T Saito

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Efficient gene transfer into the embryonic mouse brain using in vivo electroporation
    T Saito
    Department of Development and Differentiation, Kyoto University, Kyoto, 606 8507, Japan
    Dev Biol 240:237-46. 2001
  2. doi request reprint Pretransplant serum ferritin and C-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation
    J Kanda
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Bone Marrow Transplant 46:208-16. 2011
  3. ncbi request reprint Clinical factors associated with fluconazole resistance and short-term survival in patients with Candida bloodstream infection
    S Takakura
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo, Kyoto, 6068507, Japan
    Eur J Clin Microbiol Infect Dis 23:380-8. 2004
  4. pmc Ccm1, a regulatory gene controlling the induction of a carbon-concentrating mechanism in Chlamydomonas reinhardtii by sensing CO2 availability
    H Fukuzawa
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 98:5347-52. 2001
  5. ncbi request reprint Comparison of the BDProbeTec ET system with the Cobas Amplicor PCR for direct detection of Mycobacterium tuberculosis in respiratory samples
    Y Iinuma
    Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Clin Microbiol Infect Dis 22:368-71. 2003
  6. ncbi request reprint Comparison of post-translational modifications of alpha A-crystallin from normal and hereditary cataract rats
    N Fujii
    Research Reactor Institute, Kyoto University, Kumatori, Sennan, Osaka, Japan
    Amino Acids 26:147-52. 2004
  7. ncbi request reprint Effects on spectrum and susceptibility patterns of isolates causing bloodstream infection by restriction of fluoroquinolone prophylaxis in a hematology-oncology unit
    T Saito
    Department of Infection Control and Prevention, Kyoto University Hospital, 54 Kawahara cho, Shougoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Clin Microbiol Infect Dis 27:209-16. 2008
  8. doi request reprint Control of an outbreak of carbapenem-resistant Pseudomonas aeruginosa in a haemato-oncology unit
    M Nagao
    Department of Infection Control and Prevention, Kyoto University Hospital, Kyoto, Japan
    J Hosp Infect 79:49-53. 2011
  9. doi request reprint Temperature-induced A-B intersite charge transfer in an A-site-ordered LaCu(3)Fe(4)O(12) perovskite
    Y W Long
    Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nature 458:60-3. 2009
  10. ncbi request reprint Kinetic study of racemization of aspartyl residues in synthetic elastin peptides
    K Kuge
    Research Reactor Institute, Kyoto University, Kumatori, Sennan, Osaka, Japan
    Amino Acids 27:193-7. 2004

Detail Information

Publications74

  1. ncbi request reprint Efficient gene transfer into the embryonic mouse brain using in vivo electroporation
    T Saito
    Department of Development and Differentiation, Kyoto University, Kyoto, 606 8507, Japan
    Dev Biol 240:237-46. 2001
    ..Moreover, it was possible to transfect three different DNA vectors into the same cells. Thus, this method will be a powerful tool to characterize gene function in various settings due to its high efficiency and localized gene expression...
  2. doi request reprint Pretransplant serum ferritin and C-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation
    J Kanda
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Bone Marrow Transplant 46:208-16. 2011
    ..It may be prudent to limit antibacterial prophylaxis to patients with predefined risk factors to ensure the safety of HCT with the use of fewer antibiotics...
  3. ncbi request reprint Clinical factors associated with fluconazole resistance and short-term survival in patients with Candida bloodstream infection
    S Takakura
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo, Kyoto, 6068507, Japan
    Eur J Clin Microbiol Infect Dis 23:380-8. 2004
    ..2-16.1; P<0.001) and the use of appropriate therapy (odds ratio, 2.1; 95% confidence interval, 1.1-4.1; P=0.03) were independent factors significantly associated with survival after the diagnosis of Candida bloodstream infection...
  4. pmc Ccm1, a regulatory gene controlling the induction of a carbon-concentrating mechanism in Chlamydomonas reinhardtii by sensing CO2 availability
    H Fukuzawa
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 98:5347-52. 2001
    ..In addition, complementation assay and identification of the mutation site of another pleiotropic mutant, cia5, revealed that His-54 within the putative zinc-finger motif of the CCM1 is crucial to its regulatory function...
  5. ncbi request reprint Comparison of the BDProbeTec ET system with the Cobas Amplicor PCR for direct detection of Mycobacterium tuberculosis in respiratory samples
    Y Iinuma
    Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Clin Microbiol Infect Dis 22:368-71. 2003
    ..7%) samples in the BDProbeTec ET system. The high sensitivity and specificity of the BDProbeTec ET system suggest it is a useful method for the rapid and direct detection of MTB in smear-positive respiratory samples...
  6. ncbi request reprint Comparison of post-translational modifications of alpha A-crystallin from normal and hereditary cataract rats
    N Fujii
    Research Reactor Institute, Kyoto University, Kumatori, Sennan, Osaka, Japan
    Amino Acids 26:147-52. 2004
    ..These modifications were not found in the age-matched normal rats. These tendencies are consistent with aged and cataractous human lenses...
  7. ncbi request reprint Effects on spectrum and susceptibility patterns of isolates causing bloodstream infection by restriction of fluoroquinolone prophylaxis in a hematology-oncology unit
    T Saito
    Department of Infection Control and Prevention, Kyoto University Hospital, 54 Kawahara cho, Shougoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Clin Microbiol Infect Dis 27:209-16. 2008
    ..0078). Restriction of fluoroquinolone prophylaxis affects the etiology of BSI and reduces the proportion of drug-resistant organisms...
  8. doi request reprint Control of an outbreak of carbapenem-resistant Pseudomonas aeruginosa in a haemato-oncology unit
    M Nagao
    Department of Infection Control and Prevention, Kyoto University Hospital, Kyoto, Japan
    J Hosp Infect 79:49-53. 2011
    ..The final five infected patients were found by routine active surveillance, but horizontal transmission was undetectable. The MBLPA outbreak in the haemato-oncology unit was finally contained in 2008...
  9. doi request reprint Temperature-induced A-B intersite charge transfer in an A-site-ordered LaCu(3)Fe(4)O(12) perovskite
    Y W Long
    Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nature 458:60-3. 2009
    ..What is more interesting in relation to technological applications is that this above-room-temperature transition is associated with a large negative thermal expansion...
  10. ncbi request reprint Kinetic study of racemization of aspartyl residues in synthetic elastin peptides
    K Kuge
    Research Reactor Institute, Kyoto University, Kumatori, Sennan, Osaka, Japan
    Amino Acids 27:193-7. 2004
    ..7 kcal/mol, RR=5.55 x 10(-2)/yr and t=47.0 yr. These results suggest that racemization of Asp residues in elastin could occur within a human life span. We propose that D-Asp could be a useful molecular indicators of aging...
  11. doi request reprint Bone bonding bioactivity of Ti metal and Ti-Zr-Nb-Ta alloys with Ca ions incorporated on their surfaces by simple chemical and heat treatments
    A Fukuda
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Kawahara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Acta Biomater 7:1379-86. 2011
    ..Thus, with this improved bioactive treatment process these advantageous Ti-Zr-Nb-Ta alloys can serve as useful candidates for orthopedic devices...
  12. doi request reprint Close cooperation between infectious disease physicians and attending physicians can result in better management and outcome for patients with Staphylococcus aureus bacteraemia
    M Nagao
    Department of Infection Control and Prevention, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Clin Microbiol Infect 16:1783-8. 2010
    ..6-fold compared to 2002. Proactive intervention by IDPs raised awareness of optimal management of bacteraemia and improved the adherence to the standards of care, which subsequently resulted in an improvement in the outcome...
  13. doi request reprint Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting
    A Fukuda
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Kawahara cho, Sakyo ku, Japan
    Acta Biomater 7:2327-36. 2011
    ....
  14. ncbi request reprint Effect of adrenomedullin on ion transport and muscle contraction in rat distal colon
    K Fukuda
    Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
    Peptides 19:1043-7. 1998
    ..51%, 100 nM:33.4 +/- 12.7%, 100% contraction: 1.8 +/- 0.22 g), and TTX inhibits the response elicited by AM (90%). We conclude that AM modulates water and ion transport as well as bowel movement, mainly through the colonic nervous system...
  15. ncbi request reprint Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator-activated receptor-gamma
    M Inoue
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Arterioscler Thromb Vasc Biol 21:560-6. 2001
    ..In conclusion, Ox-LDL upregulates VEGF expression in macrophages and endothelial cells, at least in part, through the activation of PPARgamma...
  16. pmc Administration route-dependent vaccine efficiency of murine dendritic cells pulsed with antigens
    N Okada
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto, 607 8414, Japan
    Br J Cancer 84:1564-70. 2001
    ..Furthermore, the immunization route affects vaccine efficiency...
  17. ncbi request reprint C-type natriuretic peptide induces redifferentiation of vascular smooth muscle cells with accelerated reendothelialization
    K Doi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Arterioscler Thromb Vasc Biol 21:930-6. 2001
    ..CNP-infected group. Thus, stimulation of cGMP cascade in proliferating dedifferentiated SMCs can induce growth inhibition and redifferentiation of SMCs with accelerated reendothelialization...
  18. ncbi request reprint [Survey on clinical isolates from 13 hospitals in Akita Prefecture--changes in frequency and susceptibility of isolates by scale of hospital. Survey Group for Clinical Isolates, Chemotherapy Research Committee of Akita Prefecture]
    M Kudo
    Kudo Pediatric Clinic, Oodate City
    Kansenshogaku Zasshi 64:1514-24. 1990
    ..Serratia marcescens showed low susceptibility to many drugs. Based on the above results, we concluded that attention should be paid to S. aureus, P. aeruginosa and Enterobacter in clinical practice...
  19. ncbi request reprint Successful living donor liver transplantation in a patient with preoperative fungal infection
    T Tsuchiya
    First Department of Surgery, Fukushima Medical University, School of Medicine, Fukushima, Japan
    Transplant Proc 35:401. 2003
  20. pmc Isolation of peptides useful for differential diagnosis of Crohn's disease and ulcerative colitis
    H Saito
    Department of In Vitro Diagnostics, Otsuka Life Science Initiative, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Gut 52:535-40. 2003
    ..Aim: To isolates peptides from a phage library which are specifically recognised by antibodies in serum from patients with Crohn's disease (CD)...
  21. ncbi request reprint p53 Mutation and MDM2 amplification in inflammatory myofibroblastic tumours
    H Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Histopathology 42:431-9. 2003
    ....
  22. ncbi request reprint Impairment of G(salpha) function in human brain cortex of Alzheimer's disease: comparison with normal aging
    E Hashimoto
    Clinical Neurochemistry and NPF Center of Excellence Research Labs, Department of Psychiatry, University of Wurzburg, Germany
    J Neural Transm 111:311-22. 2004
    ..These results suggest that the disturbances of post-receptor trans-membrane signalling in AD can be attributed to functional changes of G(salpha), and these are independent of alterations in the level for those proteins in normal aging...
  23. ncbi request reprint Structural analysis of a new anti-hypertensive peptide (beta-lactosin B) isolated from a commercial whey product
    M Murakami
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, 1 1, Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    J Dairy Sci 87:1967-74. 2004
    ..5 +/- 10 mm Hg) at 8 h after oral administration in SHR, WE80BG would be suitable for application to the development of a new food expected to have anti-hypertensive effects...
  24. ncbi request reprint Prevalence of Porphyromonas gingivalis in relation to periodontal status assessed by real-time PCR
    M Kawada
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    Oral Microbiol Immunol 19:289-92. 2004
    ..These results suggest that the absolute and relative numbers of P. gingivalis are closely associated with periodontal status, and that quantitative analysis of this organism is important for the evaluation of periodontal therapy...
  25. ncbi request reprint Effects of diet consistency on the expression of insulin-like growth factors (IGFs), IGF receptors and IGF binding proteins during the development of rat masseter muscle soon after weaning
    T Saito
    Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine, 2 1 3, Tsurumi ku, Yokohama 230 8501, Japan
    Arch Oral Biol 49:777-82. 2004
    ..These findings suggest that the changes in expression of IGF-I, IGF-II, IGFR2, IGFBP3, IGFBP4 and IGFBP6 are associated with the fibre-type alteration of rat masseter muscle in response to diet consistency soon after weaning...
  26. ncbi request reprint Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol
    W Ukai
    Department of Neuropsychiatry, School of Medicine, Sapporo Medical University, Chuo Ku, Japan
    J Neural Transm 111:667-81. 2004
    ..Haloperidol but not risperidone induces caspase-dependent apoptosis by reducing cellular survival signaling, which possibly contributes to the differential clinical therapeutic efficacy and expression of side effects in schizophrenia...
  27. ncbi request reprint Reduction by phytate-reduced soybean beta-conglycinin of plasma triglyceride level of young and adult rats
    T Aoyama
    Novelty Materials Research Institute, Hannan R and D Center, Fuji Oil Co. Ltd, Izumisano, Osaka, Japan
    Biosci Biotechnol Biochem 65:1071-5. 2001
    ..These results indicate that soybean beta-conglycinin may have lowering functions not only on plasma total cholesterol level, but also on plasma triglyceride level...
  28. ncbi request reprint Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats
    A Takahashi
    Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital, Sendai, Japan
    Methods Find Exp Clin Pharmacol 26:769-73. 2004
    ..Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth...
  29. ncbi request reprint The extent of alveolar bone loss is associated with impaired glucose tolerance in Japanese men
    T Saito
    Department of Preventive Dentistry, Kyushu University, Faculty of Dental Science, Fukuoka, and Self Defense Force, Kumamoto Hospital, Kumamoto, Japan
    J Periodontol 77:392-7. 2006
    ..These findings suggest that periodontal disease is a risk factor for diabetes, although more evidence is needed...
  30. doi request reprint Cell surface Lactobacillus plantarum LA 318 glyceraldehyde-3-phosphate dehydrogenase (GAPDH) adheres to human colonic mucin
    H Kinoshita
    Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai, Miyagi, Japan
    J Appl Microbiol 104:1667-74. 2008
    ..To characterize the adhesion molecule of Lactobacillus plantarum LA 318 that shows high adhesion to human colonic mucin (HCM)...
  31. ncbi request reprint Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans
    H Ishiguro
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Pharmacogenomics J 7:380-5. 2007
    ..007; odds ratio 1.25, 95% CI, (1.06-1.47)). CB2 under such environment is associated with the physiologic effects of alcohol and CB2 antagonists may have potential as therapies for alcoholism...
  32. ncbi request reprint T-type Ca2+ channels mediate propagation of odor-induced Ca2+ transients in rat olfactory receptor neurons
    S H Gautam
    Laboratory of Physiology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Neuroscience 144:702-13. 2007
    ..These data suggest that involvement of T-type Ca(2+) channels in the propagation of odor-induced Ca(2+) transients in ORNs may contribute to signal transduction and odor sensitivity...
  33. ncbi request reprint Firing patterns of rat vestibulospinal neurons during quadrupedal standing on a pitching platform
    S Fujiwara
    Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata, 992 8510 Japan
    J Physiol Sci 56:389-92. 2006
    ..The 3 groups may play differential roles in stance control...
  34. ncbi request reprint Imprinting disruption of the CDKN1C/KCNQ1OT1 domain: the molecular mechanisms causing Beckwith-Wiedemann syndrome and cancer
    K Higashimoto
    Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
    Cytogenet Genome Res 113:306-12. 2006
    ..In this review, we describe recent advances in epigenetic control of the CDKN1C/KCNQ1OT1 imprinted domain in both humans and mice...
  35. ncbi request reprint Evaluation of energy state of islet independent of size using a newly developed ATP bioluminescence assay
    S Ishii
    Department of Surgery I, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Transplant Proc 37:3499-500. 2005
    ..These data suggest that the ATP content of islets correlates with the islet size and that EC of islets widely fluctuates following isolation, indicating a significant role of monitoring ATP and EC of islets before transplantation...
  36. ncbi request reprint Cannabinoids modulate synaptic activity in the rat supraoptic nucleus
    A Soya
    Deparment of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Neuroendocrinol 17:609-15. 2005
    ..The results indicate that cannabinoids modulate the activity of magnocellular neurosecretory neurones by presynaptic inhibition of both excitatory and inhibitory synaptic transmission...
  37. pmc Disclosure preferences regarding cancer diagnosis and prognosis: to tell or not to tell?
    H Miyata
    Department of Social Gerontology, University of Tokyo, Japan
    J Med Ethics 31:447-51. 2005
    ..Contrary to popular belief, the seriousness of the cancer and people's demographic characteristics displayed little impact in this study...
  38. pmc Age associated axonal features in HNPP with 17p11.2 deletion in Japan
    H Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 76:1109-14. 2005
    ..To clarify age related changes in the clinicopathological features of hereditary neuropathy with liability to pressure palsy (HNPP) in Japanese patients with deletion of 17p11.2, particularly concerning axonal abnormalities...
  39. ncbi request reprint Elevation of both cyclooxygenase-2 and prostaglandin E2 receptor EP3 expressions in rat placenta after uterine artery ischemia-reperfusion
    K Yamazaki
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, South 1 West 16 Sapporo 060 8543, Japan
    Placenta 27:395-401. 2006
    ..These results suggested that induction of the COX-2-EP3 system in the placenta may be one of the causes of IUGR induced by uterine ischemia, because the EP3 receptor and PGE2 are well known to mediate vasoconstriction in many organs...
  40. ncbi request reprint Implication of increased NRSF/REST binding activity in the mechanism of ethanol inhibition of neuronal differentiation
    M Tateno
    Department of Neuropsychiatry, Sapporo Medical University, School of Medicine, Sapporo, Japan
    J Neural Transm 113:283-93. 2006
    ..These results suggest that ethanol-induced potentiation of NRSF binding activity underlies the mechanism of ethanol inhibition of neuronal differentiation and decreased neurogenesis...
  41. ncbi request reprint Relationship between obesity, glucose tolerance, and periodontal disease in Japanese women: the Hisayama study
    T Saito
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    J Periodontal Res 40:346-53. 2005
    ..Mean probing pocket depth and mean attachment loss were used as the dependent variables...
  42. ncbi request reprint Quantitative analysis of NF-kappaB-expression in cartilage and synovium of rat knee induced by intra-articular injection of synthetic lipid A
    M Tanimoto
    Inflamm Res 51:357-62. 2002
    ..NF-kappaB expression in cartilage and synovium of rat knee after intra-articular injection of lipid A was investigated...
  43. ncbi request reprint Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)
    N Ueki
    Helix Research Institute, Chiba, Japan
    J Hum Genet 44:193-6. 1999
    ..Mapping of a crucial gene in modulating the STAT3 signaling pathway may provide new clues to the understanding of malignancies or genetic disorders caused by this chromosome region...
  44. pmc Resistance of Fc receptor- deficient mice to fatal glomerulonephritis
    S Y Park
    Department of Molecular Genetics, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    J Clin Invest 102:1229-38. 1998
    ..These results demonstrate that the triggering of this type of glomerulonephritis is completely dependent on FcR+ cells...
  45. ncbi request reprint ATM mutations in patients with ataxia telangiectasia screened by a hierarchical strategy
    T Sasaki
    Division of Genome Analysis, Institute of Genetic Information, Kyushu University, Fukuoka, Japan
    Hum Mutat 12:186-95. 1998
    ..Overall, mutations were found in at least 75% of the different ATM alleles examined. Possible reasons for the inability to detect mutations in some patients are discussed...
  46. pmc Increased carotenoid production by the food yeast Candida utilis through metabolic engineering of the isoprenoid pathway
    H Shimada
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Kanagawa, Japan
    Appl Environ Microbiol 64:2676-80. 1998
    ..8 mg/g (dry weight) of cells. The findings of this study illustrate how modifications in related biochemical pathways can be utilized to enhance the production of commercially desirable compounds such as carotenoids...
  47. ncbi request reprint Identification and chromosome assignment of a human gene encoding a novel phosphatidylinositol-3 kinase
    N Seki
    Laboratory of Gene Structure 1, Kazusa DNA Research Institute, Chiba, Japan
    DNA Res 4:355-8. 1997
    ..2. This region is frequently lost in a variety of human malignancies, including neuroblastoma. The novel PI3K could be a candidate target of the 1p36 alteration that occurs in neuroendocrine tumors...
  48. ncbi request reprint Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene
    T Saito
    Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan
    DNA Res 4:301-5. 1997
    ..The chromosomal location of the gene was determined by fluorescence in situ hybridization and PCR-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid mapping panel...
  49. ncbi request reprint [Simple method for typing human immunodeficiency virus type I (B, E) by PCR and chronological change of distribution of subtype (B to E) in Japan]
    M Imai
    Department of Virology, Kanagawa Prefectural Public Health Laboratory
    Kansenshogaku Zasshi 71:918-23. 1997
    ..Although the number of Japanese female heterosexuals in our sample is small, clade B was isolated in 2 cases even after 1994...
  50. ncbi request reprint Effects of calcium channel blockers on steroidogenesis stimulated by ACTH and cAMP in isolated rat adrenal cells
    M Matsuki
    Department of Medicine, Kawasaki Medical School, Okayama, Japan
    Horm Metab Res 28:374-6. 1996
    ..Steroidogenesis stimulated by ACTH (10(-10) M) or cAMP (10(-3) M) was not inhibited by nifedipine (10(-4) M), but was strongly inhibited in a concentration-dependent manner by verapamil, diltiazem and prenylamine (10(-5) to 10(-4) M)...
  51. ncbi request reprint Cross-sectional comparisons of caries time trends in nursery school children in Sendai, Japan
    H Mayanagi
    Department of Pediatric Dentistry, Tohoku University, Sendai, Japan
    Community Dent Oral Epidemiol 23:344-9. 1995
    ..That in 5-yr-olds continued decreasing slightly during the 20-yr period. The marked reduction of caries experience in nursery school children shown during the 1970's did not continue through the 1980's or the beginning of the 1990's...
  52. ncbi request reprint [Mutations of HIV-1 RT gene isolated from patients treated with AZT]
    M Kondo
    Department of Virology, Kanagawa Prefectural Public Health Laboratories
    Kansenshogaku Zasshi 67:185-9. 1993
    ..All of 18 clones obtained from the patients not treated with AZT have no mutation at any codon mentioned above...
  53. ncbi request reprint [Reverse transcriptase gene analysis of HIV-1 mutants cultured in the presence of AZT]
    M Kondo
    Department of Virology, Kanagawa Prefectural Public Health Laboratories
    Kansenshogaku Zasshi 67:992-7. 1993
    ..All of the clones of the isolates obtained from the patients (06 or 07) had mutations at codon 215 and some of them had other mutations.(ABSTRACT TRUNCATED AT 250 WORDS)..
  54. ncbi request reprint Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets
    T Saito
    Division of Biology 216 76, California Institute of Technology, Pasadena 91125, USA
    Mol Cell Neurosci 6:280-92. 1995
    ..These data suggest that DRG11 is not only a useful marker for sensory neurons, but may also function in the establishment or maintenance of connectivity between some of these neurons and their central nervous system targets...
  55. pmc Cloning and sequencing of the Escherichia coli chlEN operon involved in molybdopterin biosynthesis
    T Nohno
    Department of Pharmacology, Kawasaki Medical School, Kurashiki, Japan
    J Bacteriol 170:4097-102. 1988
    ..The chlE and chlN genes were transcribed from a common promoter, chlEp, located upstream of chlE. Transcriptional and translational signal sequences were recognized in this region...
  56. ncbi request reprint The narK gene product participates in nitrate transport induced in Escherichia coli nitrate-respiring cells
    S Noji
    Department of Biochemistry, Okayama University Dental School, Japan
    FEBS Lett 252:139-43. 1989
    ..In the narK promoter region, we defined a unique sequence that we designate as a 'nitrate box', functioning as a putative NarL-binding site, in addition to the consensus sequence of the 'anaero-box'...
  57. ncbi request reprint Human hemangiosarcomas have a common polymorphism but no mutations in the connexin37 gene
    T Saito
    Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, Lyon, France
    Int J Cancer 86:67-70. 2000
    ....
  58. ncbi request reprint Three novel mutations (G27E, insAAC, R179X) in the ORNT1 gene of Japanese patients with hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome
    S Tsujino
    Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Ann Neurol 47:625-31. 2000
    ..All 3 patients were homozygous for their respective mutations. This study confirms that defects in the ORNT1 gene cause the HHH syndrome and that the genetic basis in Japanese patients is heterogeneous...
  59. ncbi request reprint Multiple endothelial injury in epicardial coronary artery induces downstream microvascular spasm as well as remodeling partly via thromboxane A2
    S Saitoh
    Fukushima Medical University, Japan
    J Am Coll Cardiol 37:308-15. 2001
    ..This model should be useful for examining the pathophysiology and treatment of microvascular angina...
  60. ncbi request reprint Effects of diet consistency on the myosin heavy chain mRNAs of rat masseter muscle during postnatal development
    T Saito
    Second Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine, 2 1 3 Tsurumi, Tsurumi ku, 230 8501, Yokohama, Japan
    Arch Oral Biol 47:109-15. 2002
    ..e. before weaning at 19 days). No MHC I mRNA was observed in any masseter studied. These results suggest that in the rat a soft diet facilitates an even more MHC IIb-rich phenotype in the masseter muscle than a hard diet...
  61. ncbi request reprint Effects of CYP2C19 gene polymorphism on cure rates for Helicobacter pylori infection by triple therapy with proton pump inhibitor (omeprazole or rabeprazole), amoxycillin and clarithromycin in Japan
    M Dojo
    Second Department of Internal Medicine, Fukui Medical University, Japan
    Dig Liver Dis 33:671-5. 2001
    ....
  62. ncbi request reprint The murine DNA-PKcs gene consists of 86 exons dispersed in more than 250 kb
    A Fujimori
    Division of Biology and Oncology, National Institute of Radiological Sciences, Chiba, Japan
    Genomics 45:194-9. 1997
    ..The SCID mutation site (Tyr4046) has been identified in exon 85. The genomic structure of the DNA-PKcs gene provides clues for the study of various functional domains in this macromolecule...
  63. ncbi request reprint Vasopressin differentially modulates noradrenaline release in the rat supraoptic nucleus
    T Yamashita
    Department of Physiology, Jichi Medical School, Tochigi-Ken 329-0498, Japan
    Neuroreport 12:3509-11. 2001
    ..The results suggest that dendritically released vasopressin modulates noradrenaline release within the supraoptic nucleus in a bimodal fashion...
  64. ncbi request reprint Coordinate regulation of endothelin and adrenomedullin secretion by oxidative stress in endothelial cells
    T Saito
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    Am J Physiol Heart Circ Physiol 281:H1364-71. 2001
    ..These findings elucidate the coordinate expression of two local vascular hormones, ET and Am, under oxidative stress, which may protect against vascular diseases...
  65. ncbi request reprint Medullary A1 noradrenergic neurones may mediate oxytocin release after noxious stimuli
    T Onaka
    Department of Physiology, Division of Endocrinology and Metabolism, Jichi Medical School, Minamikawachi-machi, Tochigi-Ken 329-0498, Japan
    Neuroreport 12:2499-502. 2001
    ..From these and reported data, we conclude that the medullary A1 noradrenergic neurones contribute, at least in part, to oxytocin release from the pituitary after noxious stimuli...
  66. ncbi request reprint Head injuries in snowboarders compared with head injuries in skiers. A prospective analysis of 1076 patients from 1994 to 1999 in Niigata, Japan
    O Fukuda
    Department of Neurosurgery, Saito Memorial Hospital, Minami-uonuma-gun, Niigata, Japan
    Am J Sports Med 29:437-40. 2001
    ..Four snowboarders and one skier died as a result of their head injuries. Our data suggest that snowboarding head injuries may be prevented by protection of the occipital region and refraining from jumping by beginners...
  67. ncbi request reprint Expression of intercellular adhesion molecules in epithelioid sarcoma and malignant rhabdoid tumor
    T Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pathol Int 51:532-42. 2001
    ..From our results, we conclude that beta-catenin membranous expression could be a useful marker for distinguishing ES, including the proximal variant, from MRT...
  68. ncbi request reprint Mesoderm formation by isolated and cultivated 8-cell stage blastomeres of the teleost, Leucopsarion ptersii (shiro-uo)
    T Saito
    Department of Marine Biology, Graduate School of Marine Science and Technology, Tokai University, Shimizu, Shizuoka, Japan
    Int J Dev Biol 45:661-8. 2001
    ..This also indicated non-equivalence or differentiation of the blastomeres from the very early cleavage stage in teleost embryos...
  69. ncbi request reprint Chronic hypernatremia derived from hypothalamic dysfunction: impaired secretion of arginine vasopressin and enhanced renal water handling
    A Fukagawa
    Department of Medicine, Jichi Medical School, Tochigi, Japan
    Endocr J 48:233-9. 2001
    ....
  70. ncbi request reprint Induction of immediate early genes after partial hepatectomy in cholestatic liver
    H Kanno
    First Department of Surgery, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan
    J Hepatobiliary Pancreat Surg 8:259-67. 2001
    ..IEG transcription does occur after partial hepatectomy in jaundiced liver but it is enhanced and sustained, and leads to apoptosis rather than leading to the efficient proliferation of hepatocytes...
  71. ncbi request reprint A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus
    K Q Xin
    Department of Bacteriology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan
    Hum Gene Ther 12:1047-61. 2001
    ..These results demonstrate that AAV-HIV vector immunization may provide a novel and promising HIV vaccination strategy...
  72. ncbi request reprint Combined revascularization strategy for acute myocardial infarction in patients with intracoronary thrombus: preceding intracoronary thrombolysis and subsequent mechanical angioplasty
    F Ishibashi
    Cardiovascular Division, Kumamoto Central Hospital, Japan
    Jpn Circ J 65:251-6. 2001
    ..The combined therapy may potentially provide better acute phase flow restoration in AMI patients with an intracoronary thrombus in a LAD lesion...
  73. ncbi request reprint Pre-emptive therapy against cytomegalovirus (CMV) disease guided by CMV antigenemia assay after allogeneic hematopoietic stem cell transplantation: a single-center experience in Japan
    Y Kanda
    Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan
    Bone Marrow Transplant 27:437-44. 2001
    ..We concluded that antigenemia-guided pre-emptive therapy with a decreased dose of ganciclovir and response-oriented dose adjustment might be appropriate to decrease the toxicity of ganciclovir without increasing the risk of CMV disease...
  74. ncbi request reprint Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells
    I Kobayashi
    Division of Immunology, Osaka University, Japan
    Int Immunol 4:1407-12. 1992
    ..Our results suggest that overexpression of IL-6R on B cells and absence of IL-6R on peripheral CD4+ cells are concurrent with, or may contribute to, B cell hyperreactivity and T cell abnormality in this strain...