Shoichiro Tsukita

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice
    Tatsuo Miyamoto
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Japan
    J Cell Biol 169:527-38. 2005
  2. pmc Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice
    Mikio Furuse
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 156:1099-111. 2002
  3. pmc Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    Takehiro Nitta
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Cell Biol 161:653-60. 2003
  4. pmc Possible involvement of phosphorylation of occludin in tight junction formation
    A Sakakibara
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 137:1393-401. 1997
  5. pmc Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions
    M Itoh
    1Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 154:491-7. 2001
  6. pmc Where is APC going?
    Y Mimori-Kiyosue
    KAN Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto 600 8815, Japan
    J Cell Biol 154:1105-9. 2001
  7. pmc Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan
    J Cell Biol 138:181-92. 1997
  8. ncbi request reprint Expression patterns of claudins, tight junction adhesion molecules, in the inner ear
    Shin iciro Kitajiri
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan
    Hear Res 187:25-34. 2004
  9. ncbi request reprint Overcoming barriers in the study of tight junction functions: from occludin to claudin
    S Tsukita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    Genes Cells 3:569-73. 1998
  10. ncbi request reprint Claudin-based barrier in simple and stratified cellular sheets
    Shoichiro Tsukita
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto, Japan
    Curr Opin Cell Biol 14:531-6. 2002

Collaborators

Detail Information

Publications63

  1. pmc Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice
    Tatsuo Miyamoto
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Japan
    J Cell Biol 169:527-38. 2005
    ....
  2. pmc Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice
    Mikio Furuse
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 156:1099-111. 2002
    ..These findings provide the first evidence that continuous claudin-based TJs occur in the epidermis and that these TJs are crucial for the barrier function of the mammalian skin...
  3. pmc Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    Takehiro Nitta
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Cell Biol 161:653-60. 2003
    ..e., the size-selective loosening of the BBB) not only provides new insight into the basic molecular physiology of BBB but also opens a new way to deliver potential drugs across the BBB into the central nervous system...
  4. pmc Possible involvement of phosphorylation of occludin in tight junction formation
    A Sakakibara
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 137:1393-401. 1997
    ..These findings suggest that the phosphorylation of occludin is a key step in tight junction assembly...
  5. pmc Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions
    M Itoh
    1Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 154:491-7. 2001
    ..We also discuss the importance of this model from the perspective of the general molecular mechanisms behind the recruitment of PAR proteins to plasma membranes...
  6. pmc Where is APC going?
    Y Mimori-Kiyosue
    KAN Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto 600 8815, Japan
    J Cell Biol 154:1105-9. 2001
    ....
  7. pmc Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan
    J Cell Biol 138:181-92. 1997
    ....
  8. ncbi request reprint Expression patterns of claudins, tight junction adhesion molecules, in the inner ear
    Shin iciro Kitajiri
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan
    Hear Res 187:25-34. 2004
    ..These findings, i.e., very complex expression patterns of claudin species in the inner ear, would reflect the importance and the complexity of the barrier function of TJs in the inner ear...
  9. ncbi request reprint Overcoming barriers in the study of tight junction functions: from occludin to claudin
    S Tsukita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    Genes Cells 3:569-73. 1998
    ..Here, we present an overview of current progress in the identification of TJ-specific integral membrane proteins...
  10. ncbi request reprint Claudin-based barrier in simple and stratified cellular sheets
    Shoichiro Tsukita
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto, Japan
    Curr Opin Cell Biol 14:531-6. 2002
    ..Recent advances reveal that claudins - major cell adhesion molecules in tight junctions - are directly involved in this intercellular sealing, not only in simple but also in stratified cellular sheets in vertebrates...
  11. ncbi request reprint Occludin and claudins in tight-junction strands: leading or supporting players?
    S Tsukita
    Dept of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    Trends Cell Biol 9:268-73. 1999
    ..This review discusses current understanding of the molecular architecture of tight-junction strands, focusing on the recent discovery of two distinct types of tight-junction-specific integral membrane proteins, occludin and claudins...
  12. pmc Pores in the wall: claudins constitute tight junction strands containing aqueous pores
    S Tsukita
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501 Japan
    J Cell Biol 149:13-6. 2000
  13. ncbi request reprint The structure and function of claudins, cell adhesion molecules at tight junctions
    S Tsukita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Ann N Y Acad Sci 915:129-35. 2000
    ..Now that claudins have been identified, the structure and functions of TJs should be determined in detail in molecular terms...
  14. ncbi request reprint Multifunctional strands in tight junctions
    S Tsukita
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Nat Rev Mol Cell Biol 2:285-93. 2001
    ..New insights into the molecular architecture of tight junctions allow us to now discuss the structure and functions of this unique cell-cell adhesion apparatus in molecular terms...
  15. pmc Manner of interaction of heterogeneous claudin species within and between tight junction strands
    M Furuse
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 147:891-903. 1999
    ..We concluded that distinct species of claudins can interact within and between TJ strands, except in some combinations. This mode of assembly of claudins could increase the diversity of the structure and functions of TJ strands...
  16. pmc Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells
    M Furuse
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 153:263-72. 2001
    ....
  17. pmc Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 147:185-94. 1999
    ..e., the extracellular face-associated TJs. These findings indicated that claudin-5/TMVCF is an endothelial cell-specific component of TJ strands...
  18. pmc Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 147:1351-63. 1999
    ..In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed...
  19. ncbi request reprint Establishment and characterization of cultured epithelial cells lacking expression of ZO-1
    Kazuaki Umeda
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:44785-94. 2004
    ..Finally, we discussed advantageous aspects of the gene knock-out system with cultured epithelial cells in epithelial cell biology...
  20. ncbi request reprint ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation
    Kazuaki Umeda
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Kyoto 606 8501, Japan
    Cell 126:741-54. 2006
    ..When NZO-1 was forcibly recruited to lateral membranes and dimerized, claudins were dramatically polymerized. These findings indicate that ZO-1 and ZO-2 can independently determine whether and where claudins are polymerized...
  21. ncbi request reprint Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment
    Yuko Mimori-Kiyosue
    KAN Research Institute, Kyoto Research Park, Kyoto 600 8815, Japan
    Genes Cells 11:845-57. 2006
    ..This local stabilization of microtubules is essential for the formation of normal metaphase spindle, completion of anaphase and cytokinesis...
  22. ncbi request reprint Expression and distribution of ZO-3, a tight junction MAGUK protein, in mouse tissues
    Akihito Inoko
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 8:837-45. 2003
    ..However, in contrast to ZO-1/ZO-2, our knowledge of the expression and distribution of ZO-3 is still fragmentary, partly due to a lack of antibodies that specifically distinguish ZO-3 from ZO-1 and ZO-2...
  23. pmc Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells
    Atsushi Tamura
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 169:21-8. 2005
    ..Immunofluorescence and electron microscopy revealed that this achlorhydria was caused by defects in the formation/expansion of canalicular apical membranes in gastric parietal cells...
  24. ncbi request reprint Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Invest Dermatol 118:1073-9. 2002
    ....
  25. ncbi request reprint Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential
    Shin ichiro Kitajiri
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, 606 8501, Japan
    J Cell Sci 117:5087-96. 2004
    ....
  26. pmc Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins
    Makoto Adachi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 29:2372-89. 2009
    ....
  27. pmc Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein
    Makoto Adachi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 26:9003-15. 2006
    ..These findings indicate that ZO-3 is dispensable in vivo in terms of individual viability, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment...
  28. pmc Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia
    Shin ichiro Kitajiri
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 166:559-70. 2004
    ..These findings indicated the existence of complicate functional redundancy in situ among ERM proteins...
  29. ncbi request reprint Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3
    Kanehisa Fukumoto
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Kyoto 606 8501, Japan
    Biochim Biophys Acta 1772:298-306. 2007
    ....
  30. ncbi request reprint A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells
    Miho Matsuda
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 117:1247-57. 2004
    ....
  31. pmc CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex
    Yuko Mimori-Kiyosue
    KAN Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto 600 8815, Japan
    J Cell Biol 168:141-53. 2005
    ..We propose that CLASPs can mediate interactions between MT plus ends and the cell cortex and act as local rescue factors, possibly through forming a complex with EB1 at MT tips...
  32. pmc Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 171:939-45. 2005
    ..These findings indicate the critical function of tricellulin for formation of the epithelial barrier...
  33. ncbi request reprint Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 116:1959-67. 2003
    ..e. the expression of adherens and tight junction adhesion molecules, respectively)...
  34. ncbi request reprint Gene knockout analysis of two gamma-tubulin isoforms in mice
    Akiko Yuba-Kubo
    Solution Oriented Research for Science and Technology, Japan Science and Technology Corporation, Sakyo ku, Kyoto 606 8501, Japan
    Dev Biol 282:361-73. 2005
    ..These findings indicated that TUBG1 and TUBG2 are not functionally equivalent in vivo, that TUBG1 corresponds to conventional gamma-tubulin, and that TUBG2 may have some unidentified function in the brain...
  35. ncbi request reprint Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties
    Yuko Sugihara-Mizuno
    Department of Cell Biology, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 12:473-86. 2007
    ....
  36. doi request reprint The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells
    Senye Takahashi
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Sci 122:985-94. 2009
    ..These findings suggest that LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and that the turnover of TJs is regulated by ubiquitylation...
  37. pmc Loss of occludin affects tricellular localization of tricellulin
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Mol Biol Cell 19:4687-93. 2008
    ....
  38. ncbi request reprint Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic
    Junko Yamane
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Exp Cell Res 313:3472-85. 2007
    ..These observations suggest critical roles for TMF in two Rab6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER...
  39. doi request reprint abLIM3 is a novel component of adherens junctions with actin-binding activity
    Miho Matsuda
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Eur J Cell Biol 89:807-16. 2010
    ..These results suggest that abLIM3 is involved in anchoring LIM domain-binding components of AJs to circumferential actin bundles in specific cell types...
  40. ncbi request reprint Expression of claudin-5 in dermal vascular endothelia
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Exp Dermatol 12:289-95. 2003
    ..These findings confirmed that TJs in dermal vascular endothelial cells are composed of claudin-5...
  41. ncbi request reprint Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule
    Yoko Hamazaki
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 277:455-61. 2002
    ....
  42. ncbi request reprint Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes
    Shojiro Kikuchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Genet 31:320-5. 2002
    ..These findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs...
  43. pmc Dynamic behavior of paired claudin strands within apposing plasma membranes
    Hiroyuki Sasaki
    KAN Research Institute Inc, Kyoto Research Park, Chudoji, Shimogyo ku, Kyoto 600 8317, Japan
    Proc Natl Acad Sci U S A 100:3971-6. 2003
    ....
  44. pmc Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization
    Junichi Ikenouchi
    Department of Cell Biology, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 176:779-86. 2007
    ..The requirement for ZO-1 differs between belt-like AJ and TJ formation. We propose that ZO-1 is directly involved in the establishment of two distinct junctional domains, belt-like AJs and TJs, during epithelial polarization...
  45. ncbi request reprint Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation
    Takeshi Matsui
    KAN Research Institute Inc, Shimogyo ku, Kyoto 600 8815, Japan
    J Biol Chem 281:27512-25. 2006
    ..This study provides the first evidence that retroviral-like aspartic protease is functionally important in mammalian tissue organization...
  46. ncbi request reprint JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin
    Hiroe Ohnishi
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:46014-22. 2004
    ..These findings suggest that JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons...
  47. doi request reprint Generation of transgenic medaka expressing claudin7-EGFP for imaging of tight junctions in living medaka embryos
    Tatsuo Miyamoto
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cell Tissue Res 335:465-71. 2009
    ..This transgenic medaka line will thus be useful for imaging of TJs in living embryos and hence in screening for mutations affecting cell-cell adhesion...
  48. doi request reprint Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila
    Yuichi Yanagihashi
    Division of Cell Biology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe 650 0017, Japan
    J Cell Sci 125:1980-90. 2012
    ..We also show that the barrier function of the midgut to a fluorescent tracer is impaired in ssk-knockdown larvae. These results suggest that Ssk is required for the intestinal barrier function in Drosophila...
  49. ncbi request reprint Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments
    Yumiko Kiuchi-Saishin
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yonoe Koshida, Sakyo ku, Kyoto 606, Japan
    J Am Soc Nephrol 13:875-86. 2002
    ..These segment-specific expression patterns of claudins are discussed, with special reference to the physiologic functions of tight junctions in nephrons...
  50. ncbi request reprint Adenomatous polyposis coli (APC) protein regulates epithelial cell migration and morphogenesis via PDZ domain-based interactions with plasma membranes
    Yuko Mimori-Kiyosue
    KAN Research Institute, Kyoto Research Park, Kyoto 600 8815, Japan
    Genes Cells 12:219-33. 2007
    ..These results suggest that APC links MTs to plasma membranes through interactions with PDZ proteins, such that the migration and morphogenesis of epithelial cells can be properly regulated...
  51. ncbi request reprint Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos
    Kazumasa Moriwaki
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Dev Biol 312:509-22. 2007
    ..These results clearly demonstrate that the barrier function of TJs in the TE is required for normal blastocyst formation...
  52. doi request reprint Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning
    Miho Matsuda
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Exp Cell Res 314:939-49. 2008
    ..These data suggest that FL-REX is a powerful tool to identify novel proteins localized at TJs and AJs...
  53. ncbi request reprint Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: an essential role for polyphosphoinositides in vivo
    Shigenobu Yonemura
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Japan
    J Cell Sci 115:2569-80. 2002
    ....
  54. ncbi request reprint Claudins in Caenorhabditis elegans: their distribution and barrier function in the epithelium
    Akira Asano
    Tsukita Cell Axis Project, ERATO, Japan Science and Technology Corporation, Kyoto Research Park, Shimogyo ku, Japan
    Curr Biol 13:1042-6. 2003
    ..These findings indicated that multiple species of the claudin homologs, which are involved in the barrier function of the epithelium, exist in C. elegans...
  55. ncbi request reprint Claudins in occluding junctions of humans and flies
    Mikio Furuse
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Trends Cell Biol 16:181-8. 2006
    ..Interestingly, claudin-like molecules have recently been identified in septate junctions of Drosophila. Here, we present an overview of recent progress in claudin studies conducted in mammals and flies...
  56. ncbi request reprint Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia
    Hiroaki Ishikawa
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Cell Biol 7:517-24. 2005
    ..These findings indicate that Odf2 is indispensable for the formation of distal/subdistal appendages and the generation of primary cilia, but not for other cell-cycle-related centriolar functions...
  57. ncbi request reprint Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1
    Takeshi Matsui
    KAN Research Institute, Inc, Shimogyo ku, Kyoto 600 8815, Japan
    Genomics 84:384-97. 2004
    ..These findings indicated that dermokine-alpha/-beta, suprabasin, and Kdap are secreted from the spinous layer of the stratified epithelia and that these genes form a novel gene complex on the chromosome...
  58. ncbi request reprint Non-membranous granular organelle consisting of PCM-1: subcellular distribution and cell-cycle-dependent assembly/disassembly
    Akiharu Kubo
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 116:919-28. 2003
    ..These findings are discussed with special reference to the possible physiological functions of PCM-1 granules...
  59. ncbi request reprint "Search-and-capture" of microtubules through plus-end-binding proteins (+TIPs)
    Yuko Mimori-Kiyosue
    KAN Research Institute, Kyoto Research Park, Science Center Build 3, 93 Chudoji Awata cho, Shimogyo ku, Kyoto 600 8815
    J Biochem 134:321-6. 2003
    ....
  60. doi request reprint Optimized proteomic analysis on gels of cell-cell adhering junctional membrane proteins
    Yuji Yamazaki
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Biochemistry 47:5378-86. 2008
    ....
  61. ncbi request reprint A novel amphioxus cadherin that localizes to epithelial adherens junctions has an unusual domain organization with implications for chordate phylogeny
    Hiroki Oda
    Tsukita Cell Axis Project, ERATO, Japan Science and Technology Corporation, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Evol Dev 4:426-34. 2002
    ..The structural relationships of the cadherin molecules allow us to propose a possibility that cephalochordates might be basal to the sister-groups vertebrates and urochordates...