S Yamanaka

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets
    Tetsuya S Tanaka
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Dev Growth Differ 48:381-90. 2006
  2. pmc Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5)
    Hisayuki Amano
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    BMC Dev Biol 6:11. 2006
  3. pmc Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells
    Masanori Imamura
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    BMC Dev Biol 6:34. 2006
  4. doi request reprint A fresh look at iPS cells
    Shinya Yamanaka
    Center for iPS Cell Research and Application, Kyoto University, Kyoto 606 8507, Japan
    Cell 137:13-7. 2009
  5. doi request reprint Strategies and new developments in the generation of patient-specific pluripotent stem cells
    Shinya Yamanaka
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell Stem Cell 1:39-49. 2007
  6. doi request reprint Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors
    S Yamanaka
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Cell Prolif 41:51-6. 2008
  7. ncbi request reprint [Induction of pluripotent stem cells from mouse fibroblast cultures]
    Shinya Yamanaka
    Tanpakushitsu Kakusan Koso 51:2346-51. 2006
  8. ncbi request reprint Symposium: Nuclear reprogramming and the control of differentiation in mammalian embryos. Introduction
    S Yamanaka
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Reprod Biomed Online 16:11-2. 2008
  9. pmc Pluripotency and nuclear reprogramming
    Shinya Yamanaka
    Center for iPS Cell Research and Application, Kyoto University, Kyoto 606 8507, Japan
    Philos Trans R Soc Lond B Biol Sci 363:2079-87. 2008
  10. ncbi request reprint Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells
    Masayoshi Maruyama
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 280:24371-9. 2005

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets
    Tetsuya S Tanaka
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Dev Growth Differ 48:381-90. 2006
    ....
  2. pmc Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5)
    Hisayuki Amano
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    BMC Dev Biol 6:11. 2006
    ..Previous studies identified genomic clones containing the mouse ESG1 gene and five pseudogenes. However, their chromosomal localizations or physiological functions have not been determined...
  3. pmc Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells
    Masanori Imamura
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    BMC Dev Biol 6:34. 2006
    ..We previously identified a set of genes called ECATs (ES cell-associated transcripts) that are expressed at high levels in mouse ES cells. Here, we examine the expression and DNA methylation of ECATs in somatic cells and germ cells...
  4. doi request reprint A fresh look at iPS cells
    Shinya Yamanaka
    Center for iPS Cell Research and Application, Kyoto University, Kyoto 606 8507, Japan
    Cell 137:13-7. 2009
    ..The potential of induced pluripotent stem (iPS) cells is enormous, but many obstacles remain before their medical and pharmaceutical applications can be fully realized...
  5. doi request reprint Strategies and new developments in the generation of patient-specific pluripotent stem cells
    Shinya Yamanaka
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell Stem Cell 1:39-49. 2007
    ..Taken together, these studies underscore the crucial roles of transcription factors and chromatin remodeling in nuclear reprogramming...
  6. doi request reprint Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors
    S Yamanaka
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Cell Prolif 41:51-6. 2008
    ..If iPS cells can be derived from human somatic cells, then such cells may thus lead to important drug discoveries and advances in regenerative medicine...
  7. ncbi request reprint [Induction of pluripotent stem cells from mouse fibroblast cultures]
    Shinya Yamanaka
    Tanpakushitsu Kakusan Koso 51:2346-51. 2006
  8. ncbi request reprint Symposium: Nuclear reprogramming and the control of differentiation in mammalian embryos. Introduction
    S Yamanaka
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Reprod Biomed Online 16:11-2. 2008
  9. pmc Pluripotency and nuclear reprogramming
    Shinya Yamanaka
    Center for iPS Cell Research and Application, Kyoto University, Kyoto 606 8507, Japan
    Philos Trans R Soc Lond B Biol Sci 363:2079-87. 2008
    ..Here, we review the molecular mechanisms underlying pluripotency and the currently known methods of inducing pluripotency in somatic cells...
  10. ncbi request reprint Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells
    Masayoshi Maruyama
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 280:24371-9. 2005
    ..Taken together, these data demonstrate differential roles for Sox15 and Sox2 in transcriptional control in mouse ES cells...
  11. ncbi request reprint Generation of germline-competent induced pluripotent stem cells
    Keisuke Okita
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Nature 448:313-7. 2007
    ..Thus, iPS cells competent for germline chimaeras can be obtained from fibroblasts, but retroviral introduction of c-Myc should be avoided for clinical application...
  12. doi request reprint Generation of pluripotent stem cells from adult mouse liver and stomach cells
    Takashi Aoi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 321:699-702. 2008
    ..These data suggest that iPS cells are generated by direct reprogramming of lineage-committed somatic cells and that retroviral integration into specific sites is not required...
  13. ncbi request reprint Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell 131:861-72. 2007
    ..Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts...
  14. ncbi request reprint Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell 126:663-76. 2006
    ..These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors...
  15. doi request reprint Generation of mouse induced pluripotent stem cells without viral vectors
    Keisuke Okita
    Center for iPS Cell Research and Application CiRA, Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:949-53. 2008
    ..The production of virus-free iPS cells, albeit from embryonic fibroblasts, addresses a critical safety concern for potential use of iPS cells in regenerative medicine...
  16. doi request reprint Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts
    Noriko Tsubooka
    Center for iPS Cell Research and Application CiRA, Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto 606 8507, Japan
    Genes Cells 14:683-94. 2009
    ..These results demonstrated that Sall4 plays positive roles in the generation of pluripotent stem cells from blastocysts and fibroblasts...
  17. pmc Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    Hyenjong Hong
    Center for iPS Cell Research and Application CiRA, Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto 606 8507, Japan
    Nature 460:1132-5. 2009
    ..Functional analyses of these genes demonstrate that the p53-p21 pathway serves as a barrier not only in tumorigenicity, but also in iPS cell generation...
  18. pmc Promotion of direct reprogramming by transformation-deficient Myc
    Masato Nakagawa
    Center for iPS Cell Research and Application, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 107:14152-7. 2010
    ..These data demonstrate that different functional moieties of the Myc proto-oncogene products are involved in the transformation and promotion of directed reprogramming...
  19. doi request reprint Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice
    Shinji Kaichi
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Cardiovasc Res 88:314-23. 2010
    ..iPS cells can be generated even without the expression of c-Myc. The present study examined patterns of differentiation of mouse iPS cells into cardiomyocytes in three different cell lines reprogrammed by three or four factors...
  20. doi request reprint Induction of pluripotency by defined factors
    Keisuke Okita
    Center for iPS Cell Research and Application CiRA, Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto 606 8507, Japan
    Exp Cell Res 316:2565-70. 2010
    ..On the other hand, patient-specific iPS cells have already been established and used for recapitulating disease pathology...
  21. pmc Human induced pluripotent stem cells on autologous feeders
    Kazutoshi Takahashi
    Center for iPS Cell Research and Application, Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 4:e8067. 2009
    ..Instead of animal feeders, human fibroblasts can be used as feeder cells of human ES cells. However, one still has to be concerned about the existence of unidentified pathogens, such as viruses and prions in these non-autologous feeders...
  22. doi request reprint Generation of mouse-induced pluripotent stem cells with plasmid vectors
    Keisuke Okita
    Center for iPS Cell Research and Application CiRA, Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto, Japan
    Nat Protoc 5:418-28. 2010
    ..This virus-free technique reduces the safety concern for iPS cell generation and application, and provides a source of cells for the investigation of the mechanisms underlying reprogramming and pluripotency...
  23. doi request reprint Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells
    Shogo Nagata
    Stem Cell Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Genes Cells 14:1395-404. 2009
    ....
  24. doi request reprint Elite and stochastic models for induced pluripotent stem cell generation
    Shinya Yamanaka
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto 606 8507, Japan
    Nature 460:49-52. 2009
    ..Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent...
  25. doi request reprint Reprogramming of somatic cells to pluripotency
    Masato Nakagawa
    Center for iPS Research and Application Institute for Integrated Cell Material Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Adv Exp Med Biol 695:215-24. 2010
    ....
  26. ncbi request reprint [Molecular mechanisms underlying pluripotency of embryonic stem cells]
    Shinya Yamanaka
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Seikagaku 78:27-33. 2006
  27. doi request reprint iPS cells: a source of cardiac regeneration
    Yoshinori Yoshida
    Center for iPS Cell Research and Application, Kyoto University, Sakyo ku, Kyoto, Japan
    J Mol Cell Cardiol 50:327-32. 2011
    ..This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited"...
  28. ncbi request reprint Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
    Masato Nakagawa
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Nat Biotechnol 26:101-6. 2008
    ..The protocol also enabled efficient isolation of iPS cells without drug selection. Furthermore, we generated human iPS cells from adult dermal fibroblasts without MYC...
  29. ncbi request reprint Utilization of digital differential display to identify novel targets of Oct3/4
    Yoshimi Tokuzawa
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Methods Mol Biol 329:223-31. 2006
    ..Reporter gene and gel mobility shift assays are used to confirm the role of Oct3/4. Identification of novel Oct3/4 targets will facilitate our understanding of pluripotency...
  30. doi request reprint Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells
    Koichiro Homma
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Atherosclerosis 212:42-7. 2010
    ..Here, we compared the functionality of human adult ECs (HAECs), human ES-derived ECs (ESECs) and human iPS-derived ECs (iPSECs)...
  31. doi request reprint Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells
    Daisuke Taura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    FEBS Lett 583:1029-33. 2009
    ..These results demonstrate that human iPS cells have an adipogenic potential comparable to human ES cells...
  32. doi request reprint Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells
    Genta Narazaki
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Circulation 118:498-506. 2008
    ..However, detailed differentiation properties and the directional differentiation system of iPS cells have not been demonstrated...
  33. ncbi request reprint Intracellular signaling pathways regulating pluripotency of embryonic stem cells
    Keisuke Okita
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Curr Stem Cell Res Ther 1:103-11. 2006
    ..We will review the rapid progress that has been made in identifying and dissecting the intracellular signaling pathways that contribute to self-renewal of pluripotent mouse and human ES cells...
  34. pmc Nuclear reprogramming to a pluripotent state by three approaches
    Shinya Yamanaka
    Center for iPS Cell Research and Application, Kyoto University, Kyoto 606 8507, Japan
    Nature 465:704-12. 2010
    ..This remarkable discovery of cellular plasticity has important medical applications...
  35. ncbi request reprint Induction of pluripotent stem cells from fibroblast cultures
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara machi, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nat Protoc 2:3081-9. 2007
    ..The cells, named induced pluripotent stem (iPS) cells, can be differentiated into three germ layers and committed to chimeric mice. Here we describe detailed methods and tips for the generation of iPS cells...
  36. doi request reprint Generation and characterization of human induced pluripotent stem cells
    Mari Ohnuki
    Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto, Japan
    Curr Protoc Stem Cell Biol . 2009
    ..RT-PCR and immunocytochemistry for detection of pluripotent cell markers, embryoid body differentiation, and teratoma differentiation are used to determine pluripotency in vitro and in vivo, respectively...
  37. ncbi request reprint Reprogramming somatic cells towards pluripotency by defined factors
    Marc Lewitzky
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Curr Opin Biotechnol 18:467-73. 2007
    ..The re-programmed cells contribute to live chimeric mice and are transmitted via the germline...
  38. ncbi request reprint Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University and CREST, Japan Science and Technology Agency, Kyoto 606 8507, Japan
    J Biol Chem 280:32768-74. 2005
    ..Rheb also shares the same membrane-targeting pathway but because of the absence of palmitoylation is located on endomembranes...
  39. doi request reprint The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells
    Noritaka Yokoo
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    Biochem Biophys Res Commun 387:482-8. 2009
    ..Thus, human iPS cells could become an attractive tool to investigate the effects of cardioactive drugs at the individual level and to screen for individually tailored drugs against cardiac arrhythmic diseases...
  40. doi request reprint Orderly hematopoietic development of induced pluripotent stem cells via Flk-1(+) hemoangiogenic progenitors
    Akira Niwa
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Cell Physiol 221:367-77. 2009
    ..This finding highlights the potential use of iPS cells in clinical areas such as regenerative medicine, disease investigation, and drug screening...
  41. doi request reprint Transplantation of mouse induced pluripotent stem cells into the cochlea
    Koji Nishimura
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Neuroreport 20:1250-4. 2009
    ..Some transplants expressed vesicular glutamate transporter 1, which is a marker for glutamatergic neurons. These findings indicate that iPS cells can be used as a source of transplants for the regeneration of spiral ganglion neurons...
  42. ncbi request reprint Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells
    K Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Biochem Soc Trans 33:1522-5. 2005
    ..The PI3K pathway utilizes multiple downstream effectors including mTOR (mammalian target of rapamycin), which we have shown to be essential for proliferation in mouse ES cells and early embryos...
  43. doi request reprint Variation in the safety of induced pluripotent stem cell lines
    Kyoko Miura
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto, Japan
    Nat Biotechnol 27:743-5. 2009
    ..In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells...
  44. ncbi request reprint [Signaling maintaining pluripotency in ES cells]
    Shinya Yamanaka
    Tanpakushitsu Kakusan Koso 49:704-9. 2004
  45. ncbi request reprint Multiple functions of Jab1 are required for early embryonic development and growth potential in mice
    Kiichiro Tomoda
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    J Biol Chem 279:43013-8. 2004
    ..Thus, Jab1 controls cell cycle progression and cell survival by regulating multiple cell cycle signaling pathways...
  46. pmc Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
    Yoshimi Tokuzawa
    Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Mol Cell Biol 23:2699-708. 2003
    ..Fbx15-null ES cells were normal in morphology, proliferation, and differentiation. These data demonstrate that Fbx15 is a novel target of Oct3/4 but is dispensable for ES cell self-renewal, development, and fertility...
  47. ncbi request reprint The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
    Kaoru Mitsui
    Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Nara 630 0192, Japan
    Cell 113:631-42. 2003
    ..nanog-deficient ES cells lost pluripotency and differentiated into extraembryonic endoderm lineage. These data demonstrate that Nanog is a critical factor underlying pluripotency in both ICM and ES cells...
  48. ncbi request reprint Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation
    Takashi Hamazaki
    Department of Pathology, University of Florida College of Medicine, PO Box 100275, Gainesville, FL 32610, USA
    J Cell Sci 117:5681-6. 2004
    ..These data illustrate aggregation-based cell-fate specification during early embryonic development, when downregulation of Nanog plays a crucial role...
  49. ncbi request reprint Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation
    Keisuke Nimura
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Genes Cells 11:1225-37. 2006
    ..These results provide evidence for a physical and functional interaction between Dnmt3L and Dnmt3a2 in the nucleus. We propose that Dnmt3a2 recruits Dnmt3L to chromatin, and induces regional DNA methylation in germ cells...
  50. ncbi request reprint [Mechanism for maintaining pluripotency in embryonic stem cells and inner cell mass]
    Masato Nakagawa
    Tanpakushitsu Kakusan Koso 50:546-50. 2005
  51. ncbi request reprint Drosophila NAT1, a homolog of the vertebrate translational regulator NAT1/DAP5/p97, is required for embryonic germband extension and metamorphosis
    Nami Yoshikane
    Division of Morphogenesis, Department of Developmental Biology, National Institute for Basic Biology, The Graduate University for Advanced Studies, Nishigonaka Myodaijicho, Okazaki 444 8585, Japan
    Dev Growth Differ 49:623-34. 2007
    ..A phenotypic analysis of dNAT1 mutants suggests that dNAT protein plays a specific rather than general role in translational regulation...
  52. ncbi request reprint Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
    Kazutoshi Takahashi
    Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Nature 423:541-5. 2003
    ..We conclude that the transforming oncogene ERas is important in the tumour-like growth properties of ES cells...
  53. ncbi request reprint Identification of genes involved in tumor-like properties of embryonic stem cells
    Kazutoshi Takahashi
    Laboratory of Animal Molecular Technology Research and Education, Center for Genetic Information, Nara Institute of Sciences and Technology, Nara, Japan
    Methods Mol Biol 329:449-58. 2006
    ..It is largely unknown why ES cells can possess tumorigenicity without having chromosomal abnormalities. In this chapter, we introduce the methods to identify genes that play roles in tumor-like properties of ES cells...
  54. doi request reprint Cell biology: Shinya Yamanaka: modest researcher, results to brag about
    Dennis Normile
    Science 319:562. 2008
  55. ncbi request reprint Role of hypomagnesemia in chronic cyclosporine nephropathy
    Katsuyuki Miura
    Department of Pharmacology, Osaka City University Medical School, Abeno, Osaka, Japan
    Transplantation 73:340-7. 2002
    ..This experiment was conducted to elucidate the role of hypomagnesemia in the pathogenesis of chronic CsA nephropathy...
  56. pmc mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
    Mirei Murakami
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Nara 630 0192, Japan
    Mol Cell Biol 24:6710-8. 2004
    ..These data show that mTOR controls both cell size and proliferation in early mouse embryos and embryonic stem cells...
  57. ncbi request reprint Reactivation of the paternal X chromosome in early mouse embryos
    Winifred Mak
    X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London, W12 0NN, UK
    Science 303:666-9. 2004
    ..Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions...
  58. pmc Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis
    Eishou Matsuda
    Division of Gene Function in Animals, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama cho, Ikoma shi, Nara 630 0192, Japan
    Proc Natl Acad Sci U S A 101:4170-4. 2004
    ....
  59. doi request reprint New advances in iPS cell research do not obviate the need for human embryonic stem cells
    Insoo Hyun
    Cell Stem Cell 1:367-8. 2007
  60. ncbi request reprint Time 100 scientists & thinkers. Shinya Yamanaka & James Thomson
    Ian Wilmut
    Time 171:96. 2008
  61. ncbi request reprint Visfatin: a protein secreted by visceral fat that mimics the effects of insulin
    Atsunori Fukuhara
    Department of Medicine and Pathophysiology, Graduate School of Medicine, and Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Science 307:426-30. 2005
    ..Surprisingly, visfatin binds to and activates the insulin receptor. Further study of visfatin's physiological role may lead to new insights into glucose homeostasis and/or new therapies for metabolic disorders such as diabetes...