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Genomes and Genes | Mitsuhiro YanagidaSummaryAffiliation: Kyoto University Country: Japan Publications
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Basic mechanism of eukaryotic chromosome segregationMitsuhiro Yanagida
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
Philos Trans R Soc Lond B Biol Sci 360:609-21. 2005..The roles of principal players in basic chromosome segregation are discussed: most players have interphase as well as mitotic functions. A view on how the centromere/kinetochore is formed is described...
Clearing the way for mitosis: is cohesin a target?Mitsuhiro Yanagida
Mitsuhiro Yanagida is at the CREST Research Program, Japan Science Technology Corporation, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Nat Rev Mol Cell Biol 10:489-96. 2009..I propose that condensin and DNA topoisomerase II (TOP2), as well as separase, help to clear the way for mitosis...- Cellular quiescence: are controlling genes conserved?Mitsuhiro Yanagida
Okinawa Institute of Science and Technology Promotion Corporation OISTPC, Initial Research Project IRP, Uruma, Okinawa 904 2234, Japan
Trends Cell Biol 19:705-15. 2009..These latest findings suggest that genes controlling quiescence are conserved from yeast to humans, and support the use of S. pombe as a model to enhance our understanding of the causes of aging, diabetes, obesity and neurodegeneration... - Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosisNorihiko Nakazawa
Core Research for Evolutional Science and Technology Research Program, Japan Science and Technology Corporation, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
J Cell Biol 180:1115-31. 2008..The mechanism of condensin accumulation at the kinetochores may be conserved, as human condensin II fails to accumulate at kinetochores in hMis6 RNA interference-treated cells... - Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomesTomomi Kiyomitsu
Core Research for Evolutional Science and Technology Research Program, Japan Science and Technology Corporation, Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
J Cell Biol 188:791-807. 2010..hMis14, which contains a tripartite-binding domain for HP1 and two other kinetochore proteins, hMis13 and blinkin, is a cornerstone for the assembly of the inner centromere and kinetochore... 
An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformationTatsuro Yuasa
Department of Biophysics, Graduate School of Science, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan
Genes Cells 9:1069-82. 2004..pombe cdc48 mutants displayed the mitotic phenotype highly similar to separase/cut1 mutants. This approach also provides a novel way of mutant isolation, resulting in two histone H2B strains and a cohesion mutant with a new phenotype...- Separase-mediated cleavage of cohesin at interphase is required for DNA repairKoji Nagao
Department of Biophysics, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
Nature 430:1044-8. 2004..We propose that the securin-separase complex might aid DNA repair by removing local cohesin in interphase cells... - Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1Tomomi Kiyomitsu
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
Mol Cell Biol 31:998-1011. 2011..Taken together, these results indicate that blinkin functions to connect Bub1 and BubR1 with the hMis12, Ndc80, and Zwint-1 complexes, and disruption of this connection may lead to tumorigenesis... - Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair function of condensinEe Sin Chen
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwakecho, Sakyo ku, Kyoto 606 8502, Japan
Proc Natl Acad Sci U S A 101:8078-83. 2004..Cti1 is the first example of the protein that interacts with the hinge domain of SMC. Cti1 may have a supporting role for the DNA repair function of condensin... - Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeresTakeshi Hayashi
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Sakyo ku, 606 8502, Japan
Cell 118:715-29. 2004..RNAi knockdown in human cells shows that Mis16 function is conserved as RbAp48 and RbAp46 are both required for localization of human CENP-A... - Condensin but not cohesin SMC heterodimer induces DNA reannealing through protein-protein assemblyAkiko Sakai
Department of Biophysics, Graduate School of Science, Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
EMBO J 22:2764-75. 2003..SMC is eliminated from the completed double-stranded DNA. The ability of heterodimeric SMC to reanneal DNA may be regulated in vivo possibly through the non-SMC heterotrimeric complex... - Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherinYuu Kimata
CREST Research Program, Japan Science and Technology Corporation, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Kyoto 606 8501, Japan
J Cell Sci 121:1107-18. 2008..HATs and HDACs might directly target adherin and APC/C to ensure proper chromosome segregation, and anti-tumour effects of HDAC inhibitors could be attributed to this deregulation... - Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitorYuichiro Hanyu
CREST Research Project, Japan Science Technology Corporation, Kyoto, Japan
Genes Cells 14:539-54. 2009..Ssp1 and Ppe1 thus seem to antagonize in utilizing limited glucose. We also show that Ppk9 and Ssp2 are the catalytic subunits of AMPK and AMPK-related kinases, respectively, which bind to common beta-(Amk2) and gamma-(Cbs2) subunits... - Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1Tomomi Kiyomitsu
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
Dev Cell 13:663-76. 2007..Blinkin may be the center of the network for generating kinetochore-based checkpoint signaling... - Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillanceYusuke Toyoda
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan
Mol Biol Cell 17:2287-302. 2006..Cohesin and topo II have distinct, yet coordinated functions in metaphase alignment... - A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1Chikashi Obuse
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
Nat Cell Biol 6:1135-41. 2004..Double HP1 RNAi abolishes kinetochore localization of hMis12 and DC8. Therefore, centromeric HP1 may be the base to anchor the hMis12 core complex that is enriched with coiled coils and extends to outer Zwint-1 during mitosis... - Histone H2B mutations in inner region affect ubiquitination, centromere function, silencing and chromosome segregationTakeshi Maruyama
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto, Japan
EMBO J 25:2420-31. 2006..Histone H2B thus plays an important role in centromere/kinetochore formation... - Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeastYoshiharu Shiroiwa
Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto, Japan
PLoS ONE 6:e17761. 2011..The Mis6-Mal2-Sim4 complex of the fission yeast S. pombe is required for the recruitment of CenH3 (Cnp1), but its function remains obscure... - Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunitsTakeshi Hayashi
The G0 Cell Unit, Okinawa Institute of Science and Technology Promotion Corporation, Suzaki 12 22, Uruma, Okinawa 904 2234, Japan
Genes Cells 12:1357-70. 2007..Functional redundancy of the TORCs may explain the rapamycin hypersensitivity of tor2-287... - Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stressesYosuke Kawasaki
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
Cell Cycle 5:1831-9. 2006..Securin bound to separase was hyperphosphorylated. The stresses could not rescue the indestructible Cut2 and Rad21 mutants. We postulate that the stresses produce the hyperchaperonic form of Cut2 that can rescue separase mutations... - Cdc48 is required for the stability of Cut1/separase in mitotic anaphaseNobuyasu Ikai
Department of Gene Mechanism, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
J Struct Biol 156:50-61. 2006..Cells lose viability during the traverse of anaphase in cdc48 mutant cells. Cdc48 may protect Cut1/separase and Cut2/securin against the instability during polyubiquitination and degradation in the metaphase-anaphase transition... - Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1Yohta Fujita
CREST Research Project of Japan Science and Technology Corporation JST, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Kyoto 606 8501, Japan
Dev Cell 12:17-30. 2007..Telophase centromere chromatin may be primed or licensed by the hMis18 complex and RbAp46/48 to recruit CENP-A through regulating the acetylation status in the centromere... - The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochoreGohta Goshima
COE Research Project, Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwakecho, Sakyo ku, Kyoto 606 8502 Japan
EMBO J 22:2752-63. 2003..Ppe1/PP6 directly or indirectly modulates kinetochore chromatin protein Mis12 to ensure progression into normal anaphase... - Cut1/separase-dependent roles of multiple phosphorylation of fission yeast cohesion subunit Rad21 in post-replicative damage repair and mitosisYoh Adachi
CREST Research Program, Japan Science and Technology Corporation, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Kyoto, Japan
Cell Cycle 7:765-76. 2008..These complex phospho-regulations of Rad21 indicate the functional significance of cohesin in cell adaptation to a variety of cellular conditions... - Two-step, extensive alterations in the transcriptome from G0 arrest to cell division in Schizosaccharomyces pombeMizuki Shimanuki
Initial Research Project IRP, Okinawa Institute of Science and Technology Promotion Corporation OIST, Uruma 904 2234, Okinawa, Japan
Genes Cells 12:677-92. 2007.... - CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregationKeita Aoki
Core Research for Evolutional Science and Technology Research Program of Japan Science and Technology Corporation, Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
Curr Biol 16:1627-35. 2006..Cdc2 thus directly phosphorylates Dis1, and this phosphorylation regulates Dis1 localization in both metaphase and anaphase and ensures high-fidelity segregation... - Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separaseKoji Nagao
Initial Research Project, Okinawa Institute of Science and Technology, Suzaki 12 22, Uruma, Okinawa, 904 2234, Japan
Genes Cells 11:247-60. 2006.... 
Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathwayGohta Goshima
COE Research Project, Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
J Cell Biol 160:25-39. 2003..RNAi for hMis6, like that of a kinetochore kinesin CENP-E, induces mitotic arrest. Kinetochore localization of hMis12 is unaffected by CENP-A RNAi, demonstrating an independent pathway of CENP-A in human kinetochores...- Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeastKojiro Takeda
Okinawa Institute of Science and Technology, Uruma, Okinawa 904 2234, Japan
Proc Natl Acad Sci U S A 107:3540-5. 2010..Proteasome and autophagy are thus collaborative to support the lifespan of S. pombe G0 phase... - Suppression of a mitotic mutant by tRNA-Ala anticodon mutations that produce a dominant defect in late mitosisYuu Kimata
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University Kitashirakawa Oiwakecho, Sakyo ku, Kyoto 606 8501, Japan
J Cell Sci 117:2283-93. 2004..The previously identified scn1(+) (renamed as scn3(+)) turned out to be a high copy suppressor for scn1 and scn2. These are the first tRNA mutants that cause a mitotic defect... - Regulation of checkpoint kinases through dynamic interaction with Crb2Satoru Mochida
Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwakecho, Sakyo ku, Kyoto, Japan
EMBO J 23:418-28. 2004..Hyperphosphorylation of Crb2 is also dependent on its intact BRCT. Finally, we show direct interaction between Rad3 and Crb2, which is inhibitory to Rad3 activity. Hence, Crb2 is the first to interact with both Rad3 and Chk1 kinases... - Distinct modes of DNA damage response in S. pombe G0 and vegetative cellsSatoru Mochida
The G0 Cell Unit, Initial Research Project (IRP, Okinawa Institute of Science and Technology (OIST) Corporation, 12-22 Suzaki, Uruma, Okinawa 904-2234, Japan
Genes Cells 11:13-27. 2006..S. pombe G0 cells upon DNA damages thus respond distinctively from VE cells in regard with regulation of checkpoint proteins and the mode of repair that is dependent upon the use of NHEJ... - Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore functionHiroaki Murakami
CREST Research Program, Japan Science and Technology Corporation, Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto, Japan
PLoS ONE 2:e317. 2007..Previous isolation of the dis3-54 cold-sensitive mutant of fission yeast Schizosaccharomyces pombe suggested that Dis3 is also required for correct chromosome segregation... - Requirement of chromatid cohesion proteins rad21/scc1 and mis4/scc2 for normal spindle-kinetochore interaction in fission yeastYusuke Toyoda
Department of Gene Mechanisms, Graduate School of Biostudies, 606 8502, Kyoto, Japan
Curr Biol 12:347-58. 2002..The failure to form cohesion in the S phase results in premature separation of chromatids in G2/M. Mitotic kinetochores free from microtubules or the lack of tension are known to activate spindle checkpoint... - A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmidsTakuhiro Matsumura
Department of Biophysics, Graduate School of Science and Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwakecho, Sakyo ku, Kyoto 606 8502, Japan
Genes Cells 8:341-55. 2003..We intended to identify ts (temperature sensitive) strains whose growth was inhibited by multicopy plasmid pCUT1 or pCUT2 at the permissive temperature... - Cnd2 has dual roles in mitotic condensation and interphaseNobuki Aono
Graduate School of Biostatistics, Department of Gene Mechanisms, Kyoto University, Japan
Nature 417:197-202. 2002..These interphase and mitotic defects provide insight into the mechanistic role of non-SMC subunits that interact with the globular SMC domains in the heteropentameric holocomplex... - Cut1/separase C-terminus affects spindle pole body positioning in interphase of fission yeast: pointed nuclear formationTakahiro Nakamura
Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwakecho, Sakyo ku, Kyoto 606 8502 Japan
Genes Cells 7:1113-24. 2002.... - Does a GATA factor make the bed for centromeric nucleosomes?Ee Sin Chen
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
Cell Cycle 2:277-8. 2003..Transcription and/or remodeling of the nucleosomes at the centromeres may be important for the precise incorporation of CENP-A in fission yeast... - Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8Kojiro Takeda
Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Cell 122:393-405. 2005..The short-lived nature of Cut8 is crucial for feedback enrichment of the proteasome within the nucleus. This is likely to be a conserved mechanism as we describe a Cut8 homolog in flies... - Metabolic profiling of the fission yeast S. pombe: quantification of compounds under different temperatures and genetic perturbationTomáš Pluskal
The G0 Cell Unit, Okinawa Institute of Science and Technology Promotion Corporation, Suzaki 12 22, Uruma, Okinawa 904 2234, Japan
Mol Biosyst 6:182-98. 2010..These findings confirm that S. pombe can be applied as an appropriate model to monitor metabolic responses to environmental conditions as well as genetic perturbations... - The dream of every chromosome: equal segregation for a healthy life of the hostTomohiro Matsumoto
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto, Japan
Adv Exp Med Biol 570:281-310. 2005 - Condensin architecture and interaction with DNA: regulatory non-SMC subunits bind to the head of SMC heterodimerShige H Yoshimura
CREST Research Project, Department of Responses to Environmental Signals and Stresses, Graduate School of Biostudies, Kyoto University, Japan
Curr Biol 12:508-13. 2002..Thus, non-SMC trimers may regulate the ATPase activity of condensin by directly interacting with the globular domains of SMC heterodimer and alter the mode of DNA interaction. A model for the action of heteropentamer is presented... - Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?Junko Kanoh
Graduate School of Biostudies, Kyoto University, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
Genes Cells 12:1301-4. 2007..In this minireview, implications and impact of the findings, and a possibility that PIKKs are functionally related through Tel2, are discussed... - The model unicellular eukaryote, Schizosaccharomyces pombeMitsuhiro Yanagida
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwakecho, Sakyo ku, Kyoto 606 8502, Japan
Genome Biol 3:COMMENT2003. 2002..Now that its genome has been sequenced, S. pombe is ready to assume its rightful place in the pantheon of small eukaryotic giants... - Regulating sister chromatid separation by separase phosphorylationKoji Nagao
Department of Biophysics, Graduate School of Science, Kyoto University, 606-8502 Kyoto, Japan
Dev Cell 2:2-4. 2002..A recent paper in Cell highlights a second mechanism of regulation of separase in addition to the bound inhibitor securin. This second pathway involves separase phosphorylation and is dependent on CDC2... - Introduction: dissection and simplification of chromosome segregationMitsuhiro Yanagida
Department of Gene Mechanism, Graduate School of Biostudies, Kyoto University, Yoshida-Honmachi, Kyoto 606-8501, Japan
Philos Trans R Soc Lond B Biol Sci 360:481. 2005 - Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damageYasunori Fukumoto
Graduate School of Frontier Biosciences, Osaka University, Suita, Japan
DNA Repair (Amst) 1:833-45. 2002..Rhp4B in contrast acts as an accessory protein in non-transcribed strand (NTS) repair... - The nucleolus is involved in mRNA export from the nucleus in fission yeastTakashi Ideue
Department of Biology, Graduate School of Sciences, Kyushu University, Fukuoka 812 8581, Japan
J Cell Sci 117:2887-95. 2004..These findings support the notion that a subset of mRNAs in yeast is exported from the nucleus through transient association with the nucleolus... - The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separaseKazuki Kumada
Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 135 8550, Japan
J Cell Biol 172:835-46. 2006..We also demonstrated that heterozygous separase-deficient cells exhibited severely restrained increases in cell number with apparently normal mitosis in the absence of securin, which is an inhibitory partner of separase... - A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeastEe Sin Chen
Department of Biophysics, Graduate School of Science, Kyoto 606 8502, Japan
Mol Cell 11:175-87. 2003..Ams2 is abundant in S phase and associates with chromatin, including the central centromeres through binding to GATA-core sequences. Ams2 is thus a cell cycle-regulated GATA factor that is required for centromere function... - [How does fission yeast cut8 regulate the nuclear localization of proteasome?]Kijiro Takeda
Tanpakushitsu Kakusan Koso 51:1241-4. 2006 - Polo boxes and Cut23 (Apc8) mediate an interaction between polo kinase and the anaphase-promoting complex for fission yeast mitosisKaren M May
The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, The University of Edinburgh, Edinburgh EH9 3JR, UK
J Cell Biol 156:23-8. 2002..This arrest can be rescued by high expression of Plo1 kinase. We suggest that this physical interaction is crucial for mitotic progression by targeting polo kinase activity toward the APC... - Control of localization of a spindle checkpoint protein, Mad2, in fission yeastAmy E Ikui
Department of Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Cell Sci 115:1603-10. 2002..This localization was abolished in a yeast strain lacking Mad1, a protein that physically interacts with Mad2. Mad1 may anchor Mad2 to the nuclear membrane and regulate its entry into the nucleus... - The kic1 kinase of schizosaccharomyces pombe is a CLK/STY orthologue that regulates cell-cell separationZhaohua Tang
Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
Exp Cell Res 283:101-15. 2003.... - Expression of a novel 90-kDa protein, Lsd90, involved in the metabolism of very long-chain fatty acid-containing phospholipids in a mitosis-defective fission yeast mutantKazuaki Yokoyama
Faculty of Pharmaceutical Sciences, Teikyo University, Suarashi, Sagamiko machi, Sagamihara shi, Kanagawa, Japan
J Biochem 143:369-75. 2008..The amounts of VLCFA-PL that accumulated in lsd90-overexpressing lsd1/fas2 cells were significantly lower than those in lsd1/fas2 cells, suggesting the involvement of Lsd90 in the metabolism of VLCFA-PL... - Characterization of Schistosoma mansoni Sds homologue, a leucine-rich repeat protein that interacts with protein phosphatase type 1 and interrupts a G2/M cell-cycle checkpointWassim Daher
, Institut Pasteur, 1 rue du Pr Calmette, B.P. 245, F-59019 Lille Cedex, France
Biochem J 395:433-41. 2006..Similar results showing the appearance of GVBD were observed when oocytes were treated with anti-PP1 antibodies. Taken together, these observations suggest that SmSds can regulate the cell cycle by binding to PP1...