Tetsuya Tatsumi

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. ncbi Energy metabolism after ischemic preconditioning in streptozotocin-induced diabetic rat hearts
    T Tatsumi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    J Am Coll Cardiol 31:707-15. 1998
  2. ncbi Cytokine-induced nitric oxide inhibits mitochondrial energy production and induces myocardial dysfunction in endotoxin-treated rat hearts
    Tetsuya Tatsumi
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Mol Cell Cardiol 37:775-84. 2004
  3. ncbi Cytokine-induced nitric oxide production inhibits mitochondrial energy production and impairs contractile function in rat cardiac myocytes
    T Tatsumi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    J Am Coll Cardiol 35:1338-46. 2000
  4. ncbi Nitric oxide-cGMP pathway is involved in endotoxin-induced contractile dysfunction in rat hearts
    Tetsuya Tatsumi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    J Appl Physiol 96:853-60. 2004
  5. ncbi Intracoronary transplantation of non-expanded peripheral blood-derived mononuclear cells promotes improvement of cardiac function in patients with acute myocardial infarction
    Tetsuya Tatsumi
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto University Hospital, Japan
    Circ J 71:1199-207. 2007
  6. ncbi Intracellular ATP is required for mitochondrial apoptotic pathways in isolated hypoxic rat cardiac myocytes
    Tetsuya Tatsumi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Cardiovasc Res 59:428-40. 2003
  7. ncbi The dual effects of nitric oxide synthase inhibitors on ischemia-reperfusion injury in rat hearts
    Miyuki Kobara
    Second Dept. of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
    Basic Res Cardiol 98:319-28. 2003
  8. ncbi Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis
    Susumu Nishikawa
    Department of Cardiology and Vascular Regenerative Medicine, Kyoto Prefectural University of Medicine, Kyoto, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
    J Mol Cell Cardiol 40:510-9. 2006
  9. ncbi Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts
    Mitsuo Takeda
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto, Japan
    Hypertens Res 30:427-37. 2007
  10. ncbi Effects of ACE inhibition on myocardial apoptosis in an ischemia-reperfusion rat heart model
    Miyuki Kobara
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Cardiovasc Pharmacol 41:880-9. 2003

Detail Information

Publications48

  1. ncbi Energy metabolism after ischemic preconditioning in streptozotocin-induced diabetic rat hearts
    T Tatsumi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    J Am Coll Cardiol 31:707-15. 1998
    ..The aim of this study was to compare the cardioprotective effects of preconditioning in hearts from streptozotocin-induced diabetic rats with its effects in normal rat hearts...
  2. ncbi Cytokine-induced nitric oxide inhibits mitochondrial energy production and induces myocardial dysfunction in endotoxin-treated rat hearts
    Tetsuya Tatsumi
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Mol Cell Cardiol 37:775-84. 2004
    ....
  3. ncbi Cytokine-induced nitric oxide production inhibits mitochondrial energy production and impairs contractile function in rat cardiac myocytes
    T Tatsumi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    J Am Coll Cardiol 35:1338-46. 2000
    ..The present study examined whether nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) can directly inhibit aerobic energy metabolism and impair cell function in interleukin (IL)-1beta,-stimulated cardiac myocytes...
  4. ncbi Nitric oxide-cGMP pathway is involved in endotoxin-induced contractile dysfunction in rat hearts
    Tetsuya Tatsumi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    J Appl Physiol 96:853-60. 2004
    ..Our data suggest that endotoxin-induced contractile dysfunction in rat hearts is associated with NO production by myocardial iNOS and a concomitant increase in myocardial cGMP...
  5. ncbi Intracoronary transplantation of non-expanded peripheral blood-derived mononuclear cells promotes improvement of cardiac function in patients with acute myocardial infarction
    Tetsuya Tatsumi
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto University Hospital, Japan
    Circ J 71:1199-207. 2007
    ..This study was designed to examine whether intracoronary transplantation of PBMNCs improves cardiac function after acute myocardial infarction (AMI)...
  6. ncbi Intracellular ATP is required for mitochondrial apoptotic pathways in isolated hypoxic rat cardiac myocytes
    Tetsuya Tatsumi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Cardiovasc Res 59:428-40. 2003
    ..The present study examined the possibility that intracellular ATP levels dictate whether hypoxic cardiac myocytes die by apoptosis or necrosis...
  7. ncbi The dual effects of nitric oxide synthase inhibitors on ischemia-reperfusion injury in rat hearts
    Miyuki Kobara
    Second Dept. of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
    Basic Res Cardiol 98:319-28. 2003
    ..Non-vasoactive inhibition of NOS had beneficial effects due to the suppression of oxidative injury. However, strong vasoactive inhibition of NOS exacerbated the ischemia-reperfusion injury...
  8. ncbi Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis
    Susumu Nishikawa
    Department of Cardiology and Vascular Regenerative Medicine, Kyoto Prefectural University of Medicine, Kyoto, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
    J Mol Cell Cardiol 40:510-9. 2006
    ..The present study demonstrates that nicorandil regulates Bcl-2 family proteins via opening of mitoK(ATP) channels and nitric oxide-cGMP signaling and inhibits hypoxia-induced mitochondrial death pathway...
  9. ncbi Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts
    Mitsuo Takeda
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto, Japan
    Hypertens Res 30:427-37. 2007
    ....
  10. ncbi Effects of ACE inhibition on myocardial apoptosis in an ischemia-reperfusion rat heart model
    Miyuki Kobara
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Cardiovasc Pharmacol 41:880-9. 2003
    ..These results suggest that inhibition of ACE reduces myocardial infarction and apoptosis via the bradykinin B(2) receptor in part. The antiapoptotic effect of the ACE inhibitor is attributed to the changing expression of Bcl-xL...
  11. ncbi Myocardium-targeted delivery of endothelial progenitor cells by ultrasound-mediated microbubble destruction improves cardiac function via an angiogenic response
    Kan Zen
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan
    J Mol Cell Cardiol 40:799-809. 2006
    ..This non-invasive cell delivery system may be useful as a novel efficient approach for angiogenic cell therapy to the myocardium...
  12. ncbi Endothelium-targeted overexpression of constitutively active FGF receptor induces cardioprotection in mice myocardial infarction
    Shinsaku Matsunaga
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto, Japan
    J Mol Cell Cardiol 46:663-73. 2009
    ....
  13. ncbi Lethal effect of cytokine-induced nitric oxide and peroxynitrite on cultured rat cardiac myocytes
    Natsuya Keira
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
    J Mol Cell Cardiol 34:583-96. 2002
    ..These data suggest that NO production induced by cytokines can not only cause deleterious effects in the myocardial energy balance but also induce myocytes necrosis, through the formation of peroxynitrite...
  14. ncbi Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function
    Akihiro Matsui
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, 602 8566, Japan
    Circulation 116:1041-51. 2007
    ..The involvement of Ca2+-dependent tyrosine kinase PYK2 in the Akt/endothelial NO synthase pathway remains to be determined...
  15. ncbi Effects of cardiologist experience on outcomes of patients with ST-elevated myocardial infarction treated with primary PCI in a local area in Japan
    Tetsuya Nomura
    Department of Cardiovascular Medicine, Nantan General Hospital, Kyoto Prefectural University School of Medicine, Nantan city, Kyoto, Japan
    Int Heart J 52:127-30. 2011
    ..The present findings suggest the important clinical implication that younger cardiologists who have experienced PCI procedures to a certain extent can safely perform primary PCI and contribute to better prognoses of STEMI patients...
  16. ncbi Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways
    Akiko Mano
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Japan
    Circulation 110:317-23. 2004
    ....
  17. ncbi Amlodipine inhibits doxorubicin-induced apoptosis in neonatal rat cardiac myocytes
    Satoshi Yamanaka
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Am Coll Cardiol 41:870-8. 2003
    ..This effect is attributed to the antioxidant properties of amlodipine, affecting mainly hydrogen peroxide...
  18. ncbi Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis
    Hironori Hayashi
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Hypertens Res 31:363-75. 2008
    ..These proapoptotic actions of aldosterone may play a role in the progression of heart failure...
  19. ncbi Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia
    Norifumi Urao
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Circ Res 98:1405-13. 2006
    ..In conclusion, Epo treatment inhibits the neointimal hyperplasia after arterial injury in an NO-dependent manner by acting on the injured vessels and mobilizing EPCs to the neo-endothelium...
  20. ncbi p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress
    Masaki Kimata
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto, Japan
    Am J Physiol Heart Circ Physiol 299:H1908-16. 2010
    ....
  21. ncbi Echocardiographic diagnosis of pulmonary vein varix
    Jun Shiraishi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Circ J 67:796-8. 2003
    ..The diagnosis of left lower pulmonary vein varix was noninvasively confirmed by transthoracic echocardiography and transesophageal echocardiography...
  22. ncbi In-hospital outcomes of primary percutaneous coronary interventions performed at hospitals with and without on-site coronary artery bypass graft surgery
    Jun Shiraishi
    Department of Cardiology, Kyoto First Red Cross Hospital, and Department of Cardiology and Vascular Regenerative Medicine, Kyoto Prefectural University School of Medicine, Japan
    Circ J 71:1208-12. 2007
    ..However, data on the in-hospital outcomes of primary PCI performed at hospitals with and without on-site cardiac surgery are still lacking in Japan...
  23. ncbi Granulocyte colony-stimulating factor-mobilized circulating c-Kit+/Flk-1+ progenitor cells regenerate endothelium and inhibit neointimal hyperplasia after vascular injury
    Michitaka Takamiya
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan
    Arterioscler Thromb Vasc Biol 26:751-7. 2006
    ..CONCLUSIONS: The G-CSF-induced mobilization of BM-derived c-Kit+/Flk-1+ cells contributes to endothelial regeneration, and this cytokine therapy may be a feasible strategy for the promotion of re-endothelialization after angioplasty...
  24. ncbi Chronic pericardial constriction induced severe ischemic hepatitis manifesting as hypoglycemic attack
    Tetsuya Nomura
    Department of Cardiovascular Medicine, Nantan General Hospital, Nantan, Japan
    Circ J 73:183-6. 2009
    ..Hypoglycemia, which is considered secondary to reduced gluconeogenesis in the exhausted liver, is a rare complication of constrictive pericarditis...
  25. ncbi A case of deep venous thrombosis with a double inferior vena cava effectively treated by suprarenal filter implantation
    Akiko Mano
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
    Jpn Heart J 45:1063-9. 2004
    ..The present case illustrates the importance of a correct understanding of anatomy and demonstrates the effectiveness of using a suprarenal IVC filter in DVT...
  26. ncbi Cardiac sarcoidosis mimicking right ventricular dysplasia
    Jun Shiraishi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Circ J 67:169-71. 2003
    ..Reports of cardiac sarcoidosis mimicking right ventricular dysplasia are extremely rare and as this case shows, right ventricular involvement may be one of its manifestations...
  27. ncbi Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia
    Satoaki Matoba
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am Heart J 156:1010-8. 2008
    ....
  28. ncbi HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis
    Noriko Kuwahara
    Division of Hypertension and Nephrology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Cardiol 123:84-90. 2008
    ..In addition, the effects of statins on klotho protein expression and arteriosclerosis in these rats were investigated...
  29. ncbi Papillary fibroelastoma of the aortic valve: evaluation with transesophageal echocardiography and magnetic resonance imaging
    Jun Shiraishi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Jpn Heart J 44:799-803. 2003
    ..The histopathologic diagnosis was papillary fibroelastoma. When a tumor of the aortic valve exists, these examinations are useful in detecting and characterizing the tumor for optimal treatment...
  30. ncbi Carbon dioxide-rich water bathing enhances collateral blood flow in ischemic hindlimb via mobilization of endothelial progenitor cells and activation of NO-cGMP system
    Hidekazu Irie
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
    Circulation 111:1523-9. 2005
    ....
  31. ncbi [Therapeutic angiogenesis for peripheral arterial disease and ischemic heart disease by autologous bone marrow cells implantation]
    Tetsuya Tatsumi
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine
    Nippon Rinsho 64:2126-34. 2006
    ..Thus, bone marrow-derived cell transplantation therapy has been applied to acute and chronic ischemic heart diseases as well as peripheral arterial diseases, demonstrating the safety and effectiveness of therapeutic angiogenesis...
  32. ncbi [A 55-year-old man showing sudden disappearance of Q wave]
    Jun Shiraishi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kajiicho 465, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566
    J Cardiol 40:125-7. 2002
  33. ncbi Subacutely progressed extensive aortic dissection complicated with catheter-induced dissection in left main coronary artery
    Tetsuya Nomura
    Department of Cardiovascular Medicine, Nantan General Hospital, 25 Yagi Ueno, Yagi cho, Nantan city, Kyoto 629 0197, Japan
    J Cardiol 54:128-33. 2009
    ..This type of dissection is a rare complication related to coronary intervention and even in such a clinical setting, asymptomatic delayed progression of retrograde aortic dissection has not previously been reported to our knowledge...
  34. ncbi Acute myocardial infarction in young Japanese adults
    Jun Shiraishi
    Department of Cardiology, Kyoto First Red Cross Hospital, and Department of Cardiology and Vascular Regenerative Medicine, Kyoto Prefectural University School of Medicine, Japan
    Circ J 69:1454-8. 2005
    ..The prevalence and clinical manifestations of acute myocardial infarction (AMI) in young patients in Japan have not been fully investigated...
  35. ncbi Acute myocardial infarction due to a regressed giant coronary aneurysm as possible sequela of Kawasaki disease
    J Shiraishi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan, 602 8566
    J Invasive Cardiol 13:569-72. 2001
    ..The wall morphology of the coronary aneurysm using intravascular ultrasound imaging closely resembled that occurring after Kawasaki disease (KD), although our patient had no obvious past history of KD, suggesting so-called atypical KD...
  36. ncbi Important role of energy-dependent mitochondrial pathways in cultured rat cardiac myocyte apoptosis
    J Shiraishi
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
    Am J Physiol Heart Circ Physiol 281:H1637-47. 2001
    ..Our data therefore suggest that staurosporine induces cell demise through a mitochondrial death signaling pathway and that the presence of intracellular ATP favors a shift from necrosis to apoptosis through caspase activation...
  37. ncbi [Cardioprotective effect of aldosterone antagonists for ventricular remodeling]
    Tetsuya Tatsumi
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
    Nippon Rinsho 64:524-9. 2006
  38. ncbi Plasminogen activator inhibitor-1 promoter 4G/5G genotype is not a risk factor for myocardial infarction in a Japanese population
    T Sugano
    The Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Blood Coagul Fibrinolysis 9:201-4. 1998
    ..This is in contrast to the first report in Caucasians, suggesting an interaction with other genetic or environmental factors which influences the risk of myocardial infarction...
  39. ncbi Beneficial effect of cibenzoline on left ventricular pressure gradient with sigmoid septum
    Chika Konishi
    Department of Cardiology, Kyoto Prefectural Rakuto Hospital, Japan
    Circ J 68:968-71. 2004
    ..This case shows that cibenzoline may be useful in the treatment of left ventricular outflow tract obstruction caused by sigmoid septum...
  40. ncbi Usefulness of transthoracic echocardiography to detect coronary aneurysm in young adult: two cases of acute myocardial infarction due to Kawasaki disease
    Jun Shiraishi
    Department of Cardiology, Maizuru National Hospital, Yukinaga, Maizuru, Kyoto, Japan
    Echocardiography 21:165-9. 2004
    ..These cases suggest that transthoracic echocardiography plays an important role in the diagnosis and treatment of young adults with acute myocardial infarction due to Kawasaki disease...
  41. ncbi Apoptotic myocytes generate monocyte chemoattractant protein-1 and mediate macrophage recruitment
    Miyuki Kobara
    Dept of Clinical Pharmacology, Kyoto Pharmaceutical University, 5 Misasagi Nakauchi cho, Yamashina ku, Kyoto, Japan
    J Appl Physiol 104:601-9. 2008
    ..Concomitantly, activated macrophages infiltrated the areas of apoptosis remarkably. These results suggest that apoptotic myocytes produce MCP-1, which have a critical role in the active recruitment of macrophages...
  42. ncbi Obesity not associated with medium-term prognosis among Japanese male survivors hospitalized for acute myocardial infarction
    Jun Shiraishi
    Department of Cardiology, Kyoto First Red Cross Hospital, Honmachi 15 749, Higashiyama ku, Kyoto 605 0981
    J Cardiol 50:93-100. 2007
    ..Obesity is an established risk factor for coronary heart disease. However, data on the relationship between obesity and prognosis following acute myocardial infarction (AMI) are still lacking in Japan...
  43. ncbi Pathogenesis of acute myocardial infarction in young male adults with or without obesity
    Jun Shiraishi
    Department of Cardiology, Kyoto First Red Cross Hospital, Kyoto
    J Cardiol 49:13-21. 2007
    ..Obesity may be linked with coronary atherosclerosis in young males. This study investigated the etiology of acute myocardial infarction (AMI) in young Japanese male patients with or without obesity...
  44. ncbi Hyperleukocytosis in patients with leukemic follicular lymphoma
    Tohru Inaba
    Ann Hematol 86:299-300. 2007
  45. ncbi Relation of obesity to acute myocardial infarction in Japanese patients
    Jun Shiraishi
    Department of Cardiology, Kyoto First Red Cross Hospital, Japan
    Circ J 70:1525-30. 2006
    ..It remains uncertain whether obesity is an independent risk factor for coronary heart disease in young adults, as well as adults, in Japan...
  46. ncbi Medium-term prognosis of young Japanese adults having acute myocardial infarction
    Jun Shiraishi
    Department of Cardiology, Kyoto First Red Cross Hospital, Kyoto, Japan
    Circ J 70:518-24. 2006
    ..Data on the medium- and long-term prognosis of young Japanese patients with acute myocardial infarction (AMI) are still lacking...
  47. ncbi Interventional treatment for very young adults with acute myocardial infarction. Clinical manifestations and outcome
    Jun Shiraishi
    Department of Cardiology, Kyoto Prefectural Rakuto Hospital, Kyoto, Japan
    Int Heart J 46:1-12. 2005
    ..There was one death ascribed to heart failure 8 months after the initial PCI. The findings of this report suggest that PCI for very young adults with AMI can be safe and effective in the short-term...
  48. ncbi Effects of hospital volume of primary percutaneous coronary interventions on angiographic results and in-hospital outcomes for acute myocardial infarction
    Jun Shiraishi
    Department of Cardiology, Kyoto First Red Cross Hospital, Honmachi, Higashiyama ku, Kyoto 605 0981, Japan
    Circ J 72:1041-6. 2008
    ..However, the relationships among hospital primary PCI volume, angiographic results, and in-hospital prognosis in patients with acute myocardial infarction (AMI) have not been fully investigated in Japan...