Kazunori Shimizu

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. doi request reprint Evaluation systems of generated forces of skeletal muscle cell-based bio-actuators
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshidashimoadachi, Sakyo, Kyoto 606 8501, Japan
    J Biosci Bioeng 115:115-21. 2013
  2. pmc In vivo site-specific transfection of naked plasmid DNA and siRNAs in mice by using a tissue suction device
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 7:e41319. 2012
  3. doi request reprint Implantable pneumatically actuated microsystem for renal pressure-mediated transfection in mice
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Control Release 159:85-91. 2012
  4. doi request reprint Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice
    Kosuke Kusamori
    Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshidashimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Control Release 173:119-24. 2014
  5. doi request reprint Development of a suction device for stabilizing in vivo real-time imaging of murine tissues
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    J Biosci Bioeng 112:508-10. 2011
  6. doi request reprint Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    J Biosci Bioeng 115:695-9. 2013

Collaborators

Detail Information

Publications6

  1. doi request reprint Evaluation systems of generated forces of skeletal muscle cell-based bio-actuators
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshidashimoadachi, Sakyo, Kyoto 606 8501, Japan
    J Biosci Bioeng 115:115-21. 2013
    ..Such systems can be used to study the physiology of the skeletal muscle, screen drug candidates for skeletal muscle-related disorders, and improve the function of tissue-engineered skeletal muscle...
  2. pmc In vivo site-specific transfection of naked plasmid DNA and siRNAs in mice by using a tissue suction device
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 7:e41319. 2012
    ..These results indicate that the in vivo transfection method developed in this study will be a viable approach for biological research and therapies using nucleic acids...
  3. doi request reprint Implantable pneumatically actuated microsystem for renal pressure-mediated transfection in mice
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Control Release 159:85-91. 2012
    ..This is the first report of an implantable MEMS-based microsystem that demonstrates in vivo transfection to a kidney using naked plasmid DNA...
  4. doi request reprint Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice
    Kosuke Kusamori
    Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshidashimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Control Release 173:119-24. 2014
    ..These results indicate that insulin-secreting NIT-1 spheroids prepared using PNIPAAm-coated PDMS-based microwells are more effective for the treatment of type 1 diabetes than dissociated cells in suspension. ..
  5. doi request reprint Development of a suction device for stabilizing in vivo real-time imaging of murine tissues
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    J Biosci Bioeng 112:508-10. 2011
    ..In this study, we propose a suction device for stabilizing live imaging, which was used to demonstrate fluorescence detection of circulating blood cells in vessels of mouse livers...
  6. doi request reprint Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids
    Kazunori Shimizu
    Institute for Innovative NanoBio Drug Discovery and Development, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    J Biosci Bioeng 115:695-9. 2013
    ..Functional assessment suggests that the PNIPAAm microwell arrays are not toxic to the formed spheroids. The PNIPAAm microwell array developed in the present study will be useful for constructing and harvesting spheroids...