Research Topics
Genomes and Genes | Masahiko OkamotoSummaryAffiliation: Kyoto Prefectural University of Medicine Country: Japan Publications
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Publications
Management and outcome of living kidney grafts with multiple arteriesYayoi Kadotani
Department of Transplantation and Regenerative Surgery, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto, 602-8566, Japan
Surg Today 35:459-66. 2005..CONCLUSION: Multiple renal artery grafts procured by open nephrectomy can be transplanted as successfully as those with single arteries, by using meticulous suturing techniques...
Histopathologic evaluation of living kidney donor candidates by pre-operative kidney biopsyMasahiko Okamoto
Department of Organ Interaction Research Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Clin Transplant 23:58-61. 2009..Longer-term studies will be needed to clarify the outcome in both the donors and recipients in these cases...- Analysis of preexisting baseline kidney lesions revealed by biopsy in living kidney donors: relationship with clinical parameters at the time of donationMasahiko Okamoto
Department of Organ Interaction Research Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
Clin Transplant 24:27-30. 2010..A follow-up study will be required to determine whether these mild histological findings at the time of donation influence long-term outcome in the donor... - Clinicopathological evaluation of renal allograft treated with anti-CD25 monoclonal antibodyMasahiko Okamoto
Department of Organ Interaction Research Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Clin Transplant 19:49-53. 2005..The careful inspection is necessary to find out the occurrences of acute rejection more than 2 months after transplantation because immunological situation has been changing around this period... - Ten-year protocol biopsy findings of renal allografts in the calcineurin inhibitor eraMasahiko Okamoto
Department of Organ Interaction Research Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Clin Transplant 20:16-9. 2006..Longer follow-up studies are needed to confirm whether CNI should be continued or not in the long-term period following kidney transplantation for better graft survival... - The consequences for live kidney donors with preexisting glucose intolerance without diabetic complication: analysis at a single Japanese centerMasahiko Okamoto
Department of Organ Interaction Research Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
Transplantation 89:1391-5. 2010..To assess the indications for live kidney donation in glucose intolerance (GI), we analyzed perioperative complications associated with donor nephrectomies performed at our institution and followed up the long-term consequences... - Clinicopathological evaluation of renal allografts of four patients by 20-year protocol biopsiesMasahiko Okamoto
Department of Transplantation and Endocrine Surgery, Kyoto Prefectural University of Medicine, Kyoto 602, Japan
Clin Transplant 17:20-4. 2003..We conclude that the protocol biopsies even at 20 years can contribute to predict the fate of renal allografts... - Short- and long-term donor outcomes after kidney donation: analysis of 601 cases over a 35-year period at Japanese single centerMasahiko Okamoto
Department of Organ Interaction Research Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Transplantation 87:419-23. 2009..The lack of deceased donors in Japan means that living-donor kidney transplantation is necessary in as many as 80% of cases. However, there are few data on perioperative complications and long-term outcome for live kidney donors... - A case of recurrent focal segmental glomerulosclerosis (FSGS) involving massive proteinuria (>50 g/day) immediately after renal transplantationMasahiko Okamoto
Department of Organ Interaction Research Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
Clin Transplant 25:53-8. 2011..The patient's clinical course was compatible with FSGS recurrence. Although the early pathological changes were not typical of FSGS, they might be indicative of the primary lesion that subsequently progresses to typical FSGS... - Therapeutic drug monitoring of mycophenolic acid in renal transplant recipientsM Okamoto
Department of Transplantation and Regenerative Surgery, Graduate School of Medical Science, Kyoto, Japan
Transplant Proc 37:859-60. 2005..The possible target level of MPA AUC0-9 would be approximately 30 ng.hr/mL using the present immunosuppressive regimen... - Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral headMasahiko Shibatani
Department of Orthopedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Acta Orthop 79:631-6. 2008..It has been suggested that avascular osteonecrosis (AVN) of the femoral head develops early after renal transplantation. We evaluated the relationship between risk of AVN and dose of steroids administered in different time periods... - ApoB C7623T polymorphism predicts risk for steroid-induced osteonecrosis of the femoral head after renal transplantationTetsurou Hirata
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii chou, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
J Orthop Sci 12:199-206. 2007.... - Tissue factor antisense oligonucleotides prevent renal ischemia-reperfusion injuryMasahide Matsuyama
Department of Organ Transplant and Endocrine Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Kamigyouku, Kyoto, Japan
Transplantation 76:786-91. 2003..CONCLUSIONS: The results indicate that AS-1/TF inhibited the ischemia-reperfusion injury of the kidney. Microcirculatory incompetence resulting from microthrombus may cause the formation and development of necrosis... - Findings of graft biopsy specimens within 90 days after ABO blood group incompatible living donor kidney transplantation compared with ABO-identical and non-identical transplantationHidetaka Ushigome
Department of Transplantation and Regenerative Surgery, Kyoto Prefectural University Graduate School of Medical Science, Kyoto, Japan
Clin Transplant 24:16-21. 2010..AMR was difficult to be diagnosed by C4d analysis in ABO-incompatible transplant cases. Glomerular injury score, g score, may be considered as more significant and the injury should be cured thoroughly... - Clinical pharmacokinetics of mycophenolate mofetil in Japanese renal transplant recipients: A retrospective cohort study in a single centerNobuyuki Sugioka
Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan
Biol Pharm Bull 29:2099-105. 2006..However, though not frequently, AUC obtained by multiple blood sampling after MMF dosing was needed. In addition, EHRA has led to increasing interest in MMF medication... - Current status of organ transplantation in Japan and worldwideNorio Yoshimura
Department of Organ Transplant and Regenerative Surgery, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Hirokoji Kawaramachi, Kamigyo ku, Kyoto, 602 0841, Japan
Surg Today 40:514-25. 2010..Eight recipients survived and stopped parenteral nutrition with full-functioning grafts. Amendment of the Japanese law for the utilization of deceased donors should increase the number available donors in the future... - Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymorphisms related to the coagulation and fibrinolytic systems in Japanese subjectsTakeshi Asano
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Transplantation 77:220-5. 2004.... - Low molecular weight phenotype of Apo(a) is a risk factor of corticosteroid-induced osteonecrosis of the femoral head after renal transplantTetsurou Hirata
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
J Rheumatol 34:516-22. 2007..We examined the relationships between development of ONF and genetic variations and plasma level of lipoprotein(a) (Lp(a)), which is closely involved in the coagulation and fibrinolytic systems and lipid metabolism... - A case of living-related renal transplant from the donor with membranous nephropathyKiyokazu Akioka
Department of Transplantation and Regenerative Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Clin Transplant 23:62-6. 2009..Marginally appropriate donors might be considered for renal graft because of the shortage of donors. A successful outcome after kidney transplantation from a living-related donor diagnosed as membranous nephropathy is reported... - Antisense oligonucleotide for tissue factor inhibits hepatic ischemic reperfusion injuryKenji Nakamura
Department of Organ Transplant and Endocrine Surgery, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, 465 Hirokoji, Kawaramachi, Kamigyo ku, Kyoto City, Kyoto 602 8566, Japan
Biochem Biophys Res Commun 297:433-41. 2002..These results suggest that AS-1/TF can strongly suppress the expression of TF and thereby inhibit ischemic reperfusion injury to the rat liver... - Overlapped glomerular lesions of chronic rejection and recurrent lupus nephritis in transplanted kidney: a case reportNaoko Masuzawa
Department of Surgical Pathology, Graduate School of Medical Science, Kamigyo ku, Kyoto, Japan
Clin Transplant 25:49-52. 2011..Complete morphologic studies with both immunofluorescence and electron microscopic evaluations in addition to microscopic examination should be performed to elucidate complex histological findings... - Expression of cyclooxygenase-1 and -2 in human breast cancerNorio Yoshimura
Department of Organ Transplant and Endocrinological Surgery, Kyoto Prefectural University of Medicine, 465 Hirokoji, Kawaramachi, Kamigyo ku, 602 0841 Kyoto, Japan
Surg Today 33:805-11. 2003..We investigated the expression of cyclooxygenase (Cox-1 and Cox-2) in mammary tissues from patients with breast cancer... - Pulmonary embolism in a living-related kidney transplantation donorHidetaka Ushigome
Department of Organ Transplant and Endoclinological Surgery, Kyoto Prefectural University of Medicine, 465 Hirokoji, Kawaramachi, Kamikyo-ku, Kyoto 602-8566, Japan
Surg Today 33:399-402. 2003..It is very important for surgeons to realize that serious complications such as PE can develop in any case of living donor nephrectomy... - Efficacy of tonsillectomy for patients with recurrence of IgA nephropathy after kidney transplantationHidetaka Ushigome
Department of Transplantation and Regenerative Surgery, Kyoto Prefectural University Graduate School of Medical Science, Kyoto, Japan
Clin Transplant 23:17-22. 2009..Tonsillectomy had possibility to be a favorable treatment of hematuria or proteinuria in recurrent IgAN recipients... - BK virus-associated nephropathy in a kidney transplant recipient successfully treated with cidofovir, the first case in JapanKiyokazu Akioka
Department of Transplantation and Regenerative Surgery, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Int J Urol 15:369-71. 2008..BK virus DNA in the blood decreased under the threshold level. sCr was stable and remained about 2.2 mg/dl for three months after the final treatment of cidofovir... - The role of tissue factor in renal ischemic reperfusion injury of the ratHidetaka Ushigome
Department of Organ Transplant and Endocrinological Surgery, Kyoto Prefectural University of Medicine, Kyoto 602, Japan
J Surg Res 102:102-9. 2002..These results also suggest that TFPI plays a key role in modulating tissue factor-dependent blood coagulation, therefore TFPI is a strong medication for prevention of ischemic reperfusion injury... - Effect of plasma lipid on pharmacokinetics of ciclosporin and its relationship with plasma prednisolone level in renal transplant patientsNobuyuki Sugioka
Department of Pharmacokinetics, Kyoto Pharmaceutical University, Yamashina ku, and Department of Hospital Pharmacy, Kyoto Prefectural University of Medicine, Kamigyou ku Kyoto 602 8566, Japan
J Pharm Pharmacol 58:1193-200. 2006..These results suggested that monitoring of the biochemical parameters of the plasma lipid and plasma PSL level might be useful for the TDM of CyA... - [Indication and current issues in liver transplantation for hepatocellular carcinoma]Satoshi Kaihara
Department of Transplantation and Regenerative Surgery, Kyoto Prefectural University of Medicine
Nippon Shokakibyo Gakkai Zasshi 101:264-8. 2004 - The beneficial effect of high-dose mizoribine combined with cyclosporine, basiliximab, and corticosteroids on CMV infection in renal transplant recipientsNorio Yoshimura
Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, 465 Hirokoji, Kawaramachi, Kamikyo ku, Kyoto 602 8566, Japan
Clin Exp Nephrol 17:127-33. 2013..Therefore, we investigated whether high-dose MZR, at 6 mg/kg/day, would be effective and safe for kidney transplant patients in conjunction with cyclosporine (CsA), basiliximab, and corticosteroids... - ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantationTakeshi Asano
Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
Pharmacogenetics 13:675-82. 2003..An assessment of C3435T and G2677T/A polymorphisms preceding steroid treatment could be useful for predicting the resistance to ONF development... - Endoscopic resection for the diagnosis of visceral Kaposi's sarcomaJunichi Sakagami
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajiicho Hirokoji Kamigyoku, Kyoto 602-8566, Japan
J Gastroenterol 40:98-103. 2005..This is the first report of a patient with visceral Kaposi's sarcoma who underwent endoscopic resection that reliably confirmed histological diagnosis and the viral genome at the same time... - [The present status and future of organ transplantation]Norio Yoshimura
Department of Organ Transplant and Endocrine Surgery, Kyoto Prefectural University of Medicine
Nihon Rinsho Meneki Gakkai Kaishi 25:156-69. 2002 - Successful treatment of invasive pulmonary aspergillosis after ABO-incompatible living donor liver transplantation under rapid steroid withdrawal protocolSatoshi Kaihara
Transplantation 83:1408-9. 2007