Research Topics
Genomes and Genes
| Makoto TachibanaSummaryAffiliation: Kyoto University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Functional dynamics of H3K9 methylation during meiotic prophase progressionMakoto Tachibana
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto, Japan
EMBO J 26:3346-59. 2007..This genetic and biochemical evidence strongly suggests that a specific set of H3K9 methyltransferase(s) and demethylase(s) coordinately regulate gametogenesis...- G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcriptionMakoto Tachibana
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto, Japan
EMBO J 27:2681-90. 2008..This is the first clear evidence that G9a/GLP suppresses transcription by independently inducing both H3K9 and DNA methylation... - Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9Makoto Tachibana
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
Genes Dev 19:815-26. 2005..Taken together, our new findings revealed that G9a and GLP cooperatively exert H3-K9 methyltransferase function in vivo, likely through the formation of higher-order heteromeric complexes... - Histone H1 null vertebrate cells exhibit altered nucleosome architectureHideharu Hashimoto
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto, Japan
Nucleic Acids Res 38:3533-45. 2010.... 
A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9Haruki Shirato
Mitsubishi Kagaku Institute of Life Sciences, Kyoto, Japan
J Biol Chem 284:733-9. 2009..These results suggest that Jmj methylates H3-K9 and represses cyclin D1 expression through G9a and GLP, and that Jmj family proteins can regulate gene expression by not only histone demethylation but also other histone modification...
Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBPJun Ueda
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Japan
J Biol Chem 281:20120-8. 2006..These data indicate that Wiz not only contributes to the stability of G9a but also links the G9a/GLP heteromeric complex to the CtBP co-repressor machinery...- G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesisMakoto Tachibana
Department of Cell Biology, Institute for Virus Research, Kyoto University, Shogoin Kawara cho, Kyoto 606 8507, Japan
Genes Dev 16:1779-91. 2002..Our results indicate that euchromatic H3-K9 methylation regulated by G9a is essential for early embryogenesis and is involved in the transcriptional repression of developmental genes... - Proviral silencing in embryonic stem cells requires the histone methyltransferase ESETToshiyuki Matsui
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
Nature 464:927-31. 2010..We propose that a DNA-methylation-independent pathway involving KAP1 and ESET/ESET-mediated H3K9me3 is required for proviral silencing during the period early in embryogenesis when DNA methylation is dynamically reprogrammed... - Characterization of Drosophila G9a in vivo and identification of genetic interactantsYasuko Kato
Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto, Japan
Genes Cells 13:703-22. 2008..Furthermore co-expression of Lid in eye imaginal discs enhanced the rough phenotype induced by dG9a. The results suggest that the function of dG9a is negatively regulated by the PcG complex and positively regulated by Lid in vivo... - Distinct roles of TRF1 in the regulation of telomere structure and lengtheningKeiji Okamoto
Experimental Research Center for Infectious Diseases, Institute for Virus Research, and Graduate School of Biostudies, Kyoto University, 53 Shogoin, Kawara cho, Sakyo ku, Kyoto, Japan
J Biol Chem 283:23981-8. 2008.... - Histone H1 variant, H1R is involved in DNA damage responseHideharu Hashimoto
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
DNA Repair (Amst) 6:1584-95. 2007..Together, these findings provide the first genetic evidence that a specific H1 variant plays a unique and important role in the DNA damage response in vertebrates... - Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9aMiki Nishida
Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
Genes Cells 12:877-88. 2007..Furthermore, ZNF200 appear to co-localize with G9a in the nucleoplasm of HEK293 cells as discrete speckles. These results demonstrate that ZNF200 is a novel binding partner of G9a... - [Mammalian histone methyltransferases]Makoto Tachibana
Experimental Research Center for Infection Diseases, Institute for Virus Research, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Seikagaku 78:50-3. 2006 - Protein kinase A determines timing of early differentiation through epigenetic regulation with G9aKohei Yamamizu
Department of Stem Cell Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
Cell Stem Cell 10:759-70. 2012..5 and delayed development. In this study, we demonstrate molecular machinery that regulates timing of multilineage differentiation by linking signaling with epigenetics... - H3K9 methyltransferase G9a and the related molecule GLPYoichi Shinkai
Institute for Virus Research, Kyoto University, Kawara cho, Sakyo ku, Kyoto, Kyoto 606 8507, Japan
Genes Dev 25:781-8. 2011..Recently, many important studies have reported that G9a and GLP play critical roles in various biological processes. The physiological relevance of G9a/GLP-mediated epigenetic gene regulation is discussed... - Rad54 is dispensable for the ALT pathwayKoichi Akiyama
Department of Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
Genes Cells 11:1305-15. 2006..This is the first genetic evidence that mouse Rad54 is dispensable for the ALT pathway... - Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cellsKatsuaki Deguchi
Institute for Virus Research, Kyoto University, Kyoto, Japan
Biol Reprod 88:36. 2013.... - Importance of TRF1 for functional telomere structureTomohiko Iwano
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto, Japan
J Biol Chem 279:1442-8. 2004..These results strongly suggest that TRF1 interacts with other telomere-binding molecules and integrates into the functional telomere structure... - Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting centerZhenghan Xin
Departments of Biochemistry and Molecular Genetics and Pediatrics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
J Biol Chem 278:14996-5000. 2003.... - Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repressionNaoyuki Fujita
Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
J Biol Chem 278:24132-8. 2003..These data indicate that MBD1 may tether the Suv39h1-HP1 complex to methylated DNA regions, suggesting the presence of a pathway from DNA methylation to the modifications of histones for epigenetic gene regulation... - Partitioning and plasticity of repressive histone methylation states in mammalian chromatinAntoine H F M Peters
Research Institute of Molecular Pathology, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
Mol Cell 12:1577-89. 2003..Our data underscore the selective presence of distinct histone lysine methylation states in partitioning chromosomal subdomains but also reveal a surprising plasticity in propagating methylation patterns in eukaryotic chromatin... - Targeted inhibition of V(D)J recombination by a histone methyltransferaseOleg Osipovich
Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA
Nat Immunol 5:309-16. 2004..These findings indicate a key function for histone methyltransferases in the tissue- and stage-specific suppression of antigen receptor gene assembly during lymphocyte development... - DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activityKevin B Dong
Department of Medical Genetics, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada
EMBO J 27:2691-701. 2008..Taken together, these observations reveal that H3K9me3 and HP1alpha recruitment to retrotransposons occurs independent of DNA methylation in ES cells and that G9a promotes DNA methylation independent of its HMTase activity... - X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9aTatsuya Ohhata
PRESTO, Japan Science and Technology Agency JST, Kawaguchi, Japan
Genesis 40:151-6. 2004..These results demonstrate that G9a is not essential for X-inactivation... - Functional analysis of histone methyltransferase g9a in B and T lymphocytesLance R Thomas
Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA
J Immunol 181:485-93. 2008..These findings indicate that the H3K9me2 epigenetic mark affects a highly restricted set of processes during lymphocyte development and activation... - In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferasesRobert E Collins
Biochemistry and Chemistry, Emory University, Atlanta, GA 30392, USA
J Biol Chem 280:5563-70. 2005..The altered DIM-5 rescued the growth defect characteristic of dim-5 N. crassa but did not fully rescue the gross DNA hypomethylation of dim-5 strains... - Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cellsKohta Ikegami
Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences and Veterinary Medical Sciences, The University of Tokyo, Tokyo 113 8657, Japan
Genes Cells 12:1-11. 2007..Chromatin immunoprecipitation (ChIP) confirmed these loci to be targets of G9a, with decreased H3-K9 and/or -K27 dimethylation in the G9a(-/-) cells. These data indicate that G9a site-selectively contributes to DNA methylation... - Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in miceYoshiyuki Seki
Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology, RIKEN Kobe Institute, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
Development 134:2627-38. 2007..We suggest the possibility that active repression of an essential enzyme and subsequent unique cellular dynamics ensures successful implementation of genome-wide epigenetic reprogramming in migrating PGCs... - Molecular dynamics of Aurora-A kinase in living mitotic cells simultaneously visualized with histone H3 and nuclear membrane protein importinalphaKenji Sugimoto
Laboratory of Applied Molecular Biology, Division of Applied Biochemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, 1 1 Gakuen cho, Sakai, Osaka 599 8531, Japan
Cell Struct Funct 27:457-67. 2002..Immunostaining with anti-alpha or gamma-tubulin further indicated that Aurora-A was involved in the formation of mitotic spindle in metaphase as well as the subsequent chromosome movement in anaphase...