Koh Ono

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint [Diagnosis and therapy of atherosclerosis through molecular biological approaches possibility of HDL-targeting therapy by manipulation of micro RNA-33]
    Koh Ono
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Rinsho Byori 61:934-9. 2013
  2. doi request reprint Current concept of reverse cholesterol transport and novel strategy for atheroprotection
    Koh Ono
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Cardiol 60:339-43. 2012
  3. ncbi request reprint Contribution of caveolin-1 alpha and Akt to TNF-alpha-induced cell death
    Koh Ono
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto 612 8555, Japan
    Am J Physiol Lung Cell Mol Physiol 287:L201-9. 2004
  4. pmc Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells
    Jungmook Lyu
    The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Cell Res 21:911-21. 2011
  5. pmc MicroRNAs and cardiovascular diseases
    Koh Ono
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    FEBS J 278:1619-33. 2011
  6. doi request reprint Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice
    Yukinori Tamura
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Arterioscler Thromb Vasc Biol 28:2195-201. 2008
  7. doi request reprint MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene
    Naoya Sowa
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Cell Biochem 113:3455-65. 2012
  8. doi request reprint Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes
    Tomohide Takaya
    Division of Translational Research and Clinical Research Institute, Kyoto Medical Center, National Hospital Organization, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto, Japan
    J Biol Chem 283:9828-35. 2008
  9. pmc MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes
    Hitoo Nishi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 31:744-55. 2011
  10. ncbi request reprint Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo
    Shoichi Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circulation 113:679-90. 2006

Detail Information

Publications70

  1. ncbi request reprint [Diagnosis and therapy of atherosclerosis through molecular biological approaches possibility of HDL-targeting therapy by manipulation of micro RNA-33]
    Koh Ono
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Rinsho Byori 61:934-9. 2013
    ..This review summarizes the function of HDL-C in reverse cholesterol transfer from peripheral tissue and discusses the latest HDL-targeting therapeutic strategies including the manipulation of microRNAs...
  2. doi request reprint Current concept of reverse cholesterol transport and novel strategy for atheroprotection
    Koh Ono
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Cardiol 60:339-43. 2012
    ..This review summarizes the function of HDL-C in reverse cholesterol transfer from peripheral tissue and discusses the latest HDL-targeting therapeutic strategies including the manipulation of microRNAs...
  3. ncbi request reprint Contribution of caveolin-1 alpha and Akt to TNF-alpha-induced cell death
    Koh Ono
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto 612 8555, Japan
    Am J Physiol Lung Cell Mol Physiol 287:L201-9. 2004
    ..In summary, our results indicate that caveolin-1 alpha preferentially sensitizes L929 cells to TNF-alpha through the activation of a PI3K/Akt signaling pathway...
  4. pmc Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells
    Jungmook Lyu
    The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Cell Res 21:911-21. 2011
    ..These results suggest that the Smek-containing PP4 complex represses transcription of Wnt-responsive development-related genes through histone deacetylation, and that this complex is essential for ESC pluripotency maintenance...
  5. pmc MicroRNAs and cardiovascular diseases
    Koh Ono
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    FEBS J 278:1619-33. 2011
    ..In the present minireview, the current relevant findings on the role of miRNAs in cardiac diseases are updated and the target genes of these miRNAs are summarized...
  6. doi request reprint Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice
    Yukinori Tamura
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Arterioscler Thromb Vasc Biol 28:2195-201. 2008
    ..In the present study, to further examine the role of CCR2 in the development of obesity and type 2 diabetes, we studied the effect of pharmacological inhibition of CCR2 from the early stage of obesity in db/db mice...
  7. doi request reprint MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene
    Naoya Sowa
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Cell Biochem 113:3455-65. 2012
    ..In conclusion, SCP1 itself has the potential to induce cardiac hypertrophy; however, the effect is suppressed by intronic miR-26b in cardiomyocytes. miR-26b has an antagonistic effect on its host gene SCP1...
  8. doi request reprint Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes
    Tomohide Takaya
    Division of Translational Research and Clinical Research Institute, Kyoto Medical Center, National Hospital Organization, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto, Japan
    J Biol Chem 283:9828-35. 2008
    ....
  9. pmc MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes
    Hitoo Nishi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 31:744-55. 2011
    ..These findings suggested that miR-27a regulates β-MHC gene expression by targeting TRβ1 in cardiomyocytes...
  10. ncbi request reprint Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo
    Shoichi Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circulation 113:679-90. 2006
    ..However, the role of p300-histone acetyltransferase activity in LV remodeling after myocardial infarction in vivo is unknown...
  11. doi request reprint Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress
    Kazuya Nagao
    Department of Cardiovascular Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 48:1157-68. 2010
    ..These findings demonstrate that NCAM is a cardioprotective factor up-regulated under metabolic stress in cardiomyocytes and augmentation of this signal improved survival...
  12. pmc Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway
    Takahiro Horie
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Cardiovasc Res 87:656-64. 2010
    ..The aim of the present study was to investigate the role(s) of miRNAs in acute Dox-induced cardiotoxicity...
  13. ncbi request reprint Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes
    Teruhisa Kawamura
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Japan
    J Biol Chem 280:19682-8. 2005
    ..5 promoter and of endogenous cardiac beta-myosin heavy chain during the differentiation. These findings demonstrate that acetylation of GATA-4 as well as of histones is involved in the differentiation of ES cells into cardiac myocytes...
  14. doi request reprint Transmitral E/A ratio decreases in association with abdominal fat accumulation in patients with impaired glucose tolerance or mild diabetes without left ventricular hypertrophy
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto 612 8555, Japan
    Heart Vessels 25:45-50. 2010
    ..In conclusion, diastolic abnormalities without LVH can be detected in Japanese patients with IGT or mild diabetes. The E/A ratio decreases in association with abdominal fat accumulation...
  15. ncbi request reprint Intensity of statin therapy, achieved low-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after coronary revascularization. Perspectives from the CREDO-Kyoto registry cohort-2
    Masahiro Natsuaki
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 76:1369-79. 2012
    ..Association of the type of statin and the achieved level of low-density lipoprotein cholesterol (LDL-C) with cardiovascular outcome has not been fully elucidated...
  16. ncbi request reprint MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells
    Tomohide Takaya
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
    Circ J 73:1492-7. 2009
    ..Although miRNA-1 (miR-1) and miRNA-133 (miR-133) are abundantly expressed in the adult heart and involved in cardiac hypertrophy, the roles of these miRNAs in spontaneous myocardial differentiation are unknown...
  17. ncbi request reprint Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes
    Teruhisa Kawamura
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ Res 94:1492-9. 2004
    ..These findings suggest that ET-1-dependent NFATc signaling associates with p300 in the transactivation of bcl-2 gene in cardiac myocytes...
  18. doi request reprint Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice
    Shinji Kaichi
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Cardiovasc Res 88:314-23. 2010
    ..iPS cells can be generated even without the expression of c-Myc. The present study examined patterns of differentiation of mouse iPS cells into cardiomyocytes in three different cell lines reprogrammed by three or four factors...
  19. doi request reprint Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes
    Shinji Kaichi
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Fushimi ku, Kyoto, Japan
    J Cell Physiol 226:248-54. 2011
    ..5 mRNA levels in ES cells as well as GFP expression in Nkx2.5/GFP ES cells. These findings demonstrate that Cdk9 is involved in the differentiation of mouse ES cells into cardiomyocytes by interacting with GATA4...
  20. doi request reprint MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes
    Takahiro Horie
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 389:315-20. 2009
    ..The present results indicated that miR-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiomyocytes...
  21. doi request reprint Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage
    Yasuhide Kuwabara
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circ Cardiovasc Genet 4:446-54. 2011
    ..The purpose of this study was to identify the source of elevated levels of circulating miRNAs and their function in cardiovascular diseases...
  22. pmc MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes
    Hitoo Nishi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 285:4920-30. 2010
    ..The present results suggest that miR-15b may decrease mitochondrial integrity by targeting Arl2 in the heart...
  23. doi request reprint Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto 612 8555, Japan
    Atherosclerosis 208:512-7. 2010
    ..However, the balance between circulating levels of VEGF and its soluble receptors, which may reflect and/or affect cardiovascular VEGF signaling, in subjects with MetS is unknown...
  24. doi request reprint TG-interacting factor is required for the differentiation of preadipocytes
    Takahiro Horie
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Lipid Res 49:1224-34. 2008
    ..These findings suggest that insulin specifically antagonizes TGF-beta signaling in preadipocytes by stabilizing the putative Smad transcriptional corepressor TGIF and regulates adipocyte differentiation...
  25. ncbi request reprint Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1
    Natsuhiko Ehara
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 321:345-9. 2004
    ..These findings demonstrate that activators of PPARgamma perturb the anti-apoptotic effects of ET-1 in cardiac myocytes and that this perturbation is, in part, based on functional transcriptional cross-talk between NFATc and PPARgamma...
  26. doi request reprint Impact of polyvascular disease on clinical outcomes in patients undergoing coronary revascularization: an observation from the CREDO-Kyoto Registry Cohort-2
    Yuko Morikami
    Department of Cardiovascular Medicine, Kyoto University, Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Atherosclerosis 228:426-31. 2013
    ..However, clinical outcomes after coronary revascularization in patients with polyvascular disease have not been fully elucidated...
  27. doi request reprint Influence of initial acute myocardial infarction presentation on the outcome of surgical procedures after coronary stent implantation: a report from the CREDO-Kyoto PCI/CABG Registry Cohort-2
    Akihiro Tokushige
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Cardiovasc Interv Ther 28:45-55. 2013
    ..Previous observations suggesting higher risk in early surgery might not be related to the timing after stent implantation per se, but related to more morbid preoperative conditions in patients who underwent early surgery...
  28. ncbi request reprint α1-Antitrypsin low-density-lipoprotein serves as a marker of smoking-specific oxidative stress
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, Fushimi ku, Kyoto, Japan
    J Atheroscler Thromb 19:47-58. 2012
    ..Recently, two novel, oxidatively modified LDL markers, serum amyloid A-LDL (SAA-LDL) and α1-antitrypsin-LDL (AT-LDL), were identified; however, the significance of SAA-LDL and AT-LDL as cardiovascular risk markers is unknown...
  29. doi request reprint The search for Nkx2-5-regulated genes using purified embryonic stem cell-derived cardiomyocytes with Nkx2-5 gene targeting
    Yasuhiro Nakashima
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 390:821-6. 2009
    ..Several genes with Nkx2-5-dependent changes in their expression were detected and confirmed by real-time PCR. This study investigated Nkx2-5-regulated gene expression in ESCM and suggested potential targets of Nkx2-5 in cardiogenesis...
  30. doi request reprint Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5
    Minako Kinoshita
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Endocrinol 24:1978-87. 2010
    ..In this study, we identified the regulation of adipocyte differentiation by 5-HT, 5-HT(2A)R, and 5-HT(2C)R. miR-448-mediated repression of KLF5 was identified as a negative regulator for adipocyte differentiation...
  31. pmc MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice
    Takahiro Horie
    Department of Cardiovascular Medicine, Kyoto University, Kyoto, Japan
    J Am Heart Assoc 1:e003376. 2012
    ..MicroRNA (miR)-33 is known to target ABCA1 and ABCG1 in vivo...
  32. doi request reprint Long-term outcomes after percutaneous coronary intervention for chronic total occlusion (from the CREDO-Kyoto registry cohort-2)
    Erika Yamamoto
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Cardiol 112:767-74. 2013
    ..8% vs 19.6%, p <0.0001). In conclusion, successful CTO-PCI compared with failed PCI was not associated with lesser risk for 3-year mortality. However, successful CTO-PCI was associated with significantly less subsequent CABG...
  33. ncbi request reprint Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers
    Rieko Takanabe-Mori
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, Kyoto 612 8555, Japan
    J Atheroscler Thromb 20:585-90. 2013
    ..LOX-1 interacts with C-reactive protein (CRP) and plays an important role in inflammatory diseases. We therefore hypothesized that LOX-1 may be involved in the onset of smoking-induced vascular inflammation...
  34. doi request reprint Statins activate GATA-6 and induce differentiated vascular smooth muscle cells
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto 612 8555, Japan
    Biochem Biophys Res Commun 374:731-6. 2008
    ..These findings suggest that statins activate GATA-6 and induce differentiated VSMCs...
  35. doi request reprint Progranulin expression in advanced human atherosclerotic plaque
    Yoji Kojima
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Atherosclerosis 206:102-8. 2009
    ..Since injury, inflammation and repair are common features in the progression of atherosclerosis, it is conceivable that PGRN plays a role in atherogenesis...
  36. doi request reprint Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice
    Rieko Takanabe-Mori
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1 1 Mukaihata cho, Fukakusa, Fushimi ku, Kyoto 612 8555, Japan
    Biochem Biophys Res Commun 398:576-80. 2010
    ..Thus, LOX-1 is required for the HFD-induced expression of proinflammatory cytokines in the adipose tissue of obese mice...
  37. doi request reprint Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet
    Rieko Takanabe
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
    Biochem Biophys Res Commun 376:728-32. 2008
    ....
  38. ncbi request reprint FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes
    Maretoshi Hirai
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 279:37640-50. 2004
    ..These findings demonstrate that FOG-2 represses hypertrophic responses in cardiac myocytes and that p300 is involved in these repressive effects...
  39. pmc Distinct characteristics of circulating vascular endothelial growth factor-a and C levels in human subjects
    Hiromichi Wada
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    PLoS ONE 6:e29351. 2011
    ..In conclusion, these findings demonstrate that VEGF-C, rather than VEGF-A, is closely related to dyslipidemia and atherosclerosis...
  40. doi request reprint CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model
    Hironobu Matsumae
    Department of Cardiovascular Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Arterioscler Thromb Vasc Biol 28:1077-83. 2008
    ..We hypothesized that knockdown of CCN1 may inhibit VSMC proliferation and suppress neointimal hyperplasia...
  41. doi request reprint Impact of statin therapy on late target lesion revascularization after sirolimus-eluting stent implantation (from the CREDO-Kyoto Registry Cohort-2)
    Masahiro Natsuaki
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Am J Cardiol 109:1387-96. 2012
    ..74, 95% confidence interval 0.46 to 1.20, p = 0.23). In conclusion, statin therapy at hospital discharge was associated with a significantly lower risk for late TLR after SES implantation...
  42. pmc MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo
    Takahiro Horie
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 107:17321-6. 2010
    ..Moreover, miR-33-deficient mice had significantly higher serum HDL cholesterol levels than WT mice. These data establish a critical role for miR-33 in the regulation of ABCA1 expression and HDL biogenesis in vivo...
  43. doi request reprint Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes
    Takahiro Horie
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Cell Physiol 215:733-42. 2008
    ..These results demonstrate that AMPK and PI3-K/Akt have an additive effect on oxidative stress-mediated GLUT4 translocation...
  44. doi request reprint Comparison of three-year clinical outcomes after sirolimus-eluting stent implantation among insulin-treated diabetic, non-insulin-treated diabetic, and non-diabetic patients from j-Cypher registry
    Tomohisa Tada
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Cardiol 107:1155-62. 2011
    ..However, regarding serious cardiovascular events, an excess risk was seen only in the DM-insulin group. The risk of serious cardiovascular events was similar between the DM-non-insulin and non-DM groups...
  45. doi request reprint Roles of microRNAs and myocardial cell differentiation
    Tomohide Takaya
    Division of Translational Research, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Prog Mol Biol Transl Sci 111:139-52. 2012
    ..In this report, microRNA is outlined, focusing on its role in myocardial differentiation...
  46. ncbi request reprint Trichostatin A induces myocardial differentiation of monkey ES cells
    Mohsen Hosseinkhani
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 356:386-91. 2007
    ..Thus, such induction as well as inhibition of histone deacetylase may be involved in TSA-induced differentiation of cynomolgus monkey ES cells into cardiomyocytes...
  47. ncbi request reprint Impact of diabetes on cardiovascular outcomes in hemodialysis patients undergoing coronary revascularization
    Masahiro Natsuaki
    Department of Cardiovascular of Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circ J 75:1616-25. 2011
    ....
  48. doi request reprint Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts
    Yodo Tamaki
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Mol Cell Cardiol 57:72-81. 2013
    ..Blockade of S100A4 may have therapeutic potential in cardiac hypertrophy and HF by attenuating cardiac fibrosis...
  49. doi request reprint Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure: association with adiponectin
    Shin Watanabe
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    Eur J Heart Fail 12:1214-22. 2010
    ..The association of IGF axis with serum adiponectin level, a prognostic marker of HF as well as a regulator of glucose/fatty acid metabolism, was also analysed...
  50. ncbi request reprint MicroRNAs and Lipoprotein Metabolism
    Takahiro Horie
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
    J Atheroscler Thromb 21:17-22. 2014
    ..In this review, we describe the current understanding of the function of miRNAs in lipid homeostasis, with a focus on lipoprotein metabolism. ..
  51. doi request reprint Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice
    Masayuki Sugimoto
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Japan
    Atherosclerosis 204:388-94. 2009
    ....
  52. ncbi request reprint Inter- and intra-observer variability for assessment of the synergy between percutaneous coronary intervention with TAXUS and cardiac surgery (SYNTAX) score and association of the SYNTAX score with clinical outcome in patients undergoing unprotected left
    Hiroki Shiomi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ J 75:1130-7. 2011
    ..The purpose of this study is to assess inter- and intra-observer variability for the assessment of the SYNTAX score in patients undergoing ULMCA stenting in daily clinical practice...
  53. pmc Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia
    Noriko Satoh-Asahara
    Division of Diabetic Research, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan
    Diabetes Care 35:2631-9. 2012
    ..In this study, we examined the effect of EPA on M1/M2-like phenotypes of peripheral blood monocytes in obese dyslipidemic patients...
  54. ncbi request reprint Small dense LDL-cholesterol relative to LDL-cholesterol is a strong independent determinant of hypoadiponectinemia in metabolic syndrome
    Noriko Satoh
    Division of Metabolic Research, Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center, 1 1 Fukakusa, Mukaihata cho, Fushimi ku, Kyoto 612 8555, Japan
    Circ J 72:932-9. 2008
    ..However, a precise analysis of the actual amount of sd-LDL-cholesterol (sd-LDL-C) in patients with metabolic syndrome (MS) has not been performed. Methods and..
  55. ncbi request reprint Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation
    Yukiko Abe
    Department of Cardiovascular Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto, 606 8507, Japan
    Am J Physiol Heart Circ Physiol 292:H2387-96. 2007
    ..13 +/- 0.09 mm). These results demonstrate that leptin induces the elongation of cardiac myocytes via a JAK/STAT pathway and chronic leptin infusion causes eccentric dilatation with augmented systolic function after myocardial infarction...
  56. ncbi request reprint Amiodarone inhibits interleukin 6 production and attenuates myocardial injury induced by viral myocarditis in mice
    Haruyasu Ito
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cytokine 17:197-202. 2002
    ..This study suggests that the beneficial effects of amiodarone in viral myocarditis may be mediated by decreasing interleukin 6 production in myocardial tissue...
  57. ncbi request reprint CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway
    Yoshinori Yoshida
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 355:611-8. 2007
    ..The antiapoptotic effect of CCN1 on cardiac myocytes together with its proangiogenic property could be beneficial in the treatment of ischemic heart disease...
  58. ncbi request reprint Circulating hepatocyte growth factor as a diagnostic marker of thrombus formation in patients with cerebral infarction
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Circ J 66:216-8. 2002
    ..The results suggests that circulating HGF is a reliable early marker of cerebral infarction, and that this new sensitive HGF assay may be useful for diagnosing cerebral thrombosis...
  59. doi request reprint L/T-type and L/N-type calcium-channel blockers attenuate cardiac sympathetic nerve activity in patients with hypertension
    Chika Ogura
    Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawaharacho, Shogoin, Sakyo ku, Kyoto606 8507, Japan
    Blood Press 21:367-71. 2012
    ..Antihypertensive monotherapy with efonidipine or cilnidipine attenuates cardiac sympathetic nerve activity more effectively than amlodipine monotherapy...
  60. pmc MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
    Takahiro Horie
    1 Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan 2 Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan 3
    Nat Commun 4:2883. 2013
    ..These results elucidate a novel interaction between SREBP-1 and SREBP-2 mediated by miR-33 in vivo. ..
  61. ncbi request reprint Suppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF-kappaB inhibitor
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8397, Japan
    Eur J Heart Fail 6:137-44. 2004
    ....
  62. ncbi request reprint Expression of p300 protects cardiac myocytes from apoptosis in vivo
    Teruhisa Kawamura
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 315:733-8. 2004
    ..These findings demonstrate that overexpression of p300 protects cardiac myocytes from doxorubicin-induced apoptosis and reduces the extent of acute heart failure in adult mice in vivo...
  63. ncbi request reprint Preformed angiotensin II is present in human mast cells
    Masatake Hara
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cardiovasc Drugs Ther 18:415-20. 2004
    ..However, their function remains unclear. In this study, preformed angiotensin II (ANG II), a potent growth factor, was found to be contained in, and released by, human mast cells...
  64. pmc Evidence for a role of mast cells in the evolution to congestive heart failure
    Masatake Hara
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8397, Japan
    J Exp Med 195:375-81. 2002
    ..These observations suggest that mast cells play a critical role in the progression of heart failure. Stabilization of mast cells may represent a new approach in the management of heart failure...
  65. ncbi request reprint Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan
    Toshikazu Jinnai
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ J 73:1498-503. 2009
    ..The effect of polymorphisms of CYP2C19, CYP3A4 and P2Y(12) on the antiplatelet effect of clopidogrel in clinical patients was examined in the present study...
  66. ncbi request reprint Serum adiponectin level as an independent predictor of mortality in patients with congestive heart failure
    Toshihiro Tamura
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    Circ J 71:623-30. 2007
    ..This study aimed to assess the significance of serum adiponectin as a prognostic marker for Japanese CHF patients...
  67. ncbi request reprint Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis
    Katsura Kitaura-Inenaga
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Circ J 67:881-4. 2003
    ..These findings suggest that mast cell chymase and tryptase participate in the acute inflammation and remodeling process of viral myocarditis...
  68. pmc Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death
    Koh Ono
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell Biol 23:665-76. 2003
    ..The increase in lysosomal size may due to intracellular self-digestion of dying cells. Big lysosomes are easy to rupture, and the release of hydrolytic enzymes from ruptured lysosomes can cause plasma membrane disruption...
  69. ncbi request reprint A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese
    Koh Ono
    National Cardiovascular Center, Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Atherosclerosis 173:315-9. 2004
    ..The AA genotype of HMOX1 reduced the incidence of ischemic heart disease, possibly due to the high expression level of HMOX1...
  70. pmc Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death
    Sung Ouk Kim
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 197:1441-52. 2003
    ..This paper delineates the dual signaling pathways that are required for Nur77 induction in macrophages and demonstrates a role of Nur77 in caspase-independent cell death...