Nozomi Yamaguchi

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. doi request reprint Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro
    Takashi Kasai
    Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Neurosci Lett 436:52-6. 2008
  2. ncbi request reprint Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord
    Nozomi Yamaguchi
    Department of Cell Biology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Biol Chem 277:6806-12. 2002
  3. ncbi request reprint Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    FEBS J 273:3678-86. 2006
  4. ncbi request reprint Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5
    Yoshihisa Watanabe
    Department of Cell Biology, Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 324:333-40. 2004
  5. ncbi request reprint A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Japan
    FEBS J 272:4911-23. 2005
  6. ncbi request reprint cAMP-dependent regulation of spinesin/TMPRSS5 gene expression in astrocytes
    Tatsuyuki Yamaguchi
    Department of Neurology and Gerontology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Neurosci Res 86:610-7. 2008
  7. ncbi request reprint Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate
    Terukazu Nakamura
    Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Prostate 54:299-305. 2003
  8. ncbi request reprint Endothelial dysfunction in adult patients with a history of Kawasaki disease
    Ayumi Niboshi
    Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Eur J Pediatr 167:189-96. 2008
  9. ncbi request reprint Molecular cloning and characterization of chymopasin, a novel serine protease from rat pancreas
    Yoshio Sogame
    Third Department of Internal Medicine, Research Institute for Neurological Disease and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pancreas 25:378-86. 2002
  10. ncbi request reprint Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    Ann N Y Acad Sci 977:216-23. 2002

Collaborators

  • Shinichi Mitsui
  • Tatsuo Yamada
  • Masaki Tanaka
  • Eleftherios Diamandis
  • F Kametani
  • Masato Kato
  • Yoshihisa Watanabe
  • Tatsuyuki Yamaguchi
  • Masanori Nakagawa
  • Ayumi Niboshi
  • Takashi Kasai
  • Toshiaki Numajiri
  • Akira Okui
  • Yuta Nomura
  • Terukazu Nakamura
  • Yoshio Sogame
  • Kenji Hamaoka
  • Takahiko Tokuda
  • Toshiki Mizuno
  • Koichi Sakata
  • Kenichi Nishino
  • Toshihiro Ishida
  • Yasuo Hisa
  • Kentaro Kawarabuki
  • Hidetoshi Uemura
  • Tsuneharu Miki
  • Yasuhiro Aoyama
  • Kazunari Akiyoshi
  • Masahiro Ikeda
  • Mayuko Mitsuyoshi
  • Junichi Sakagami
  • Saori Osawa
  • Ami Takatera
  • Keisho Kataoka
  • Noriko Usui

Detail Information

Publications15

  1. doi request reprint Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro
    Takashi Kasai
    Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Neurosci Lett 436:52-6. 2008
    ....
  2. ncbi request reprint Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord
    Nozomi Yamaguchi
    Department of Cell Biology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Biol Chem 277:6806-12. 2002
    ..Further analyses are required to clarify its roles at the synapses and in oligodendrocytes...
  3. ncbi request reprint Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    FEBS J 273:3678-86. 2006
    ..We suggest that not only alternative splicing but also tissue-specific use of multiple promoters regulate the expression and intracellular trafficking of KLK11/hippostasin isoforms...
  4. ncbi request reprint Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5
    Yoshihisa Watanabe
    Department of Cell Biology, Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 324:333-40. 2004
    ..Therefore, m-spinesin variants may have distinct biological functions arising from organ-specific variant expression...
  5. ncbi request reprint A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Japan
    FEBS J 272:4911-23. 2005
    ..Our results suggest that prosemin is a novel serine protease of the chromosome 16 cluster that is highly expressed in the pancreas. The usefulness of this serine protease as a candidate tumor marker should be further examined...
  6. ncbi request reprint cAMP-dependent regulation of spinesin/TMPRSS5 gene expression in astrocytes
    Tatsuyuki Yamaguchi
    Department of Neurology and Gerontology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Neurosci Res 86:610-7. 2008
    ..These results indicate that m-spinesin is involved in the function of astrocytes in the spinal cord and that there may be astrocyte-specific regulation of its gene expression...
  7. ncbi request reprint Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate
    Terukazu Nakamura
    Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Prostate 54:299-305. 2003
    ..Hippostasin is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain-type and prostate-type. We previously reported alternative expression of hippostasin in prostate cancer cell lines...
  8. ncbi request reprint Endothelial dysfunction in adult patients with a history of Kawasaki disease
    Ayumi Niboshi
    Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Eur J Pediatr 167:189-96. 2008
    ..This study revealed that the adult patients with a history of KD had systemic vascular endothelial dysfunction, and also suggested that a history of KD was possibly one of the risk factors for early onset of atherosclerosis...
  9. ncbi request reprint Molecular cloning and characterization of chymopasin, a novel serine protease from rat pancreas
    Yoshio Sogame
    Third Department of Internal Medicine, Research Institute for Neurological Disease and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pancreas 25:378-86. 2002
    ..Pancreas secretes many enzymes for food digestion into the pancreatic juice. We cloned a novel serine protease, chymopasin, from rat pancreas...
  10. ncbi request reprint Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease
    Shinichi Mitsui
    Department of Cell Biology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    Ann N Y Acad Sci 977:216-23. 2002
    ..Further, some such patients showed extremely low levels of CSF neurosin. Our results suggest that neurosin is an aging-related protease and that a decreased CSF concentration of neurosin may be a risk factor for developing AD...
  11. ncbi request reprint The expression of a motoneuron-specific serine protease, motopsin (PRSS12), after facial nerve axotomy in mice
    Toshiaki Numajiri
    Department of Plastic and Reconstructive Surgery, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    J Plast Reconstr Aesthet Surg 59:393-7. 2006
    ..In contrast, expression of growth-associated protein-43 (GAP-43) was induced at the day 3. These results suggest that the recovery of motopsin expression is correlated with the recovery of the facial motor neuronal function...
  12. ncbi request reprint Mosaic serine proteases in the mammalian central nervous system
    Shinichi Mitsui
    Department of Neurobiology and Anatomy, Kochi Medical School, Oko cho, Nankoku 783 8505, Japan
    Front Biosci 13:1991-2000. 2008
    ..Recent reports indicate the significance of this protease for cognitive function. We mention the fibrinolytic protease, tissue plasminogen activator (tPA), which has physiological and pathological functions in the CNS...
  13. ncbi request reprint Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation
    Shinichi Mitsui
    Department of Neurobiology and Anatomy, Kochi Medical School, Oko cho, Nankoku 783 8505, Japan
    Brain Res 1136:1-12. 2007
    ....
  14. ncbi request reprint Protein refolding assisted by self-assembled nanogels as novel artificial molecular chaperone
    Yuta Nomura
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida Hommachi, Sakyo ku, 606 8501 Kyoto, Japan
    FEBS Lett 553:271-6. 2003
    ..The present nanogel system was also effective at the renaturation of inclusion body of a recombinant protein of the serine protease family...
  15. ncbi request reprint Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 62:295-300. 2002
    ..This is the first reported immunological assay for hK11. Analysis of this biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma...