Affiliation: Kyoto University
Ikeda H, Nakaoka S, de Boer R, Morita S, Misawa N, Koyanagi Y, et al
. Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model. Retrovirology. 2016;13:23 pubmed publisher
..This reveals that Vpu markedly increases the rate of viral replication in vivo. Combining experiments with mathematical modeling, we provide an estimate for the contribution of Vpu to viral replication in humanized mice. ..
Yamada E, Nakaoka S, Klein L, Reith E, Langer S, Hopfensperger K, et al
. Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo. Cell Host Microbe. 2018;23:110-120.e7 pubmed publisher
Yoshikawa R, Takeuchi J, Yamada E, Nakano Y, Ren F, Tanaka H, et al
. Vif determines the requirement for CBF-Î² in APOBEC3 degradation. J Gen Virol. 2015;96:887-92 pubmed publisher
..These findings suggested that primate lentiviruses have adapted to use CBF-Î², an evolutionary stable protein, to counteract APOBEC3 proteins of their hosts after diverging from other lentiviruses. ..
Yoshikawa R, Takeuchi J, Yamada E, Nakano Y, Misawa N, Kimura Y, et al
. Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3. J Virol. 2017;91: pubmed publisher
..Our findings can be a clue to elucidate the complicated evolutionary processes by which lentiviruses adapt to mammals. ..
Sato K, Misawa N, Takeuchi J, Kobayashi T, Izumi T, Aso H, et al
. Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model. J Virol. 2018;92: pubmed publisher
..We further demonstrate a gain-of-function evolution of SIVcpz in infected humanized mice. Our study reveals that pandemic HIV-1 has emerged through at least two steps: preadaptation and subsequent gain-of-function mutations. ..
Sato K, Yamamoto S, Misawa N, Yoshida T, Miyazawa T, Koyanagi Y. Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species. Retrovirology. 2009;6:53 pubmed publisher
..The cell type-specific effect of hBST-2 may be critical to elucidate the mechanism of BST-2-dependent suppression of virus release. ..
Yamada E, Yoshikawa R, Nakano Y, Misawa N, Koyanagi Y, Sato K. Impacts of humanized mouse models on the investigation of HIV-1 infection: illuminating the roles of viral accessory proteins in vivo. Viruses. 2015;7:1373-90 pubmed publisher
..This review describes the current knowledge of the roles of HIV-1 accessory proteins in viral infection, replication, and pathogenicity in vivo, which are revealed by the studies using humanized mouse models. ..
Yoshikawa R, Izumi T, Yamada E, Nakano Y, Misawa N, Ren F, et al
. A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection. J Virol. 2016;90:474-85 pubmed publisher
..The experimental-phylogenetic investigation sheds light on the evolutionary history of the domestic cat, which was likely influenced by lentiviral infection. ..
Nakano Y, Aso H, Soper A, Yamada E, Moriwaki M, Juarez Fernandez G, et al
. A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif. Retrovirology. 2017;14:31 pubmed publisher
..This review provides a comprehensive summary of current knowledge with respect to the evolutionary dynamics occurring at this pivotal host-virus interface. ..