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Genomes and Genes | Fumiaki SatoSummaryAffiliation: Kyoto University Country: Japan Publications
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Publications
Promotion effects of hot water on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 ratsZhi Gang Li
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Oncol Rep 10:421-6. 2003..Our study further confirmed that the drinking of hot beverages increased the risk of esophageal carcinogenesis, and the drinking hot tea will abolish the inhibitory effects of EGCG on this disease...- CpG island hypermethylation in progression of esophageal and gastric cancerFumiaki Sato
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Cancer 106:483-93. 2006..In this review, a variety of information is summarized regarding gene hypermethylation in esophageal and gastric cancer... - Role of delta-opioid receptor function in neurogenesis and neuroprotectionMinoru Narita
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo, 142 8501, Japan
J Neurochem 97:1494-505. 2006..These findings raise the possibility that delta-opioid receptors play a crucial role in neurogenesis and neuroprotection, mainly through the activation of Trk-dependent tyrosine kinase, which could be linked to PI3K, PKC, CaMKII and MEK... - Sparse logistic regression with Lp penalty for biomarker identificationZhenqiu Liu
University of Maryland, USA
Stat Appl Genet Mol Biol 6:Article6. 2007..Our computational results show that Lp Logistic regression (p <1) outperforms the L1 logistic regression and SCAD SVM. Software is available upon request from the first author... 
Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical featuresFumiaki Sato
Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 3:e1890. 2008..In this study, we developed a 3-tiered risk stratification strategy, based on systematically selected epigenetic and clinical parameters, to improve Barrett's esophagus surveillance efficiency...- Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell linesCristian M Ortiz
Department of Pathology, Valencia University, Hospital General Universitario de Valencia, Avenida tres cruces N degrees 2, CP 46014, Valencia, Spain
Diagn Pathol 5:41. 2010..Using a stable knockdown cell line, we revealed the effect of fascin on cell growth, cell adhesion and tumor formation... - MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan CriteriaFumiaki Sato
Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
PLoS ONE 6:e16435. 2011..In this study, we utilized microRNA expression profiling to assess the risk of HCC recurrence after liver resection... - Intra-platform repeatability and inter-platform comparability of microRNA microarray technologyFumiaki Sato
Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan
PLoS ONE 4:e5540. 2009..This study provided the basic information about the performance and the problems specific to the current microRNA microarray systems... 
MicroRNAs and epigeneticsFumiaki Sato
Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
FEBS J 278:1598-609. 2011..The present minireview details recent discoveries involving the epigenetics-miRNA regulatory circuit, suggesting possible biological insights into gene-regulatory mechanisms that may underlie a variety of diseases...- Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinomaTetsuo Ito
Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Cancer Res 68:3214-24. 2008..Thus, PTTG1 constitutes a potential biomarker and therapeutic target in ESCCs with lymph node metastases... - The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and BimTakatsugu Kan
Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287, USA
Gastroenterology 136:1689-700. 2009..Barrett's esophagus (BE) is a highly premalignant disease that predisposes to the development of esophageal adenocarcinoma (EAC); however, the involvement of microRNAs (miRs) in BE-EAC carcinogenic progression is not known... - Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progressionZhe Jin
Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, 1503 East Jefferson Street, Baltimore, MD 21231, USA
Cancer Epidemiol Biomarkers Prev 17:111-7. 2008.... - Reprimo methylation is a potential biomarker of Barrett's-Associated esophageal neoplastic progressionJames P Hamilton
Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Clin Cancer Res 12:6637-42. 2006.... - Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instabilityKarsten Schulmann
Division of Gastroenterology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Gastroenterology 129:74-85. 2005..Furthermore, HPP1 methylation occurs early, in 7% of nondysplastic and approximately half of dysplastic mucosae, whereas RAB32 methylation occurs at the transition to invasive growth, being rarer in dysplasias... - Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesisZhe Jin
Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Cancer 112:43-9. 2008..The aim of the current study was to investigate whether and at what stage promoter hypermethylation of SST is involved in human esophageal carcinogenesis... - Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factorsZhe Jin
Division of Gastroenterology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
Int J Cancer 123:2331-6. 2008..These findings suggest that hypermethylation of CDH13 is a common, tissue-specific event in human EAC, occurs early during BE-associated neoplastic progression, and correlates with known clinical neoplastic progression risk factors... - Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanningYuriko Mori
Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine and Greenebaum Cancer Center and Baltimore Veterans Affairs Hospital, Baltimore, Maryland, USA
Cancer Res 64:2434-8. 2004..This methylation screening strategy should identify additional genes inactivated by epigenetic silencing in colorectal and other cancers... - Hypermethylation of tachykinin-1 is a potential biomarker in human esophageal cancerZhe Jin
Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Clin Cancer Res 13:6293-300. 2007..Our aim was to investigate whether and at what stage hypermethylation of the tachykinin-1 (TAC1) gene is associated with human esophageal neoplastic transformation... - A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancerYuriko Mori
Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Gastroenterology 131:797-808. 2006..Gene silencing via promoter hypermethylation is a central event in the pathogenesis of cancers. To identify novel methylation targets in colon cancer, we conducted a genome-wide, microarray-based, in silico, and epigenetic search... - Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cellsAtsuko Yanagida
Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Biochim Biophys Acta 1812:1403-11. 2011..Since Sept4(-/-)mice are prone to liver fibrosis, we aimed to identify the unknown molecular network underlying liver fibrosis by probing the association between loss of Sept4 and accelerated transdifferentiation of HSCs... - Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genesElena Deacu
Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Cancer Res 64:7690-6. 2004.... - Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinomaFumiaki Sato
Gastroenterology Division, Department of Medicine, University of Maryland School of Medicine and Gastroenterology Service, Baltimore, Maryland 21201, USA
Cancer Res 62:6820-2. 2002..In conclusion, our data suggest that methylation of HPP1 is a relatively common early event in UC-associated carcinogenesis. HPP1 offers potential as a biomarker for the early detection of cancer or dysplasia in UC... - Polo-like kinase and survivin are esophageal tumor-specific promotersFumiaki Sato
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem Biophys Res Commun 342:465-71. 2006..9-fold and 28.5-fold higher, respectively, than in normal lung and renal cells. The promoters of PLK and survivin could be useful tools for developing EC-specific gene therapy vectors... - Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumorsAndreea Olaru
Department of Medicine, University of Maryland School of Medicine and Baltimore Veteran s Affairs Hospital, Baltimore, Maryland 21201, USA
Lab Invest 83:1867-71. 2003..We conclude that ACTRII is probably involved in both non-MSI-H and MSI-H colorectal carcinogenesis, but more frequently in the latter subgroup... - Prediction of lymph node metastasis with use of artificial neural networks based on gene expression profiles in esophageal squamous cell carcinomaTakatsugu Kan
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Ann Surg Oncol 11:1070-8. 2004..This systematic analysis combining SAM with ANN was very useful for the prediction of lymph node metastasis in esophageal cancers and could be applied clinically in the near future... - An unsupervised approach to identify molecular phenotypic components influencing breast cancer featuresFlorin M Selaru
Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Cancer Res 64:1584-8. 2004..Moreover, these findings illustrate the potential of PCs analysis to detect molecular phenotypic bases for relevant clinical or biological features of human tumors in general... - Promoter methylation and response to chemotherapy and radiation in esophageal cancerJames P Hamilton
Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Clin Gastroenterol Hepatol 4:701-8. 2006..In addition, increased methylation of a 9-gene panel correlated significantly with poor responsiveness to chemoradiation... - The impact of microsatellite instability on the molecular phenotype of colorectal tumorsYuriko Mori
Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
Cancer Res 63:4577-82. 2003..Thus, both components 3 and 10 reflected different aspects of MSI and helped to establish principal components analysis as a useful tool to identify and characterize distinct biological features of human malignancy... - Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cellsJohn M Abraham
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 2:e964. 2007..The rapidly growing field of targeted tumor therapy often utilizes an antibody, sometimes tagged with a tumor-ablating material such as radioisotope, directed against a specific molecule... - MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinomaYukako Imanaka
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
J Hum Genet 56:270-6. 2011..Our study highlights an important regulatory role for miR-141 in the development of cisplatin resistance in ESCC... - MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1)Soken Tsuchiya
Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
J Biol Chem 286:420-8. 2011..Taken together, our findings show an important role for miR-210 as a tumor-suppressive microRNA with effects on cancer cell proliferation... - An inducible short-hairpin RNA vector against osteopontin reduces metastatic potential of human esophageal squamous cell carcinoma in vitro and in vivoTetsuo Ito
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Clin Cancer Res 12:1308-16. 2006..CONCLUSIONS: Our findings suggest that osteopontin overexpression may play an important role in progression of ESCC and osteopontin could be a potential target of ESCC therapy... - Trastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cellsTakehiro Ichikawa
Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
PLoS ONE 7:e31422. 2012..In this study, we identified trastuzumab-responsive microRNAs that are involved in the therapeutic effects of trastuzumab... - Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencingYoshinao Ruike
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 20 Yoshida Shimoadachi cho Sakyo ku, Kyoto 606 8501, Japan
BMC Genomics 11:137. 2010..However, the mechanisms that underlie methylome changes are not well understood nor is the genomic distribution of DNA methylation changes well characterized... - An ultrasensitive new DNA microarray chip provides gene expression profiles for preoperative esophageal cancer biopsies without RNA amplificationTetsuo Ito
Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Oncology 73:366-75. 2007..This study evaluated the usefulness of an ultrasensitive new DNA microarray chip, which has a unique array structure, for the clinical diagnosis of esophageal cancer using preoperative biopsies... - Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colonTong Tong Zou
Department of Medicine, Division of Gastroenterology and Greenebaum Cancer Center, University of Maryland School of Medicine and Baltimore VA Hospital, Baltimore, Maryland, MD 21201, USA
Oncogene 21:4855-62. 2002..Our data suggests that a large-scale approach may be undertaken with the purpose of identifying biomarkers relevant to cancer progression... - MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cellsSoken Tsuchiya
Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
Nucleic Acids Res 37:3821-7. 2009..Therefore, we concluded that both miR-338-3p and miR-451 are necessary for the development of epithelial cell polarity... - Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cellsKazuya Terasawa
Department of Pharmcogenomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Japan
FEBS J 276:3269-76. 2009..These results reveal that the ERK signal regulates miR-221/222 expression, and that these miRNAs might contribute to NGF-dependent cell survival in PC12 cells... - Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancersYuriko Mori
Department of Medicine, University of Maryland School of Medicine, Baltimore Veterans Affairs Hospital, Baltimore, Maryland 21201, USA
Cancer Res 62:3641-5. 2002..2%), and an endoplasmic reticulum chaperone protein gene SEC63 (37.5%). The mutational spectra for genes with high mutation frequencies were also significantly different between MSI-H gastric and colorectal cancers... - Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 ratsZhi Gang Li
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Int J Oncol 21:1275-83. 2002..These results indicated that EGCG significantly inhibits the NMBA-induced rat esophageal carcinogenesis and it inhibitory effects may partly target cyclin D1 and COX-2 expression, and PGE2 production... - Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cellsKeiko Iwaisako
Department of Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
J Hepatol 49:768-78. 2008..We disclose the quiescent hepatic stellate cells (HSCs)-specific expression of a septin subunit Sept4 in the liver, and explore the significance of the septin system in liver fibrosis... - Indications for abdominal para-aortic lymph node dissection in patients with esophageal squamous cell carcinomaYutaka Shimada
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kawaracho Shogoin Sakyo-ku, Japan
Surgery 132:93-9. 2002..Patients with lower thoracic esophageal cancer who are suspected to have perigastric lymph node metastasis and APAL micrometastases may be considered for APAL dissection... - Artificial neural networks distinguish among subtypes of neoplastic colorectal lesionsFlorin M Selaru
Department of Medicine, Division of Gastroenterology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
Gastroenterology 122:606-13. 2002..CONCLUSIONS: Our results suggest that ANNs have the potential to discriminate among subtly different clinical entities, such as IBDNs and SACs, as well as to identify gene subsets having the power to make these diagnostic distinctions... - Paratracheal lymph node metastasis is associated with cervical lymph node metastasis in patients with thoracic esophageal squamous cell carcinomaFumiaki Sato
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Japan
Ann Surg Oncol 9:65-70. 2002..CONCLUSIONS: The paratracheal lymph node is most associated with (CLNM) of thoracic esophageal squamous cell carcinoma... - Expression of cyclooxygenase-2 is associated with carcinogenesis of the lower part of thoracic esophageal squamous cell carcinoma and p53 expressionAtsushi Kawabe
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Oncology 62:46-54. 2002..p53 expression was associated with the expression of COX-2 (p = 0.0122). Our findings suggest that COX-2 may play a role in the development of squamous cell carcinoma in the lower part of the thoracic esophagus... - Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression riskKarsten Schulmann
Division of Gastroenterology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Oncogene 24:4138-48. 2005..These findings have implications regarding risk stratification, early EAC detection, and the appropriate endoscopic surveillance interval for patients with BE... - Prediction of survival in patients with esophageal carcinoma using artificial neural networksFumiaki Sato
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Cancer 103:1596-605. 2005..0001). CONCLUSIONS: ANNs can be used to construct a highly accurate prognostic model for patients with esophageal carcinoma. Sensitivity analysis based on ANNs is a powerful tool for seeking optimal data sets... - Mutational and LOH analyses of the chromosome 4q region in esophageal adenocarcinomaAnca Sterian
Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Oncology 70:168-72. 2006..1-3. The results imply that mutational or other alterations at these loci may be involved in the pathogenesis of esophageal adenocarcinoma. Candidate tumor suppressor genes located within these regions merit further study... - An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinomaSuna Wang
Department of Medicine, Division of Gastroenterology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore 21201, USA
Oncogene 22:467-70. 2003..These data suggest that LOH at 7q31-q35 is involved in the origin or progression of at least a subset of esophageal carcinomas, but that ST7 is not the target gene of this somatic event... - Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinomaKeishi Yamashita
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, 720 Rutland Avenue, Ross Building 818, Baltimore, MD 21205, USA
Cancer Cell 2:485-95. 2002..Pharmacologic reversal of epigenetic silencing is a powerful approach for comprehensive identification of tumor suppressor genes in human cancers... - Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancerYan Xu
Department of Medicine, Division of Gastroenterology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore VA Hospital, 21201, USA
Cancer Res 62:3493-7. 2002..Finally, the 160 genes selected by SAM may merit further study as biomarkers of neoplastic progression in the esophagus, as well as in elucidating pathological mechanisms underlying BA and CA...