Ohtsura Niwa

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies
    Ohtsura Niwa
    Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Oncogene 22:7078-86. 2003
  2. ncbi request reprint The novel surveillance mechanism of the Trp53-dependent s-phase checkpoint ensures chromosome damage repair and preimplantation-stage development of mouse embryos fertilized with x-irradiated sperm
    Tsutomu Shimura
    Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Radiat Res 158:735-42. 2002
  3. ncbi request reprint Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes
    Megumi Toyoshima
    Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Oncogene 24:3229-35. 2005
  4. pmc p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm
    Tsutomu Shimura
    Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 22:2220-8. 2002
  5. ncbi request reprint Persistent induction of somatic reversions of the pink-eyed unstable mutation in F1 mice born to fathers irradiated at the spermatozoa stage
    Kazunori Shiraishi
    Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Radiat Res 157:661-7. 2002
  6. doi request reprint Radiation induction of delayed recombination in Schizosaccharomyces pombe
    Jun Takeda
    Department of Radiation System Biology, Radiation Biology Center, Kyoto University, Yoshida Konoe, Kyoto, Japan
    DNA Repair (Amst) 7:1250-61. 2008
  7. ncbi request reprint Indirect mechanisms of genomic instability and the biological significance of mutations at tandem repeat loci
    Ohtsura Niwa
    Kyoto University Radiation Biology Center, Yoshida Konoe, Kyoto 606 8501, Japan
    Mutat Res 598:61-72. 2006
  8. ncbi request reprint Generation of pluripotent stem cells from neonatal mouse testis
    Mito Kanatsu-Shinohara
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cell 119:1001-12. 2004
  9. doi request reprint BM-ca is a newly defined type I/II anti-CD20 monoclonal antibody with unique biological properties
    Michio Nishida
    Late Effects Studies, Radiation Biology Center, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Int J Oncol 38:335-44. 2011

Detail Information

Publications9

  1. ncbi request reprint Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies
    Ohtsura Niwa
    Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Oncogene 22:7078-86. 2003
    ..Among these, transmission of genomic instability to the second generation of irradiated parents is limited to the mouse minisatellite system, and awaits further clarification in other experimental systems...
  2. ncbi request reprint The novel surveillance mechanism of the Trp53-dependent s-phase checkpoint ensures chromosome damage repair and preimplantation-stage development of mouse embryos fertilized with x-irradiated sperm
    Tsutomu Shimura
    Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Radiat Res 158:735-42. 2002
    ..These results suggest that the Trp53-dependent S-phase checkpoint is a surveillance mechanism involved in the repair of chromosome damage and ensures the preimplantation-stage development of sperm-irradiated embryos...
  3. ncbi request reprint Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes
    Megumi Toyoshima
    Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Oncogene 24:3229-35. 2005
    ..Taken together, the transcription-independent function of p53 associated with the DNA-binding domain is involved in the S-phase checkpoint in collaboration with yet another unidentified target protein(s)...
  4. pmc p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm
    Tsutomu Shimura
    Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 22:2220-8. 2002
    ..These results revealed the presence of p53-dependent pronuclear cross talk and a novel function of p53 in the S-phase DNA damage checkpoint of mouse zygotes...
  5. ncbi request reprint Persistent induction of somatic reversions of the pink-eyed unstable mutation in F1 mice born to fathers irradiated at the spermatozoa stage
    Kazunori Shiraishi
    Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Radiat Res 157:661-7. 2002
    ..The present study demonstrates the presence of a long-lasting memory of DNA damage and the persistent up-regulation of recombinogenic activity in the retinal pigment epithelium of the developing fetus...
  6. doi request reprint Radiation induction of delayed recombination in Schizosaccharomyces pombe
    Jun Takeda
    Department of Radiation System Biology, Radiation Biology Center, Kyoto University, Yoshida Konoe, Kyoto, Japan
    DNA Repair (Amst) 7:1250-61. 2008
    ..These results suggest that the epigenetic damage memory induced by DNA DSB upregulates untargeted and delayed recombination in S. pombe...
  7. ncbi request reprint Indirect mechanisms of genomic instability and the biological significance of mutations at tandem repeat loci
    Ohtsura Niwa
    Kyoto University Radiation Biology Center, Yoshida Konoe, Kyoto 606 8501, Japan
    Mutat Res 598:61-72. 2006
    ....
  8. ncbi request reprint Generation of pluripotent stem cells from neonatal mouse testis
    Mito Kanatsu-Shinohara
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cell 119:1001-12. 2004
    ..The ability to derive multipotential stem cells from the neonatal testis has important implications for germ cell biology and opens the possibility of using these cells for biotechnology and medicine...
  9. doi request reprint BM-ca is a newly defined type I/II anti-CD20 monoclonal antibody with unique biological properties
    Michio Nishida
    Late Effects Studies, Radiation Biology Center, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Int J Oncol 38:335-44. 2011
    ..Overall, the present data show that BM-ca is a novel anti-CD20 mAb that may be classified as a type I/II. The therapeutics efficacy of BM-ca awaits its use in clinical trials...