastasis after curative resection of HCC...
  73. ncbi request reprint Resistant hepatic hydrothorax: a successful case with treatment by nCPAP
    Ken Ichi Takahashi
    Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Respir Med 99:262-4. 2005
    ..The mechanism for the improvement may have been the intrathoracic positive pressure during sleep induced by the nCPAP treatment during sleep. nCPAP treatment may provide a new therapy for resistant hepatic hydrothorax...
  74. doi request reprint Effects of extracellular matrixes and growth factors on the hepatic differentiation of human embryonic stem cells
    Takamichi Ishii
    Laboratory of Embryonic Stem Cell Research, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Am J Physiol Gastrointest Liver Physiol 295:G313-21. 2008
    ..In conclusion, we therefore found this protocol to effectively differentiate multiple hESC lines to early hepatocytes using activin A and HGF on Matrigel...
  75. doi request reprint In vitro hepatic maturation of human embryonic stem cells by using a mesenchymal cell line derived from murine fetal livers
    Takamichi Ishii
    Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Cell Tissue Res 339:505-12. 2010
    ..The co-culture method was thus successfully shown to induce the differentiation of hESC-derived endodermal cells into functional hepatocyte-like cells...
  76. ncbi request reprint Suppressed complement activation in human decay accelerating factor transgenic porcine liver cross-circulated with nonhuman primates
    Takakazu Matsushita
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto, Japan
    Transplantation 75:1807-12. 2003
    ..We developed an extracorporeal liver perfusion (ECLP) system as a liver-assist device. In this study, we evaluated the safety of the ECLP using human decay accelerating factor (hDAF) transgenic porcine livers in healthy baboons...
  77. ncbi request reprint Percutaneous radiofrequency ablation therapy after intrathoracic saline solution infusion for liver tumor in the hepatic dome
    Toshiya Shibata
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    J Vasc Interv Radiol 13:313-5. 2002
    ..No severe complications occurred and complete therapeutic effects were obtained. Percutaneous RF ablation therapy with intrathoracic saline solution injection seems to be a feasible alternative to other ablation therapies...
  78. ncbi request reprint Targeted chromosome elimination from ES-somatic hybrid cells
    Hiroyuki Matsumura
    Stem Cell Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nat Methods 4:23-5. 2007
    ..We attribute hybrid-cell pluripotency to the expression of Nanog from the reprogrammed somatic-cell nuclei...
  79. doi request reprint A multi-institution phase II study of gemcitabine/S-1 combination chemotherapy for patients with advanced biliary tract cancer
    Masashi Kanai
    Outpatient Oncology Unit, Kyoto University Hospital, 54 Shogoin Kawahara cho Sakyo ku, Kyoto, Japan
    Cancer Chemother Pharmacol 67:1429-34. 2011
    ..We aimed to evaluate the efficacy and safety of gemcitabine/S-1 combination chemotherapy for the treatment of patients with advanced biliary tract cancer...
  80. doi request reprint Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation
    Masayo Aoki
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto, Japan
    Am J Physiol Renal Physiol 295:F165-70. 2008
    ..These results indicate that kidney-specific expression of human OCT2 is regulated by methylation of the proximal promoter region, interfering with the transactivation by USF1...
  81. ncbi request reprint Bioartificial liver with whole blood perfusion
    Yuichiro Ueda
    Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    ASAIO J 49:401-6. 2003
    ..No significant hemolysis or thrombus that affected the BAL system and the canine were observed. These results suggest that our BAL system is a promising liver assist device through which patients' whole blood can be perfused...
  82. ncbi request reprint Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi-institutional analysis of 425 patients with definition of a histologic prognostic index
    Gregory Y Lauwers
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Surg Pathol 26:25-34. 2002
    ..The combination of these histologic parameters provides adequate prognostic stratification...
  83. pmc Preoperative predictors of survival after resection of small hepatocellular carcinomas
    Jeffrey D Wayne
    International Cooperative Study Group on Hepatocellular Carcinoma Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Surg 235:722-30; discussion 730-1. 2002
    ..To determine preoperative predictors of survival that can guide the choice of treatment for patients with small hepatocellular cancers (HCCs)...
  84. ncbi request reprint Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation
    Nestor F Esnaola
    Department of Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Gastrointest Surg 6:224-32; discussion 232. 2002
    ..3; 95% CI, 2.0 to 19.9). Tumor size and grade are strong predictors of microvascular invasion. A tumor biopsy with pathologic grading at the time of pretransplantation ablative therapy could improve selection of patients with HCC for OLT...
  85. pmc Comparison of clinicopathologic characteristics and outcomes after resection in patients with hepatocellular carcinoma treated in the United States, France, and Japan
    Nestor F Esnaola
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Ann Surg 238:711-9. 2003
    ..To compare the clinicopathologic characteristics and outcomes after resection of patients with hepatocellular carcinoma (HCC) treated in the United States, France, and Japan...
  86. ncbi request reprint Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: results of a multicenter study
    Jean Marc Regimbeau
    Hopital Beaujon, Paris, France
    J Surg Oncol 85:36-41. 2004
    ..Recurrence after partial liver resection for hepatocellular carcinoma (HCC) is a major cause of death from this disease. To identify risk factors for early death from recurrence after liver resection for HCC...
  87. ncbi request reprint Comparative analysis of ATP-binding cassette (ABC) transporter gene expression levels in peripheral blood leukocytes and in liver with hepatocellular carcinoma
    Mohsen A Moustafa
    Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Aoba ku, Sendai 980 8575, Japan
    Cancer Sci 95:530-6. 2004
    ..Administration of chemotherapeutic agents which are substrates of ABCA1, B4 and G2 should be effective for the treatment of HCC...
  88. ncbi request reprint Hepatitis serology predicts tumor and liver-disease characteristics but not prognosis after resection of hepatocellular carcinoma
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    J Gastrointest Surg 8:794-804; discussion 804-5. 2004
    ..The prognosis after resection of HCC is influenced by tumor factors and liver disease, but not by HBV or HCV infection. The treatment for HCC should be dictated by the extent of underlying liver disease rather than by hepatitis serology...
  89. ncbi request reprint Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: results of a multicenter study
    Timothy M Pawlik
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Surgery 137:403-10. 2005
    ..We evaluated the efficacy of hepatic resection and the factors affecting survival after resection in such patients...
  90. ncbi request reprint Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma
    Timothy M Pawlik
    Department of Surgery, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Arch Surg 140:450-7; discussion 457-8. 2005
    ..A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection...
  91. ncbi request reprint Functional evaluation of bioartificial liver using RT-PCR
    Satoshi Fujita
    Institute for Frontier Medical Sciences, Kyoto University, Japan
    Biomed Mater Eng 15:211-8. 2005
    ..Additionally, the RT-PCR is so sensitive that we can measure much more minute quantity of various proteins. Consequently, this method is useful for comprehensive evaluation of BAL functions...
  92. ncbi request reprint Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma
    Timothy M Pawlik
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Liver Transpl 11:1086-92. 2005
    ....
  93. ncbi request reprint Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database
    Kelvin K Ng
    Centre for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg Oncol 12:364-73. 2005
    ..This study evaluated the long-term outcome of patients with hepatic resection for large (>5 cm in diameter) or multinodular (more than three nodules) HCC by using a multi-institutional database...
  94. ncbi request reprint Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients
    Kenichi Takayasu
    Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
    Gastroenterology 131:461-9. 2006
    ..To elucidate the survival of the patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze the factors affecting the survivals...
  95. ncbi request reprint [Retrospective analysis of clinical results in eight patients with advanced hepatocellular carcinoma with lung metastases treated by TS-1]
    Hiromitsu Nagata
    Dept of Surgery, Graduate School of Medicine, Kyoto University
    Gan To Kagaku Ryoho 34:233-5. 2007
    ..Randomized controlled trials are necessary to clarify survival benefits in patients with advanced HCC with lung metastasis...
  96. doi request reprint Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey
    Susumu Eguchi
    Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Surgery 143:469-75. 2008
    ..Although a surgical resection is an important modality for the treatment of hepatocellular carcinoma (HCC), the impact of the operative method on both the patient survival and disease-free survival (DFS) still remains controversial...
  97. ncbi request reprint Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis
    Naoshi Nishida
    Department of Internal Medicine, Division of Gastroenterology, Sammons Cancer Center, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA
    Cancer Res 67:4586-94. 2007
    ..HCCs with extensive methylation harbor frequent beta-catenin mutations, whereas HCCs with high levels of CIN are associated with p53 mutations, suggesting the presence of two independent pathways for the pathogenesis of HCC...
  98. pmc Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    Naoshi Nishida
    Division of Gastroenterology, Department of Internal Medicine and Charles A Sammons Cancer Center, Dallas, TX, USA
    Hepatology 47:908-18. 2008
    ..However, the group 3 loci showed more dense and frequent methylation in HCV-positive cancers compared with both HBV-positive cancers and virus-negative cancers (P < 0.0001)...
  99. pmc Staging of hepatocellular carcinoma: assessment of the Japanese TNM and AJCC/UICC TNM systems in a cohort of 13,772 patients in Japan
    Masami Minagawa
    Liver Cancer Study Group of Japan and the Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Ann Surg 245:909-22. 2007
    ....
  100. ncbi request reprint Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver
    Motonobu Furukawa
    Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Aoba ku, Sendai 980 8575, Japan
    Cancer Sci 95:520-9. 2004
    ....
  101. ncbi request reprint First international symposium of current issues for nationwide survey of primary liver cancer in Korea, Taiwan and Japan
    Kenichi Takayasu
    Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 37:233-40. 2007