Masashi Ueda

Summary

Affiliation: Radioisotopes Research Laboratory, Kyoto University Hospital
Location: Kyoto, Japan

Publications

  1. ncbi Evaluation of radioiodinated 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine as a ligand for SPECT investigations of brain nicotinic acetylcholine receptors
    Hideo Saji
    Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Ann Nucl Med 16:189-200. 2002
  2. doi Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells
    Takashi Kudo
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Nucl Med 50:942-9. 2009
  3. ncbi GLP-1 receptor antagonist as a potential probe for pancreatic beta-cell imaging
    Eri Mukai
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Biochem Biophys Res Commun 389:523-6. 2009
  4. pmc Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects
    M Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Br J Pharmacol 159:1201-10. 2010
  5. doi Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Nucl Med Mol Imaging 37:1566-74. 2010
  6. doi In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: persistent agonist binding inhibits the expression of antiallodynic effects
    Masashi Ueda
    Faculty of Medicine, Radioisotopes Research Laboratory, Kyoto University Hospital, Kyoto University, Kyoto 606 8507, Japan
    Synapse 65:77-83. 2011
  7. doi PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel 18F-labeled biotin derivative
    Takashi Kudo
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Imaging Biol 13:1003-10. 2011
  8. doi Evaluation of [125I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor: comparison among single-photon emission computed tomography/X-ray computed tomography imaging, autoradiography, and immunohistochemistry
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Cancer Sci 102:2090-6. 2011
  9. doi Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo
    Ikuhiko Nakase
    Institute for Chemical Research, Kyoto University, Kyoto 611 0011, Japan
    J Control Release 159:181-8. 2012
  10. doi Technetium-99m labeled pyridyl benzofuran derivatives as single photon emission computed tomography imaging probes for β-amyloid plaques in Alzheimer's brains
    Yan Cheng
    Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Med Chem 55:2279-86. 2012

Collaborators

Detail Information

Publications26

  1. ncbi Evaluation of radioiodinated 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine as a ligand for SPECT investigations of brain nicotinic acetylcholine receptors
    Hideo Saji
    Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Ann Nucl Med 16:189-200. 2002
    ..These results suggested that [123I]5IA is a promising radiopharmaceutical for SPECT studies of central nAChRs in human subjects...
  2. doi Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells
    Takashi Kudo
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Nucl Med 50:942-9. 2009
    ..The purpose of this study was to evaluate the feasibility of (123)I-IPOS as an imaging probe for HIF-1-active tumor hypoxia...
  3. ncbi GLP-1 receptor antagonist as a potential probe for pancreatic beta-cell imaging
    Eri Mukai
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Biochem Biophys Res Commun 389:523-6. 2009
    ..Imaging analysis showed that the fluorescent GFP signals and the radioactive signals were correspondingly located. Thus, the GLP-1R antagonist exendin(9-39) may serve as a useful probe for pancreatic beta-cell imaging...
  4. pmc Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects
    M Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Br J Pharmacol 159:1201-10. 2010
    ..The purpose of this study was to elucidate these issues using 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine (5IA), a nACh receptor agonist, and [(125)I]5IA...
  5. doi Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Nucl Med Mol Imaging 37:1566-74. 2010
    ..In this study, we aimed to investigate the feasibility of the pretargeting method using POS and (123)I-IBB for rapid imaging of HIF-1-active tumours...
  6. doi In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: persistent agonist binding inhibits the expression of antiallodynic effects
    Masashi Ueda
    Faculty of Medicine, Radioisotopes Research Laboratory, Kyoto University Hospital, Kyoto University, Kyoto 606 8507, Japan
    Synapse 65:77-83. 2011
    ..These findings suggest that not clearance of 5IA but desensitization of nAChRs caused by persistent binding of 5IA is responsible for the disappearance of antiallodynic effects...
  7. doi PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel 18F-labeled biotin derivative
    Takashi Kudo
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Imaging Biol 13:1003-10. 2011
    ..We aimed to evaluate the feasibility of using streptavidin-biotin-based pretargeting for positron emission tomography (PET) imaging of hypoxia-inducible factor (HIF)-1-active tumors...
  8. doi Evaluation of [125I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor: comparison among single-photon emission computed tomography/X-ray computed tomography imaging, autoradiography, and immunohistochemistry
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Cancer Sci 102:2090-6. 2011
    ..01). These findings indicate that [(125) I]IPOS accumulation reflects HIF-1 expression. Thus, [(123/125) I]IPOS can serve as a useful probe for the molecular imaging of HIF-1-active tumors...
  9. doi Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo
    Ikuhiko Nakase
    Institute for Chemical Research, Kyoto University, Kyoto 611 0011, Japan
    J Control Release 159:181-8. 2012
    ..These results suggest the potential of r8 as a prototypic tumor-targeting vector...
  10. doi Technetium-99m labeled pyridyl benzofuran derivatives as single photon emission computed tomography imaging probes for β-amyloid plaques in Alzheimer's brains
    Yan Cheng
    Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Med Chem 55:2279-86. 2012
    ..99m)Tc]BAT-Bp-2 may be a potential SPECT probe for imaging β-amyloid plaques in Alzheimer's brains...
  11. doi Novel ¹⁸F-labeled benzoxazole derivatives as potential positron emission tomography probes for imaging of cerebral β-amyloid plaques in Alzheimer's disease
    Mengchao Cui
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Med Chem 55:9136-45. 2012
    ..The results suggest [(18)F]24 to be a useful PET agent for detecting Aβ plaques in the living human brain...
  12. doi Development of [(90)Y]DOTA-conjugated bisphosphonate for treatment of painful bone metastases
    Kazuma Ogawa
    Advanced Science Research Center, Kanazawa University, Kanazawa, Japan
    Nucl Med Biol 36:129-35. 2009
    ..By applying a similar concept, we hypothesized that a bone-specific directed (90)Y-labeled radiopharmaceutical could be developed...
  13. doi Cardioprotective effects of erythropoietin in rats subjected to ischemia-reperfusion injury: assessment of infarct size with 99mTc-annexin V
    Tomoki Doue
    Department of Cardiology and Nephrology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Nucl Med 49:1694-700. 2008
    ..In this study, we assessed the effect of EPO on (99m)Tc-annexin V myocardial uptake and whether the accumulation of (99m)Tc-annexin V can predict cardiac remodeling and functional deterioration...
  14. doi Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart
    Yasushi Kiyono
    Biomedical Imaging Research Center, University of Fukui, Fukui 910 1193, Japan
    Nucl Med Biol 35:213-8. 2008
    ..In the current study, we assessed the applicability of radioiodinated (S,S)-IPBM to NET imaging in the heart...
  15. ncbi Evaluation of 5-(11)C-methyl-A-85380 as an imaging agent for PET investigations of brain nicotinic acetylcholine receptors
    Yasuhiko Iida
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Nucl Med 45:878-84. 2004
    ....
  16. ncbi Quantification of human nicotinic acetylcholine receptors with 123I-5IA SPECT
    Marcelo Mamede
    Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Nucl Med 45:1458-70. 2004
    ..123I-5IA shows higher affinity toward the nAChR alpha4beta2 subtype, enhanced receptor subtype selectivity, good safety, and low nonspecific binding...
  17. ncbi 5-[123I]Iodo-A-85380: assessment of pharmacological safety, radiation dosimetry and SPECT imaging of brain nicotinic receptors in healthy human subjects
    Masashi Ueda
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Ann Nucl Med 18:337-44. 2004
    ..These results suggest that [123I]5IA is a promising ligand for imaging nAChRs in humans, with an acceptable dosimetry and pharmacological safety at the dose required for adequate SPECT imaging...
  18. ncbi Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model
    Youji Kitamura
    Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    J Pharmacol Sci 100:142-8. 2006
    ..These results suggest that zinc released from synaptic vesicles may provide a protective effect against ischemic neuronal injury...
  19. ncbi Synthesis and evaluation of radioiodinated (S,S)-2-(alpha-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter
    Naoki Kanegawa
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan
    Eur J Nucl Med Mol Imaging 33:639-47. 2006
    ....
  20. ncbi Change of central cholinergic receptors following lesions of nucleus basalis magnocellularis in rats: search for an imaging index suitable for the early detection of Alzheimer's disease
    Mikako Ogawa
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nucl Med Biol 33:249-54. 2006
    ..However, muscarinic receptors were not affected. These results suggested that neuronal dysfunction in AD could be diagnosed at an early stage by imaging nicotinic acetylcholine receptors...
  21. ncbi Rhemium-186-monoaminemonoamidedithiol-conjugated bisphosphonate derivatives for bone pain palliation
    Kazuma Ogawa
    Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Nucl Med Biol 33:513-20. 2006
    ..These findings provide useful information on the design of bone-seeking therapeutic radiopharmaceuticals...
  22. ncbi Quantification of nicotinic acetylcholine receptors in Parkinson's disease with (123)I-5IA SPECT
    Naoya Oishi
    Human Brain Research Center, Kyoto University Graduate School of Medicine, Shogoin, Kyoto, Japan
    J Neurol Sci 256:52-60. 2007
    ..These findings suggest that patients with PD without dementia can show reductions especially in the brainstem and frontal cortex. They also suggest that dopamine agonists can have a negative influence on the distribution of nAChRs...
  23. ncbi Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study
    Marcelo Mamede
    Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Nucl Med 48:1829-35. 2007
    ..However, changes in nAChRs after cigarette smoking cessation in humans are poorly understood. The aim of this study was to detect the dynamic changes of nAChRs after smoking and smoking cessation in the brains of living subjects...
  24. doi 5-Iodo-A-85380, a specific ligand for alpha 4 beta 2 nicotinic acetylcholine receptors, prevents glutamate neurotoxicity in rat cortical cultured neurons
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Brain Res 1199:46-52. 2008
    ..In conclusion, 5IA is possibly not only useful for the treatment and prevention of glutamate neurotoxicity, but also as an available tool for elucidating the mechanism of neuroprotection associated with alpha 4 beta 2 nAChRs...
  25. pmc In vivo visualization of heterogeneous intratumoral distribution of hypoxia-inducible factor-1α activity by the fusion of high-resolution SPECT and morphological imaging tests
    Hirofumi Fujii
    Functional Imaging Division, National Cancer Center Hospital East, Kashiwa 277 8577, Japan
    J Biomed Biotechnol 2012:262741. 2012
    ..We aimed to clearly visualize heterogeneous distribution of hypoxia-inducible factor 1α (HIF) activity in tumor tissues in vivo...
  26. ncbi [Development of a method of high-contrasted nuclear medical imaging of hypoxia-inducible factor-1-active tumor by using a pretargeting approach]
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan
    Yakugaku Zasshi 132:595-600. 2012
    ..Rapid and high-contrast imaging of HIF-1-active tumors can be achieved with this pretargeting method...