Affiliation: Kyoto University
Okamura H, Doi M, Fustin J, Yamaguchi Y, Matsuo M. Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences. Adv Drug Deliv Rev. 2010;62:876-84 pubmed publisher
..Disrupting this exquisitely harmonious system causes abnormal expression of cell-type specific clock-controlled genes, as revealed by the etiology of life-style related diseases such as hypertension. ..
Yamaguchi Y, Okamura H. Vasopressin Signal Inhibition in Aged Mice Decreases Mortality under Chronic Jet Lag. iScience. 2018;5:118-122 pubmed publisher
..Moreover, we found that pharmacological inactivation of V1a and V1b signaling decreased mortality even in aged wild-type mice, thus providing a potential pharmaceutical intervention for shiftwork-related health problems. ..
Chao H, Doi M, Fustin J, Chen H, Murase K, Maeda Y, et al
. Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway. Nat Commun. 2017;8:2238 pubmed publisher
..These data provide clear evidence that the Period genes not only orchestrate dynamic changes in metabolic activity, but also regulate homeostatic self-renewal of hepatocytes through Mkp1-Erk1/2 signaling pathway. ..
Okamura H, Doi M, Yamaguchi Y, Fustin J. Hypertension due to loss of clock: novel insight from the molecular analysis of Cry1/Cry2-deleted mice. Curr Hypertens Rep. 2011;13:103-8 pubmed publisher
..The human homologue of this aldosterone-producing, cell-specific enzyme was also characterized and represents a new possibility in the pathogenesis of hypertension. ..
Yamamura K, Doi M, Hayashi H, Ota T, Murai I, Hotta Y, et al
. Immunolocalization of murine type VI 3Î²-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta. Mol Cell Endocrinol. 2014;382:131-138 pubmed publisher
..Taken together, our data revealed that Hsd3b6 is localized in multiple specific tissues and cell types, perhaps thereby involved in biosynthesis of a number of tissue-specific steroid hormones with different physiological roles. ..