Koh Ono

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. request reprint
    Ono K, Iwanaga Y, Hirayama M, Kawamura T, Sowa N, Hasegawa K. Contribution of caveolin-1 alpha and Akt to TNF-alpha-induced cell death. Am J Physiol Lung Cell Mol Physiol. 2004;287:L201-9 pubmed
    ..In summary, our results indicate that caveolin-1 alpha preferentially sensitizes L929 cells to TNF-alpha through the activation of a PI3K/Akt signaling pathway. ..
  2. Lyu J, Jho E, Lu W. Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells. Cell Res. 2011;21:911-21 pubmed publisher
    ..These results suggest that the Smek-containing PP4 complex represses transcription of Wnt-responsive development-related genes through histone deacetylation, and that this complex is essential for ESC pluripotency maintenance. ..
  3. Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, et al. MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol. Circ Res. 2017;120:835-847 pubmed publisher
    ..Our results demonstrate that miR-33 is involved in cardiac remodeling, and it preserves lipid raft cholesterol content in fibroblasts and maintains adaptive fibrotic responses in the remodeling heart. ..
  4. Nakao T, Horie T, Baba O, Nishiga M, Nishino T, Izuhara M, et al. Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways. Arterioscler Thromb Vasc Biol. 2017;37:2161-2170 pubmed publisher
    ..MiR-33 deficiency in recipient mice was also shown to contribute the inhibition of AAA formation. These data strongly suggest that inhibition of miR-33 will be effective as a novel strategy for treating AAA. ..

Detail Information

Publications4

  1. request reprint
    Ono K, Iwanaga Y, Hirayama M, Kawamura T, Sowa N, Hasegawa K. Contribution of caveolin-1 alpha and Akt to TNF-alpha-induced cell death. Am J Physiol Lung Cell Mol Physiol. 2004;287:L201-9 pubmed
    ..In summary, our results indicate that caveolin-1 alpha preferentially sensitizes L929 cells to TNF-alpha through the activation of a PI3K/Akt signaling pathway. ..
  2. Lyu J, Jho E, Lu W. Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells. Cell Res. 2011;21:911-21 pubmed publisher
    ..These results suggest that the Smek-containing PP4 complex represses transcription of Wnt-responsive development-related genes through histone deacetylation, and that this complex is essential for ESC pluripotency maintenance. ..
  3. Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, et al. MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol. Circ Res. 2017;120:835-847 pubmed publisher
    ..Our results demonstrate that miR-33 is involved in cardiac remodeling, and it preserves lipid raft cholesterol content in fibroblasts and maintains adaptive fibrotic responses in the remodeling heart. ..
  4. Nakao T, Horie T, Baba O, Nishiga M, Nishino T, Izuhara M, et al. Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways. Arterioscler Thromb Vasc Biol. 2017;37:2161-2170 pubmed publisher
    ..MiR-33 deficiency in recipient mice was also shown to contribute the inhibition of AAA formation. These data strongly suggest that inhibition of miR-33 will be effective as a novel strategy for treating AAA. ..