Kazuto Nosaka

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. doi request reprint Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae
    Kazuto Nosaka
    Department of Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kita ku, Kyoto 603 8334, Japan
    FEBS Lett 582:3991-6. 2008
  2. ncbi request reprint Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae
    Kazuto Nosaka
    Department of Chemistry, Kyoto Prefectural University of Medicine, Kita ku, Kyoto 603 8334, Japan
    Mol Microbiol 58:467-79. 2005
  3. ncbi request reprint Recent progress in understanding thiamin biosynthesis and its genetic regulation in Saccharomyces cerevisiae
    Kazuto Nosaka
    Department of Chemistry, Kyoto Prefectural University of Medicine, Kita ku, Kyoto, 603 8334, Japan
    Appl Microbiol Biotechnol 72:30-40. 2006
  4. ncbi request reprint Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae
    Mari Onozuka
    Department of Radioisotope Laboratory, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    FEMS Yeast Res 8:266-75. 2008
  5. doi request reprint Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation
    Kazuto Nosaka
    Department of Chemistry, Hyogo College of Medicine, Nishinomiya, Japan
    FEMS Microbiol Lett 330:140-7. 2012
  6. ncbi request reprint Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene
    Mari Onozuka
    Department of Biochemistry and Molecular Biology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:274-7. 2005
  7. doi request reprint Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant
    Kenichi Akaji
    Department of Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kita ku, Kyoto 603 8334, Japan
    Bioorg Med Chem 16:9400-8. 2008
  8. doi request reprint Evaluation of retro-inverso modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster
    Tadashi Tatsumi
    Department of Medicinal Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kita ku, Kyoto 603 8334, Japan
    Bioorg Med Chem 18:2720-7. 2010
  9. doi request reprint Synthesis of [19, 35, 36-(13)C(3)]-labeled TAK779 as a molecular probe
    Hiroyuki Konno
    Department of Chemistry, Kyoto Prefectural University of Medicine, Kita ku, Japan
    Bioorg Med Chem 17:5769-74. 2009
  10. ncbi request reprint NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth
    Erika Jin
    Department of Biology, Kyoto Prefectural University of Medicine, Taisyogun Nishitakatsukasa cho 13, Kita ku, Kyoto 603 8334, Japan
    Neurochem Int 51:216-26. 2007

Collaborators

Detail Information

Publications14

  1. doi request reprint Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae
    Kazuto Nosaka
    Department of Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kita ku, Kyoto 603 8334, Japan
    FEBS Lett 582:3991-6. 2008
    ..We explored the hypothesis that Thi3p causes a conformational change in Pdc2p leading to full transactivation activity under favorable conditions...
  2. ncbi request reprint Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae
    Kazuto Nosaka
    Department of Chemistry, Kyoto Prefectural University of Medicine, Kita ku, Kyoto 603 8334, Japan
    Mol Microbiol 58:467-79. 2005
    ..This is the first report of the involvement of the TDP-binding motif in genetic regulation...
  3. ncbi request reprint Recent progress in understanding thiamin biosynthesis and its genetic regulation in Saccharomyces cerevisiae
    Kazuto Nosaka
    Department of Chemistry, Kyoto Prefectural University of Medicine, Kita ku, Kyoto, 603 8334, Japan
    Appl Microbiol Biotechnol 72:30-40. 2006
    ..Thiamin-hyperproducing yeast and fermented food containing a high content of thiamin are expected to be available in the future based on the progress in understanding thiamin biosynthesis and its genetic regulation in S. cerevisiae...
  4. ncbi request reprint Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae
    Mari Onozuka
    Department of Radioisotope Laboratory, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    FEMS Yeast Res 8:266-75. 2008
    ..It is proposed that the thiaminase II activity of Thi20p is involved in the thiamin salvage pathway by catalyzing the hydrolysis of HMP precursors in S. cerevisiae...
  5. doi request reprint Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation
    Kazuto Nosaka
    Department of Chemistry, Hyogo College of Medicine, Nishinomiya, Japan
    FEMS Microbiol Lett 330:140-7. 2012
    ..On the other hand, the association of Pdc2p with PDC5 was unaffected by thiamin. We also identified a DNA element in the upstream region of PDC5, which can bind to Pdc2p and is required for the expression of PDC5...
  6. ncbi request reprint Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene
    Mari Onozuka
    Department of Biochemistry and Molecular Biology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:274-7. 2005
    ..These findings indicate the importance of the Sp1 cis-element in regulating the hTPK1 gene expression...
  7. doi request reprint Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant
    Kenichi Akaji
    Department of Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kita ku, Kyoto 603 8334, Japan
    Bioorg Med Chem 16:9400-8. 2008
    ..The results indicated for the first time that the tetrapeptide sequence is enough for inhibitory activities of peptide-aldehyde derivatives...
  8. doi request reprint Evaluation of retro-inverso modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster
    Tadashi Tatsumi
    Department of Medicinal Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kita ku, Kyoto 603 8334, Japan
    Bioorg Med Chem 18:2720-7. 2010
    ..Inhibitory activities of the new inhibitors suggest that partially modified RI inhibitors would interact with HTLV-1 protease in the same manner as the parent hydroxyethylamine inhibitor...
  9. doi request reprint Synthesis of [19, 35, 36-(13)C(3)]-labeled TAK779 as a molecular probe
    Hiroyuki Konno
    Department of Chemistry, Kyoto Prefectural University of Medicine, Kita ku, Japan
    Bioorg Med Chem 17:5769-74. 2009
    ....
  10. ncbi request reprint NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth
    Erika Jin
    Department of Biology, Kyoto Prefectural University of Medicine, Taisyogun Nishitakatsukasa cho 13, Kita ku, Kyoto 603 8334, Japan
    Neurochem Int 51:216-26. 2007
    ..Taken together, the NGF-dependent formation of ruffles might not require Ras/PI-3k/Akt/GSK-3beta, but these pathways might contribute to the formation of intact neurites due to combined actions including Rac1...
  11. doi request reprint Intracellular dynamics of topoisomerase I inhibitor, CPT-11, by slit-scanning confocal Raman microscopy
    Yoshinori Harada
    Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Hirokoji Kawaramachi, Kamigyo ku, Kyoto 602 8566, Japan
    Histochem Cell Biol 132:39-46. 2009
    ..We conclude that Raman spectromicroscopic imaging is useful for pharmacokinetic studies of anticancer drugs in living cells...
  12. ncbi request reprint Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase
    Mari Onozuka
    Department of Biochemistry, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:156-62. 2003
    ..53-fold of the wild-type). It was therefore suggested that the residues Gln-96, Thr-99, Arg-131, and Asp-133 are conserved as functionally significant components for substrate recognition in thiamin pyrophosphokinase...
  13. ncbi request reprint Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae
    Yuko Kawasaki
    Department of Food Microbiology, Doshisha Women s College, Kamigyo ku, Kyoto 602 0893, Japan
    Curr Genet 47:156-62. 2005
    ..We discuss the possibility that HMP is not involved in the pathway of de novo thiamin synthesis in S. cerevisiae...
  14. ncbi request reprint Thiamine-responsive congenital lactic acidosis: clinical and biochemical studies
    Mitsuo Toyoshima
    Division of Child Neurology, Institute of Neurological Science, Faculty of Medicine, Tottori University, Yonago, Japan
    Pediatr Neurol 33:98-104. 2005
    ..Careful monitoring of lactate and pyruvate would be useful in determining thiamine dosage...