Chiaki Takahashi

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor
    Chiaki Takahashi
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:118-23. 2006
  2. pmc Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression
    Chiaki Takahashi
    Department of Medial Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Mol Cell Biol 24:10406-15. 2004
  3. pmc Wild-type NRas and KRas perform distinct functions during transformation
    Poppy P Fotiadou
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:6742-55. 2007
  4. pmc Rb and N-ras function together to control differentiation in the mouse
    Chiaki Takahashi
    Department of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 23:5256-68. 2003
  5. doi What we learn from transformation suppressor genes: lessons from RECK
    Makoto Noda
    Department of Molecular Oncology and Global COE Program, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Future Oncol 6:1105-16. 2010
  6. ncbi Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents
    Kayoko Nakaji
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Stroke 37:2816-23. 2006
  7. ncbi Recklessness as a hallmark of aggressive cancer
    Makoto Noda
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Cancer Sci 98:1659-65. 2007
  8. ncbi Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions
    Satoshi Kawashima
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Neurochem 104:376-85. 2008
  9. pmc Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis
    Takehiro Arai
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:9855-60. 2003
  10. ncbi Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice
    Junseo Oh
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Oncogene 23:5041-8. 2004

Collaborators

Detail Information

Publications25

  1. ncbi Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor
    Chiaki Takahashi
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:118-23. 2006
    ..These findings suggest that the loss of the proto-oncogene Nras in certain cellular contexts can promote malignant tumor progression...
  2. pmc Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression
    Chiaki Takahashi
    Department of Medial Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Mol Cell Biol 24:10406-15. 2004
    ..These observations suggest that Rb and K-ras function together in vivo, in the contexts of both embryonic and tumor development, and that the ability to affect differentiation is a major facet of the tumor suppressor function of pRb...
  3. pmc Wild-type NRas and KRas perform distinct functions during transformation
    Poppy P Fotiadou
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:6742-55. 2007
    ..Our analyses suggest a previously unappreciated convergence of different Ras isoforms on the dynamics of the processes involved in transformation...
  4. pmc Rb and N-ras function together to control differentiation in the mouse
    Chiaki Takahashi
    Department of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 23:5256-68. 2003
    ..Our findings suggest that the control of differentiation and proliferation by Rb are genetically separable...
  5. doi What we learn from transformation suppressor genes: lessons from RECK
    Makoto Noda
    Department of Molecular Oncology and Global COE Program, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Future Oncol 6:1105-16. 2010
    ..In this article we discuss the promise, limitations and recent innovations in this approach, taking one transformation suppressor gene, RECK, as an example...
  6. ncbi Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents
    Kayoko Nakaji
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Stroke 37:2816-23. 2006
    ..In the present study, we asked whether MMP-2 is involved in the BBB disruption and the subsequent WM lesions after chronic cerebral hypoperfusion...
  7. ncbi Recklessness as a hallmark of aggressive cancer
    Makoto Noda
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Cancer Sci 98:1659-65. 2007
    ..Here we review the recent advances in RECK research and discuss some of the important issues to be addressed in future studies...
  8. ncbi Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions
    Satoshi Kawashima
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Neurochem 104:376-85. 2008
    ....
  9. pmc Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis
    Takehiro Arai
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:9855-60. 2003
    ..FAP68 has recently been identified as a gene responsible for familial glomuvenous malformation. These results suggest that p185 forms a multiprotein complex and plays an important role in vascular morphogenesis...
  10. ncbi Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice
    Junseo Oh
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Oncogene 23:5041-8. 2004
    ..In the absence of MMP-2 and MT1-MMP, myoblast fusion in vitro is also significantly retarded. These findings suggest functional overlap in mice between the two MMPs with distinct molecular natures...
  11. ncbi Transcriptional control of the RECK metastasis/angiogenesis suppressor gene
    Regina Maki Sasahara
    Instituto de Quimica, Universidade de Sao Paulo, CP 26077, Sao Paulo 05513 970, SP, Brazil
    Cancer Detect Prev 26:435-43. 2002
    ..Understanding of the mechanisms which control RECK gene transcription may lead to the development of new strategies for cancer prevention and treatment...
  12. ncbi Genetic interaction between Rb and N-ras: differentiation control and metastasis
    Chiaki Takahashi
    The 21st Century Center of Excellence Program, Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer Res 66:9345-8. 2006
    ..Here, we discuss the genetic interaction between Rb and ras and the development of a mouse model of medullary thyroid carcinoma...
  13. ncbi The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors
    Michiko Echizenya
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Japan
    Oncogene 24:5850-7. 2005
    ..These findings suggest that MyoD down regulates RECK to facilitate myotube formation, whereas MRF4 up regulates RECK to promote other aspects of myogenesis that require extracellular matrix integrity...
  14. ncbi The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer
    Taku Takeuchi
    Department of Surgery, Nara Medical University, Kashihara City, Nara, Japan
    Clin Cancer Res 10:5572-9. 2004
    ..However, the clinical relevance of these findings remains to be fully documented. Here we examined the expression of RECK and one of its targets, MMP-9, in colorectal cancer tissue...
  15. ncbi RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity
    Teruyuki Muraguchi
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Nat Neurosci 10:838-45. 2007
    ..These findings indicate that RECK is a physiological inhibitor of ADAM10, an upstream regulator of Notch signaling and a critical modulator of brain development...
  16. ncbi A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer
    Masashi Koto
    Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aobaku, Sendai, Japan
    Radiother Oncol 85:429-34. 2007
    ..We aimed to evaluate the clinical outcome of stereotactic body radiotherapy (SBRT) in the treatment of stage I NSCLC...
  17. ncbi The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways
    Takao Miki
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Biol Chem 282:12341-52. 2007
    ..This modulation was correlated with the accelerated internalization and decay of MT1-MMP and CD13. This study unveils the novel function and target molecules of RECK...
  18. ncbi Prognostic significance of reversion-inducing cysteine-rich protein with Kazal motifs expression in resected pathologic stage IIIA N2 non-small-cell lung cancer
    Kazumasa Takenaka
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Shogoin kawahara cho 54, Sakyo ku, Kyoto, 606 8507, Japan
    Ann Surg Oncol 12:817-24. 2005
    ..In this study, further analyses focused on pN2 disease were conducted to assess the clinical significance of RECK expression...
  19. ncbi Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa
    Masafumi Ihara
    Biochemistry and Cell Biology Unit, HMRO, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Dev Cell 8:343-52. 2005
    ..Thus, cortical organization based on circular assembly of the septin cytoskeleton is essential for the structural and mechanical integrity of mammalian spermatozoa...
  20. ncbi Construction of a remote radiotherapy planning system
    Yoshihiro Ogawa
    Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    Int J Clin Oncol 10:26-9. 2005
    ..We constructed a remote radiotherapy planning system, and we examined the usefulness of and faults in our system in this study...
  21. ncbi Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK
    Junseo Oh
    National Cancer Institute, Center for Cancer Research, Cell and Cancer Biology Branch, Bethesda, Maryland, USA
    Cancer Res 64:9062-9. 2004
    ..Secondly, TIMP-2 can disrupt VEGF signaling required for initiation of hMVEC migration. Third, TIMP-2 can enhance expression of RECK via Rap1 signaling resulting in an indirect, time-dependent inhibition of endothelial cell migration...
  22. ncbi Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer
    Kazumasa Takenaka
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Eur J Cancer 40:1617-23. 2004
    ..009; Hazard ratio (HR), 0.474 with a 95% Confidence interval (CI) of 0.271-0.830). In conclusion, RECK-status is a significant prognostic factor correlated with tumour angiogenesis in NSCLC patients...
  23. ncbi Results of radiation therapy for uterine cervical cancer using high dose rate remote after loading system
    Yoshihiro Ogawa
    Department of Radiation Oncology, Tohoku University Graduate School of Medicine Sendai 980 8574, Japan
    Tohoku J Exp Med 199:229-38. 2003
    ..5%, 11.0% and 25.2%, respectively. Radiation therapy using HDR-RALS was very effective. While the dose of whole pelvic irradiation was increased, the actuarial incidence of all complications was increased...
  24. ncbi RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling
    Makoto Noda
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Cancer Metastasis Rev 22:167-75. 2003
    ....
  25. ncbi [The membrane-anchored metalloproteinase inhibitor RECK]
    Chiaki Takahashi
    Tanpakushitsu Kakusan Koso 47:1889-95. 2002