Yasuhiko Tabata


Affiliation: Kyoto University
Country: Japan


  1. Jo J, Tabata Y. How controlled release technology can aid gene delivery. Expert Opin Drug Deliv. 2015;12:1689-701 pubmed publisher
    ..Technologies to deliver genes to cell aggregates will play an important role in the promotion of regenerative research and therapy. ..
  2. Murata Y, Jo J, Tabata Y. Intracellular controlled release of molecular beacon prolongs the time period of mRNA visualization. Tissue Eng Part A. 2019;: pubmed publisher
    ..It is concluded that the intracellular controlled release of MB is a promising to achieve the long-term and continuous visualization of mRNA. ..
  3. Kuttappan S, Mathew D, Jo J, Tanaka R, Menon D, Ishimoto T, et al. Dual release of growth factor from nanocomposite fibrous scaffold promotes vascularisation and bone regeneration in rat critical sized calvarial defect. Acta Biomater. 2018;78:36-47 pubmed publisher
    ..The growth factor was loaded in a simple manner, which would ensure ease of use for the end-user, especially for the surgeons treating a patient in an operating room. ..
  4. Shibata M, Takagi G, Kudo M, Kurita J, Kawamoto Y, Miyagi Y, et al. Enhanced Sternal Healing Through Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel. Tissue Eng Part A. 2018;24:1406-1412 pubmed publisher
    ..This novel therapy could potentially help prevent complications, such as deep sternal wound infection and could result in early postoperative ambulation after median sternotomy. ..
  5. Phaechamud T, Yodkhum K, Charoenteeraboon J, Tabata Y. Chitosan-aluminum monostearate composite sponge dressing containing asiaticoside for wound healing and angiogenesis promotion in chronic wound. Mater Sci Eng C Mater Biol Appl. 2015;50:210-25 pubmed publisher
    ..The sponge extractions were non-toxic to the cells moreover they promoted NHDF and NHEK cell proliferation. Asiaticoside and asiaticoside-contained dressings exhibited dose-dependent angiogenic activity in CAM model. ..
  6. Kim Y, Tabata Y. Dual-controlled release system of drugs for bone regeneration. Adv Drug Deliv Rev. 2015;94:28-40 pubmed publisher
    ..In this paper, various dual-controlled release systems of drugs aiming at bone regeneration are overviewed explaining the type of drugs and their release materials. ..
  7. Toda H, Yamamoto M, Uyama H, Tabata Y. Fabrication of hydrogels with elasticity changed by alkaline phosphatase for stem cell culture. Acta Biomater. 2016;29:215-227 pubmed publisher
    ..This is the novel report describing to demonstrate that the dynamic alteration of hydrogel substrate elasticity could modulate the osteoblastic gene expression of human MSC in vitro. ..
  8. Tan G, Tabata Y. Chondroitin-6-sulfate attenuates inflammatory responses in murine macrophages via suppression of NF-?B nuclear translocation. Acta Biomater. 2014;10:2684-92 pubmed publisher
    ..Further investigations reveal that the anti-inflammatory effects of C6S on activated m? may be ascribed at least in part to suppression of NF-?B nuclear translocation. ..
  9. Tamura R, Uemoto S, Tabata Y. Augmented liver targeting of exosomes by surface modification with cationized pullulan. Acta Biomater. 2017;57:274-284 pubmed publisher
    ..Furthermore the greater therapeutic effects against the liver injury compared with unmodified original exosomes was observed. ..

More Information


  1. Sakata M, Tonomura H, Itsuji T, Ishibashi H, Takatori R, Mikami Y, et al. Bone regeneration of osteoporotic vertevral body defects using PRP and gelatin ?-TCP sponges. Tissue Eng Part A. 2017;: pubmed publisher
    ..PRP combined with gelatin ?-TCP sponges could be potentially useful for developing a new approach to vertebroplasty for osteoporotic vertebral fracture. ..
  2. Yamamoto M, Hokugo A, Takahashi Y, Nakano T, Hiraoka M, Tabata Y. Combination of BMP-2-releasing gelatin/β-TCP sponges with autologous bone marrow for bone regeneration of X-ray-irradiated rabbit ulnar defects. Biomaterials. 2015;56:18-25 pubmed publisher
    ..It is concluded that the combination of bone marrow with the BMP-2-releasing gelatin/β-TCP sponge is a promising technique to induce bone regeneration at segmental bone defects after X-ray irradiation. ..
  3. Kim Y, Tabata Y. Enhancement of wound closure by modifying dual release patterns of stromal-derived cell factor-1 and a macrophage recruitment agent from gelatin hydrogels. J Tissue Eng Regen Med. 2017;11:2999-3013 pubmed publisher
    ..Copyright © 2016 John Wiley & Sons, Ltd. ..
  4. Zhang T, Wu J, Xu Q, Wang X, Lu J, Hu Y, et al. Design of magnetic gene complexes as effective and serum resistant gene delivery systems for mesenchymal stem cells. Int J Pharm. 2017;520:1-13 pubmed publisher
    ..To conclude, the current study presented a novel option for genetic modification of MSCs in an effective, relatively safe and serum compatible way. ..
  5. Chandana E, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, et al. Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. BMC Dev Biol. 2010;10:84 pubmed publisher
    ..Our findings implicate Reck in vascular remodeling, possibly through non-sprouting angiogenesis, in both maternal and embyonic tissues. ..
  6. Hirai K, Tabata Y, Hasegawa S, Sakai Y. Enhanced intestinal anastomotic healing with gelatin hydrogel incorporating basic fibroblast growth factor. J Tissue Eng Regen Med. 2016;10:E433-E442 pubmed publisher
    ..Therefore controlled release of bFGF enhanced healing of an intestinal anastomosis during the early postoperative period and is a promising method to suppress anastomotic leakage. Copyright © 2013 John Wiley & Sons, Ltd. ..
  7. Toda H, Yamamoto M, Uyama H, Tabata Y. Effect of hydrogel elasticity and ephrinB2-immobilized manner on Runx2 expression of human mesenchymal stem cells. Acta Biomater. 2017;58:312-322 pubmed publisher
    ..This is the novel report describing to demonstrate that the Runx2 expression of MSC is synergistically influenced by the hydrogels elasticity and their manner of ephrinB2 immobilized. ..