N Satoh

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Ciona intestinalis: an emerging model for whole-genome analyses
    Nori Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Trends Genet 19:376-81. 2003
  2. pmc An intrinsic genetic program for autonomous differentiation of muscle cells in the ascidian embryo
    N Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Proc Natl Acad Sci U S A 93:9315-21. 1996
  3. doi request reprint An aboral-dorsalization hypothesis for chordate origin
    Nori Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, Japan
    Genesis 46:614-22. 2008
  4. ncbi request reprint The ascidian genome contains another T-domain gene that is expressed in differentiating muscle and the tip of the tail of the embryo
    H Yasuo
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, 606 01, Japan
    Dev Biol 180:773-9. 1996
  5. ncbi request reprint The ascidian tadpole larva: comparative molecular development and genomics
    Nori Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Nat Rev Genet 4:285-95. 2003
  6. doi request reprint Urochordate genomes
    N Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
    Genome Dyn 2:198-212. 2006
  7. ncbi request reprint Ascidian embryos as a model system to analyze expression and function of developmental genes
    N Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Differentiation 68:1-12. 2001
  8. ncbi request reprint Regulatory blueprint for a chordate embryo
    Kaoru S Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Science 312:1183-7. 2006
  9. ncbi request reprint Evolutionary alterations of the minimal promoter for notochord-specific Brachyury expression in ascidian embryos
    H Takahashi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 126:3725-34. 1999
  10. ncbi request reprint Characterization of an ascidian maternal T-box gene, As-mT
    N Takada
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Int J Dev Biol 42:1093-100. 1998

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. ncbi request reprint Ciona intestinalis: an emerging model for whole-genome analyses
    Nori Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Trends Genet 19:376-81. 2003
  2. pmc An intrinsic genetic program for autonomous differentiation of muscle cells in the ascidian embryo
    N Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Proc Natl Acad Sci U S A 93:9315-21. 1996
    ....
  3. doi request reprint An aboral-dorsalization hypothesis for chordate origin
    Nori Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, Japan
    Genesis 46:614-22. 2008
    ..Namely, the dorsalization of the aboral side of the ancestral embryo may have been a key developmental event that led to the formation of the basic chordate body plan...
  4. ncbi request reprint The ascidian genome contains another T-domain gene that is expressed in differentiating muscle and the tip of the tail of the embryo
    H Yasuo
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, 606 01, Japan
    Dev Biol 180:773-9. 1996
    ..Interestingly, the combined pattern of spatial expression of As-T and As-T2 appears to correspond to that of a single vertebrate Brachyury gene...
  5. ncbi request reprint The ascidian tadpole larva: comparative molecular development and genomics
    Nori Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Nat Rev Genet 4:285-95. 2003
    ....
  6. doi request reprint Urochordate genomes
    N Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
    Genome Dyn 2:198-212. 2006
    ....
  7. ncbi request reprint Ascidian embryos as a model system to analyze expression and function of developmental genes
    N Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Differentiation 68:1-12. 2001
    ..This review is aimed to highlight the recent advances in ascidian embryology...
  8. ncbi request reprint Regulatory blueprint for a chordate embryo
    Kaoru S Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Science 312:1183-7. 2006
    ..These diagrams constitute a blueprint for the Ciona embryo and provide a foundation for understanding the evolutionary origins of the chordate body plan...
  9. ncbi request reprint Evolutionary alterations of the minimal promoter for notochord-specific Brachyury expression in ascidian embryos
    H Takahashi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 126:3725-34. 1999
    ....
  10. ncbi request reprint Characterization of an ascidian maternal T-box gene, As-mT
    N Takada
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Int J Dev Biol 42:1093-100. 1998
    ..However, the expression of these genes as well as a mesenchyme-specific gene and histochemical activity of endoderm-specific alkaline phosphatase were evident by the mid-tailbud stage...
  11. ncbi request reprint Developmental expression of Pax1/9 genes in urochordate and hemichordate gills: insight into function and evolution of the pharyngeal epithelium
    M Ogasawara
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 126:2539-50. 1999
    ..The Pax1/9 genes therefore might provide the first developmental genetic corroboration of hypotheses of organ-level homology that unifies hemichordates, urochordates and cephalochordates...
  12. ncbi request reprint Pattern of Brachyury gene expression in starfish embryos resembles that of hemichordate embryos but not of sea urchin embryos
    E Shoguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Mech Dev 82:185-9. 1999
    ..Namely, ApBra is expressed in an archenteron invagination region and a stomodaeum invagination region...
  13. ncbi request reprint Isolation of cDNA clones for genes that are expressed in the tail region of the ascidian tailbud embryo
    H Takahashi
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Int J Dev Biol 41:691-8. 1997
    ..These results suggest that, in addition to tissue-specific genes, the activities of a set of region-specific genes are associated with tail formation in the ascidian embryo...
  14. ncbi request reprint Structure and the evolutionary implication of the triplicated complement factor B genes of a urochordate ascidian, Ciona intestinalis
    Fumiko Y Yoshizaki
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113 0033, Japan
    Immunogenetics 56:930-42. 2005
    ....
  15. ncbi request reprint T-box genes in the ascidian Ciona intestinalis: characterization of cDNAs and spatial expression
    Naohito Takatori
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, Japan
    Dev Dyn 230:743-53. 2004
    ....
  16. ncbi request reprint A Twist-like bHLH gene is a downstream factor of an endogenous FGF and determines mesenchymal fate in the ascidian embryos
    Kaoru S Imai
    Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 130:4461-72. 2003
    ..Therefore, two different but partially overlapping mechanisms are required for the expression of Twist-like1 in the mesenchymal precursors, which triggers the differentiation of the mesenchyme in Ciona embryos...
  17. ncbi request reprint The expression of nonchordate deuterostome Brachyury genes in the ascidian Ciona embryo can promote the differentiation of extra notochord cells
    G Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, 606 8502, Kyoto, Japan
    Mech Dev 96:155-63. 2000
    ..Evolutionary alteration in the genetic circuitry, especially downstream of this transcription factor, seems critical for the evolution of notochord and chordate body plan...
  18. ncbi request reprint Synergistic action of HNF-3 and Brachyury in the notochord differentiation of ascidian embryos
    Y Shimauchi
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Int J Dev Biol 45:643-52. 2001
    ..Treatment of notochord precursor cells isolated from the 32-cell stage embryoswith bFGF resulted in upregulation of both the HNF-3 and Brachyury genes...
  19. ncbi request reprint (beta)-catenin mediates the specification of endoderm cells in ascidian embryos
    K Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 127:3009-20. 2000
    ..These results suggest that the accumulation of (beta)-catenin in the nuclei of endoderm progenitor cells is the first step in the process of ascidian endoderm specification...
  20. ncbi request reprint Gene expression profiles in Ciona intestinalis tailbud embryos
    Y Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
    Development 128:2893-904. 2001
    ..The sequence information will also be used for further genome scientific approach to explore molecular mechanisms involved in the formation of one of the most primitive chordate body plans...
  21. ncbi request reprint Early embryonic expression of a LIM-homeobox gene Cs-lhx3 is downstream of beta-catenin and responsible for the endoderm differentiation in Ciona savignyi embryos
    Y Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 128:3559-70. 2001
    ..These results strongly suggest that a LIM-homeobox gene Cs-lhx3 is one of the beta-catenin downstream genes and that its early expression in embryonic endodermal cells is responsible for their differentiation...
  22. ncbi request reprint Expression of muscle-related genes and two MyoD genes during amphioxus notochord development
    Aki Urano
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Evol Dev 5:447-58. 2003
    ....
  23. ncbi request reprint Multiple functions of a Zic-like gene in the differentiation of notochord, central nervous system and muscle in Ciona savignyi embryos
    Kaoru S Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, 606 8502, Japan
    Development 129:2723-32. 2002
    ..Cs-ZicL may provide a future experimental system to explore how the gene expression in multiple embryonic regions is controlled and how the single gene can perform different functions in multiple types of embryonic cells...
  24. ncbi request reprint Muscle actin genes and muscle cells in the appendicularian, Oikopleura longicauda: phylogenetic relationships among muscle tissues in the urochordates
    A Nishino
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Exp Zool 288:135-50. 2000
    ....
  25. ncbi request reprint Regulation of the muscle-specific expression and function of an ascidian T-box gene, As-T2
    Y Mitani
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
    Development 128:3717-28. 2001
    ..Taking into account the recent finding of maternal molecules for muscle differentiation, we propose a model for a genetic cascade that includes As-T2 as a regulator of muscle cell differentiation in the ascidian embryo...
  26. pmc Germ-line transgenesis of the Tc1/mariner superfamily transposon Minos in Ciona intestinalis
    Yasunori Sasakura
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 100:7726-30. 2003
    ..In addition, an enhancer-trap line was obtained. This is a demonstration of efficient, Minos-mediated transgenesis in marine invertebrates...
  27. ncbi request reprint Both the functional specificity and autoregulative activity of two ascidian T-box genes HrBra and HrTbx6 are likely to be mediated by the DNA-binding domain
    Hiroki Takahashi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Growth Differ 47:173-85. 2005
    ..Our results suggest that the autoregulative activity of these two ascidian T-box genes is also mediated by the DNA-binding domain, not by the transcription activation domain of the encoded proteins...
  28. ncbi request reprint Ciona intestinalis cDNA projects: expressed sequence tag analyses and gene expression profiles during embryogenesis
    Yutaka Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Gene 287:83-96. 2002
    ..All of the data fully characterized may be viewed at the web site http://ghost.zool.kyoto-u.ac.jp...
  29. ncbi request reprint Evolution of chordate actin genes: evidence from genomic organization and amino acid sequences
    T Kusakabe
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    J Mol Evol 44:289-98. 1997
    ..These results suggest that the chordate ancestor had at least two muscle actin isoforms and that the vertebrate actin isoforms evolved after the separation of the vertebrates and urochordates...
  30. ncbi request reprint FGF signals are involved in the differentiation of notochord cells and mesenchyme cells of the ascidian Halocynthia roretzi
    Y Shimauchi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
    Development 128:2711-21. 2001
    ....
  31. ncbi request reprint A starfish homolog of mouse T-brain-1 is expressed in the archenteron of Asterina pectinifera embryos: possible involvement of two T-box genes in starfish gastrulation
    E Shoguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Dev Growth Differ 42:61-8. 2000
    ..These observations suggest implication of the two T-box genes, with different roles, in starfish gastrulation...
  32. ncbi request reprint Identification and characterization of maternally expressed genes with mRNAs that are segregated with the endoplasm of early ascidian embryos
    K Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Int J Dev Biol 43:125-33. 1999
    ..Although we were not able to deduce their functions, this is the first report of maternal genes with mRNAs that are segregated with the endoplasm of ascidian embryos...
  33. ncbi request reprint Brachyury (T) gene expression and notochord development in Oikopleura longicauda (Appendicularia, Urochordata)
    A Nishino
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 211:219-31. 2001
    ..Furthermore, these results provide basic knowledge for comprehensive understanding of the cellular- and molecular-based mechanisms needed to build the characteristic cytoarchitecture of notochord that varies among tunicate species...
  34. ncbi request reprint T-brain homologue (HpTb) is involved in the archenteron induction signals of micromere descendant cells in the sea urchin embryo
    Takuya Fuchikami
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi Hiroshima 739 8526, Japan
    Development 129:5205-16. 2002
    ....
  35. ncbi request reprint Conserved expression pattern of BMP-2/4 in hemichordate acorn worm and echinoderm sea cucumber embryos
    Yoshito Harada
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Zoolog Sci 19:1113-21. 2002
    ..This is in agreement with the homology between their basic larval body plans with respect to coelomogenesis and allows us to discuss the evolutionary counterparts of the coelomopore complex in chordates...
  36. ncbi request reprint A bHLH transcription factor gene, Twist-like 1, is essential for the formation of mesodermal tissues of Ciona juveniles
    Miki Tokuoka
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Biol 288:387-96. 2005
    ..The present results therefore indicate that Twist-like 1 is required for the differentiation of most mesodermal precursors of adults...
  37. ncbi request reprint Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks
    Kaoru S Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Development 131:4047-58. 2004
    ....
  38. ncbi request reprint Action of morpholinos in Ciona embryos
    Y Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
    Genesis 30:103-6. 2001
    ..All of these results indicate that morpholino act in Ciona embryos to specifically block the function of endogenous genes as well as exogenously introduced genes. genesis 30: 103--106, 2001...
  39. ncbi request reprint Posterior end mark, a novel maternal gene encoding a localized factor in the ascidian embryo
    S Yoshida
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Development 122:2005-12. 1996
    ..The ascidian tadpole is regarded as a prototype of vertebrates, implying a similar function of pem in vertebrate embryogenesis...
  40. ncbi request reprint Further characterization of genes expressed during Ciona intestinalis metamorphosis
    A Nakayama
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Differentiation 70:429-37. 2002
    ..The expression patterns of some of these clones were changed during the larval period...
  41. ncbi request reprint Brachyury expression in tailless Molgulid ascidian embryos
    Norio Takada
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Evol Dev 4:205-11. 2002
    ..In light of these results, we are continuing to investigate how and why notochord development is lost in tailless molgulid ascidian embryos...
  42. ncbi request reprint Group B sox genes that contribute to specification of the vertebrate brain are expressed in the apical organ and ciliary bands of hemichordate larvae
    Shunsuke Taguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Zoolog Sci 19:57-66. 2002
    ....
  43. doi request reprint Genomic cis-regulatory networks in the early Ciona intestinalis embryo
    Atsushi Kubo
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, Japan
    Development 137:1613-23. 2010
    ....
  44. ncbi request reprint Isolation and characterization of genes that are expressed during Ciona intestinalis metamorphosis
    A Nakayama
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 211:184-9. 2001
    ..This gene may be involved in the dynamic arrangement of cells during ascidian metamorphosis...
  45. ncbi request reprint Ascidian homologs of mammalian thyroid peroxidase genes are expressed in the thyroid-equivalent region of the endostyle
    M Ogasawara
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Exp Zool 285:158-69. 1999
    ..These results provide the first evidence at the gene expression level for shared function between a part of the ascidian endostyle and the vertebrate follicular thyroid gland. J. Exp. Zool. ( Mol. Dev. Evol. ) 285:158-169, 1999...
  46. ncbi request reprint Genomic organization and the 5' upstream sequences associated with the specific spatio-temporal expression of HrEpiC, an epidermis-specific gene of the ascidian Halocynthia roretzi
    K Ishida
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Cell Mol Biol (Noisy-le-grand) 45:523-36. 1999
    ..We discussed how the spatio-temporal expression pattern of HrEpiC1 is regulated by the two modules...
  47. ncbi request reprint Temporal expression patterns of 39 Brachyury-downstream genes associated with notochord formation in the Ciona intestinalis embryo
    K Hotta
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Dev Growth Differ 41:657-64. 1999
    ..These gene activities may be associated with changes in cell shape and adhesion during the intercalation and extension of the notochord cells...
  48. ncbi request reprint An enhancer trap in the ascidian Ciona intestinalis identifies enhancers of its Musashi orthologous gene
    Satoko Awazu
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Biol 275:459-72. 2004
    ..These results clearly demonstrate that an enhancer trap event that entrapped enhancers of Ci-Musashi occurred in C. intestinalis...
  49. ncbi request reprint Expression of Tbx6, a muscle lineage T-box gene, in the tailless embryo of the ascidian Molgula tectiformis
    Norio Takada
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Dev Genes Evol 212:354-6. 2002
  50. ncbi request reprint A genomewide survey of developmentally relevant genes in Ciona intestinalis. IV. Genes for HMG transcriptional regulators, bZip and GATA/Gli/Zic/Snail
    Lixy Yamada
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 213:245-53. 2003
    ..The present comprehensive analysis therefore provides a means to study the role of these transcription factors in developmental processes of basal chordates...
  51. doi request reprint M-Ras evolved independently of R-Ras and its neural function is conserved between mammalian and ascidian, which lacks classical Ras
    Etsuko Keduka
    Department of Biology, Graduate School of Science, Chiba University, 1 33 Yayoicho, Inageku, Chiba, Chiba 263 8522, Japan
    Gene 429:49-58. 2009
    ..These results suggest that the ascidian M-Ras orthologue compensates for lacked classical Ras and plays essential roles in neurogenesis in the ascidian...
  52. pmc Transposon-mediated insertional mutagenesis revealed the functions of animal cellulose synthase in the ascidian Ciona intestinalis
    Yasunori Sasakura
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 102:15134-9. 2005
    ..It is likely that ascidian cellulose synthase is required for the coordination of the metamorphic events in the trunk and tail in addition to cellulose biosynthesis...
  53. ncbi request reprint Genes expressed in the amphioxus notochord revealed by EST analysis
    M M Suzuki
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Japan
    Dev Biol 224:168-77. 2000
    ....
  54. ncbi request reprint Early development of amphioxus nervous system with special reference to segmental cell organization and putative sensory cell precursors: a study based on the expression of pan-neuronal marker gene Hu/elav
    G Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Exp Zool 291:354-64. 2001
    ..Taking recent gene expression studies and anatomical studies into consideration, we discuss ontogenetic and phylogenetic features of the amphioxus nervous system...
  55. ncbi request reprint Expression cloning of an ascidian syndecan suggests its role in embryonic cell adhesion and morphogenesis
    Y Satou
    Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Dev Biol 211:198-207. 1999
    ..However, the formation of pigment cells of the sensory organs was markedly disturbed. These results indicate that an appropriate level of syndecan expression is required for normal cell adhesion and morphogenesis of the ascidian embryo...
  56. ncbi request reprint Cloning and characterization of an ascidian homolog of the human 8-oxoguanine DNA glycosylase (Ogg1) that is involved in the repair of 8-oxo-7,8-dihydroguanine in DNA in Ciona intestinalis
    G Jin
    Laboratory of Radiation Biology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, Japan
    Int J Radiat Biol 82:241-50. 2006
    ..To address these issues, we first identified 8-oxo-7,8-dihydroguanine (8-oxoG)-DNA glycosylase (Ogg1) of the ascidian Ciona intestinalis as a good model system...
  57. ncbi request reprint Developmental expression of the hemichordate otx ortholog
    Y Harada
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
    Mech Dev 91:337-9. 2000
    ..Expression remains evident in the archenteron through gastrulation and then disappears. A new expression domain appears near the mouth along the preoral and postoral ciliated bands in the early tornaria larva...
  58. ncbi request reprint Morpholino-based gene knockdown screen of novel genes with developmental function in Ciona intestinalis
    Lixy Yamada
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 130:6485-95. 2003
    ..These results suggest that screening for developmental genes by the reverse genetic approach in Ciona intestinalis embryos is effective for identifying novel genes with developmental functions required for the development of chordates...
  59. pmc Ciona intestinalis Hox gene cluster: Its dispersed structure and residual colinear expression in development
    Tetsuro Ikuta
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachiohji, Tokyo 192 0397, Japan
    Proc Natl Acad Sci U S A 101:15118-23. 2004
    ..In light of these observations, we suggest that the cluster organization and colinearity of the Hox genes are under dispersing and disintegrating conditions in C. intestinalis...
  60. ncbi request reprint The simple tail of chordates: phylogenetic significance of appendicularians
    A Nishino
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
    Genesis 29:36-45. 2001
    ..We emphasize future possibilities for a comprehensive understanding of the divergent patterns in lifestyle of tunicates as well as for investigating the phylogenetic novelty and innovation of chordates such as the tail...
  61. ncbi request reprint Expression of the otx gene in the ciliary bands during sea cucumber embryogenesis
    E Shoguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
    Genesis 27:58-63. 2000
    ..The expression gradually disappeared during further development and was not detected in juveniles. These results indicate that the gene responsible for chordate brain formation is expressed in the ciliary bands of auricularia larvae...
  62. ncbi request reprint Microarray analysis of zygotic expression of transcription factor genes and cell signaling molecule genes in early Ciona intestinalis embryos
    Makoto Hamaguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Dev Growth Differ 49:27-37. 2007
    ....
  63. ncbi request reprint Germline transgenesis of the ascidian Ciona intestinalis by electroporation
    Terumi Matsuoka
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, Japan
    Genesis 41:67-72. 2005
    ....
  64. ncbi request reprint Large-scale characterization of genes specific to the larval nervous system in the ascidian Ciona intestinalis
    Yasuaki Mochizuki
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, Japan
    Genesis 36:62-71. 2003
    ..Thus, the nervous system-specific genes in Ciona larvae will provide not only probes for determining their function but also clues for exploring the complex network of nervous system-specific genes...
  65. ncbi request reprint Dynamic changes in developmental gene expression in the basal chordate Ciona intestinalis
    Takeshi Kawashima
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Growth Differ 47:187-99. 2005
    ..This kind of information is essential to form a comprehensive understanding of the overarching expression-control plan by which the basic chordate body is formed...
  66. ncbi request reprint A genomewide survey of developmentally relevant genes in Ciona intestinalis. III. Genes for Fox, ETS, nuclear receptors and NFkappaB
    Kasumi Yagi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 213:235-44. 2003
    ..The present results therefore provide molecular information for the investigation of complex developmental processes, and an insight into chordate evolution...
  67. ncbi request reprint Gene expression profiles in young adult Ciona intestinalis
    Michio Ogasawara
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 212:173-85. 2002
    ....
  68. ncbi request reprint A genomewide survey of developmentally relevant genes in Ciona intestinalis. IX. Genes for muscle structural proteins
    Shota Chiba
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 213:291-302. 2003
    ..This may reflect different functional requirements of the locomotor larval muscle as opposed to the non-locomotor muscles of the sessile adult, and/or the biosynthetic demands of extremely rapid larval development...
  69. ncbi request reprint EST analysis of gene expression in testis of the ascidian Ciona intestinalis
    Kazuo Inaba
    Asamushi Marine Biological Station, Graduate School of Science, Tohoku University, Asamushi, Aomori, Japan
    Mol Reprod Dev 62:431-45. 2002
    ..The large majority of the genes expressed in Ciona testis show no significant matches to known proteins and the further analysis of these genes may shed new light on the molecular mechanism of spermatogenesis and sperm functions...
  70. ncbi request reprint A genomewide survey of developmentally relevant genes in Ciona intestinalis. VI. Genes for Wnt, TGFbeta, Hedgehog and JAK/STAT signaling pathways
    Kyosuke Hino
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 213:264-72. 2003
    ..Therefore, Ciona intestinalis may provide an experimental system for exploring the basic genetic cascade associated with the signaling pathways in chordates...
  71. ncbi request reprint An ascidian homologue of vertebrate BMPs-5-8 is expressed in the midline of the anterior neuroectoderm and in the midline of the ventral epidermis of the embryo
    T Miya
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Mech Dev 57:181-90. 1996
    ..This HrBMPa expression profile resembled that of Xenopus BMP-7, implying a primordial function of BMP-7 among vertebrate BMPs-5-8...
  72. ncbi request reprint Isolation and characterization of endostyle-specific genes in the ascidian Ciona intestinalis
    M Ogasawara
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Biol Bull 195:60-9. 1998
    ....
  73. pmc Pathophysiological role of leptin in obesity-related hypertension
    M Aizawa-Abe
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Clin Invest 105:1243-52. 2000
    ..This study demonstrates BP elevation in transgenic skinny mice and obese KKA(y) mice that are both hyperleptinemic, thereby suggesting the pathophysiological role of leptin in some forms of obesity-related hypertension...
  74. ncbi request reprint Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin
    Y Ogawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Diabetes 48:1822-9. 1999
    ..The present study provides evidence that leptin is an adipocyte-derived antidiabetic hormone in vivo and suggests its pathophysiologic and therapeutic implications in diabetes...
  75. ncbi request reprint Tripartite organization of the ancestral chordate brain and the antiquity of placodes: insights from ascidian Pax-2/5/8, Hox and Otx genes
    H Wada
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Development 125:1113-22. 1998
    ..Therefore, placodes are not likely to be a newly acquired feature in vertebrates, but may have already been possessed by the earliest chordates...
  76. ncbi request reprint Further EST analysis of endocrine genes that are preferentially expressed in the neural complex of Ciona intestinalis: receptor and enzyme genes associated with endocrine system in the neural complex
    Toshio Sekiguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Gen Comp Endocrinol 150:233-45. 2007
    ..These data provide the molecular basis for further functional studies of the endocrine role of the neural complex of ascidians...
  77. doi request reprint Regulatory genes in the ancestral chordate genomes
    Yutaka Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606 8501, Japan
    Dev Genes Evol 218:715-21. 2008
    ..The inferred regulatory gene sets of the ancestral chordate would be an important foundation for understanding how tadpole-type larvae, a unique characteristic of chordates, evolved...
  78. ncbi request reprint Amphi-Eomes/Tbr1: an amphioxus cognate of vertebrate Eomesodermin and T-Brain1 genes whose expression reveals evolutionarily distinct domain in amphioxus development
    Gouki Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    J Exp Zool 294:136-45. 2002
    ....
  79. ncbi request reprint An essential role of a FoxD gene in notochord induction in Ciona embryos
    Kaoru S Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 129:3441-53. 2002
    ..The present experimental results suggest that the expression and function of Cs-FGF4/6/9 and Cs-FoxD are not interdependent, and that the Notch pathway is involved in B-line notochord induction downstream of Cs-FoxD...
  80. ncbi request reprint An integrated database of the ascidian, Ciona intestinalis: towards functional genomics
    Yutaka Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Zoolog Sci 22:837-43. 2005
    ..These advances continue to increase the utility of Ciona intestinalis as a model organism whilst the integrated database will be useful for researchers in comparative and evolutionary genomics...
  81. ncbi request reprint [Evolutionary genomics in the ascidian, Ciona intestinalis]
    Yutaka Satou
    Tanpakushitsu Kakusan Koso 50:774-8. 2005
  82. ncbi request reprint Ci-Tbx6b and Ci-Tbx6c are key mediators of the maternal effect gene Ci-macho1 in muscle cell differentiation in Ciona intestinalis embryos
    Kasumi Yagi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Biol 282:535-49. 2005
    ..The two T-box genes are primary mediators of macho1 function, and cooperation between the zygotically expressed transcription factors is indispensable for muscle cell differentiation in Ciona embryos...
  83. ncbi request reprint Microarray analysis of localization of maternal transcripts in eggs and early embryos of the ascidian, Ciona intestinalis
    Lixy Yamada
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Biol 284:536-50. 2005
    ..Therefore, we concluded that the posterior-most localization and mitochondria-like distribution appear to be major specialized patterns of maternal transcripts in early Ciona embryos...
  84. ncbi request reprint A genome-wide survey of genes for enzymes involved in pigment synthesis in an ascidian, Ciona intestinalis
    Keisuke Takeuchi
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Zoolog Sci 22:723-34. 2005
    ..intestinalis will provide an experimental system to explore molecular mechanisms underlying color patterns, through future genome-wide studies...
  85. ncbi request reprint macho-1-Related genes in Ciona embryos
    Yutaka Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 212:87-92. 2002
    ..We propose a possible evolutionary scenario in which an ancestral Zic-related gene gave rise to both the macho-1-like muscle determinant gene as well as neuronal Zic genes...
  86. doi request reprint Genome-wide network of regulatory genes for construction of a chordate embryo
    Eiichi Shoguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Biol 316:498-509. 2008
    ..Thus, this study provides the first comprehensive evidence that the physical clustering of regulatory genes, or their target genes, is not relevant for the genome-wide control of gene expression during development...
  87. ncbi request reprint Effects of 5-aza-2'-deoxycytidine on the gene expression profile during embryogenesis of the Ascidian ciona intestinalis: a microarray analysis
    Akane Sasaki
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan
    Zoolog Sci 24:648-55. 2007
    ..In addition, genes associated with the stress response and cell defense were upregulated, whereas genes involved in cell adhesion were downregulated...
  88. ncbi request reprint Novel genes involved in Ciona intestinalis embryogenesis: characterization of gene knockdown embryos
    Mayuko Hamada
    CREST, Japan Science Technology Agency, Kawaguchi, Saitama, Japan
    Dev Dyn 236:1820-31. 2007
    ..The type of large-scale screening used is, therefore, a powerful approach to identify novel genes with significant developmental functions, the details of which will be determined in future studies...
  89. ncbi request reprint Genomic resources for ascidians: sequence/expression databases and genome projects
    Nori Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Methods Cell Biol 74:759-74. 2004
  90. ncbi request reprint Fgf genes in the basal chordate Ciona intestinalis
    Yutaka Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 212:432-8. 2002
    ..The identification of these six FGF genes in the basal chordate gave us an insight into the diversification of specific subfamilies of vertebrate FGFs...
  91. ncbi request reprint Large scale EST analyses in Ciona intestinalis: its application as Northern blot analyses
    Yutaka Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 213:314-8. 2003
    ..Here we present evidence that this is the case, and that the EST count can therefore be used like "Northern blot analysis" of Ciona genes...
  92. ncbi request reprint Region specific gene expressions in the central nervous system of the ascidian embryo
    Kaoru S Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Mech Dev 119:S275-7. 2002
    ..In addition, the putative forebrain and midbrain expressed Ci-FgfL and Ci-Fgf9/16/20, respectively. Therefore, the regionalization of the ascidian larval central nervous system was also marked by the expression of Fgf genes...
  93. ncbi request reprint A zinc finger transcription factor, ZicL, is a direct activator of Brachyury in the notochord specification of Ciona intestinalis
    Kasumi Yagi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 131:1279-88. 2004
    ..These results provide evidence that ZicL directly activates Brachyury, leading to specification and subsequent differentiation of notochord cells...
  94. ncbi request reprint Region specific gene expressions in the central nervous system of the ascidian embryo
    Kaoru S Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Gene Expr Patterns 2:319-21. 2002
    ..In addition, the putative forebrain and midbrain expressed Ci-FgfL and Ci-Fgf9/16/20, respectively. Therefore, the regionalization of the ascidian larval central nervous system was also marked by the expression of Fgf genes...
  95. ncbi request reprint A genomewide survey of developmentally relevant genes in Ciona intestinalis. X. Genes for cell junctions and extracellular matrix
    Yasunori Sasakura
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 213:303-13. 2003
    ..In vertebrates these ancestral cell junctions appear to have evolved into more diverse, and possibly more complex, forms, compared with those in their urochordate siblings...
  96. ncbi request reprint Fluorescent in situ hybridization to ascidian chromosomes
    Eiichi Shoguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Zoolog Sci 21:153-7. 2004
    ..We also show that this method is efficient for coupling two so-far independent scaffolds into one longer scaffold when two BAC clones represent sequences located at either end of the two scaffolds...
  97. ncbi request reprint Development of Ciona intestinalis juveniles (through 2nd ascidian stage)
    Shota Chiba
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Zoolog Sci 21:285-98. 2004
    ..These descriptions and staging system provide a basis for studying cellular and molecular mechanisms underlying the development of adult organs and tissues of this basal chordate...
  98. ncbi request reprint Novel endostyle-specific genes in the ascidian Ciona intestinalis
    Akane Sasaki
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Zoolog Sci 20:1025-30. 2003
    ..The predicted amino acid sequence of Ci-Ends10 showed similarity to Trip230, and that of Ci-Ends11 resembled Ptp4E. These molecules might be useful for further analysis of the development, function and evolution of the endostyle...
  99. ncbi request reprint Identification of downstream genes of the ascidian muscle determinant gene Ci-macho1
    Kasumi Yagi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Biol 274:478-89. 2004
    ..Furthermore, some of the genes including three Wnt genes noted in the quantitative analyses implied that Ci-macho1 is involved in the differentiation of endoderm and mesenchyme via intracellular communications...
  100. ncbi request reprint Three distinct lineages of mesenchymal cells in Ciona intestinalis embryos demonstrated by specific gene expression
    Miki Tokuoka
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Biol 274:211-24. 2004
    ..These results provide evidence that the differentiation of each of the three mesenchyme lineages of Ciona embryos is characterized by the expression of a specific set of genes, whose expression is controlled differentially...
  101. ncbi request reprint A genomewide survey of developmentally relevant genes in Ciona intestinalis. VIII. Genes for PI3K signaling and cell cycle
    Takeshi Kawashima
    Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Dev Genes Evol 213:284-90. 2003
    ..Since Ciona is regarded as one of the most primitive extant chordates, the present analysis gives us an insight into how these fundamental biological genes are evolved or are conserved during chordate evolution...