Affiliation: Kyoto University
- Yamashita T, Takahashi Y, Nishikawa M, Takakura Y. Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation. Eur J Pharm Biopharm. 2016;98:1-8 pubmed publisher..These results indicate that the exosome isolation method markedly affects the dispersibility and filtration efficiency of the exosomes. ..
- Takagi S, Takahashi Y, Sugimura K, Nishikawa M, Takakura Y. Application of Magnesium Pyrophosphate-Based Sponge-Like Microparticles to Enhance the Delivery Efficiency and Adjuvant Effects of Polyriboinosinic-Polyribocytidylic Acid in Immune Cells. J Pharm Sci. 2016;105:766-772 pubmed publisher..4 cells, polyI:C-MgPP substantially increased OVA presentation. These results indicate that MgPP is a useful delivery vehicle for polyI:C and that polyI:C-MgPP is an effective immune cell adjuvant. ..
- Ando M, Fujimoto M, Takahashi Y, Nishikawa M, Hamana A, Takakura Y. Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein of a Fibrin Clot-Binding Peptide With Interferon Gamma for Cancer Gene Therapy. J Pharm Sci. 2017;106:892-897 pubmed publisher..These results indicate that targeted delivery of IFN? to fibrin clots through IFN?-mmp-CREKA fusion can enhance the therapeutic efficacy of IFN? in cancer gene therapy. ..