Yoko Okamoto

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. doi request reprint Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia
    Yoko Okamoto
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neuroreport 20:990-6. 2009
  2. doi request reprint Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease
    Kenji Matsumura
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Bioorg Med Chem 21:3356-62. 2013
  3. pmc Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains
    Masahiro Ono
    Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    ACS Chem Neurosci 2:269-75. 2011
  4. doi request reprint Selective white matter abnormalities in a novel rat model of vascular dementia
    Akihiro Kitamura
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Neurobiol Aging 33:1012.e25-35. 2012
  5. pmc Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts
    Yoko Okamoto
    Department of Neurology, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    Acta Neuropathol 123:381-94. 2012
  6. doi request reprint Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia
    Yoshiki Hase
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Exp Neurol 233:523-33. 2012
  7. pmc Development of novel 123I-labeled pyridyl benzofuran derivatives for SPECT imaging of β-amyloid plaques in Alzheimer's disease
    Masahiro Ono
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 8:e74104. 2013
  8. doi request reprint Novel ¹⁸F-labeled benzoxazole derivatives as potential positron emission tomography probes for imaging of cerebral β-amyloid plaques in Alzheimer's disease
    Mengchao Cui
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Med Chem 55:9136-45. 2012
  9. doi request reprint Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease
    Hiroyuki Watanabe
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Bioorg Med Chem Lett 22:5700-3. 2012
  10. doi request reprint Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation
    Hidefumi Ito
    Department of Neurology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Japan
    Acta Neuropathol 122:223-9. 2011

Collaborators

Detail Information

Publications14

  1. doi request reprint Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia
    Yoko Okamoto
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neuroreport 20:990-6. 2009
    ..These results indicate that cortical microinfarcts are caused by the pathomechanism related to Alzheimer's disease, most likely to amyloid angiopathy...
  2. doi request reprint Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease
    Kenji Matsumura
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Bioorg Med Chem 21:3356-62. 2013
    ..12-0.33%ID/g at 60 min after the injection) the brain. In conclusion, appropriate structural modifications of SBIM derivatives could lead to more useful agents for the in vivo imaging of NFT in AD brains...
  3. pmc Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains
    Masahiro Ono
    Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    ACS Chem Neurosci 2:269-75. 2011
    ..54%ID/g, 2 min postinjection) into and a rapid washout (0.25%ID/g, 60 min postinjection) from the brain. [(123)I]TH2 should be further investigated as a potential imaging agent for detecting tau pathology...
  4. doi request reprint Selective white matter abnormalities in a novel rat model of vascular dementia
    Akihiro Kitamura
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Neurobiol Aging 33:1012.e25-35. 2012
    ..This led to significant spatial working memory impairment of a magnitude similar to the 2VO rats at 28 days postoperation. The 2VGO model may more closely mimic cognitive impairment subsequent to selective white matter damage...
  5. pmc Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts
    Yoko Okamoto
    Department of Neurology, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    Acta Neuropathol 123:381-94. 2012
    ..Our results suggest that cerebral hypoperfusion accelerates CAA, and thus promotes CMIs...
  6. doi request reprint Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia
    Yoshiki Hase
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Exp Neurol 233:523-33. 2012
    ..Particular emphasis will be placed on the plasma-microvessel interface...
  7. pmc Development of novel 123I-labeled pyridyl benzofuran derivatives for SPECT imaging of β-amyloid plaques in Alzheimer's disease
    Masahiro Ono
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 8:e74104. 2013
    ..These combined results warrant further investigation of [(123)I]8 as a SPECT imaging agent for visualizing Aβ plaques in the AD brain. ..
  8. doi request reprint Novel ¹⁸F-labeled benzoxazole derivatives as potential positron emission tomography probes for imaging of cerebral β-amyloid plaques in Alzheimer's disease
    Mengchao Cui
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Med Chem 55:9136-45. 2012
    ..The results suggest [(18)F]24 to be a useful PET agent for detecting Aβ plaques in the living human brain...
  9. doi request reprint Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease
    Hiroyuki Watanabe
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Bioorg Med Chem Lett 22:5700-3. 2012
    ..6-1.4%ID/g at 30 min). In fluorescence staining experiments using AD brain sections, 14 clearly stained NFTs. 3-OI may serve as a new molecular scaffold for developing novel NFT imaging agents...
  10. doi request reprint Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation
    Hidefumi Ito
    Department of Neurology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Japan
    Acta Neuropathol 122:223-9. 2011
    ..We postulate that optineurinopathy is closely linked with TDP-proteinopathy and speculate that this heterozygous E478G mutation would cause ALS by acting through a dominant-negative mechanism...
  11. pmc The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice
    Mahito Yamada
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e16567. 2011
    ..Therefore, we investigated whether chronic cerebral hypoperfusion influences cognitive ability or amyloid β deposition in amyloid precursor protein (APP) overexpressing transgenic mice...
  12. doi request reprint Suitability of the montreal cognitive assessment versus the mini-mental state examination in detecting vascular cognitive impairment
    Masafumi Ihara
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Stroke Cerebrovasc Dis 22:737-41. 2013
    ..Our findings suggest that the MoCA-J is more sensitive than the MMSE in screening for cognitive impairment in patients with subcortical vascular cognitive impairment. ..
  13. ncbi request reprint Leukoencephalopathy with cognitive impairment following tocilizumab for the treatment of rheumatoid arthritis (RA)
    Katsuya Kobayashi
    Department of Neurology, Kyoto University Hospital, Kyoto
    Intern Med 48:1307-9. 2009
    ..The leukoencephalopathy might have been caused by a mechanism related to tocilizumab itself. It is strongly recommended to perform MRI if a patient develops any cognitive impairment during tocilizumab therapy...
  14. pmc Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model
    Yoko Okamoto
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 6:e20427. 2011
    ..To further investigate the role of 14-3-3 proteins in ALS, we performed immunohistochemical analysis of 14-3-3 proteins and compared their distributions with those of SOD1 in FALS patients and SOD1-overexpressing mice...