Yoshinori Shichida

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Evolution of opsins and phototransduction
    Yoshinori Shichida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Philos Trans R Soc Lond B Biol Sci 364:2881-95. 2009
  2. ncbi request reprint Amino acid residues responsible for the meta-III decay rates in rod and cone visual pigments
    Shigeki Kuwayama
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, and CREST, Japan Science and Technology Agency, Kyoto, Japan
    Biochemistry 44:2208-15. 2005
  3. pmc Covalent bond between ligand and receptor required for efficient activation in rhodopsin
    Take Matsuyama
    Department of Biophysics, Graduate School of Science and CREST JST, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 285:8114-21. 2010
  4. pmc Photochemical nature of parietopsin
    Kazumi Sakai
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 51:1933-41. 2012
  5. ncbi request reprint Cephalochordate melanopsin: evolutionary linkage between invertebrate visual cells and vertebrate photosensitive retinal ganglion cells
    Mitsumasa Koyanagi
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Curr Biol 15:1065-9. 2005
  6. ncbi request reprint Expression and comparative characterization of Gq-coupled invertebrate visual pigments and melanopsin
    Akihisa Terakita
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    J Neurochem 105:883-90. 2008
  7. pmc Rod visual pigment optimizes active state to achieve efficient G protein activation as compared with cone visual pigments
    Keiichi Kojima
    From the Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 289:5061-73. 2014
  8. pmc Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain
    Masataka Yanagawa
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 288:9593-601. 2013
  9. pmc A pivot between helices V and VI near the retinal-binding site is necessary for activation in rhodopsins
    Hisao Tsukamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 285:7351-7. 2010
  10. doi request reprint Comparative studies on the late bleaching processes of four kinds of cone visual pigments and rod visual pigment
    Keita Sato
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 51:4300-8. 2012

Collaborators

Detail Information

Publications54

  1. pmc Evolution of opsins and phototransduction
    Yoshinori Shichida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Philos Trans R Soc Lond B Biol Sci 364:2881-95. 2009
    ..We will show how the advances in molecular biology and biophysics have given us insights into how evolution works at the molecular level...
  2. ncbi request reprint Amino acid residues responsible for the meta-III decay rates in rod and cone visual pigments
    Shigeki Kuwayama
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, and CREST, Japan Science and Technology Agency, Kyoto, Japan
    Biochemistry 44:2208-15. 2005
    ....
  3. pmc Covalent bond between ligand and receptor required for efficient activation in rhodopsin
    Take Matsuyama
    Department of Biophysics, Graduate School of Science and CREST JST, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 285:8114-21. 2010
    ....
  4. pmc Photochemical nature of parietopsin
    Kazumi Sakai
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 51:1933-41. 2012
    ..Thus, parietopsin behaves as an "evolutionary intermediate" between invertebrate and vertebrate visual opsins...
  5. ncbi request reprint Cephalochordate melanopsin: evolutionary linkage between invertebrate visual cells and vertebrate photosensitive retinal ganglion cells
    Mitsumasa Koyanagi
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Curr Biol 15:1065-9. 2005
    ..The cephalochordate rhabdomeric photoreceptor represents an evolutionary link between the invertebrate visual photoreceptor and the vertebrate circadian photoreceptor...
  6. ncbi request reprint Expression and comparative characterization of Gq-coupled invertebrate visual pigments and melanopsin
    Akihisa Terakita
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    J Neurochem 105:883-90. 2008
    ..Our findings are also important in that this is the first report describes a heterologous large-scale expression of the Gq-coupled invertebrate visual pigments in cultured cells...
  7. pmc Rod visual pigment optimizes active state to achieve efficient G protein activation as compared with cone visual pigments
    Keiichi Kojima
    From the Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 289:5061-73. 2014
    ..These results indicated that efficient Gt activation by rhodopsin, resulting from an optimized active state of rhodopsin, is one of the causes of the high amplification efficiency of rods. ..
  8. pmc Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain
    Masataka Yanagawa
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 288:9593-601. 2013
    ....
  9. pmc A pivot between helices V and VI near the retinal-binding site is necessary for activation in rhodopsins
    Hisao Tsukamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 285:7351-7. 2010
    ....
  10. doi request reprint Comparative studies on the late bleaching processes of four kinds of cone visual pigments and rod visual pigment
    Keita Sato
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 51:4300-8. 2012
    ..These results strongly suggest that rhodopsin and S, M1, and M2 cone visual pigments share a molecular mechanism for activation, whereas the L-group pigment may have a special reaction mechanism involving the chloride-binding site...
  11. ncbi request reprint Generation of knock-in mice carrying third cones with spectral sensitivity different from S and L cones
    Akishi Onishi
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    Zoolog Sci 22:1145-56. 2005
    ....
  12. ncbi request reprint Photoisomerization efficiency in UV-absorbing visual pigments: protein-directed isomerization of an unprotonated retinal Schiff base
    Kei Tsutsui
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 46:6437-45. 2007
    ..These results suggest that the mouse UV pigment has a specific mechanism for the efficient photoisomerization of its unprotonated Schiff base chromophore...
  13. doi request reprint Conformational change of the transmembrane helices II and IV of metabotropic glutamate receptor involved in G protein activation
    Takahiro Yamashita
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    J Neurochem 106:850-9. 2008
    ..These results provided the model that the conformational changes at the cytoplasmic ends of helices II and IV of mGluR are involved in the efficient G protein coupling...
  14. pmc Evolution of Mammalian Opn5 as a Specialized UV-absorbing Pigment by a Single Amino Acid Mutation
    Takahiro Yamashita
    From the Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 289:3991-4000. 2014
    ..Therefore, mammalian Opn5m may work exclusively as a short wavelength sensor in the brain as well as in the retina with the assistance of an 11-cis-retinal-supplying system. ..
  15. doi request reprint Direct observation of the pH-dependent equilibrium between metarhodopsins I and II and the pH-independent interaction of metarhodopsin II with transducin C-terminal peptide
    Keita Sato
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 49:736-41. 2010
    ..Therefore, there is no need for proton uptake by the protein moiety of opsin for the binding to the peptide...
  16. ncbi request reprint Two isoforms of chicken melanopsins show blue light sensitivity
    Masaki Torii
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FEBS Lett 581:5327-31. 2007
    ..The melanopsin isoforms found in this study may function as pineal circadian photoreceptors...
  17. doi request reprint Functional analysis of the second extracellular loop of rhodopsin by characterizing split variants
    Kazumi Sakai
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Photochem Photobiol Sci 9:1490-7. 2010
    ..These results suggest that ECL2 'mechanically' drives the conformational change of rhodopsin...
  18. ncbi request reprint Direct observation of the complex formation of GDP-bound transducin with the rhodopsin intermediate having a visible absorption maximum in rod outer segment membranes
    Takefumi Morizumi
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan, and CREST, Japan Science and Technology Agency, Japan
    Biochemistry 44:9936-43. 2005
    ..Our results strongly suggest that the protein conformational change of the rhodopsin intermediate after binding to Gt is important for the induction of the nucleotide release from the alpha-subunit of Gt...
  19. ncbi request reprint Counterion displacement in the molecular evolution of the rhodopsin family
    Akihisa Terakita
    Department of Biophysics, Graduate School of Science, Kyoto University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kyoto 606 8502, Japan
    Nat Struct Mol Biol 11:284-9. 2004
    ..Thus an ancestral vertebrate rhodopsin probably acquired the Glu113 counterion, followed by structural optimization for efficient G protein activation during molecular evolution...
  20. ncbi request reprint Mechanism of G-protein activation by rhodopsin
    Yoshinori Shichida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, CREST, Japan Science and Technology Agency, Japan
    Photochem Photobiol 83:70-5. 2007
    ..Thus, the GDP-GTP exchange reaction, namely G-protein activation, by rhodopsin proceeds through at least two steps, with conformational changes in both rhodopsin and the G-protein...
  21. pmc A rhodopsin exhibiting binding ability to agonist all-trans-retinal
    Hisao Tsukamoto
    Department of Biophysics, Graduate School of Science, Kyoto University and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 102:6303-8. 2005
    ..In addition, an additional mechanism was acquired in vertebrate rhodopsin to prevent completely the binding of exogenous all-trans-retinal during molecular evolution...
  22. pmc Physiological properties of rod photoreceptor cells in green-sensitive cone pigment knock-in mice
    Keisuke Sakurai
    Department of Biophysics, Graduate School of Science, Kyoto University and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kyoto 606 8502, Japan
    J Gen Physiol 130:21-40. 2007
    ..Therefore, the abilities of rhodopsin to generate a large single photon response and to retain high thermal stability in darkness are factors that have been necessary for the evolution of scotopic vision...
  23. ncbi request reprint Molecular properties of rod and cone visual pigments from purified chicken cone pigments to mouse rhodopsin in situ
    Hiroo Imai
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Photochem Photobiol Sci 4:667-74. 2005
    ..In the present paper, we summarize the spectroscopic properties of cone pigments and describe our studies with mouse rhodopsin utilizing a high performance charge coupled device (CCD) spectrophotometer...
  24. doi request reprint G protein subtype specificity of rhodopsin intermediates metarhodopsin Ib and metarhodopsin II
    Takefumi Morizumi
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Photochem Photobiol 85:57-62. 2009
    ..These results suggested that meta-Ib is the state that exhibits specific interaction with G protein as meta-II does, although meta-Ib exhibits a slightly lenient binding selectivity compared to that of meta-II...
  25. pmc Molecular properties of rhodopsin and rod function
    Hiroo Imai
    Department of Biophysics, Graduate School of Science, Kyoto University and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kyoto 606 8502, Japan
    J Biol Chem 282:6677-84. 2007
    ..Thus, the present study clearly reveals how the molecular properties of rhodopsin affect the amplitude, shape, and kinetics of the rod response...
  26. doi request reprint Spectroscopic analysis of the effect of chloride on the active intermediates of the primate L group cone visual pigment
    Takefumi Morizumi
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 51:10017-23. 2012
    ..These results suggest that the acquisition of H197 would be due to the most red-shifted absorption maximum, resulting in fast formation of the active state...
  27. doi request reprint Photosensitivities of rhodopsin mutants with a displaced counterion
    Kei Tsutsui
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 49:10089-97. 2010
    ..Interestingly, all of the mutants exhibited greatly increased hydroxylamine sensitivity. This result suggests that the counterion in vertebrate visual pigments is optimally located for the stability of the Schiff base linkage...
  28. doi request reprint E113 is required for the efficient photoisomerization of the unprotonated chromophore in a UV-absorbing visual pigment
    Kei Tsutsui
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 47:10829-33. 2008
    ..These results suggest that E113 facilitates photoisomerization in both UV-absorbing and visible light-absorbing visual pigments and provide a possible explanation for the complete conservation of E113 among vertebrate UV pigments...
  29. pmc β-arrestin functionally regulates the non-bleaching pigment parapinopsin in lamprey pineal
    Emi Kawano-Yamashita
    Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Osaka, Japan
    PLoS ONE 6:e16402. 2011
    ..Such changes would have followed the evolution of vertebrate visual pigments, which generate unstable photoproducts that independently decay by chromophore dissociation...
  30. doi request reprint Thermal recovery of iodopsin from photobleaching intermediates
    Yasushi Imamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Photochem Photobiol 84:941-8. 2008
    ..As progress of the bleaching process is a consequence of protein conformational change, it is suppressed at low temperatures, resulting in thermal back-isomerization...
  31. ncbi request reprint Chloride-dependent spectral tuning mechanism of L-group cone visual pigments
    Takahiro Yamashita
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 52:1192-7. 2013
    ..Thus, we concluded that these three amino acid residues are the main determinants of the chloride-dependent spectral shift in L-group pigments...
  32. ncbi request reprint Photochemical properties of mammalian melanopsin
    Take Matsuyama
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    Biochemistry 51:5454-62. 2012
    ..Although it is unclear whether extramelanopsin would have any physiological role, it could potentially allow wavelength-dependent regulation of melanopsin functions...
  33. doi request reprint Multiple functions of Schiff base counterion in rhodopsins
    Kei Tsutsui
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, 606 8502, Japan
    Photochem Photobiol Sci 9:1426-34. 2010
    ..Finally, differences in the position of the counterion between vertebrate visual pigments and other opsins and its relevance to the molecular evolution of opsins are discussed...
  34. ncbi request reprint Assignment of the vibrational modes of the chromophores of iodopsin and bathoiodopsin: low-temperature fourier transform infrared spectroscopy of 13C- and 2H-labeled iodopsins
    Takahiro Hirano
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 45:1285-94. 2006
    ..These results indicated that iodopsin's chromophore has a unique structure near its center and that this difference is enhanced by the binding of chloride nearby...
  35. ncbi request reprint Cone visual pigments
    Yasushi Imamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochim Biophys Acta 1837:664-73. 2014
    ..This article is part of a Special Issue entitled: Retinal Proteins - You can teach an old dog new tricks. ..
  36. doi request reprint Efficiencies of activation of transducin by cone and rod visual pigments
    Yasushi Imamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 52:3010-8. 2013
    ..The substantially longer lifetime of the Gt activating state of Rh would be necessary to suppress the spontaneous quenching by the stochastic decay of the Gt-activating state when a rod responds to a single photon...
  37. doi request reprint Vertebrate ancient-long opsin has molecular properties intermediate between those of vertebrate and invertebrate visual pigments
    Keita Sato
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 50:10484-90. 2011
    ..Thus, the molecular properties of VA/VAL opsin give insights into the mechanism of conversion of the molecular properties from invertebrate to vertebrate visual pigments...
  38. ncbi request reprint Two-step mechanism of interaction of rhodopsin intermediates with the C-terminal region of the transducin alpha-subunit
    Takefumi Morizumi
    Department of Biophysics, Graduate School of Science, Kyoto University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kyoto 606 8502
    J Biochem 134:259-67. 2003
    ..These results indicate that rearrangement of the C-terminal region of Gt(alpha) after the binding of a rhodopsin intermediate is necessary for the GDP-GTP exchange reaction on Gt(alpha)...
  39. doi request reprint The C-terminus of the G protein α subunit controls the affinity of nucleotides
    Naoki Kimata
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Biochemistry 51:2768-74. 2012
    ..Therefore, our results strongly suggest that there is a long-range interlink between the C-terminus of Giα and its nucleotide-binding site...
  40. doi request reprint Depth perception from image defocus in a jumping spider
    Takashi Nagata
    Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Osaka, Japan
    Science 335:469-71. 2012
    ..Therefore, we propose a depth perception mechanism based on how much the retinal image is defocused...
  41. doi request reprint First cytoplasmic loop of glucagon-like peptide-1 receptor can function at the third cytoplasmic loop position of rhodopsin
    Takahiro Yamashita
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Photochem Photobiol 84:931-6. 2008
    ..This result strongly suggested that different families of GPCRs have maintained molecular architectures of their ancestral types to generate a common mechanism, namely exposure of the cytoplasmic loop, to activate peripheral G protein...
  42. pmc Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein
    Takahiro Yamashita
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 107:22084-9. 2010
    ..Because cOpn5m is the only UV-sensitive opsin among the opsins found so far in chicken, this study provides the molecular basis for UV reception in chicken...
  43. ncbi request reprint Sexual difference in color sense in a lycaenid butterfly, Narathura japonica
    Michio Imafuku
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo, Kyoto, Japan
    Zoolog Sci 24:611-3. 2007
    ..This male-specific UV-sensitivity is discussed in terms of ecological factors...
  44. ncbi request reprint Activation switch in the transmembrane domain of metabotropic glutamate receptor
    Masataka Yanagawa
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Mol Pharmacol 76:201-7. 2009
    ....
  45. ncbi request reprint Expression and localization of an exogenous G protein-coupled receptor fused with the rhodopsin C-terminal sequence in the retinal rod cells of knockin mice
    Takashi Kodama
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Exp Eye Res 80:859-69. 2005
    ..In addition, a substantial fraction of the hET(B)R was successfully transported to the outer segment, suggesting that the addition of the C-terminal sequence of rhodopsin enabled hET(B)R to be translocated to the outer segment...
  46. pmc Bistable UV pigment in the lamprey pineal
    Mitsumasa Koyanagi
    Department of Biophysics, Graduate School of Science, Kyoto University and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Kyoto 606 8502 Japan
    Proc Natl Acad Sci U S A 101:6687-91. 2004
    ..Furthermore, we isolated the parapinopsin homologues from fish and frog pineal complexes that exhibit UV sensitivity, suggesting that parapinopsin is a common molecular basis for pineal UV reception in the vertebrate...
  47. pmc Single-molecule observation of the ligand-induced population shift of rhodopsin, a G-protein-coupled receptor
    Ryo Maeda
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan
    Biophys J 106:915-24. 2014
    ..These findings provide dynamical insights into the activation mechanisms of G-protein-coupled receptors. ..
  48. ncbi request reprint Effect of anion binding on the thermal reverse reaction of bathoiodopsin: anion stabilizes two forms of iodopsin
    Takahiro Hirano
    Department of Biophysics, Graduate School of Science, Kyoto University, Japan
    Biochemistry 42:12700-7. 2003
    ..Thus, iodopsin exhibits two conformational states, each of which is stabilized by the binding of chloride and nitrate, respectively...
  49. ncbi request reprint Conserved proline residue at position 189 in cone visual pigments as a determinant of molecular properties different from rhodopsins
    Shigeki Kuwayama
    Department of Biophysics, Graduate School of Science, Kyoto University, and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Kyoto 606 8502, Japan
    Biochemistry 41:15245-52. 2002
    ..The completely conserved nature of proline at position 189 could provide a clue to the molecular evolution of the pigments...
  50. ncbi request reprint Diversity of visual pigments from the viewpoint of G protein activation--comparison with other G protein-coupled receptors
    Yoshinori Shichida
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Photochem Photobiol Sci 2:1237-46. 2003
    ....
  51. ncbi request reprint A novel constitutively active mutation in the second cytoplasmic loop of metabotropic glutamate receptor
    Takahiro Yamashita
    Department of Biophysics, Graduate School of Science, Kyoto University and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Kyoto, Japan
    J Neurochem 91:484-92. 2004
    ....
  52. pmc Comparative fluorescence resonance energy transfer analysis of metabotropic glutamate receptors: implications about the dimeric arrangement and rearrangement upon ligand bindings
    Masataka Yanagawa
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 286:22971-81. 2011
    ..Thus, the glutamate-dependent synergistic relocation of the helix Vs in the dimer is important for the signal flow from the extracellular ligand binding domain to the cytoplasmic surface of the mGluR...
  53. pmc Farnesylation of retinal transducin underlies its translocation during light adaptation
    Hidetoshi Kassai
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113 0033, Japan
    Neuron 47:529-39. 2005
    ....
  54. ncbi request reprint Amphioxus homologs of Go-coupled rhodopsin and peropsin having 11-cis- and all-trans-retinals as their chromophores
    Mitsumasa Koyanagi
    Department of Biophysics, Graduate School of Science, Kyoto University, 606 8502, Kyoto, Japan
    FEBS Lett 531:525-8. 2002
    ..The results strongly suggest that the physiological function of peropsin would be a retinal photoisomerase, while 11-cis configuration is necessary for the Go-coupled opsin groups...