Fumiaki Sato

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi Promotion effects of hot water on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats
    Zhi Gang Li
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Oncol Rep 10:421-6. 2003
  2. ncbi CpG island hypermethylation in progression of esophageal and gastric cancer
    Fumiaki Sato
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer 106:483-93. 2006
  3. ncbi Role of delta-opioid receptor function in neurogenesis and neuroprotection
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    J Neurochem 97:1494-505. 2006
  4. ncbi Sparse logistic regression with Lp penalty for biomarker identification
    Zhenqiu Liu
    University of Maryland, USA
    Stat Appl Genet Mol Biol 6:Article6. 2007
  5. pmc Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features
    Fumiaki Sato
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1890. 2008
  6. pmc Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines
    Cristian M Ortiz
    Department of Pathology, Valencia University, Hospital General Universitario de Valencia, Avenida tres cruces N degrees 2, CP 46014, Valencia, Spain
    Diagn Pathol 5:41. 2010
  7. pmc Intra-platform repeatability and inter-platform comparability of microRNA microarray technology
    Fumiaki Sato
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan
    PLoS ONE 4:e5540. 2009
  8. doi MicroRNAs and epigenetics
    Fumiaki Sato
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    FEBS J 278:1598-609. 2011
  9. pmc MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan Criteria
    Fumiaki Sato
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e16435. 2011
  10. pmc The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim
    Takatsugu Kan
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287, USA
    Gastroenterology 136:1689-700. 2009

Collaborators

Detail Information

Publications52

  1. ncbi Promotion effects of hot water on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats
    Zhi Gang Li
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Oncol Rep 10:421-6. 2003
    ..Our study further confirmed that the drinking of hot beverages increased the risk of esophageal carcinogenesis, and the drinking hot tea will abolish the inhibitory effects of EGCG on this disease...
  2. ncbi CpG island hypermethylation in progression of esophageal and gastric cancer
    Fumiaki Sato
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer 106:483-93. 2006
    ..In this review, a variety of information is summarized regarding gene hypermethylation in esophageal and gastric cancer...
  3. ncbi Role of delta-opioid receptor function in neurogenesis and neuroprotection
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
    J Neurochem 97:1494-505. 2006
    ..These findings raise the possibility that delta-opioid receptors play a crucial role in neurogenesis and neuroprotection, mainly through the activation of Trk-dependent tyrosine kinase, which could be linked to PI3K, PKC, CaMKII and MEK...
  4. ncbi Sparse logistic regression with Lp penalty for biomarker identification
    Zhenqiu Liu
    University of Maryland, USA
    Stat Appl Genet Mol Biol 6:Article6. 2007
    ..Our computational results show that Lp Logistic regression (p <1) outperforms the L1 logistic regression and SCAD SVM. Software is available upon request from the first author...
  5. pmc Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features
    Fumiaki Sato
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1890. 2008
    ..In this study, we developed a 3-tiered risk stratification strategy, based on systematically selected epigenetic and clinical parameters, to improve Barrett's esophagus surveillance efficiency...
  6. pmc Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines
    Cristian M Ortiz
    Department of Pathology, Valencia University, Hospital General Universitario de Valencia, Avenida tres cruces N degrees 2, CP 46014, Valencia, Spain
    Diagn Pathol 5:41. 2010
    ..Using a stable knockdown cell line, we revealed the effect of fascin on cell growth, cell adhesion and tumor formation...
  7. pmc Intra-platform repeatability and inter-platform comparability of microRNA microarray technology
    Fumiaki Sato
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan
    PLoS ONE 4:e5540. 2009
    ..This study provided the basic information about the performance and the problems specific to the current microRNA microarray systems...
  8. doi MicroRNAs and epigenetics
    Fumiaki Sato
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    FEBS J 278:1598-609. 2011
    ..The present minireview details recent discoveries involving the epigenetics-miRNA regulatory circuit, suggesting possible biological insights into gene-regulatory mechanisms that may underlie a variety of diseases...
  9. pmc MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan Criteria
    Fumiaki Sato
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e16435. 2011
    ..In this study, we utilized microRNA expression profiling to assess the risk of HCC recurrence after liver resection...
  10. pmc The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim
    Takatsugu Kan
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287, USA
    Gastroenterology 136:1689-700. 2009
    ..Barrett's esophagus (BE) is a highly premalignant disease that predisposes to the development of esophageal adenocarcinoma (EAC); however, the involvement of microRNAs (miRs) in BE-EAC carcinogenic progression is not known...
  11. pmc Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma
    Tetsuo Ito
    Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 68:3214-24. 2008
    ..Thus, PTTG1 constitutes a potential biomarker and therapeutic target in ESCCs with lymph node metastases...
  12. doi Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, 1503 East Jefferson Street, Baltimore, MD 21231, USA
    Cancer Epidemiol Biomarkers Prev 17:111-7. 2008
    ....
  13. ncbi Reprimo methylation is a potential biomarker of Barrett's-Associated esophageal neoplastic progression
    James P Hamilton
    Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:6637-42. 2006
    ..We also sought to determine whether Reprimo expression could be restored in vitro by the demethylating agent 5-aza-deoxycytidine (5AzaC)...
  14. ncbi Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability
    Karsten Schulmann
    Division of Gastroenterology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 129:74-85. 2005
    ..We sought to determine the frequency of high-level microsatellite instability (MSI-H) and the mutational and methylation profile of MSI-H IBD-related neoplasms (IBDNs)...
  15. ncbi Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning
    Yuriko Mori
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine and Greenebaum Cancer Center and Baltimore Veterans Affairs Hospital, Baltimore, Maryland, USA
    Cancer Res 64:2434-8. 2004
    ..This methylation screening strategy should identify additional genes inactivated by epigenetic silencing in colorectal and other cancers...
  16. ncbi Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 112:43-9. 2008
    ..The aim of the current study was to investigate whether and at what stage promoter hypermethylation of SST is involved in human esophageal carcinogenesis...
  17. doi Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Int J Cancer 123:2331-6. 2008
    ..These findings suggest that hypermethylation of CDH13 is a common, tissue-specific event in human EAC, occurs early during BE-associated neoplastic progression, and correlates with known clinical neoplastic progression risk factors...
  18. ncbi A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer
    Yuriko Mori
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 131:797-808. 2006
    ..Gene silencing via promoter hypermethylation is a central event in the pathogenesis of cancers. To identify novel methylation targets in colon cancer, we conducted a genome-wide, microarray-based, in silico, and epigenetic search...
  19. ncbi Hypermethylation of tachykinin-1 is a potential biomarker in human esophageal cancer
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 13:6293-300. 2007
    ..Our aim was to investigate whether and at what stage hypermethylation of the tachykinin-1 (TAC1) gene is associated with human esophageal neoplastic transformation...
  20. ncbi Polo-like kinase and survivin are esophageal tumor-specific promoters
    Fumiaki Sato
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem Biophys Res Commun 342:465-71. 2006
    ..9-fold and 28.5-fold higher, respectively, than in normal lung and renal cells. The promoters of PLK and survivin could be useful tools for developing EC-specific gene therapy vectors...
  21. doi Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells
    Atsuko Yanagida
    Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochim Biophys Acta 1812:1403-11. 2011
    ..Since Sept4(-/-)mice are prone to liver fibrosis, we aimed to identify the unknown molecular network underlying liver fibrosis by probing the association between loss of Sept4 and accelerated transdifferentiation of HSCs...
  22. ncbi Prediction of lymph node metastasis with use of artificial neural networks based on gene expression profiles in esophageal squamous cell carcinoma
    Takatsugu Kan
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Ann Surg Oncol 11:1070-8. 2004
    ....
  23. ncbi Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors
    Andreea Olaru
    Department of Medicine, University of Maryland School of Medicine and Baltimore Veteran s Affairs Hospital, Baltimore, Maryland 21201, USA
    Lab Invest 83:1867-71. 2003
    ..We conclude that ACTRII is probably involved in both non-MSI-H and MSI-H colorectal carcinogenesis, but more frequently in the latter subgroup...
  24. ncbi Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes
    Elena Deacu
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 64:7690-6. 2004
    ....
  25. ncbi An unsupervised approach to identify molecular phenotypic components influencing breast cancer features
    Florin M Selaru
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cancer Res 64:1584-8. 2004
    ..Moreover, these findings illustrate the potential of PCs analysis to detect molecular phenotypic bases for relevant clinical or biological features of human tumors in general...
  26. doi MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma
    Yukako Imanaka
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Hum Genet 56:270-6. 2011
    ..Our study highlights an important regulatory role for miR-141 in the development of cisplatin resistance in ESCC...
  27. pmc MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1)
    Soken Tsuchiya
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 286:420-8. 2011
    ..Taken together, our findings show an important role for miR-210 as a tumor-suppressive microRNA with effects on cancer cell proliferation...
  28. ncbi An inducible short-hairpin RNA vector against osteopontin reduces metastatic potential of human esophageal squamous cell carcinoma in vitro and in vivo
    Tetsuo Ito
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Cancer Res 12:1308-16. 2006
    ....
  29. ncbi The impact of microsatellite instability on the molecular phenotype of colorectal tumors
    Yuriko Mori
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Cancer Res 63:4577-82. 2003
    ..Thus, both components 3 and 10 reflected different aspects of MSI and helped to establish principal components analysis as a useful tool to identify and characterize distinct biological features of human malignancy...
  30. ncbi Promoter methylation and response to chemotherapy and radiation in esophageal cancer
    James P Hamilton
    Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Gastroenterol Hepatol 4:701-8. 2006
    ..Accordingly, our aim was to find methylation markers that could be used to predict response to chemoradiation...
  31. ncbi Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma
    Fumiaki Sato
    Gastroenterology Division, Department of Medicine, University of Maryland School of Medicine and Gastroenterology Service, Baltimore, Maryland 21201, USA
    Cancer Res 62:6820-2. 2002
    ..In conclusion, our data suggest that methylation of HPP1 is a relatively common early event in UC-associated carcinogenesis. HPP1 offers potential as a biomarker for the early detection of cancer or dysplasia in UC...
  32. pmc Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells
    John M Abraham
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 2:e964. 2007
    ..The rapidly growing field of targeted tumor therapy often utilizes an antibody, sometimes tagged with a tumor-ablating material such as radioisotope, directed against a specific molecule...
  33. pmc Trastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cells
    Takehiro Ichikawa
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 7:e31422. 2012
    ..In this study, we identified trastuzumab-responsive microRNAs that are involved in the therapeutic effects of trastuzumab...
  34. pmc Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing
    Yoshinao Ruike
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 20 Yoshida Shimoadachi cho Sakyo ku, Kyoto 606 8501, Japan
    BMC Genomics 11:137. 2010
    ..However, the mechanisms that underlie methylome changes are not well understood nor is the genomic distribution of DNA methylation changes well characterized...
  35. ncbi An ultrasensitive new DNA microarray chip provides gene expression profiles for preoperative esophageal cancer biopsies without RNA amplification
    Tetsuo Ito
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncology 73:366-75. 2007
    ..This study evaluated the usefulness of an ultrasensitive new DNA microarray chip, which has a unique array structure, for the clinical diagnosis of esophageal cancer using preoperative biopsies...
  36. pmc MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells
    Soken Tsuchiya
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    Nucleic Acids Res 37:3821-7. 2009
    ..Therefore, we concluded that both miR-338-3p and miR-451 are necessary for the development of epithelial cell polarity...
  37. doi Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells
    Kazuya Terasawa
    Department of Pharmcogenomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Japan
    FEBS J 276:3269-76. 2009
    ..These results reveal that the ERK signal regulates miR-221/222 expression, and that these miRNAs might contribute to NGF-dependent cell survival in PC12 cells...
  38. ncbi Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers
    Yuriko Mori
    Department of Medicine, University of Maryland School of Medicine, Baltimore Veterans Affairs Hospital, Baltimore, Maryland 21201, USA
    Cancer Res 62:3641-5. 2002
    ..2%), and an endoplasmic reticulum chaperone protein gene SEC63 (37.5%). The mutational spectra for genes with high mutation frequencies were also significantly different between MSI-H gastric and colorectal cancers...
  39. ncbi Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats
    Zhi Gang Li
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Int J Oncol 21:1275-83. 2002
    ..These results indicated that EGCG significantly inhibits the NMBA-induced rat esophageal carcinogenesis and it inhibitory effects may partly target cyclin D1 and COX-2 expression, and PGE2 production...
  40. doi Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells
    Keiko Iwaisako
    Department of Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Hepatol 49:768-78. 2008
    ..We disclose the quiescent hepatic stellate cells (HSCs)-specific expression of a septin subunit Sept4 in the liver, and explore the significance of the septin system in liver fibrosis...
  41. ncbi Indications for abdominal para-aortic lymph node dissection in patients with esophageal squamous cell carcinoma
    Yutaka Shimada
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kawaracho Shogoin Sakyo ku, Japan
    Surgery 132:93-9. 2002
    ..Abdominal para-aortic lymph node (APAL) dissection of esophageal cancer is not widely accepted. The aim of this article is to propose the indications for APAL dissection in esophageal cancer patients from the viewpoint of micrometastases...
  42. ncbi Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon
    Tong Tong Zou
    Department of Medicine, Division of Gastroenterology and Greenebaum Cancer Center, University of Maryland School of Medicine and Baltimore VA Hospital, Baltimore, Maryland, MD 21201, USA
    Oncogene 21:4855-62. 2002
    ..Our data suggests that a large-scale approach may be undertaken with the purpose of identifying biomarkers relevant to cancer progression...
  43. doi Potential clinical applications of matrix metalloproteinase inhibitors and their future prospects
    Wenzhao Li
    Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Biol Markers 28:117-30. 2013
    ..Although studies with these agents have met with limited clinical success, the field of MMPIs is still expanding, and generation of highly effective and selective MMPIs might be a promising direction of this research area. ..
  44. ncbi Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions
    Florin M Selaru
    Department of Medicine, Division of Gastroenterology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 122:606-13. 2002
    ..The current study evaluated the ability of artificial neural networks (ANNs) based on complementary DNA (cDNA) microarray data to discriminate between these 2 types of colorectal lesions...
  45. ncbi Expression of cyclooxygenase-2 is associated with carcinogenesis of the lower part of thoracic esophageal squamous cell carcinoma and p53 expression
    Atsushi Kawabe
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Oncology 62:46-54. 2002
    ..p53 expression was associated with the expression of COX-2 (p = 0.0122). Our findings suggest that COX-2 may play a role in the development of squamous cell carcinoma in the lower part of the thoracic esophagus...
  46. ncbi Paratracheal lymph node metastasis is associated with cervical lymph node metastasis in patients with thoracic esophageal squamous cell carcinoma
    Fumiaki Sato
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Japan
    Ann Surg Oncol 9:65-70. 2002
    ..We determined which lymph node metastases were associated with cervical lymph node metastases of thoracic esophageal squamous cell carcinoma...
  47. ncbi Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk
    Karsten Schulmann
    Division of Gastroenterology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Oncogene 24:4138-48. 2005
    ..These findings have implications regarding risk stratification, early EAC detection, and the appropriate endoscopic surveillance interval for patients with BE...
  48. ncbi Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer
    Yan Xu
    Department of Medicine, Division of Gastroenterology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore VA Hospital, 21201, USA
    Cancer Res 62:3493-7. 2002
    ..Finally, the 160 genes selected by SAM may merit further study as biomarkers of neoplastic progression in the esophagus, as well as in elucidating pathological mechanisms underlying BA and CA...
  49. ncbi Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma
    Keishi Yamashita
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 720 Rutland Avenue, Ross Building 818, Baltimore, MD 21205, USA
    Cancer Cell 2:485-95. 2002
    ..Pharmacologic reversal of epigenetic silencing is a powerful approach for comprehensive identification of tumor suppressor genes in human cancers...
  50. ncbi Prediction of survival in patients with esophageal carcinoma using artificial neural networks
    Fumiaki Sato
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer 103:1596-605. 2005
    ..To create a comprehensive prognostic model for esophageal carcinoma, artificial neural networks (ANNs) were applied to the analysis of a range of patient-related and tumor-related variables...
  51. ncbi An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma
    Suna Wang
    Department of Medicine, Division of Gastroenterology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore 21201, USA
    Oncogene 22:467-70. 2003
    ..These data suggest that LOH at 7q31-q35 is involved in the origin or progression of at least a subset of esophageal carcinomas, but that ST7 is not the target gene of this somatic event...
  52. ncbi Mutational and LOH analyses of the chromosome 4q region in esophageal adenocarcinoma
    Anca Sterian
    Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Oncology 70:168-72. 2006
    ..Findings from loss of heterozygosity (LOH) studies have suggested that the long arm of chromosome 4 might harbor tumor suppressor genes relevant to esophageal adenocarcinoma...