Takayuki Ohshima

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4
    Takayuki Ohshima
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 278:50833-42. 2003
  2. ncbi Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification
    Takayuki Ohshima
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 279:29551-7. 2004
  3. ncbi BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3
    Takayuki Hishiki
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 282:28335-43. 2007
  4. pmc Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination
    Osamu Isono
    Laboratory of Human Tumor Viruses, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 283:34273-82. 2008
  5. ncbi Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3
    Hiroshi Koga
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 279:52978-83. 2004
  6. ncbi Suppression of hepatitis C virus replicon by TGF-beta
    Takayuki Murata
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Virology 331:407-17. 2005
  7. ncbi HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein
    Jun Matsumoto
    Laboratory of Human Tumor Viruses, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Oncogene 24:1001-10. 2005
  8. ncbi Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53
    Jye Yee Lin
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    FEBS Lett 573:15-8. 2004
  9. pmc Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
    Hiroaki Daitoku
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Ten noudai, Tsukuba, Ibaraki 305 8577, Japan
    Proc Natl Acad Sci U S A 101:10042-7. 2004
  10. ncbi Relevance of nuclear localization and functions of RNA helicase A
    Hidetoshi Fujita
    Institute of Medical Science, St Marianna University School of Medicine, Kanagawa 216 8512, Japan
    Int J Mol Med 15:555-60. 2005

Collaborators

  • Makoto Hijikata
  • Jun Matsumoto
  • Keiji Tanaka
  • Yusuke Miyanari
  • Yasushi Saeki
  • Kunitada Shimotohno
  • Osamu Isono
  • Takayuki Hishiki
  • Hidetoshi Fujita
  • Takayuki Murata
  • Akiyoshi Fukamizu
  • Toshihiro Nakajima
  • Satoko Aratani
  • Hiroaki Daitoku
  • Hiroshi Koga
  • Jye Yee Lin
  • Takeshi Ego
  • Takayuki Oishi
  • Masashi Yamaji
  • Masahiro Hosaka
  • Ryouji Fujii
  • Mitsutoki Hatta
  • Hitomi Matsuzaki
  • Makoto Miyagishi

Detail Information

Publications10

  1. ncbi Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4
    Takayuki Ohshima
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 278:50833-42. 2003
    ..These findings illustrate a novel regulatory mechanism by which Smad-dependent transcriptional activation cooperatively modulates Smad proteins through receptor-mediated phosphorylation and sumoylation...
  2. ncbi Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification
    Takayuki Ohshima
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 279:29551-7. 2004
    ..These results suggest that the PPARgamma-dependent transactivation pathway seems to be modulated by SUMO-1 modification and may serve as a novel target for apoptosis-induction therapy in cancer cells...
  3. ncbi BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3
    Takayuki Hishiki
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 282:28335-43. 2007
    ..In addition to stimulating transcription from the HTLV-1 LTR, Tax also enhances BCL3 expression; thus, transcription from the LTR is regulated by both positive and negative feedback mechanisms...
  4. pmc Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination
    Osamu Isono
    Laboratory of Human Tumor Viruses, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 283:34273-82. 2008
    ..These findings disclose a novel viral strategy to utilize the cellular proteolytic system for viral propagation...
  5. ncbi Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3
    Hiroshi Koga
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 279:52978-83. 2004
    ..These results provide important clues toward understanding the molecular mechanism of Tax-dependent transcriptional activation of the HTLV-I LTR...
  6. ncbi Suppression of hepatitis C virus replicon by TGF-beta
    Takayuki Murata
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Virology 331:407-17. 2005
    ..These results suggest a novel insight into the mechanisms of liver diseases caused by HCV...
  7. ncbi HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein
    Jun Matsumoto
    Laboratory of Human Tumor Viruses, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Oncogene 24:1001-10. 2005
    ..These results suggest dual effects of HBZ on the suppression of AP-1 activity by inhibiting c-Jun function, which may contribute to the dysregulation of cell proliferation...
  8. ncbi Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53
    Jye Yee Lin
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    FEBS Lett 573:15-8. 2004
    ..In particular, in cells treated with adriamycin that is a DNA damaging agent and that enhances phosphorylation of p53 at Ser-20, SUMO conjugation of p53 was severely impaired possibly by reduced affinity of Ubc9 to p53...
  9. pmc Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
    Hiroaki Daitoku
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Ten noudai, Tsukuba, Ibaraki 305 8577, Japan
    Proc Natl Acad Sci U S A 101:10042-7. 2004
    ..Our findings establish Foxo1 as a direct and functional target for Sir2 in mammalian systems...
  10. ncbi Relevance of nuclear localization and functions of RNA helicase A
    Hidetoshi Fujita
    Institute of Medical Science, St Marianna University School of Medicine, Kanagawa 216 8512, Japan
    Int J Mol Med 15:555-60. 2005
    ..Our results indicated that the intracellular localization of RHA might be regulated by not only NLS and NES but also functional domains...