- Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout miceKoichi Tanda
Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan
Mol Brain 2:19. 2009..We also examined the role of nNOS in dopamine/DARPP-32 signaling in striatal slices from nNOS KO mice and the effects of the administration of a dopamine D1 receptor agonist on behavior in nNOS KO mice...
- Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout miceKeizo Takao
Genetic Engineering and Functional Genomics Group, Frontier Technology Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
PLoS ONE 5:e9460. 2010..These findings indicate that CaMKIV might not be essential for fear memory or spatial memory, although it is possible that the activities of other neural mechanisms or signaling pathways compensate for the CaMKIV deficiency...
- Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrusYuichiro Hayashi
Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
Mol Brain 7:44. 2014..In this study, we used a brain-region specific knock-in mouse expressing an NMDA receptor that is defective for the Mg2+ block in order to test its role in neural information processing...
- Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disordersNobuyuki Yamasaki
Frontier Technology Center, Kyoto University Graduate School of Medicine, Japan
Mol Brain 1:6. 2008..Based on these results, we propose that an "immature DG" in adulthood might induce alterations in behavior and serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders...