Yutaka Satou


Affiliation: Kyoto University
Country: Japan


  1. Yu D, Oda Ishii I, Kubo A, Satou Y. The regulatory pathway from genes directly activated by maternal factors to muscle structural genes in ascidian embryos. Development. 2019;: pubmed publisher
    ..b occupancy. Thus, the genetic pathway starting with Tbx6-r.b and Zic-r.b, which are activated by maternal factors and ending with expression of muscle structural genes, has been revealed. ..
  2. Kobayashi K, Maeda K, Tokuoka M, Mochizuki A, Satou Y. Controlling Cell Fate Specification System by Key Genes Determined from Network Structure. iScience. 2018;4:281-293 pubmed publisher
    ..Since this method is applicable to all nonlinear dynamic systems, we propose this method as a tool for controlling gene regulatory networks and reprogramming cell fates. ..
  3. Satou Y, Hirayama K, Mita K, Fujie M, Chiba S, Yoshida R, et al. Sustained heterozygosity across a self-incompatibility locus in an inbred ascidian. Mol Biol Evol. 2015;32:81-90 pubmed publisher
    ..4-Mb heterozygous region. High structural variations might suppress recombination, and this long heterozygous region might represent a preliminary stage of structural differentiation of chromosomes. ..
  4. Tokuoka M, Kobayashi K, Satou Y. Distinct regulation of Snail in two muscle lineages of the ascidian embryo achieves temporal coordination of muscle development. Development. 2018;145: pubmed publisher
    ..Such shortcuts might be required for coordinating developmental programs in embryos in which cells become separated progressively from stem cells, including germline cells. ..
  5. Oda Ishii I, Abe T, Satou Y. Dynamics of two key maternal factors that initiate zygotic regulatory programs in ascidian embryos. Dev Biol. 2018;437:50-59 pubmed publisher
    ..Thus, these two maternal factors have different dynamics, which establish the pre-pattern for zygotic genetic programs in 16-cell embryos. ..
  6. Oda Ishii I, Satou Y. Initiation of the zygotic genetic program in the ascidian embryo. Semin Cell Dev Biol. 2018;84:111-117 pubmed publisher
    ..Here, we review the initial processes that occur until the 16-cell stage in ascidian embryos. ..
  7. Satou Y, Imai K. Ascidian Zic Genes. Adv Exp Med Biol. 2018;1046:87-106 pubmed publisher
    ..Thus, ascidian Zic genes play central roles in specification of mesodermal and neural fates. ..
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    Satou Y, Imai K, Levine M, Kohara Y, Rokhsar D, Satoh N. A genomewide survey of developmentally relevant genes in Ciona intestinalis. I. Genes for bHLH transcription factors. Dev Genes Evol. 2003;213:213-21 pubmed
  9. Satou Y, Shin I T, Kohara Y, Satoh N, Chiba S. A genomic overview of short genetic variations in a basal chordate, Ciona intestinalis. BMC Genomics. 2012;13:208 pubmed publisher
    ..Our results provide a framework for studying evolution of the animal genome, as well as a useful resource for a wide range of C. intestinalis researchers. ..

More Information


  1. Sakamaki K, Nozaki M, Kominami K, Satou Y. The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish. BMC Genomics. 2007;8:141 pubmed publisher
    ..Based on these results, we presume the mechanism of apoptosis induction via death receptors was evolutionarily established during the appearance of vertebrates...
  2. Satou Y, Yagi K, Imai K, Yamada L, Nishida H, Satoh N. macho-1-Related genes in Ciona embryos. Dev Genes Evol. 2002;212:87-92 pubmed publisher
    ..We propose a possible evolutionary scenario in which an ancestral Zic-related gene gave rise to both the macho-1-like muscle determinant gene as well as neuronal Zic genes...
  3. Satou Y, Imai K, Satoh N. Fgf genes in the basal chordate Ciona intestinalis. Dev Genes Evol. 2002;212:432-8 pubmed publisher
    ..The identification of these six FGF genes in the basal chordate gave us an insight into the diversification of specific subfamilies of vertebrate FGFs...
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    Satou Y, Kawashima T, Shoguchi E, Nakayama A, Satoh N. An integrated database of the ascidian, Ciona intestinalis: towards functional genomics. Zoolog Sci. 2005;22:837-43 pubmed
    ..These advances continue to increase the utility of Ciona intestinalis as a model organism whilst the integrated database will be useful for researchers in comparative and evolutionary genomics...
  5. Satou Y, Satoh N. Cataloging transcription factor and major signaling molecule genes for functional genomic studies in Ciona intestinalis. Dev Genes Evol. 2005;215:580-96 pubmed publisher
    ..3% of the catalogued signal transduction molecule genes (117/119) have now been verified by cDNA sequences. Thus, the present study greatly improves the resources available for functional genomic studies in C. intestinalis...
  6. Satou Y, Mineta K, Ogasawara M, Sasakura Y, Shoguchi E, Ueno K, et al. Improved genome assembly and evidence-based global gene model set for the chordate Ciona intestinalis: new insight into intron and operon populations. Genome Biol. 2008;9:R152 pubmed publisher