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Genomes and Genes | Chiaki TakahashiSummaryAffiliation: Kyoto University Country: Japan Publications
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Publications
Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumorChiaki Takahashi
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 38:118-23. 2006..These findings suggest that the loss of the proto-oncogene Nras in certain cellular contexts can promote malignant tumor progression...
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppressionChiaki Takahashi
Department of Medial Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
Mol Cell Biol 24:10406-15. 2004..These observations suggest that Rb and K-ras function together in vivo, in the contexts of both embryonic and tumor development, and that the ability to affect differentiation is a major facet of the tumor suppressor function of pRb...- Wild-type NRas and KRas perform distinct functions during transformationPoppy P Fotiadou
Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Mol Cell Biol 27:6742-55. 2007..Our analyses suggest a previously unappreciated convergence of different Ras isoforms on the dynamics of the processes involved in transformation... - Rb and N-ras function together to control differentiation in the mouseChiaki Takahashi
Department of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Mol Cell Biol 23:5256-68. 2003..Our findings suggest that the control of differentiation and proliferation by Rb are genetically separable... 
What we learn from transformation suppressor genes: lessons from RECKMakoto Noda
Department of Molecular Oncology and Global COE Program, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Future Oncol 6:1105-16. 2010..In this article we discuss the promise, limitations and recent innovations in this approach, taking one transformation suppressor gene, RECK, as an example...- Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodentsKayoko Nakaji
Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Stroke 37:2816-23. 2006..In the present study, we asked whether MMP-2 is involved in the BBB disruption and the subsequent WM lesions after chronic cerebral hypoperfusion... - Recklessness as a hallmark of aggressive cancerMakoto Noda
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
Cancer Sci 98:1659-65. 2007..Here we review the recent advances in RECK research and discuss some of the important issues to be addressed in future studies... - Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctionsSatoshi Kawashima
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
J Neurochem 104:376-85. 2008.... - Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesisTakehiro Arai
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:9855-60. 2003..FAP68 has recently been identified as a gene responsible for familial glomuvenous malformation. These results suggest that p185 forms a multiprotein complex and plays an important role in vascular morphogenesis... - Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in miceJunseo Oh
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Oncogene 23:5041-8. 2004..In the absence of MMP-2 and MT1-MMP, myoblast fusion in vitro is also significantly retarded. These findings suggest functional overlap in mice between the two MMPs with distinct molecular natures... - Transcriptional control of the RECK metastasis/angiogenesis suppressor geneRegina Maki Sasahara
, , CP 26077, , SP, Brazil
Cancer Detect Prev 26:435-43. 2002..Understanding of the mechanisms which control RECK gene transcription may lead to the development of new strategies for cancer prevention and treatment... - Genetic interaction between Rb and N-ras: differentiation control and metastasisChiaki Takahashi
The 21st Century Center of Excellence Program, Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Cancer Res 66:9345-8. 2006..Here, we discuss the genetic interaction between Rb and ras and the development of a mouse model of medullary thyroid carcinoma... - The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factorsMichiko Echizenya
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Japan
Oncogene 24:5850-7. 2005..These findings suggest that MyoD down regulates RECK to facilitate myotube formation, whereas MRF4 up regulates RECK to promote other aspects of myogenesis that require extracellular matrix integrity... - The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancerTaku Takeuchi
Department of Surgery, Nara Medical University, Kashihara City, Nara, Japan
Clin Cancer Res 10:5572-9. 2004..However, the clinical relevance of these findings remains to be fully documented. Here we examined the expression of RECK and one of its targets, MMP-9, in colorectal cancer tissue... - RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activityTeruyuki Muraguchi
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
Nat Neurosci 10:838-45. 2007..These findings indicate that RECK is a physiological inhibitor of ADAM10, an upstream regulator of Notch signaling and a critical modulator of brain development... - A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancerMasashi Koto
Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aobaku, Sendai, Japan
Radiother Oncol 85:429-34. 2007..We aimed to evaluate the clinical outcome of stereotactic body radiotherapy (SBRT) in the treatment of stage I NSCLC... - The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathwaysTakao Miki
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
J Biol Chem 282:12341-52. 2007..This modulation was correlated with the accelerated internalization and decay of MT1-MMP and CD13. This study unveils the novel function and target molecules of RECK... - Prognostic significance of reversion-inducing cysteine-rich protein with Kazal motifs expression in resected pathologic stage IIIA N2 non-small-cell lung cancerKazumasa Takenaka
Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Shogoin-kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan
Ann Surg Oncol 12:817-24. 2005..031). RECK expression in involved N2 nodes was significantly higher than in primary tumors (P < .001). CONCLUSIONS: RECK status was a novel prognostic factor in pathologic stage IIIA N2 NSCLC... - Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoaMasafumi Ihara
Biochemistry and Cell Biology Unit, HMRO, Kyoto University Graduate School of Medicine, Kyoto, Japan
Dev Cell 8:343-52. 2005..Thus, cortical organization based on circular assembly of the septin cytoskeleton is essential for the structural and mechanical integrity of mammalian spermatozoa... - Construction of a remote radiotherapy planning systemYoshihiro Ogawa
Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
Int J Clin Oncol 10:26-9. 2005..We constructed a remote radiotherapy planning system, and we examined the usefulness of and faults in our system in this study... - Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECKJunseo Oh
National Cancer Institute, Center for Cancer Research, Cell and Cancer Biology Branch, Bethesda, Maryland, USA
Cancer Res 64:9062-9. 2004..Secondly, TIMP-2 can disrupt VEGF signaling required for initiation of hMVEC migration. Third, TIMP-2 can enhance expression of RECK via Rap1 signaling resulting in an indirect, time-dependent inhibition of endothelial cell migration... - Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancerKazumasa Takenaka
Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
Eur J Cancer 40:1617-23. 2004..009; Hazard ratio (HR), 0.474 with a 95% Confidence interval (CI) of 0.271-0.830). In conclusion, RECK-status is a significant prognostic factor correlated with tumour angiogenesis in NSCLC patients... - Results of radiation therapy for uterine cervical cancer using high dose rate remote after loading systemYoshihiro Ogawa
Department of Radiation Oncology, Tohoku University Graduate School of Medicine Sendai 980 8574, Japan
Tohoku J Exp Med 199:229-38. 2003..5%, 11.0% and 25.2%, respectively. Radiation therapy using HDR-RALS was very effective. While the dose of whole pelvic irradiation was increased, the actuarial incidence of all complications was increased... - RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodelingMakoto Noda
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Cancer Metastasis Rev 22:167-75. 2003.... - [The membrane-anchored metalloproteinase inhibitor RECK]Chiaki Takahashi
Tanpakushitsu Kakusan Koso 47:1889-95. 2002