Yasushi Okuno

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Efficient tree-matching methods for accurate carbohydrate database queries
    Kiyoko F Aoki
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Genome Inform 14:134-43. 2003
  2. pmc KCaM (KEGG Carbohydrate Matcher): a software tool for analyzing the structures of carbohydrate sugar chains
    Kiyoko F Aoki
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 32:W267-72. 2004
  3. pmc GEM-TREND: a web tool for gene expression data mining toward relevant network discovery
    Chunlai Feng
    Department of Systems Bioscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshidashimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    BMC Genomics 10:411. 2009
  4. pmc GLIDA: GPCR--ligand database for chemical genomics drug discovery--database and tools update
    Yasushi Okuno
    Department of Pharmacoinformatics, Center for Integrative Education of Pharmacy Frontier, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Nucleic Acids Res 36:D907-12. 2008
  5. pmc Adverse event profiles of platinum agents: data mining of the public version of the FDA adverse event reporting system, AERS, and reproducibility of clinical observations
    Toshiyuki Sakaeda
    Center for Integrative Education in Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Int J Med Sci 8:487-91. 2011
  6. pmc Analysis of multiple compound-protein interactions reveals novel bioactive molecules
    Hiroaki Yabuuchi
    Department of Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Mol Syst Biol 7:472. 2011
  7. ncbi request reprint Heuristics for chemical compound matching
    Masahiro Hattori
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Genome Inform 14:144-53. 2003
  8. doi request reprint Dissecting kinase profiling data to predict activity and understand cross-reactivity of kinase inhibitors
    Satoshi Niijima
    Department of Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Chem Inf Model 52:901-12. 2012
  9. pmc Correlation index-based responsible-enzyme gene screening (CIRES), a novel DNA microarray-based method for enzyme gene involved in glycan biosynthesis
    Harumi Yamamoto
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto, Japan
    PLoS ONE 2:e1232. 2007
  10. doi request reprint Laplacian linear discriminant analysis approach to unsupervised feature selection
    Satoshi Niijima
    Department of Pharmacoinformatics, Center for Integrative Education of Pharmacy Frontier, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    IEEE/ACM Trans Comput Biol Bioinform 6:605-14. 2009

Detail Information

Publications48

  1. ncbi request reprint Efficient tree-matching methods for accurate carbohydrate database queries
    Kiyoko F Aoki
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Genome Inform 14:134-43. 2003
    ..Because we use similarity scores as opposed to a distance metric, our methods are more readily used to display trees of higher similarity. We present the two methods developed for this purpose and illustrate its validity...
  2. pmc KCaM (KEGG Carbohydrate Matcher): a software tool for analyzing the structures of carbohydrate sugar chains
    Kiyoko F Aoki
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 32:W267-72. 2004
    ..Analogously to BLAST, users are thus able to compare glycan structures of interest with glycans from different glycan databases using a variety of tree-alignment options. KCaM is currently available at http://glycan.genome.ad.jp...
  3. pmc GEM-TREND: a web tool for gene expression data mining toward relevant network discovery
    Chunlai Feng
    Department of Systems Bioscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshidashimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    BMC Genomics 10:411. 2009
    ..In order to support researchers to utilize the public gene expression data more effectively, we developed a web tool for finding similar gene expression data and generating its co-expression networks from a publicly available database...
  4. pmc GLIDA: GPCR--ligand database for chemical genomics drug discovery--database and tools update
    Yasushi Okuno
    Department of Pharmacoinformatics, Center for Integrative Education of Pharmacy Frontier, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Nucleic Acids Res 36:D907-12. 2008
    ..GLIDA is publicly available at http://pharminfo.pharm.kyoto-u.ac.jp/services/glida/. We hope that it will prove very useful for Chemical Genomics research and GPCR-related drug discovery...
  5. pmc Adverse event profiles of platinum agents: data mining of the public version of the FDA adverse event reporting system, AERS, and reproducibility of clinical observations
    Toshiyuki Sakaeda
    Center for Integrative Education in Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Int J Med Sci 8:487-91. 2011
    ..Adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to confirm platinum agent-associated adverse events, and to clarify the rank-order of these drugs in terms of susceptibility...
  6. pmc Analysis of multiple compound-protein interactions reveals novel bioactive molecules
    Hiroaki Yabuuchi
    Department of Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Mol Syst Biol 7:472. 2011
    ..The results of this study indicate that data derived from chemical genomics can be highly useful for exploring chemical space, and this systems biology perspective could accelerate drug discovery processes...
  7. ncbi request reprint Heuristics for chemical compound matching
    Masahiro Hattori
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Genome Inform 14:144-53. 2003
    ..Finally, we showed the effectiveness of our heuristics for compound pairs along metabolic pathways...
  8. doi request reprint Dissecting kinase profiling data to predict activity and understand cross-reactivity of kinase inhibitors
    Satoshi Niijima
    Department of Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Chem Inf Model 52:901-12. 2012
    ..We further illustrate that the preference of given compounds for kinases of interest is better understood by residue-fragment pairs, which could provide both biological and chemical insights into cross-reactivity...
  9. pmc Correlation index-based responsible-enzyme gene screening (CIRES), a novel DNA microarray-based method for enzyme gene involved in glycan biosynthesis
    Harumi Yamamoto
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto, Japan
    PLoS ONE 2:e1232. 2007
    ..However, a systematic approach for assessing the correlation between glycan expression and glycan-related gene expression has not been reported previously...
  10. doi request reprint Laplacian linear discriminant analysis approach to unsupervised feature selection
    Satoshi Niijima
    Department of Pharmacoinformatics, Center for Integrative Education of Pharmacy Frontier, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    IEEE/ACM Trans Comput Biol Bioinform 6:605-14. 2009
    ..It performs even better than Fisher score for some of the data sets, despite the fact that LLDA-RFE is fully unsupervised...
  11. pmc The KEGG resource for deciphering the genome
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 32:D277-80. 2004
    ..New efforts are being made to abstract knowledge, both computationally and manually, about ortholog clusters in the KO (KEGG Orthology) database, and to collect and analyze carbohydrate structures in the GLYCAN database...
  12. pmc Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method
    Soken Tsuchiya
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    BMC Genomics 10:35. 2009
    ..Mast cells (MCs) play pivotal roles in allergy and innate immunity and consist of heterogenous subclasses. However, the molecular basis determining the different characteristics of these multiple MC subclasses remains unclear...
  13. pmc GLIDA: GPCR-ligand database for chemical genomic drug discovery
    Yasushi Okuno
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida shimo adachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Nucleic Acids Res 34:D673-7. 2006
    ..GLIDA is publicly available at http://gdds.pharm.kyoto-u.ac.jp:8081/glida. We hope that it will prove very useful for chemical genomic research and GPCR-related drug discovery...
  14. pmc Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS
    Kaori Kadoyama
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    J Exp Clin Cancer Res 30:93. 2011
    ..The present study was performed to confirm whether the database could suggest the hypersensitivity reactions caused by anticancer agents, paclitaxel, docetaxel, procarbazine, asparaginase, teniposide, and etoposide...
  15. pmc Data mining of the public version of the FDA Adverse Event Reporting System
    Toshiyuki Sakaeda
    Center for Integrative Education in Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Int J Med Sci 10:796-803. 2013
    ..In this article, the latest information on this area is summarized for future pharmacoepidemiological studies and/or pharmacovigilance analyses. ..
  16. doi request reprint Cross-target view to feature selection: identification of molecular interaction features in ligand-target space
    Satoshi Niijima
    Department of Systems Bioscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Chem Inf Model 51:15-24. 2011
    ..These results suggest that our approach has the potential to uncover the molecular basis for ligand selectivity and off-target effects...
  17. pmc MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells
    Soken Tsuchiya
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    Nucleic Acids Res 37:3821-7. 2009
    ..Therefore, we concluded that both miR-338-3p and miR-451 are necessary for the development of epithelial cell polarity...
  18. pmc Quantitative transcriptomic profiling of branching in a glycosphingolipid biosynthetic pathway
    Hiromu Takematsu
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto 606 8501, Japan
    J Biol Chem 286:27214-24. 2011
    ..Collectively, these data suggest that transcriptomic assessment of macromolecule biosynthetic pathways can disclose a global regulatory mechanism(s) even when unexpected...
  19. doi request reprint Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines
    Yoshinao Ruike
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho Sakyo ku, Kyoto 606 8501, Japan
    J Hum Genet 53:515-23. 2008
    ..The data collected here will be of value for further studies into the function of miRNA...
  20. ncbi request reprint Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions
    Masaaki Kotera
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Am Chem Soc 126:16487-98. 2004
    ....
  21. doi request reprint Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleus
    Mari Sakaida
    1Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Psychopharmacol 27:1058-69. 2013
    ..The results of the present study indicated that ECS treatment could modulate PVN functions through altered gene expression, which may contribute to its antidepressant effects. ..
  22. ncbi request reprint Adverse event profile of tigecycline: data mining of the public version of the U.S. Food and Drug Administration adverse event reporting system
    Kaori Kadoyama
    Center for Integrative Education in Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Biol Pharm Bull 35:967-70. 2012
    ..The adverse events suggested were in agreement with information provided by the manufacturer, suggesting that off-label use hardly results in unexpected adverse events, presumably due to usage with extreme caution...
  23. pmc Adverse event profiles of 5-fluorouracil and capecitabine: data mining of the public version of the FDA Adverse Event Reporting System, AERS, and reproducibility of clinical observations
    Kaori Kadoyama
    Center for Integrative Education in Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Int J Med Sci 9:33-9. 2012
    ..The safety profiles of oral fluoropyrimidines were compared with 5-fluorouracil (5-FU) using adverse event reports (AERs) submitted to the Adverse Event Reporting System, AERS, of the US Food and Drug Administration (FDA)...
  24. doi request reprint Systems biology and systems chemistry: new directions for drug discovery
    J B Brown
    Department of Systems Bioscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Chem Biol 19:23-8. 2012
    ..We review some of the recent developments in systems-level research for drug design and discovery, and discuss the directions that some drug design efforts are heading toward...
  25. ncbi request reprint Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways
    Masahiro Hattori
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Am Chem Soc 125:11853-65. 2003
    ..Furthermore, it was found that the pathway modules identified by similar compound structures sometimes overlap with the pathway modules identified by genomic contexts, namely, by operon structures of enzyme genes...
  26. doi request reprint Histamine synthesis is required for granule maturation in murine mast cells
    Shunsuke Nakazawa
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Eur J Immunol 44:204-14. 2014
    ..These results suggest that histamine promotes granule maturation in mast cells and acts as an proinflammatory mediator. ..
  27. pmc Statin-associated muscular and renal adverse events: data mining of the public version of the FDA adverse event reporting system
    Toshiyuki Sakaeda
    Center for Development of Integrative Education in Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e28124. 2011
    ....
  28. pmc Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation
    Yuko Naito
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 27:3008-22. 2007
    ..Thus, Neu5Gc is required for optimal negative regulation, and the reaction is specifically suppressed in activated B cells, i.e., germinal center B cells...
  29. doi request reprint Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells
    Hirotsugu Takano
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    FEBS Lett 582:1444-50. 2008
    ..The gene expression profile obtained by the microarray analyses was found to reflect many aspects of the differentiation. Our system is thus helpful to gain deeper insights into terminal differentiation of CTMCs...
  30. ncbi request reprint A probabilistic model for mining implicit 'chemical compound-gene' relations from literature
    Shanfeng Zhu
    Bioinformatics Center, Institute for Chemical Research, Kyoto University Gokasho, Uji, Japan
    Bioinformatics 21:ii245-51. 2005
    ..Our focus is to mine implicit 'chemical compound and gene' relations from the co-occurrence in the literature...
  31. ncbi request reprint Comprehensive analysis of the effect of phytoestrogen, daidzein, on a testicular cell line, using mRNA and protein expression profile
    Tetsuya Adachi
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachicho, Sakyo ku, Kyoto 606 8501, Japan
    Food Chem Toxicol 43:529-35. 2005
    ....
  32. ncbi request reprint Augmentation of drug-induced cell death by ER protein BRI3BP
    Tetsuo Yamazaki
    The 21st Century Center of Excellence Program, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 362:971-5. 2007
    ..Taken together, BRI3BP, widely expressed in animal cell types, seems to possess a pro-apoptotic property and can potentiate drug-induced apoptosis...
  33. doi request reprint Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus
    Eri Segi-Nishida
    Department of Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neuropharmacology 71:164-73. 2013
    ..Our data show an effect of ECS on increased expression of anorexigenic factors in the VMH, and suggest a role in the regulation of energy homeostasis by ECS...
  34. pmc LIGAND: database of chemical compounds and reactions in biological pathways
    Susumu Goto
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 30:402-4. 2002
    ..genome.ad.jp/ligand/). LIGAND may be also downloaded by anonymous FTP (ftp://ftp.genome.ad.jp/pub/kegg/ligand/)...
  35. doi request reprint Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6
    Masao Doi
    Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Nat Med 16:67-74. 2010
    ..Translation of these findings to humans will require clinical examination of human HSD3B1 gene, which we found to be functionally similar to mouse Hsd3b6...
  36. pmc Application of a New Probabilistic Model for Mining Implicit Associated Cancer Genes from OMIM and Medline
    Shanfeng Zhu
    Bioinformatics Center, Institute for Chemical Research, Kyoto University
    Cancer Inform 2:361-71. 2007
    ..Further experiments showed that MAM found new cancer-gene relations which are unknown in the literature. Supplementary information can be found at http://www.bic.kyotou.ac.jp/pathway/zhusf/CancerInformatics/Supplemental2006.html...
  37. doi request reprint Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag
    Yoshiaki Yamaguchi
    Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Science 342:85-90. 2013
    ....
  38. pmc Platinum agent-induced hypersensitivity reactions: data mining of the public version of the FDA adverse event reporting system, AERS
    Toshiyuki Sakaeda
    Center for Development of Integrative Education in Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Int J Med Sci 8:332-8. 2011
    ..Adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to confirm the platinum agent-associated mild, severe, and lethal hypersensitivity reactions...
  39. doi request reprint Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors
    Jun Takahashi
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Bioorg Med Chem Lett 20:1718-20. 2010
    ..A quantitative structure-activity relationship (QSAR) study indicated that logS might be a key feature of the improved compounds...
  40. ncbi request reprint MicroRNA: biogenetic and functional mechanisms and involvements in cell differentiation and cancer
    Soken Tsuchiya
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Pharmacol Sci 101:267-70. 2006
    ..These evidences offer the possibility that miRNAs would be potentially useful for drug discovery...
  41. ncbi request reprint [In silico drug discovery based on the integration of bioinformatics and chemoinformatics]
    Yasushi Okuno
    Department of Pharmacoinformatics, Centre for Integrative Education of Pharmacy Frontier, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Yakugaku Zasshi 128:1645-51. 2008
    ..These are promising approaches to accelerating drug discovery processes...
  42. ncbi request reprint Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins
    Atsushi Ikeda
    Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 363:835-9. 2007
    ..Moreover, gene expression was slightly altered in the JP-DKO cerebellum. Therefore, the mutant PCs bear marginal but widespread abnormalities, all of which likely cause cerebellar motor defects in JP-DKO mice...
  43. ncbi request reprint Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Immunol 175:2606-12. 2005
    ..These results suggest that the PGE2-EP2 system contributes to the local production of G-CSF during acute inflammation...
  44. doi request reprint Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer
    Hiroaki Kawanishi
    Department of Urology, Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Clin Cancer Res 14:2579-87. 2008
    ..The purpose of this study was to identify proteins that are potentially involved in the tumor invasion of bladder cancer...
  45. ncbi request reprint Microarray evaluation of EP4 receptor-mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 322:911-7. 2004
    ..These results suggest that PGE(2) inhibits a crucial step of the adipocyte differentiation process by acting on the EP4 receptor in 3T3-L1 cells...
  46. ncbi request reprint Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Toxicol Lett 167:106-13. 2006
    ..DNA microarray analysis using RNA prepared from tumor marker-positive foci and control tissues provided a candidate gene link to the early stage of carcinogenesis and hepatotoxicity...
  47. ncbi request reprint [New progress in crystallization technology of membrane protein and introduction of pharamaceutical innovation value chain]
    Tsuyoshi Inoue
    Graduate School of Engineering Osaka University, Yamada oka, Suita City, Japan
    Yakugaku Zasshi 128:497-505. 2008
    ..In this paper, we report the recent research work on the crystallization of membrane proteins and the development of a method for in silico drug discovery...
  48. pmc Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis
    Masateru Yamada
    Pharmaceutical Research Laboratories, Toray Industries, Inc, 1111 Tebiro Kamakura, Kanagawa 248 8555, Japan
    Proc Natl Acad Sci U S A 102:7736-41. 2005
    ..Our results show that CK2 plays a critical role in the progression of immunogenic renal injury, and therefore, CK2 is a potential target for GN therapy...